JPH10507464A - レボブピバカインとその類似体の晶出 - Google Patents
レボブピバカインとその類似体の晶出Info
- Publication number
- JPH10507464A JPH10507464A JP8513738A JP51373896A JPH10507464A JP H10507464 A JPH10507464 A JP H10507464A JP 8513738 A JP8513738 A JP 8513738A JP 51373896 A JP51373896 A JP 51373896A JP H10507464 A JPH10507464 A JP H10507464A
- Authority
- JP
- Japan
- Prior art keywords
- levobupivacaine
- resolving agent
- water
- enantiomer
- tartaric acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Compounds Of Unknown Constitution (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Epoxy Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.溶剤中で酒石酸分割剤との反応をおこなうことによって次式(I): (式中、RはHまたはC1-8アルキルを示す) で表される光学的に濃縮された化合物の製造法において、該反応を水および/ま たは0.5当量よりも少量の該分割剤の存在下でおこなうことを特徴とする該化 合物(I)の製造法。 2.Rがプロピルである請求項1記載の方法。 3.Rがブチルである請求項1記載の方法。 4.分割剤が(S,S)−酒石酸である請求項1から3いずれかに記載の方法。 5.溶剤がC1-6アルカノールを含有する請求項1から4いずれかに記載の方 法。 6.水と溶剤の混合物が水を0.1〜20%含有する請求項1から5いずれか に記載の方法。 7.式(I)で表される化合物1モル当量あたり0.2〜0.5モル当量の分割剤 を使用する請求項1から6いずれかに記載の方法。 8.鏡像体をヒドロクロリド塩に変換させることをさらに含む請求項1から7 いずれかに記載の方法。 9.レボブピバカインを製造するための請求項1から8いずれかに記載の方法 。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9421476.4 | 1994-10-25 | ||
GB9421476A GB9421476D0 (en) | 1994-10-25 | 1994-10-25 | Process and salt |
GBGB9504926.8A GB9504926D0 (en) | 1995-03-10 | 1995-03-10 | Crystallisation |
GB9504926.8 | 1995-03-10 | ||
PCT/GB1995/002513 WO1996012699A1 (en) | 1994-10-25 | 1995-10-23 | Crystallisation of levobupivacaine and analogues thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH10507464A true JPH10507464A (ja) | 1998-07-21 |
JP3911545B2 JP3911545B2 (ja) | 2007-05-09 |
Family
ID=26305863
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51373896A Expired - Lifetime JP3911545B2 (ja) | 1994-10-25 | 1995-10-23 | レボブピバカインとその類似体の晶出 |
Country Status (16)
Country | Link |
---|---|
US (1) | US5994548A (ja) |
EP (1) | EP0788480B1 (ja) |
JP (1) | JP3911545B2 (ja) |
AT (1) | ATE245629T1 (ja) |
AU (1) | AU698637B2 (ja) |
CA (1) | CA2200355C (ja) |
DE (1) | DE69531356T2 (ja) |
DK (1) | DK0788480T3 (ja) |
ES (1) | ES2202375T3 (ja) |
FI (1) | FI117438B (ja) |
HU (1) | HU227420B1 (ja) |
MX (1) | MX9703024A (ja) |
NO (1) | NO309266B1 (ja) |
PL (1) | PL183210B1 (ja) |
PT (1) | PT788480E (ja) |
WO (1) | WO1996012699A1 (ja) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR0002246A (pt) * | 2000-04-06 | 2003-04-15 | Cristalia Prod Quimicos Farm | Processo de obtenção dos enantiÈmeros da bupivacaìna racêmica, processo de obtenção de composições farmacêuticas a base de levobupivacaìna: composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis e utilização das composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis |
BRPI0104491B8 (pt) * | 2001-10-10 | 2021-05-25 | Cristalia Produtos Quim Farmaceuticos Ltda | n-(2,6-dimetilfenil)-1-propil-2-piperidinocarboxamida; processo de obtenção dos enantiômeros; mistura não racêmica dos anantiômeros e seu processo de obtenção e composição farmacêutica. |
US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
AU2003299659A1 (en) | 2002-12-13 | 2004-07-09 | Durect Corporation | Oral drug delivery system comprising high viscosity liquid carrier materials |
US7094812B2 (en) * | 2003-04-24 | 2006-08-22 | Xerox Corporations | Colorant compositions |
US6790267B1 (en) * | 2003-04-24 | 2004-09-14 | Xerox Corporation | Colorant compositions |
NZ553369A (en) | 2004-09-17 | 2010-11-26 | Durect Corp | Sustained local anesthetic composition containing preferably a sugar ester such as saib |
