JPH09509172A - 免疫抑制活性を有する６−置換ミコフェノール酸および誘導体 - Google Patents

免疫抑制活性を有する６−置換ミコフェノール酸および誘導体

Info

Publication number
JPH09509172A
JPH09509172A JP7521866A JP52186695A JPH09509172A JP H09509172 A JPH09509172 A JP H09509172A JP 7521866 A JP7521866 A JP 7521866A JP 52186695 A JP52186695 A JP 52186695A JP H09509172 A JPH09509172 A JP H09509172A
Authority
JP
Japan
Prior art keywords
formula
methyl
compound
dihydro
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP7521866A
Other languages
English (en)
Japanese (ja)
Inventor
アルティス、ディーン・アール
エルワーシー、トッド・アール
ハウレー、ロナルド・シー
ラフヘッド、ディビッド・ジー
モーガン、ディビッド・ジェイ・ジュニア
ネルソン、ピーター・エイチ
パターソン、ジョン・ダブリュー・ジュニア
ジョグレン、エリック・ビー
スミス、ディビッド・ビー
ウォルトス、アン・マリー
ウェイカート、ロバート・ジェイ
ガルシア、アリシア・セ
セルトゥチェ、マリオ・エフェ
アンドラデ、フィデンシオ・エフェ
ヘルナンデス、マリア・テ・エレ
ムラ、フランシスコ・エキス・テ
マルチン、テレサ・ア・テ
Original Assignee
シンテックス（ユー・エス・エイ）・インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by シンテックス（ユー・エス・エイ）・インコーポレイテッド filed Critical シンテックス（ユー・エス・エイ）・インコーポレイテッド
Publication of JPH09509172A publication Critical patent/JPH09509172A/ja
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP7521866A 1994-02-18 1995-02-16 免疫抑制活性を有する６−置換ミコフェノール酸および誘導体 Ceased JPH09509172A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/198,725 1994-02-18
US08/198,725 US5444072A (en) 1994-02-18 1994-02-18 6-substituted mycophenolic acid and derivatives
PCT/US1995/001785 WO1995022536A1 (fr) 1994-02-18 1995-02-16 Derives substitues en 6 de l'acide mycophenolique a effet immunosuppresseur

Publications (1)

Publication Number Publication Date
JPH09509172A true JPH09509172A (ja) 1997-09-16

Family

ID=22734546

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7521866A Ceased JPH09509172A (ja) 1994-02-18 1995-02-16 免疫抑制活性を有する６−置換ミコフェノール酸および誘導体

Country Status (28)

