AU4254696A - Novel substituted dtpa derivatives, their metal complexes, pharmaceutical compositions containing these complexes and their use in diagnosis and therapy - Google Patents

Novel substituted dtpa derivatives, their metal complexes, pharmaceutical compositions containing these complexes and their use in diagnosis and therapy

Info

Publication number
AU4254696A
AU4254696A AU42546/96A AU4254696A AU4254696A AU 4254696 A AU4254696 A AU 4254696A AU 42546/96 A AU42546/96 A AU 42546/96A AU 4254696 A AU4254696 A AU 4254696A AU 4254696 A AU4254696 A AU 4254696A
Authority
AU
Australia
Prior art keywords
complexes
diagnosis
therapy
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU42546/96A
Other languages
English (en)
Inventor
Thomas Balzer
Michael Bauer
Werner Krause
Franz-Karl Maier
Andreas Muhler
Wolf-Rudiger Press
Gabriele Schuhmann-Giampieri
Ulrich Speck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of AU4254696A publication Critical patent/AU4254696A/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Pathology (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU42546/96A 1994-11-30 1995-11-20 Novel substituted dtpa derivatives, their metal complexes, pharmaceutical compositions containing these complexes and their use in diagnosis and therapy Abandoned AU4254696A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US387408 1982-06-11
US35108694A 1994-11-30 1994-11-30
US351086 1994-11-30
US38740895A 1995-02-13 1995-02-13
PCT/EP1995/004548 WO1996016928A1 (de) 1994-11-30 1995-11-20 Neuartig substituierte dtpa-derivate, deren metallkomplexe, diese komplexe enthaltende pharmazeutische mittel und deren verwendung in der diagnostik und therapie

Publications (1)

Publication Number Publication Date
AU4254696A true AU4254696A (en) 1996-06-19

Family

ID=26996938

Family Applications (3)

Application Number Title Priority Date Filing Date
AU42546/96A Abandoned AU4254696A (en) 1994-11-30 1995-11-20 Novel substituted dtpa derivatives, their metal complexes, pharmaceutical compositions containing these complexes and their use in diagnosis and therapy
AU42994/96A Abandoned AU4299496A (en) 1994-11-30 1995-11-20 Novel multiple-substituent dtpa derivatives and metal complexes thereof, pharmaceutical compositions containing such complexes, their use in diagnosis and therapy, methods ofpreparing the complexing agents and complexes and methods of preparing the pharmaceutical compositions
AU39227/95A Abandoned AU3922795A (en) 1994-11-30 1995-11-20 Use of metal complexes as liver and gall bladder radiodiagnosis agents in computer tomography

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU42994/96A Abandoned AU4299496A (en) 1994-11-30 1995-11-20 Novel multiple-substituent dtpa derivatives and metal complexes thereof, pharmaceutical compositions containing such complexes, their use in diagnosis and therapy, methods ofpreparing the complexing agents and complexes and methods of preparing the pharmaceutical compositions
AU39227/95A Abandoned AU3922795A (en) 1994-11-30 1995-11-20 Use of metal complexes as liver and gall bladder radiodiagnosis agents in computer tomography

Country Status (15)

Country Link
US (4) US5672335A (pt-PT)
EP (3) EP0794939A1 (pt-PT)
JP (3) JPH10511934A (pt-PT)
CN (1) CN1167444A (pt-PT)
AU (3) AU4254696A (pt-PT)
CA (3) CA2206397A1 (pt-PT)
CZ (1) CZ166897A3 (pt-PT)
FI (3) FI972288A0 (pt-PT)
HU (1) HUT77284A (pt-PT)
IL (3) IL116208A0 (pt-PT)
MX (1) MX9703880A (pt-PT)
NO (3) NO972457L (pt-PT)
PL (1) PL320462A1 (pt-PT)
SK (1) SK68997A3 (pt-PT)
WO (3) WO1996016928A1 (pt-PT)