US20070027105A1 (en) | 2005-07-26 | 2007-02-01 | Alza Corporation | Peroxide removal from drug delivery vehicle |
US20090187024A1 (en) * | 2006-04-25 | 2009-07-23 | Dishman Pharmaceuticals And Chemicals Ltd. | Ropivacaine hydrochloride anhydrate and the preparation thereof |
PL2117521T3 (pl) | 2006-11-03 | 2012-11-30 | Durect Corp | Transdermalne systemy dostarczania zawierające bupiwakainę |
EP2219622A1 (en) | 2007-12-06 | 2010-08-25 | Durect Corporation | Methods useful for the treatment of pain, arthritic conditions, or inflammation associated with a chronic condition |
ES2383714T3 (es) * | 2008-01-15 | 2012-06-25 | Pharmathen S.A. | Proceso para preparar un compuesto (S)-1-alquil-2',6'-pipecoloxilidídico |
US20100260844A1 (en) | 2008-11-03 | 2010-10-14 | Scicinski Jan J | Oral pharmaceutical dosage forms |
CN103073484B (zh) * | 2013-01-28 | 2014-10-22 | 山东诚创医药技术开发有限公司 | 一种甲哌卡因及其光学对映体的制备方法 |
US9572885B2 (en) | 2013-03-15 | 2017-02-21 | Durect Corporation | Compositions with a rheological modifier to reduce dissolution variability |
RU2021114918A (ru) * | 2016-12-26 | 2021-07-09 | Целликс Био Прайвет Лимитед | Композиции и способы лечения хронической боли |
CA3167217A1 (en) | 2020-01-13 | 2021-07-22 | Durect Corporation | Sustained release drug delivery systems with reduced impurities and related methods |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE341404B (ja) * | 1967-05-18 | 1971-12-27 | Sterling Drug Inc | |
US4695576A (en) * | 1984-07-09 | 1987-09-22 | Astra Lake Medel Aktiebolag | L-N-n-propylpipecolic acid-2,6-xylidide |
-
1995
- 1995-10-23 WO PCT/GB1995/002513 patent/WO1996012699A1/en active IP Right Grant
- 1995-10-23 HU HU9702372A patent/HU227420B1/hu unknown
- 1995-10-23 CA CA002200355A patent/CA2200355C/en not_active Expired - Lifetime
- 1995-10-23 US US08/849,418 patent/US5994548A/en not_active Expired - Lifetime
- 1995-10-23 PL PL95319829A patent/PL183210B1/pl unknown
- 1995-10-23 AU AU37048/95A patent/AU698637B2/en not_active Expired
- 1995-10-23 DK DK95934738T patent/DK0788480T3/da active
- 1995-10-23 PT PT95934738T patent/PT788480E/pt unknown
- 1995-10-23 MX MX9703024A patent/MX9703024A/es unknown
- 1995-10-23 ES ES95934738T patent/ES2202375T3/es not_active Expired - Lifetime
- 1995-10-23 AT AT95934738T patent/ATE245629T1/de active
- 1995-10-23 EP EP95934738A patent/EP0788480B1/en not_active Expired - Lifetime
- 1995-10-23 JP JP51373896A patent/JP3911545B2/ja not_active Expired - Lifetime
- 1995-10-23 DE DE69531356T patent/DE69531356T2/de not_active Expired - Lifetime
-
1997
- 1997-04-22 FI FI971711A patent/FI117438B/fi not_active IP Right Cessation
- 1997-04-24 NO NO971903A patent/NO309266B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ATE245629T1 (de) | 2003-08-15 |
AU3704895A (en) | 1996-05-15 |
ES2202375T3 (es) | 2004-04-01 |
JP3911545B2 (ja) | 2007-05-09 |
NO971903D0 (no) | 1997-04-24 |
DK0788480T3 (da) | 2003-09-29 |
MX9703024A (es) | 1997-10-31 |
PL183210B1 (pl) | 2002-06-28 |
WO1996012699A1 (en) | 1996-05-02 |
CA2200355A1 (en) | 1996-05-02 |
FI971711A0 (fi) | 1997-04-22 |
HU227420B1 (en) | 2011-05-30 |
DE69531356T2 (de) | 2004-05-27 |
CA2200355C (en) | 2007-03-06 |
EP0788480B1 (en) | 2003-07-23 |
PT788480E (pt) | 2003-12-31 |
FI117438B (fi) | 2006-10-13 |
HUT77631A (hu) | 1998-06-29 |
AU698637B2 (en) | 1998-11-05 |
DE69531356D1 (de) | 2003-08-28 |
NO309266B1 (no) | 2001-01-08 |
PL319829A1 (en) | 1997-09-01 |
FI971711A (fi) | 1997-04-22 |
NO971903L (no) | 1997-04-24 |
US5994548A (en) | 1999-11-30 |
EP0788480A1 (en) | 1997-08-13 |
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