JPH10507927A - 改良されたアデノウイルスおよびその使用法 - Google Patents
改良されたアデノウイルスおよびその使用法Info
- Publication number
- JPH10507927A JPH10507927A JP8514800A JP51480096A JPH10507927A JP H10507927 A JPH10507927 A JP H10507927A JP 8514800 A JP8514800 A JP 8514800A JP 51480096 A JP51480096 A JP 51480096A JP H10507927 A JPH10507927 A JP H10507927A
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- adenovirus
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
- C12N2810/6009—Vectors comprising as targeting moiety peptide derived from defined protein from viruses dsDNA viruses
- C12N2810/6018—Adenoviridae
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
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- Biomedical Technology (AREA)
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- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.(a)ウイルス遺伝子をコードする配列の不在下で、複製およびビリオン包 被化に必要なアデノウイルス5’および3’逆方向末端反復配列、ならびにパッ ケージング/エンハンサードメインのDNA配列、またはそれに相当するDNA 配列を含んで成るアデノウイルスのゲノムの一部のDNA配列、またはそれに相 当するDNA配列; (b)選択した遺伝子の発現を支配する調節配列に操作可能に連結された選択し た遺伝子、該遺伝子は(a)のDNAに操作可能に連結され、そしてインビボま たはインビトロで標的細胞中で発現できる、 を含んで成る組換えシャトルベクター。 2.上記DNA配列(a)が、天然のアデノウイルス5’逆方向末端反復配列お よびパッケージング配列を含んで成る、請求の範囲第1項に記載のベクター。 3.上記DNA配列(a)が、天然のアデノウイルス3’逆方向末端反復配列を 含んで成る、請求の範囲第1項に記載のベクター。 4.上記の選択した遺伝子(b)がレポーター遺伝子である、請求の範囲第1項 に記載のベクター。 5.上記レポーター遺伝子が、β-ガラクトシダーゼ、アルカリホスファターゼ およびグリーン蛍光タンパク質をコードする遺伝子から成る群から選択される、 請求の範囲第4項に記載のベクター。 6.上記の選択した遺伝子(b)が治療用遺伝子である、請求の範囲第1項に記 載のベクター。 7.上記治療用遺伝子が、正常CFTR遺伝子、DMDベッカー対立遺伝子およ び正常LDL遺伝子から成る群から選択される、請求の範囲第 6項に記載のベクター。 8.天然のアデノウイルス配列マップ単位0−1の代わりに改質されたアデノウ イルス配列を含んで成り、この改質は該ウイルスのパッケージング効率を下げ、 該ウイルスは生産的なウイルス感染を支配するために必要な選択したアデノウイ ルス遺伝子も含む、不能化アデノウイルスヘルパーウイルス。 9.上記改質配列が: i.アデノウイルスマップ単位0−1の断片; ii.5’逆方向末端反復配列を含み、そして1から4つの選択したパッケージン グ配列の間の(i)の断片、 iii.少なくとも1つの天然のPAC配列の代わりに、少なくとも1つのPAC 共通配列を含む(i)の改質断片;および iv.該天然のPAC配列を改質配列を含むように突然変異させた(ii)の改質断 片、 を含んで成る、請求の範囲第8項に記載のヘルパーウイルス。 10.上記改質配列が、Ad5塩基対1−269を含んで成る、請求の範囲第8 項に記載のウイルス。 11.上記配列(ii)がAd5塩基対1−321を含んで成る、請求の範囲第8 項に記載のウイルス。 12.上記ヘルパーアデノウイルスがポリ−カチオン配列と結合している、請求 の範囲第8項に記載のウイルス。 13.組換えアデノウイルスの生成法であって、選択した宿主細胞を、 (a)組換えシャトルベクター、該シャトルベクターは i.ウイルス遺伝子をコードする配列の不在下で、複製およびビリオ ン包被化に必要なアデノウイルス5’および3’シス−要素を含んで成るアデノ ウイルスのゲノムの一部のDNA配列、またはそれに相当するDNA配列; ii.選択した遺伝子の発現を支配する調節配列に操作可能に連結された選択し た遺伝子、該遺伝子は(a)のDNAに操作可能に連結され、そしてインビボま たはインビトロで標的細胞中で発現できる、 を含んで成り、および (b)生産的なウイルス感染のために必要な十分なアデノウイルス遺伝子配列を 含んで成るヘルパーアデノウイルス、ここで該トランスフェクトされた宿主細胞 は、(i)および(ii)のDNAをアデノウイルスカプシド中に含んで成る組換 えウイルスの形成を可能する、 を用いてトランスフェクトし、そして 該細胞から組換えウイルスを単離そして精製する、 工程を含んで成る、上記方法。 14.上記ヘルパーウイルスが、天然のアデノウイルス配列マップ単位0−1の 代わりに改質アデノウイルス配列を含んで成る不能化ヘルパーウイルスであり、 この改質が該ヘルパーウイルスのパッケージング効率を下げ、該ヘルパーウイル スは生産的ウイルス感染を支配するために必要な選択したアデノウイルス遺伝子 も含む、請求の範囲第13項に記載の方法。 15.上記ヘルパーウイルスがポリ−カチオン配列と会合している、請求の範囲 第13項に記載の方法。 16.上記ベクターが上記ヘルパーアデノウイルス結合体と1つの粒子 中で会合している、請求の範囲第13項に記載の方法。 17.上記ヘルパーウイルスが、E1aおよびE1b遺伝子の全部または一部の欠失を 含むアデノウイルス配列である、請求の範囲第13項に記載の方法。 18.上記ヘルパーウイルスが、E3遺伝子の全部または一部の欠失を含むアデ ノウイルス配列である、請求の範囲第13項に記載の方法。 19.i.ウイルス遺伝子をコードする配列の不在下で、複製およびビリオン包 被化に必要なアデノウイルス5’および3’シス−要素を含んで成るアデノウイ ルスのゲノムの一部のDNAまたはそれに相当するDNA; ii.選択した遺伝子の発現を支配する調節配列に操作可能に連結された選択した 遺伝子、該遺伝子は(a)のDNAに連結され、そしてインビボまたはインビト ロで標的細胞中で発現できる、 を含んで成り、 該DNAおよび遺伝子がアデノウイルスカプシド中に包膜されている、組換え アデノウイルス。 20.上記ウイルスカプシドが、2、4、5、7、12および40型から成る群 から選択されるアデノウイルス血清型のカプシドである、請求の範囲第19項に 記載のウイルス。 21.上記の選択した遺伝子がCFTR遺伝子、DMD遺伝子およびLDL遺伝 子である、請求の範囲第19項に記載のウイルス。 22.選択した遺伝子を標的細胞の染色体に送達し、そして組み込むために適当 な医薬組成物の製造のための、請求の範囲第19項に記載の組換えアデノウイル スの使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33138194A | 1994-10-28 | 1994-10-28 | |
US08/331,381 | 1994-10-28 | ||
PCT/US1995/014017 WO1996013597A2 (en) | 1994-10-28 | 1995-10-27 | Improved adenovirus and methods of use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH10507927A true JPH10507927A (ja) | 1998-08-04 |
