JPH101495A5 - - Google Patents
Info
- Publication number
- JPH101495A5 JPH101495A5 JP1997055983A JP5598397A JPH101495A5 JP H101495 A5 JPH101495 A5 JP H101495A5 JP 1997055983 A JP1997055983 A JP 1997055983A JP 5598397 A JP5598397 A JP 5598397A JP H101495 A5 JPH101495 A5 JP H101495A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- group
- glycosyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE96103866:8 | 1996-03-12 | ||
| EP96103866 | 1996-03-12 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPH101495A JPH101495A (ja) | 1998-01-06 |
| JPH101495A5 true JPH101495A5 (https=) | 2005-01-20 |
| JP4392065B2 JP4392065B2 (ja) | 2009-12-24 |
Family
ID=8222555
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP05598397A Expired - Fee Related JP4392065B2 (ja) | 1996-03-12 | 1997-03-11 | 腫瘍および炎症性疾患治療用の新規プロドラッグ |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US5935995A (https=) |
| EP (1) | EP0795334B1 (https=) |
| JP (1) | JP4392065B2 (https=) |
| KR (1) | KR100466467B1 (https=) |
| CN (1) | CN1168733C (https=) |
| AT (1) | ATE316799T1 (https=) |
| AU (1) | AU708202B2 (https=) |
| BG (1) | BG61900B1 (https=) |
| BR (1) | BRPI9701248B1 (https=) |
| CA (1) | CA2199664C (https=) |
| CZ (1) | CZ297994B6 (https=) |
| DE (1) | DE59712561D1 (https=) |
| DK (1) | DK0795334T3 (https=) |
| ES (1) | ES2257756T3 (https=) |
| HU (1) | HU228764B1 (https=) |
| NO (1) | NO320322B1 (https=) |
| NZ (1) | NZ314368A (https=) |
| PL (1) | PL189604B1 (https=) |
| RO (1) | RO120951B1 (https=) |
| RU (1) | RU2191021C2 (https=) |
| SG (1) | SG50011A1 (https=) |
| SI (1) | SI0795334T1 (https=) |
| TR (1) | TR199700178A2 (https=) |
| UA (1) | UA50719C2 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5525606A (en) | 1994-08-01 | 1996-06-11 | The United States Of America As Represented By The Department Of Health And Human Services | Substituted 06-benzylguanines and 6(4)-benzyloxypyrimidines |
| DE19720312A1 (de) * | 1997-05-15 | 1998-11-19 | Hoechst Ag | Zubereitung mit erhöhter in vivo Verträglichkeit |
| US6395299B1 (en) | 1999-02-12 | 2002-05-28 | Biostream, Inc. | Matrices for drug delivery and methods for making and using the same |
| US6716452B1 (en) * | 2000-08-22 | 2004-04-06 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| CN1250563C (zh) | 1999-05-04 | 2006-04-12 | 斯特拉坎有限公司 | 雄激素糖苷及其产生雄性征的活性 |
| US6191119B1 (en) * | 1999-10-15 | 2001-02-20 | Supergen, Inc. | Combination therapy including 9-nitro-20(S)-camptothecin |
| US8394813B2 (en) | 2000-11-14 | 2013-03-12 | Shire Llc | Active agent delivery systems and methods for protecting and administering active agents |
| DE10058596A1 (de) * | 2000-11-25 | 2002-06-06 | Aventis Pharma Gmbh | Verfahren zum Screening von chemischen Verbindungen zur Modulierung der Wechselwirkung einer EVH1-Domäne oder eines Proteins mit einer EVH1-Domäne mit einer EVH1-Bindedomäne oder einem Protein mit einer EVH1-Bindedomäne sowie ein Verfahren zum Nachweis besagter Wechselwirkung |
| US20060014697A1 (en) | 2001-08-22 | 2006-01-19 | Travis Mickle | Pharmaceutical compositions for prevention of overdose or abuse |
| US7169752B2 (en) | 2003-09-30 | 2007-01-30 | New River Pharmaceuticals Inc. | Compounds and compositions for prevention of overdose of oxycodone |