Country Link
US (2) US5444072A (fr)
EP (1) EP0745075B1 (fr)
JP (1) JPH09509172A (fr)
CN (1) CN1141040A (fr)
AT (1) ATE210127T1 (fr)
AU (1) AU1917095A (fr)
BR (1) BR9506835A (fr)
CA (1) CA2183533A1 (fr)
CO (1) CO4340735A1 (fr)
DE (1) DE69524389T2 (fr)
DK (1) DK0745075T3 (fr)
ES (1) ES2168359T3 (fr)
FI (1) FI963221A (fr)
GT (1) GT199500006A (fr)
HK (1) HK1012634A1 (fr)
HR (1) HRP950071A2 (fr)
IL (1) IL112667A (fr)
IS (1) IS4265A (fr)
MY (1) MY130110A (fr)
PE (1) PE23096A1 (fr)
PH (1) PH31406A (fr)
PT (1) PT745075E (fr)
SI (1) SI0745075T1 (fr)
SV (1) SV1995000006A (fr)
TW (1) TW369532B (fr)
UY (2) UY23909A1 (fr)
WO (1) WO1995022536A1 (fr)
ZA (1) ZA951295B (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807876A (en) * 1996-04-23 1998-09-15 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme
US6054472A (en) * 1996-04-23 2000-04-25 Vertex Pharmaceuticals, Incorporated Inhibitors of IMPDH enzyme
CZ298463B6 (cs) * 1996-04-23 2007-10-10 Vertex Pharmaceuticals Incorporated Deriváty mocoviny pro použití jako inhibitory IMPDH enzymu a farmaceutické prostredky, které je obsahují
US6128582A (en) * 1996-04-30 2000-10-03 Vertex Pharmaceuticals Incorporated Molecules comprising an IMPDH-like binding pocket and encoded data storage medium capable of graphically displaying them
EP1366766A1 (fr) * 1997-03-14 2003-12-03 Vertex Pharmaceuticals Incorporated Inhibiteurs de l'enzyme IMPDH
WO1998040381A1 (fr) * 1997-03-14 1998-09-17 Vertex Pharmaceuticals Incorporated Inhibiteurs de l'enzyme impdh
US5932600A (en) * 1997-03-14 1999-08-03 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme
AU6037499A (en) * 1998-09-14 2000-04-03 Vertex Pharmaceuticals Incorporated Methods of treating viral disease
US6420403B1 (en) 1998-10-29 2002-07-16 Edwin J. Iwanowicz Inhibitors of IMPDH enzyme
JP2002528499A (ja) 1998-10-29 2002-09-03 ブリストル−マイヤーズ スクイブ カンパニー Ｉｍｐｄｈ酵素のインヒビターであるアミノ核誘導化合物
US6596747B2 (en) 1998-10-29 2003-07-22 Bristol-Myers Squibb Company Compounds derived from an amine nucleus and pharmaceutical compositions comprising same
EP1127054A4 (fr) * 1998-10-29 2006-11-02 Bristol Myers Squibb Co Nouveaux inhibiteurs de l'enzyme impdh
US6514979B1 (en) 1999-03-03 2003-02-04 University Of Maryland Biotechnology Institute Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor
EE200100492A (et) 1999-03-19 2002-12-16 Vertex Pharmaceuticals Incorporated Ensüümi IMPDH inhibiitorid
US6107052A (en) * 1999-06-09 2000-08-22 Roche Diagnostics Corporation Enzymatic measurement of mycophenolic acid
WO2001000622A1 (fr) 1999-06-25 2001-01-04 Vertex Pharmaceuticals Incorporated Promedicaments a base d'inhibiteurs carbamates de l'impdh
US6811998B2 (en) 1999-06-25 2004-11-02 Roche Diagnostics Operations, Inc. Conjugates of uncompetitive inhibitors of inosine monophosphate dehydrogenase
AU2001255538B2 (en) * 2000-04-24 2006-03-30 Bristol-Myers Squibb Company Heterocycles that are inhibitors of IMPDH enzyme
US7179791B2 (en) * 2001-01-11 2007-02-20 Duke University Inhibiting GS-FDH to modulate NO bioactivity
US20030105073A1 (en) * 2001-10-23 2003-06-05 Haughan Alan Findlay Quinolone derivatives
TW200301698A (en) * 2001-12-21 2003-07-16 Bristol Myers Squibb Co Acridone inhibitors of IMPDH enzyme
AU2003300076C1 (en) 2002-12-30 2010-03-04 Angiotech International Ag Drug delivery from rapid gelling polymer composition
US20050187170A1 (en) * 2003-06-16 2005-08-25 Biocryst Pharmaceuticals, Inc. Enhancing the efficiency of RNA polymerase inhibitors by using inosine monophosphate dehydrogenase inhibitors
US7276362B2 (en) 2004-01-30 2007-10-02 Roche Diagnostics Operations, Inc. Recombinant histidine-tagged inosine monophosphate dehydrogenase polypeptides
EP1768662A2 (fr) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Immuno-potentialisateurs a petites molecules et analyses visant a detecter leur presence
CN102952105A (zh) * 2011-08-26 2013-03-06 中国科学院上海药物研究所 一类霉酚酸衍生物、其制备方法和用途
CN104597238B (zh) * 2015-01-27 2016-08-17 苏州博源医疗科技有限公司 一种霉酚酸均相酶免疫检测试剂及其制备和检测方法
WO2017210262A1 (fr) 2016-06-02 2017-12-07 Steven Baranowitz Prévention et traitement d'infections virales
US10603299B2 (en) 2016-06-02 2020-03-31 Steven Baranowitz Prevention and treatment of viral infections
US12011429B2 (en) 2016-06-02 2024-06-18 Steven Baranowitz Prevention and treatment of viral infections
CN106674170B (zh) * 2016-12-30 2019-03-15 国家海洋局第三海洋研究所 三种苯酚类衍生物的制备方法及其在制备抗hiv药物中的应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5542995B2 (fr) * 1972-02-24 1980-11-04
US3825571A (en) * 1971-07-31 1974-07-23 Chugai Pharmaceutical Co Ltd Mycophenolic acid derivatives
JPS5529994B2 (fr) * 1972-03-02 1980-08-07
US4686234A (en) * 1985-11-27 1987-08-11 Syntex (U.S.A) Inc. Mycophenolic acid derivatives in the treatment of inflammatory diseases, in particular rheumatoid arthritis
US4725622A (en) * 1986-01-23 1988-02-16 Syntex (U.S.A.) Inc. Mycophenolic acid derivatives in the treatment of rheumatoid arthritis
US4959387A (en) * 1986-01-23 1990-09-25 Syntex (U.S.A.) Inc. Mycophenolic acid derivatives in the treatment of rheumatoid arthritis
US4861776A (en) * 1987-01-30 1989-08-29 Syntex (U.S.A) Inc. Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof, compositions and use
US4748173A (en) * 1987-01-30 1988-05-31 Syntex (U.S.A.) Inc. Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof and pharmaceutical compositions
US4727069A (en) * 1987-01-30 1988-02-23 Syntex (U.S.A.) Inc. Heterocyclic aminoalkyl esters of mycophenolic acid, derivatives thereof and pharmaceutical compositions
US4753935A (en) * 1987-01-30 1988-06-28 Syntex (U.S.A.) Inc. Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions
JPH0637486B2 (ja) * 1988-05-18 1994-05-18 三共株式会社 新規抗生物質フタレキシンおよびその製造法
CA2086642C (fr) * 1992-01-09 2004-06-15 Randall E. Morris Methode de traitement des maladies vasculaires hyperproliferatives
US5247083A (en) * 1992-07-10 1993-09-21 Syntex (U.S.A.) Inc. Direct esterification of mycophenolic acid