JP3565859B2 JP3565859B2 (ja) | 2004-09-15 |
Family
ID=23293713
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51480096A Expired - Lifetime JP3565859B2 (ja) | 1994-10-28 | 1995-10-27 | 改良されたアデノウイルスおよびその使用法 |
Country Status (12)
Country | Link |
---|---|
US (2) | US6001557A (ja) |
EP (1) | EP0787200B1 (ja) |
JP (1) | JP3565859B2 (ja) |
AT (1) | ATE293701T1 (ja) |
AU (1) | AU704391B2 (ja) |
CA (1) | CA2203809C (ja) |
DE (1) | DE69534166T2 (ja) |
DK (1) | DK0787200T3 (ja) |
ES (1) | ES2240980T3 (ja) |
MX (1) | MX9703104A (ja) |
PT (1) | PT787200E (ja) |
WO (1) | WO1996013597A2 (ja) |
Families Citing this family (157)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5670488A (en) * | 1992-12-03 | 1997-09-23 | Genzyme Corporation | Adenovirus vector for gene therapy |
US20020164782A1 (en) | 1999-02-10 | 2002-11-07 | Gregory Richard J. | Adenovirus vectors for gene therapy |
US6080569A (en) * | 1993-06-24 | 2000-06-27 | Merck & Co., Inc. | Adenovirus vectors generated from helper viruses and helper-dependent vectors |
US20020136708A1 (en) | 1993-06-24 | 2002-09-26 | Graham Frank L. | System for production of helper dependent adenovirus vectors based on use of endonucleases |
US6379943B1 (en) | 1999-03-05 | 2002-04-30 | Merck & Co., Inc. | High-efficiency Cre/loxp based system for construction of adenovirus vectors |
US6465253B1 (en) | 1994-09-08 | 2002-10-15 | Genvec, Inc. | Vectors and methods for gene transfer to cells |
US5846782A (en) | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
US5856152A (en) * | 1994-10-28 | 1999-01-05 | The Trustees Of The University Of Pennsylvania | Hybrid adenovirus-AAV vector and methods of use therefor |
FR2730504B1 (fr) * | 1995-02-13 | 1997-03-28 | Rhone Poulenc Rorer Sa | Procede de preparation de genomes d'adenovirus recombinants |
US5770442A (en) * | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
US6127525A (en) * | 1995-02-21 | 2000-10-03 | Cornell Research Foundation, Inc. | Chimeric adenoviral coat protein and methods of using same |
US6281010B1 (en) | 1995-06-05 | 2001-08-28 | The Trustees Of The University Of Pennsylvania | Adenovirus gene therapy vehicle and cell line |
US5756283A (en) * | 1995-06-05 | 1998-05-26 | The Trustees Of The University Of Pennsylvania | Method for improved production of recombinant adeno-associated viruses for gene therapy |
US5985846A (en) * | 1995-06-07 | 1999-11-16 | Baylor College Of Medicine | Gene therapy for muscular dystrophy |
US6974694B2 (en) | 1995-06-07 | 2005-12-13 | Advec, Inc. | Adenoviruses for control of gene expression |
US6187757B1 (en) | 1995-06-07 | 2001-02-13 | Ariad Pharmaceuticals, Inc. | Regulation of biological events using novel compounds |
ES2333425T5 (es) * | 1995-06-15 | 2012-08-28 | Crucell Holland B.V. | Sistemas de empaquetado para adenovirus recombinante humano destinados a terapia génica |
US6783980B2 (en) * | 1995-06-15 | 2004-08-31 | Crucell Holland B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
WO1997045550A2 (en) * | 1996-05-31 | 1997-12-04 | Baxter International Inc. | Mini-adenoviral vector |
US5994132A (en) * | 1996-10-23 | 1999-11-30 | University Of Michigan | Adenovirus vectors |
FR2755975B1 (fr) * | 1996-11-15 | 1999-05-07 | Rhone Poulenc Rorer Sa | Virus recombinants bicistroniques utiles pour le traitement de pathologies liees aux dyslipoproteinemies |
US6403370B1 (en) * | 1997-02-10 | 2002-06-11 | Genstar Therapeutics Corporation | Oncolytic/immunogenic complementary-adenoviral vector system |
FR2761689B1 (fr) | 1997-04-02 | 1999-06-25 | Transgene Sa | Fibre adenovirale modifiee et adenovirus cibles |