| ES2330731T3 (es) | 2001-08-30 | 2009-12-15 | Chemocentryx, Inc. | Compuestos biciclicos como inhibidores de la union de quimioquina a us28. |
| CA2490626A1 (en) * | 2002-06-20 | 2003-12-31 | Nippon Suisan Kaisha, Ltd. | Prodrug, medicinal utilization thereof and process for producing the same |
| US8133881B2 (en) | 2003-01-13 | 2012-03-13 | Shire Llc | Carbohydrate conjugates to prevent abuse of controlled substances |
| US7160867B2 (en) | 2003-05-16 | 2007-01-09 | Isotechnika, Inc. | Rapamycin carbohydrate derivatives |
| JP2007530664A (ja) * | 2004-03-30 | 2007-11-01 | ペインセプター ファーマ コーポレーション | ゲートイオンチャンネルを調節するための組成物及び方法 |
| US7825096B2 (en) * | 2004-09-08 | 2010-11-02 | The United States Of America As Represented By The Department Of Health And Human Services | O6-alkylguanine-DNA alkyltransferase inactivators and beta-glucuronidase cleavable prodrugs |
| EP1896040B1 (en) * | 2005-06-29 | 2012-08-01 | Threshold Pharmaceuticals, Inc. | Phosphoramidate alkylator prodrugs |
| MX2009010820A (es) * | 2007-04-06 | 2010-03-18 | Ziopharm Oncology Inc | Sales de mostaza isofosforamida y analogos de la misma. |
| GB0907551D0 (en) * | 2009-05-01 | 2009-06-10 | Univ Dundee | Treatment or prophylaxis of proliferative conditions |
| CN102574846B (zh) * | 2009-09-02 | 2014-12-03 | 奥克兰联合服务有限公司 | 激酶抑制剂、其前药形式及它们在治疗中的用途 |
| KR101253399B1 (ko) | 2010-10-26 | 2013-04-11 | 영남대학교 산학협력단 | 아포지단백질 ａ－ｉ 및 그 변이체를 포함한 재조합 고밀도지단백질을 이용한 라파마이신 제형 |
| KR101628872B1 (ko) * | 2014-05-28 | 2016-06-09 | 주식회사 레고켐 바이오사이언스 | 자가-희생 기를 포함하는 화합물 |
| AU2016359235B2 (en) | 2015-11-25 | 2022-09-15 | Ligachem Biosciences Inc. | Antibody-drug conjugates comprising branched linkers and methods related thereto |
| AU2016359230B2 (en) | 2015-11-25 | 2020-04-23 | Ligachem Biosciences Inc. | Conjugates comprising self-immolative groups and methods related thereto |
| KR102847348B1 (ko) | 2015-11-25 | 2025-08-19 | 주식회사 리가켐바이오사이언스 | 펩타이드 그룹을 포함하는 접합체 및 이와 관련된 제조방법 |
| KR20180090290A (ko) | 2015-12-04 | 2018-08-10 | 시애틀 지네틱스, 인크. | 사차화 튜불리신 화합물들의 컨쥬게이트들 |
| US11793880B2 (en) | 2015-12-04 | 2023-10-24 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
| CA3058360A1 (en) | 2017-03-29 | 2018-10-04 | Legochem Biosciences, Inc. | Pyrrolobenzodiazepine dimer prodrug and ligand-linker conjugate compound of the same |
| AU2019216531A1 (en) | 2018-02-02 | 2020-09-24 | Maverix Oncology, Inc. | Small molecule drug conjugates of gemcitabine monophosphate |
| CN112601555A (zh) | 2018-05-09 | 2021-04-02 | 乐高化学生物科学股份有限公司 | 与抗cd19抗体药物结合物相关的组合物和方法 |
| KR20210028544A (ko) | 2019-09-04 | 2021-03-12 | 주식회사 레고켐 바이오사이언스 | 인간 ror1에 대한 항체를 포함하는 항체 약물 접합체 및 이의 용도 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5284856A (en) * | 1988-10-28 | 1994-02-08 | Hoechst Aktiengesellschaft | Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one derivatives |
| DE3836676A1 (de) * | 1988-10-28 | 1990-05-03 | Hoechst Ag | Die verwendung von 4h-1-benzopyran-4-on-derivaten, neue 4h-1-benzopyran-4-on-derivate und diese enthaltende arzneimittel |
| JP3273608B2 (ja) * | 1989-01-23 | 2002-04-08 | アクゾ・エヌ・ヴエー | 治療薬の部位特異的インビボ活性化 |
| DE4106389A1 (de) * | 1991-02-28 | 1992-09-03 | Behringwerke Ag | Fusionsproteine zur prodrug-aktivierung, ihre herstellung und verwendung |