Also Published As

Publication number Publication date
ZA951295B (en) 1996-08-16
DE69524389T2 (de) 2002-08-29
ATE210127T1 (de) 2001-12-15
AU1917095A (en) 1995-09-04
MY130110A (en) 2007-06-29
HK1012634A1 (en) 1999-08-06
ES2168359T3 (es) 2002-06-16
PE23096A1 (es) 1996-06-04
WO1995022536A1 (fr) 1995-08-24
UY25263A1 (es) 2001-01-31
SI0745075T1 (en) 2002-06-30
UY23909A1 (es) 1995-03-06
US5536747A (en) 1996-07-16
CA2183533A1 (fr) 1995-08-24
US5444072A (en) 1995-08-22
DK0745075T3 (da) 2002-03-04
IL112667A0 (en) 1995-05-26
EP0745075A1 (fr) 1996-12-04
GT199500006A (es) 1996-08-10
CO4340735A1 (es) 1996-07-30
DE69524389D1 (de) 2002-01-17
TW369532B (en) 1999-09-11
HRP950071A2 (en) 1997-06-30
IL112667A (en) 2000-07-16
FI963221A0 (fi) 1996-08-16
BR9506835A (pt) 1997-10-14
IS4265A (is) 1995-08-19
PH31406A (en) 1998-10-29
FI963221A (fi) 1996-10-16
SV1995000006A (es) 1996-09-30
PT745075E (pt) 2002-05-31
CN1141040A (zh) 1997-01-22
EP0745075B1 (fr) 2001-12-05

Similar Documents

Publication Publication Date Title
JPH09509172A (ja) 免疫抑制活性を有する６−置換ミコフェノール酸および誘導体
JPH09509174A (ja) ミコフェノール酸の５−置換誘導体
EP0745074B1 (fr) Derives 4-amino de l'acide mycophenolique a effet immunosuppresseur
US5972936A (en) Benzofuran carboxamides and their therapeutic use
EP0165810B1 (fr) Dérivés de benzofuranne et de benzothiophène, leur application pour inhiber la biosynthèse de leucotriène aux mammifères et compositions pharmaceutiques contenant ces dérivés
CA2352786C (fr) Derives de benzofuranne, leur procede de preparation et leurs utilisations
US6262073B1 (en) Pharmaceutical methods of use of 5-substituted and 5,5 disubstituted-3,4-dihydroxy-2(5H)-furanones
JP2003516400A (ja) ヒドロキシルスチルベンならびに新規スチルベン誘導体および類似体による抗炎症治療および乾癬治療ならびにプロテインキナーゼ阻害
JPH05140142A (ja) アミノクマラン誘導体
JPH09509170A (ja) 免疫抑制活性を有する４−アミノ−６−置換ミコフェノール酸および誘導体
JPH09509173A (ja) ５−置換ミコフェノール酸の４−アミノ誘導体
US6670388B1 (en) Fatty acid synthase inhibitors
CA2025478A1 (fr) Trans -2,3-dihydro-5-hydroxybenzofuranes substitues en 2,3 en tant qu'inhibiteurs de la biosynthese des leukotrienes
JPH03170476A (ja) 抗炎症フラノン誘導体およびその用途
EP0420571A2 (fr) 1,2,3,4,41,9b-hexahydro-8-hydroxy-dibenzofuran-3-ols substitués en 6 et/ou en 7 comme inhibiteurs de la biosynthèse de leukotriène
JPS60161980A (ja) １，３−ジチオ−ル−２−イリデン誘導体

Legal Events

Date Code Title Description
A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20050301

A313 Final decision of rejection without a dissenting response from the applicant

Free format text: JAPANESE INTERMEDIATE CODE: A313

Effective date: 20050714

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20050823