WO1998054345A1 (en) * | 1997-05-30 | 1998-12-03 | Baxter International Inc. | Mini-adenoviral vector |
US6251677B1 (en) | 1997-08-25 | 2001-06-26 | The Trustees Of The University Of Pennsylvania | Hybrid adenovirus-AAV virus and methods of use thereof |
US6696423B1 (en) | 1997-08-29 | 2004-02-24 | Biogen, Inc. | Methods and compositions for therapies using genes encoding secreted proteins such as interferon-beta |
US6995006B2 (en) * | 1997-09-05 | 2006-02-07 | Targeted Genetics Corporation | Methods for generating high titer helper-free preparations of released recombinant AAV vectors |
US6346415B1 (en) * | 1997-10-21 | 2002-02-12 | Targeted Genetics Corporation | Transcriptionally-activated AAV inverted terminal repeats (ITRS) for use with recombinant AAV vectors |
EP1034266A1 (en) * | 1997-11-25 | 2000-09-13 | Princeton University | Method for preparing adenovirus vectors, vectors so prepared, and uses thereof |
US6984635B1 (en) | 1998-02-13 | 2006-01-10 | Board Of Trustees Of The Leland Stanford Jr. University | Dimerizing agents, their production and use |
US5981225A (en) * | 1998-04-16 | 1999-11-09 | Baylor College Of Medicine | Gene transfer vector, recombinant adenovirus particles containing the same, method for producing the same and method of use of the same |
WO1999055365A1 (en) | 1998-04-30 | 1999-11-04 | Cornell Research Foundation, Inc. | Adenoviral vectors with tandem fiber proteins |
US20030017138A1 (en) | 1998-07-08 | 2003-01-23 | Menzo Havenga | Chimeric adenoviruses |
GB9817660D0 (en) * | 1998-08-13 | 1998-10-07 | Angeletti P Ist Richerche Bio | Adenoviral vectors encoding erythropoietin and their use in gene therapy |
CN1342206A (zh) | 1998-08-28 | 2002-03-27 | 杜克大学 | 在IVa2,100K和/或preterminal protein序列上有缺失的腺病毒 |
AU767975B2 (en) | 1998-09-11 | 2003-11-27 | Genvec, Inc. | Alternatively targeted adenovirus |
HUP0105230A3 (en) * | 1998-09-25 | 2003-10-28 | Aventis Pharma Sa | Use of specific hybrid promoters for controlling tissue expression |
FR2783839B1 (fr) * | 1998-09-25 | 2002-12-06 | Aventis Pharma Sa | Utilisation de promoteurs specifiques hybrides pour controler l'expression tissulaire |
US6929946B1 (en) | 1998-11-20 | 2005-08-16 | Crucell Holland B.V. | Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells |
US6387368B1 (en) | 1999-02-08 | 2002-05-14 | The Trustees Of The University Of Pennsylvania | Hybrid adenovirus-AAV virus and methods of use thereof |
JP2004501602A (ja) * | 1999-02-18 | 2004-01-22 | メルク アンド カンパニー インコーポレイテッド | エンドヌクレアーゼの使用に基づくヘルパー依存アデノウイルスベクターの生産のためのシステム |
US6913922B1 (en) | 1999-05-18 | 2005-07-05 | Crucell Holland B.V. | Serotype of adenovirus and uses thereof |
US6492169B1 (en) | 1999-05-18 | 2002-12-10 | Crucell Holland, B.V. | Complementing cell lines |
US6867022B1 (en) | 2000-01-21 | 2005-03-15 | Regents Of The University Of Michigan | Replication deficient adenovirus vectors and methods of making and using them |
US7052904B2 (en) * | 2000-01-31 | 2006-05-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Hybrid adeno-retroviral vector for the transfection of cells |
US6998263B2 (en) * | 2000-02-09 | 2006-02-14 | Genvec, Inc. | Methods of preparing and using a viral vector library |
US20020025931A1 (en) | 2000-03-24 | 2002-02-28 | Rachel Meyers | 3714, 16742, 23546, and 13887 novel protein kinase molecules and uses therefor |
AU2001255575B2 (en) * | 2000-04-28 | 2006-08-31 | The Trustees Of The University Of Pennsylvania | Recombinant aav vectors with aav5 capsids and aav5 vectors pseudotyped in heterologous capsids |
US6680172B1 (en) | 2000-05-16 | 2004-01-20 | Regents Of The University Of Michigan | Treatments and markers for cancers of the central nervous system |