| ES2102367T3 (es) * | 1990-05-18 | 1997-08-01 | Hoechst Ag | Amidas de acidos isoxazol-4-carboxilicos y amidas de acidos hidroxialquiliden-cianoaceticos, medicamentos que contienen estos compuestos y su utilizacion. |
| FR2676058B1 (fr) * | 1991-04-30 | 1994-02-25 | Hoechst Lab | Prodrogues glycosylees, leur procede de preparation et leur utilisation dans le traitement des cancers. |
| EP0538799B1 (en) * | 1991-10-25 | 1995-03-15 | TUNGSRAM Részvénytársaság | Single-capped low-pressure discharge lamp |
| DE4233152A1 (de) * | 1992-10-02 | 1994-04-07 | Behringwerke Ag | Antikörper-Enzym-Konjugate zur Prodrug-Aktivierung |
| CA2081281A1 (en) * | 1992-10-23 | 1994-04-24 | Shing-Ming Wang | Activation of glucuronide prodrugs by ligand-beta-glucuronidase conjugates for chemotherapy |
| DE4236237A1 (de) * | 1992-10-27 | 1994-04-28 | Behringwerke Ag | Prodrugs, ihre Herstellung und Verwendung als Arzneimittel |
| DE4314556A1 (de) * | 1993-05-04 | 1994-11-10 | Behringwerke Ag | Modifizierte Antikörperenzymkonjugate und Fusionsproteine sowie ihre Anwendung zur tumorselektiven Therapie |
| EP0647450A1 (en) * | 1993-09-09 | 1995-04-12 | BEHRINGWERKE Aktiengesellschaft | Improved prodrugs for enzyme mediated activation |
| DE4417865A1 (de) * | 1994-05-20 | 1995-11-23 | Behringwerke Ag | Kombination von Tumornekrose-induzierenden Substanzen mit Substanzen, die durch Nekrosen aktiviert werden, zur selektiven Tumortherapie |
-
1997
- 1997-02-27 EP EP97103162A patent/EP0795334B1/de not_active Expired - Lifetime
- 1997-02-27 DK DK97103162T patent/DK0795334T3/da active
- 1997-02-27 DE DE59712561T patent/DE59712561D1/de not_active Expired - Lifetime
- 1997-02-27 ES ES97103162T patent/ES2257756T3/es not_active Expired - Lifetime
- 1997-02-27 AT AT97103162T patent/ATE316799T1/de active
- 1997-02-27 SI SI9730727T patent/SI0795334T1/sl unknown
- 1997-03-03 RO RO97-00402A patent/RO120951B1/ro unknown
- 1997-03-06 BG BG101290A patent/BG61900B1/bg unknown
- 1997-03-06 RU RU97103585/14A patent/RU2191021C2/ru not_active IP Right Cessation
- 1997-03-07 AU AU16205/97A patent/AU708202B2/en not_active Ceased
- 1997-03-10 NZ NZ314368A patent/NZ314368A/xx not_active IP Right Cessation
- 1997-03-10 PL PL97318878A patent/PL189604B1/pl unknown
- 1997-03-10 TR TR97/00178A patent/TR199700178A2/xx unknown
- 1997-03-11 CN CNB971034656A patent/CN1168733C/zh not_active Expired - Fee Related
- 1997-03-11 NO NO19971116A patent/NO320322B1/no not_active IP Right Cessation
- 1997-03-11 US US08/814,655 patent/US5935995A/en not_active Expired - Lifetime
- 1997-03-11 CZ CZ0074297A patent/CZ297994B6/cs not_active IP Right Cessation
- 1997-03-11 BR BRPI9701248A patent/BRPI9701248B1/pt not_active IP Right Cessation
- 1997-03-11 UA UA97031095A patent/UA50719C2/uk unknown
- 1997-03-11 CA CA002199664A patent/CA2199664C/en not_active Expired - Fee Related
- 1997-03-11 JP JP05598397A patent/JP4392065B2/ja not_active Expired - Fee Related
- 1997-03-12 SG SG1997000702A patent/SG50011A1/en unknown
- 1997-03-12 KR KR1019970008174A patent/KR100466467B1/ko not_active Expired - Fee Related
- 1997-03-12 HU HU9700579A patent/HU228764B1/hu not_active IP Right Cessation
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