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GB9501560D0 (en) 1995-01-26 1995-03-15 Nycomed Imaging As Contrast agents
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IT1283650B1 (it) * 1996-08-02 1998-04-23 Bracco Spa Chelati paramagnetici ad alta relassivita' in siero
US6458337B1 (en) 1996-08-02 2002-10-01 Dibra S.P.A Diagnostic imaging contrast agent with improved in serum relaxivity
US6403055B1 (en) 1996-08-02 2002-06-11 Dibra S.P.A. Diagnostic imaging contrast agent with improved in serum relaxivity
IT1290417B1 (it) * 1996-08-02 1998-12-03 Bracco Spa Composti chelanti derivati di acidi poliamminopolicarbossilici, loro chelati con ioni metallici paramagnetici, loro preparazione ed
US7521531B2 (en) 1996-08-28 2009-04-21 Immunomedics, Inc. Methods for the purification of stable radioiodine conjugates
US6558669B1 (en) 1996-08-28 2003-05-06 Immunomedics, Inc. Stable radioiodine conjugates and methods for their synthesis
WO1998028258A1 (en) 1996-12-23 1998-07-02 Bracco Research S.A. Compositions for increasing the mri contrast in visualising the digestive tract of patients
DE19719033C1 (de) * 1997-04-29 1999-01-28 Schering Ag Ionenpaare, Verfahren zu ihrer Herstellung und ihre Verwendung als Kontrastmittel
US6019959A (en) * 1997-07-31 2000-02-01 Schering Aktiengesellschaft Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis
US6153655A (en) 1998-04-17 2000-11-28 Enzon, Inc. Terminally-branched polymeric linkers and polymeric conjugates containing the same
US6767741B1 (en) 1999-08-27 2004-07-27 Invitrogen Corporation Metal binding compounds and their use in cell culture medium compositions
EP1362053B1 (en) * 2001-02-20 2007-11-14 Enzon, Inc. Terminally-branched polymeric linkers and polymeric conjugates containing the same
DE10127126A1 (de) * 2001-06-05 2002-12-19 Forschungszentrum Juelich Gmbh Geschützte Tyrosinderivate, Verfahren zu deren Herstellung und deren Verwendung zur Herstellung von O-(2-[·18·F]-Fluorethyl)-L-tyrosin
US6627394B2 (en) 2001-07-19 2003-09-30 Common Sense Ltd. Diagnostic pad
EP1805188A4 (en) 2004-09-30 2010-03-03 Mds Analytical Technologies Us COMPLEXES OF LUMINESCENT LANTHANIDES
GB0423506D0 (en) * 2004-10-22 2004-11-24 Univ Belfast Light emitting complex salts
EP2717934A4 (en) * 2011-06-06 2015-01-14 Oregon State X-RAY CONTRACTS FROM WISMUT PARTICLES
CA2873652A1 (en) * 2012-05-18 2013-11-21 Markus Berger Bis azainositol heavy metal complexes for x-ray imaging
BR102013023479B1 (pt) * 2013-09-12 2022-07-26 Uniao Brasileira De Educação E Assistência Processo de síntese de compostos de coordenação à base de lantanídeo
CN109613177B (zh) 2014-07-01 2021-08-20 科蒙森斯公司 用于鉴定羊水的诊断组合物
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
ES2814555T3 (es) 2016-11-28 2021-03-29 Bayer Pharma AG Compuestos de quelato de gadolinio con alta relaxividad para usar en la obtención de imágenes por resonancia magnética
JP6836471B2 (ja) 2017-07-20 2021-03-03 株式会社神戸製鋼所 流体流通装置
JP7120802B2 (ja) 2017-07-20 2022-08-17 株式会社神戸製鋼所 流体流通装置及びその流通異常検知方法
CN107573291A (zh) * 2017-10-27 2018-01-12 上海司太立制药有限公司 一种钆塞酸二钠配体杂质的制备方法和用途
AU2019382881A1 (en) 2018-11-23 2021-05-20 Bayer Aktiengesellschaft Formulation of contrast media and process of preparation thereof
EP4059925A1 (en) 2021-03-15 2022-09-21 Bayer Aktiengesellschaft New contrast agent for use in magnetic resonance imaging
EP4335462A1 (en) 2022-09-09 2024-03-13 Bayer AG Contrast agents for use in diagnostic computed tomography imaging
EP4335840A1 (en) 2022-09-09 2024-03-13 Bayer Aktiengesellschaft New contrast agents for use in diagnostic imaging

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US4339426A (en) * 1980-03-18 1982-07-13 Regents Of The University Of California Bleomycin analog
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Also Published As

Publication number Publication date
FI972286A (fi) 1997-05-29
CZ166897A3 (en) 1997-09-17
HUT77284A (hu) 1998-03-30
US5885548A (en) 1999-03-23
NO972460D0 (no) 1997-05-29
FI972288A (fi) 1997-05-29
WO1996016929A1 (de) 1996-06-06
EP0794799A2 (de) 1997-09-17
CA2206576A1 (en) 1996-06-06
IL116206A0 (en) 1996-01-31
JPH11503405A (ja) 1999-03-26
MX9703880A (es) 1997-08-30
FI972287A0 (fi) 1997-05-29
US5746995A (en) 1998-05-05
NO972457D0 (no) 1997-05-29
JPH10511934A (ja) 1998-11-17
JPH10509961A (ja) 1998-09-29
US5853699A (en) 1998-12-29
CA2206397A1 (en) 1996-06-06
US5672335A (en) 1997-09-30
WO1996016928A1 (de) 1996-06-06
AU3922795A (en) 1996-06-19
NO972459D0 (no) 1997-05-29
EP0794938A1 (de) 1997-09-17
SK68997A3 (en) 1997-11-05
AU4299496A (en) 1996-06-19
CA2206522A1 (en) 1996-06-06
NO972457L (no) 1997-07-30
FI972287A (fi) 1997-05-29
EP0794939A1 (de) 1997-09-17
CN1167444A (zh) 1997-12-10
NO972459L (no) 1997-07-29
WO1996016677A3 (de) 1996-09-12
WO1996016677A2 (de) 1996-06-06
FI972288A0 (fi) 1997-05-29
PL320462A1 (en) 1997-09-29
FI972286A0 (fi) 1997-05-29
IL116208A0 (en) 1996-01-31
NO972460L (no) 1997-05-29
IL116209A0 (en) 1996-01-31

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