US20020081707A1 (en) * | 2000-06-29 | 2002-06-27 | Donna Armentano | Methods for helper-dependent adenoviral vector production |
US20080194022A1 (en) * | 2000-08-03 | 2008-08-14 | Clarke Michael F | Isolation and use of solid tumor stem cells |
US8044259B2 (en) | 2000-08-03 | 2011-10-25 | The Regents Of The University Of Michigan | Determining the capability of a test compound to affect solid tumor stem cells |
US6984522B2 (en) * | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
DE60138403D1 (de) | 2000-09-26 | 2009-05-28 | Crucell Holland Bv | Adenovirale vektoren für die übertragung von genen in zellen der skelettmuskulatur oder myoblasten |
WO2002061104A2 (en) * | 2001-01-30 | 2002-08-08 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Hybrid adenoviral vector |
US20040136963A1 (en) * | 2001-06-22 | 2004-07-15 | The Trustees Of The University Of Pennsylvania | Simian adenovirus vectors and methods of use |
EP1404842A2 (en) * | 2001-06-29 | 2004-04-07 | Novartis AG | Perv screening method and use thereof |
US7229774B2 (en) | 2001-08-02 | 2007-06-12 | Regents Of The University Of Michigan | Expression profile of prostate cancer |
WO2003014367A1 (en) * | 2001-08-08 | 2003-02-20 | The Trustees Of The University Of Pennsylvania | Method for purification of viral vectors having proteins which bind sialic acid |
US7217570B2 (en) | 2001-08-23 | 2007-05-15 | The Wistar Institute Of Anatomy And Biology | Organotypic intestinal culture and methods of use thereof |
US20030092161A1 (en) * | 2001-09-19 | 2003-05-15 | The Trustees Of The University Of Pennsylvania | Compositions and methods for production of recombinant viruses, and uses therefor |
KR100452409B1 (ko) * | 2001-11-15 | 2004-10-12 | 이제호 | Smad를 고형악성종양의 유전자 치료에 사용하는 용도 |
EP1944043A1 (en) | 2001-11-21 | 2008-07-16 | The Trustees of the University of Pennsylvania | Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use |
PL209133B1 (pl) | 2001-11-21 | 2011-07-29 | Univ Pennsylvania | Rekombinowany adenowirus, obejmująca go izolowana komórka gospodarza, oraz kompozycja i zastosowanie |
JP2005532036A (ja) | 2002-01-09 | 2005-10-27 | 理化学研究所 | 癌プロフィール |
US7977049B2 (en) | 2002-08-09 | 2011-07-12 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
CA2421269A1 (en) | 2002-08-09 | 2004-02-09 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
CA2899360A1 (en) | 2002-08-21 | 2004-04-08 | Revivicor, Inc. | Porcine animals lacking any expression of functional alpha 1,3 galactosyltransferase |
EP1403385A1 (en) * | 2002-09-27 | 2004-03-31 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Method for assaying replication of HBV and testing susceptibility to drugs |
US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
AU2003300076C1 (en) | 2002-12-30 | 2010-03-04 | Angiotech International Ag | Drug delivery from rapid gelling polymer composition |
AU2004256425A1 (en) | 2003-06-09 | 2005-01-20 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
EP1636370B1 (en) * | 2003-06-20 | 2014-04-16 | The Trustees of The University of Pennsylvania | Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses |
WO2005023292A1 (en) | 2003-09-03 | 2005-03-17 | The General Hospital Corporation | Methods of treating restenosis |
WO2005115477A2 (en) | 2004-04-13 | 2005-12-08 | Quintessence Biosciences, Inc. | Non-natural ribonuclease conjugates as cytotoxic agents |
DE602005026269D1 (de) * | 2004-04-28 | 2011-03-24 | Univ Pennsylvania | Sequenzielle freisetzung immunogener moleküle über adenoviren und adeno-assoziierte viren vermittelte abgaben |
ES2442225T3 (es) * | 2004-04-28 | 2014-02-10 | The Trustees Of The University Of Pennsylvania | Régimen de inmunización con cebado de adenovirus suprimido en E4 y potenciación de adenovirus suprimido en E1 |
US7858323B2 (en) | 2004-06-09 | 2010-12-28 | The Regents Of The University Of Michigan | Phage microarray profiling of the humoral response to disease |
JP2008507294A (ja) | 2004-07-26 | 2008-03-13 | ダウ グローバル テクノロジーズ インコーポレイティド | 菌株遺伝子操作による改善されたタンパク質発現のための方法 |
JP2008515908A (ja) | 2004-10-06 | 2008-05-15 | ユニバーシティー オブ ロチェスター | 組織因子経路を阻害する薬剤を使用する、肺高血圧症の治療 |
US8999944B2 (en) | 2005-01-20 | 2015-04-07 | University Of Rochester | Thioredoxin interacting protein (TXNIP) as regulator of vascular function |
CA2612021A1 (en) * | 2005-06-13 | 2006-12-28 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
AU2006292827B2 (en) | 2005-08-09 | 2013-02-14 | Revivicor, Inc. | Transgenic ungulates expressing CTLA4-IG and uses thereof |
AU2006291054B2 (en) | 2005-09-12 | 2011-10-13 | The Brigham And Women's Hospital, Inc. | Recurrent gene fusions in prostate cancer |
US8652467B2 (en) * | 2005-10-14 | 2014-02-18 | The Regents Of The University Of Michigan | Dek protein compositions and methods of using the same |
US7794951B2 (en) * | 2005-10-18 | 2010-09-14 | University Of Massachusetts Medical School | SREBP2gc transcription factors and uses thereof |
US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
CA2628116A1 (en) | 2005-10-31 | 2007-12-13 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
CA2628255C (en) * | 2005-10-31 | 2016-04-19 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
US8278104B2 (en) * | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
US8129187B2 (en) * | 2005-12-13 | 2012-03-06 | Kyoto University | Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2 |
US20090227032A1 (en) * | 2005-12-13 | 2009-09-10 | Kyoto University | Nuclear reprogramming factor and induced pluripotent stem cells |
EP2208786B1 (en) * | 2005-12-13 | 2018-08-01 | Kyoto University | Nuclear reprogramming factor |
EP1994043A4 (en) | 2006-02-10 | 2009-05-20 | Univ Cincinnati | PROTEIN-A PHOSPHATASE INHIBITOR AS REGULATOR OF CARDIAC FUNCTION |
AR053600A1 (es) | 2006-04-28 | 2007-05-09 | Fundacion Inst Leloir | Un fragmento aislado de adn del promotor humano de a33 y su uso para dirigir la expresion de un gen heterologo en celulas tumorales |
JP2009541333A (ja) * | 2006-06-23 | 2009-11-26 | クインテセンス バイオサイエンシーズ インコーポレーティッド | 修飾リボヌクレアーゼ |
EP2049151A4 (en) | 2006-07-17 | 2010-03-24 | Quintessence Biosciences Inc | METHOD AND COMPOSITIONS FOR THE TREATMENT OF CANCER |
WO2008030605A2 (en) * | 2006-09-08 | 2008-03-13 | The Regents Of The University Of Michigan | Herv group ii viruses in lymphoma and cancer |
EP2106439B1 (en) | 2007-01-24 | 2014-11-12 | The Regents of the University of Michigan | Compositions and methods for treating and diagnosing pancreatic cancer |
AU2008245696B2 (en) | 2007-04-27 | 2013-11-07 | Pelican Technology Holdings, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
US9580719B2 (en) | 2007-04-27 | 2017-02-28 | Pfenex, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
US9213999B2 (en) * | 2007-06-15 | 2015-12-15 | Kyoto University | Providing iPSCs to a customer |
JP2008307007A (ja) * | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
US10745701B2 (en) | 2007-06-28 | 2020-08-18 | The Trustees Of Princeton University | Methods of identifying and treating poor-prognosis cancers |
US20090324596A1 (en) * | 2008-06-30 | 2009-12-31 | The Trustees Of Princeton University | Methods of identifying and treating poor-prognosis cancers |
CA2692441C (en) | 2007-07-06 | 2020-01-21 | The Regents Of The University Of Michigan | Solute carrier family 45 member 3 (slc45a3) and ets family gene fusions in prostate cancer |
US20090047269A1 (en) | 2007-08-16 | 2009-02-19 | The Regents Of The University Of Michigan | Metabolomic cancer targets |
US8697062B2 (en) * | 2007-10-08 | 2014-04-15 | Quintessence Biosciences, Inc. | Compositions and methods for ribonuclease-based therapeutics |
CA2706258C (en) | 2007-11-28 | 2017-06-06 | The Trustees Of The University Of Pennsylvania | Simian subfamily e adenoviruses sadv-39, -25.2, -26, -30, -37, and -38 and uses thereof |
JP5758124B2 (ja) | 2007-11-28 | 2015-08-05 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | サルサブファミリーCアデノウイルスSAdV−40、−31および−34ならびにそれらの用途 |
CN102016011B (zh) | 2008-03-04 | 2013-12-11 | 宾夕法尼亚大学托管会 | 猿猴腺病毒sadv-36、-42.1、-42.2和-44及其应用 |
US8193151B2 (en) * | 2008-04-25 | 2012-06-05 | Northwestern University | Methods for treating atrial or ventricular arrhythmias |
US8518884B2 (en) | 2008-04-25 | 2013-08-27 | Northwestern University | Methods for treating atrial or ventricular arrhythmias by administering a G-protein alpha inhibitor |
CA2695522C (en) * | 2008-05-02 | 2019-01-15 | Kyoto University | Method of nuclear reprogramming |
WO2009149191A2 (en) | 2008-06-03 | 2009-12-10 | University Of Rochester | Methods of treating inflammatory intestinal disease and managing symptoms thereof |
WO2010037041A2 (en) | 2008-09-26 | 2010-04-01 | Oncomed Pharmaceuticals, Inc. | Frizzled-binding agents and uses thereof |
EP2334695B1 (en) | 2008-10-01 | 2015-12-23 | Quintessence Biosciences, Inc. | Therapeutic ribonucleases |
JP5809978B2 (ja) | 2008-10-31 | 2015-11-11 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | サルアデノウイルスSAdV−43、−45、−46、−47、−48、−49および−50ならびにそれらの用途 |
JP2012514475A (ja) | 2009-01-09 | 2012-06-28 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 癌における再現性の遺伝子融合物 |
KR101763093B1 (ko) | 2009-02-02 | 2017-07-28 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 시미안 아데노바이러스 핵산- 및 아미노산-서열, 이를 포함하는 벡터 및 이의 용도 |
WO2010107991A2 (en) | 2009-03-18 | 2010-09-23 | Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Use of ixolaris, a tissue factor inhibitor, for the treatment and prevention of cancer |
KR101764437B1 (ko) | 2009-03-20 | 2017-08-02 | 메소블라스트, 아이엔씨. | 재프로그램된 다분화능 세포의 생성 방법 |
CN102575232B (zh) | 2009-05-29 | 2015-07-22 | 宾夕法尼亚大学托管会 | 猿腺病毒41及其应用 |
CN106390107B (zh) | 2009-06-10 | 2019-12-31 | 纽约大学 | 病理tau蛋白的免疫靶向 |
TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Wnt拮抗劑及治療和篩選方法 |
WO2011116209A2 (en) * | 2010-03-17 | 2011-09-22 | The Regents Of The University Of Michigan | Using phage epitopes to profile the immune response |
CA2794674A1 (en) | 2010-04-01 | 2011-10-06 | Oncomed Pharmaceuticals, Inc. | Frizzled-binding agents and uses thereof |
JP2013523175A (ja) | 2010-04-14 | 2013-06-17 | イーエムディー・ミリポア・コーポレーション | 高力価、高純度のウイルスストックの作製方法及びその使用方法 |
EP2643465B1 (en) | 2010-11-23 | 2016-05-11 | The Trustees Of The University Of Pennsylvania | Subfamily e simian adenovirus a1321 and uses thereof |
US20130344053A1 (en) | 2010-12-28 | 2013-12-26 | University Of Rochester | Methods of Modifying Insulin Signaling Using Biliverdin Reductase (BVR) and BVR Derived Peptides |
WO2013001372A2 (en) | 2011-06-30 | 2013-01-03 | University Of Oslo | Methods and compositions for inhibition of activation of regulatory t cells |
US10980879B2 (en) | 2011-07-06 | 2021-04-20 | Sykehuset Sørlandet Hf | EGFR targeted therapy |
WO2013036875A1 (en) | 2011-09-07 | 2013-03-14 | Mount Sinai School Of Medicine | Ceramidase and cell differentiation |
DK2797613T3 (da) | 2011-10-27 | 2020-03-02 | Wellstat Ophthalmics Corp | Vektorer, der koder for rod-derived cone viability-faktor |
CN105473723A (zh) | 2012-05-18 | 2016-04-06 | 宾夕法尼亚大学托管会 | 亚家族e猿腺病毒a1302、a1320、a1331和a1337及其用途 |
EP2908853B1 (en) | 2012-10-21 | 2018-12-05 | University Of Rochester | Thy1 (cd90) as a therapy to control adipose tissue accumulation |
WO2014066328A1 (en) | 2012-10-23 | 2014-05-01 | Oncomed Pharmaceuticals, Inc. | Methods of treating neuroendocrine tumors using wnt pathway-binding agents |
AU2013362134B2 (en) | 2012-12-21 | 2018-07-05 | Sykehuset Sorlandet Hf | EGFR targeted therapy of neurological disorders and pain |
JP2016510411A (ja) | 2013-02-04 | 2016-04-07 | オンコメッド ファーマシューティカルズ インコーポレイテッド | Wnt経路インヒビターによる処置の方法およびモニタリング |
US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
US9822418B2 (en) | 2013-04-22 | 2017-11-21 | Icahn School Of Medicine At Mount Sinai | Mutations in PDGFRB and NOTCH3 as causes of autosomal dominant infantile myofibromatosis |
WO2016057387A1 (en) | 2014-10-06 | 2016-04-14 | The Trustees Of The University Of Pennsylvania | Compositions and methods for isolation of circulating tumor cells (ctc) |
EP3371211A4 (en) | 2015-11-04 | 2019-08-21 | Icahn School of Medicine at Mount Sinai | METHOD FOR THE TREATMENT OF TUMORS AND CANCER AND IDENTIFICATION OF CANDIDATE PATIENTS FOR SUCH TREATMENT |
US10377801B2 (en) | 2015-11-04 | 2019-08-13 | Northwestern University | Amelioration of chronic kidney disease |
WO2017189730A1 (en) | 2016-04-26 | 2017-11-02 | Icahn School Of Medicine At Mount Sinai | Treatment of hippo pathway mutant tumors and methods of identifying subjects as candidates for treatment |
WO2018013509A1 (en) | 2016-07-11 | 2018-01-18 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Compositions and methods for diagnosing and treating arrhythmias |
RU2019119272A (ru) | 2016-11-23 | 2020-12-24 | Гритстоун Онколоджи, Инк. | Вирусная доставка неоантигенов |
US11241436B2 (en) | 2017-01-25 | 2022-02-08 | Northwestern University | Autophagy inducers for treatment of CNS conditions |
AU2018266705B2 (en) | 2017-05-08 | 2023-05-04 | Gritstone Bio, Inc. | Alphavirus neoantigen vectors |
RU2762854C2 (ru) | 2017-07-05 | 2021-12-23 | Ноуском Аг | Последовательности нуклеиновых кислот и аминокислотные последовательности аденовирусов человекообразных обезьян, исключая человека, содержащие их векторы, и их применения |
AU2018372906A1 (en) | 2017-11-22 | 2020-06-11 | The Regents Of The University Of Michigan | Compositions and methods for treating cancer |
AU2019205330A1 (en) | 2018-01-04 | 2020-08-27 | Iconic Therapeutics Llc | Anti-tissue factor antibodies, antibody-drug conjugates, and related methods |
BR122024002387A2 (pt) | 2019-05-30 | 2024-03-12 | Gritstone Bio, Inc. | Vetores de adenovírus, composição farmacêutica, sequência de nucleotídeo isolada, célula isolada, vetor, kit, usos de um vetor, método para fabricar o vetor, métodos para produzir um vírus e vetor viral |
TW202208398A (zh) | 2020-07-01 | 2022-03-01 | 義大利商萊伊錫拉有限責任公司 | 大猩猩腺病毒核酸及胺基酸序列,包含彼之載體,及其用途 |
AU2021320896A1 (en) | 2020-08-06 | 2023-03-23 | Gritstone Bio, Inc. | Multiepitope vaccine cassettes |
JP2023537818A (ja) | 2020-08-11 | 2023-09-06 | マスキュロスケレタル トランスプラント ファウンデーション | 胎盤由来組成物を用いた心疾患を治療するための方法 |
WO2022221462A1 (en) | 2021-04-13 | 2022-10-20 | Kriya Therapeutics, Inc. | Vector constructs for delivery of nucleic acids encoding therapeutic vlcad or mcad and methods of using the same |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5166320A (en) * | 1987-04-22 | 1992-11-24 | University Of Connecticut | Carrier system and method for the introduction of genes into mammalian cells |
US5585362A (en) * | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
US5240846A (en) * | 1989-08-22 | 1993-08-31 | The Regents Of The University Of Michigan | Gene therapy vector for cystic fibrosis |
US5670488A (en) * | 1992-12-03 | 1997-09-23 | Genzyme Corporation | Adenovirus vector for gene therapy |
AU7906691A (en) * | 1990-05-23 | 1991-12-10 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Adeno-associated virus (aav)-based eucaryotic vectors |
CA2115742A1 (en) * | 1991-08-20 | 1993-03-04 | Ronald G. Crystal | Adenovirus mediated transfer of genes to the gastrointestinal tract |
US5252479A (en) * | 1991-11-08 | 1993-10-12 | Research Corporation Technologies, Inc. | Safe vector for gene therapy |
FR2688514A1 (fr) * | 1992-03-16 | 1993-09-17 | Centre Nat Rech Scient | Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant. |
WO1994008026A1 (en) * | 1992-09-25 | 1994-04-14 | Rhone-Poulenc Rorer S.A. | Adenovirus vectors for the transfer of foreign genes into cells of the central nervous system, particularly in brain |
AU680459B2 (en) * | 1992-12-03 | 1997-07-31 | Genzyme Corporation | Gene therapy for cystic fibrosis |
WO1994017832A1 (en) * | 1993-02-09 | 1994-08-18 | The Scripps Research Institute | Targeting and delivery of genes and antiviral agents into cells by the adenovirus penton |
FR2705686B1 (fr) * | 1993-05-28 | 1995-08-18 | Transgene Sa | Nouveaux adénovirus défectifs et lignées de complémentation correspondantes. |
JP3532566B2 (ja) * | 1993-06-24 | 2004-05-31 | エル. グラハム,フランク | 遺伝子治療のためのアデノウイルスベクター |
SK282843B6 (sk) * | 1993-07-13 | 2002-12-03 | Rhone-Poulenc Rorer S. A. | Defektný rekombinantný adenovírus a farmaceutický prostriedok s jeho obsahom |
US5543328A (en) * | 1993-08-13 | 1996-08-06 | Genetic Therapy, Inc. | Adenoviruses having modified fiber proteins |
US7252989B1 (en) * | 1994-04-04 | 2007-08-07 | Board Of Regents, The University Of Texas System | Adenovirus supervector system |
JPH10507061A (ja) * | 1994-04-28 | 1998-07-14 | ザ ユニバーシティ オブ ミシガン | アデノウイルス中にパッケージされたプラスミドdnaを用いる遺伝子送達ベクターおよびパッケージング細胞株 |
DE69535178T2 (de) * | 1994-06-10 | 2006-12-14 | Genvec, Inc. | Adenoviren-vektor systeme und zelllinien |
FR2726285B1 (fr) * | 1994-10-28 | 1996-11-29 | Centre Nat Rech Scient | Adenovirus depourvus de particules contaminantes viables, preparation et utilisation |
US5856152A (en) | 1994-10-28 | 1999-01-05 | The Trustees Of The University Of Pennsylvania | Hybrid adenovirus-AAV vector and methods of use therefor |
US5872005A (en) * | 1994-11-03 | 1999-02-16 | Cell Genesys Inc. | Packaging cell lines for adeno-associated viral vectors |
AU709498B2 (en) * | 1994-12-12 | 1999-09-02 | Genetic Therapy, Inc. | Improved adenoviral vectors and producer cells |
US5652224A (en) * | 1995-02-24 | 1997-07-29 | The Trustees Of The University Of Pennsylvania | Methods and compositions for gene therapy for the treatment of defects in lipoprotein metabolism |
US5872154A (en) | 1995-02-24 | 1999-02-16 | The Trustees Of The University Of Pennsylvania | Method of reducing an immune response to a recombinant adenovirus |
US5756283A (en) | 1995-06-05 | 1998-05-26 | The Trustees Of The University Of Pennsylvania | Method for improved production of recombinant adeno-associated viruses for gene therapy |
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CA2203809A1 (en) | 1996-05-09 |
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MX9703104A (es) | 1998-07-31 |
WO1996013597A2 (en) | 1996-05-09 |
ATE293701T1 (de) | 2005-05-15 |
WO1996013597A3 (en) | 1996-10-31 |
AU704391B2 (en) | 1999-04-22 |
AU4405496A (en) | 1996-05-23 |
JP3565859B2 (ja) | 2004-09-15 |
EP0787200A2 (en) | 1997-08-06 |
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