JPH07508676A - 多重積層ブリスターパック中に凍結乾燥した投薬物を製造する改良方法 - Google Patents
多重積層ブリスターパック中に凍結乾燥した投薬物を製造する改良方法Info
- Publication number
- JPH07508676A JPH07508676A JP6512933A JP51293394A JPH07508676A JP H07508676 A JPH07508676 A JP H07508676A JP 6512933 A JP6512933 A JP 6512933A JP 51293394 A JP51293394 A JP 51293394A JP H07508676 A JPH07508676 A JP H07508676A
- Authority
- JP
- Japan
- Prior art keywords
- blister
- outer layers
- dosage
- layers
- blister film
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004519 manufacturing process Methods 0.000 title claims description 9
- 239000002552 dosage form Substances 0.000 title claims description 6
- 238000007710 freezing Methods 0.000 claims abstract description 11
- 230000008014 freezing Effects 0.000 claims abstract description 11
- 238000000034 method Methods 0.000 claims description 16
- 239000003814 drug Substances 0.000 claims description 15
- 229940079593 drug Drugs 0.000 claims description 15
- 239000000463 material Substances 0.000 claims description 15
- 239000010409 thin film Substances 0.000 claims description 15
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical group [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 13
- 229910052782 aluminium Inorganic materials 0.000 claims description 13
- 239000010408 film Substances 0.000 claims description 12
- -1 polyethylene Polymers 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 7
- 229920000642 polymer Polymers 0.000 claims description 5
- 239000004952 Polyamide Substances 0.000 claims description 4
- 239000004743 Polypropylene Substances 0.000 claims description 4
- 229920002647 polyamide Polymers 0.000 claims description 4
- 229920001155 polypropylene Polymers 0.000 claims description 4
- 229920000915 polyvinyl chloride Polymers 0.000 claims description 4
- 239000004800 polyvinyl chloride Substances 0.000 claims description 4
- 239000004922 lacquer Substances 0.000 claims description 2
- 239000004698 Polyethylene Substances 0.000 claims 4
- 229920000573 polyethylene Polymers 0.000 claims 4
- 235000000177 Indigofera tinctoria Nutrition 0.000 claims 1
- 229940097275 indigo Drugs 0.000 claims 1
- COHYTHOBJLSHDF-UHFFFAOYSA-N indigo powder Natural products N1C2=CC=CC=C2C(=O)C1=C1C(=O)C2=CC=CC=C2N1 COHYTHOBJLSHDF-UHFFFAOYSA-N 0.000 claims 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 claims 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims 1
- 238000007789 sealing Methods 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 abstract description 5
- 239000010410 layer Substances 0.000 abstract 3
- 239000011229 interlayer Substances 0.000 abstract 1
- 230000008602 contraction Effects 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000000859 sublimation Methods 0.000 description 2
- 230000008022 sublimation Effects 0.000 description 2
- 241001137251 Corvidae Species 0.000 description 1
- 241000287462 Phalacrocorax carbo Species 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 210000004709 eyebrow Anatomy 0.000 description 1
- 229940110366 glister Drugs 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000002420 orchard Substances 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B15/00—Layered products comprising a layer of metal
- B32B15/04—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B15/08—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
- A61J1/035—Blister-type containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B1/00—Layered products having a non-planar shape
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B15/00—Layered products comprising a layer of metal
- B32B15/20—Layered products comprising a layer of metal comprising aluminium or copper
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B27/08—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/30—Layered products comprising a layer of synthetic resin comprising vinyl (co)polymers; comprising acrylic (co)polymers
- B32B27/304—Layered products comprising a layer of synthetic resin comprising vinyl (co)polymers; comprising acrylic (co)polymers comprising vinyl halide (co)polymers, e.g. PVC, PVDC, PVF, PVDF
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/32—Layered products comprising a layer of synthetic resin comprising polyolefins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/34—Layered products comprising a layer of synthetic resin comprising polyamides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
- B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
- B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
- B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
- B65D75/325—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
- B65D75/327—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming several compartments
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2439/00—Containers; Receptacles
- B32B2439/80—Medical packaging
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Mechanical Engineering (AREA)
- Engineering & Computer Science (AREA)
- Composite Materials (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Packages (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Laminated Bodies (AREA)
- Wrappers (AREA)
- Medicinal Preparation (AREA)
- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
- Seasonings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Abstract
Description
Claims (11)
- 1.(a)実質的に類似の熱膨張係数をもつ第一および第二の外層ならびにこの 第一および第二の外層の間に位置する不透過性中間層を包含する多重積層ブリス ターフィルムの凹所に液状投薬物を導入し、(b)この投薬物を冷凍し、 (c)この投薬物を次いで凍結乾燥し、さらに(d)このブリスターフィルムに 藍皮シートを付着させて投薬物をブリスターフィルムの凹所に密封することを包 含する、ブリスターパック中に凍結乾燥した投薬物の製造方法。
- 2.前記のブリスターフィルムの中間層がアルミニウムである請求の範囲1の方 法。
- 3.前記のブリスターフィルムの第一および第二の外層が同一物質から作られる 請求の範囲1の方法。
- 4.前記のブリスターフィルムの外層の少なくとも一つが重合体物質である請求 の範囲1の方法。
- 5.前記の重合体物質がポリエチレン、ポリアミド、ポリ塩化ビニルおよびポリ プロピレンからなる群から選ばれる重合体の一種以上から本質的になる請求の範 囲4の方法。
- 6.前記のブリスターフィルムの第一および第二の外層が実質的に同じ厚さを有 する請求の範囲1の方法。
- 7.前記のブリスターフィルムの外層の少なくとも一つが複数の薄膜層からなる 請求の範囲1の方法。
- 8.前記の薄膜層の一つがラッカー層または下塗リ層である請求の範囲7の方法 。
- 9.前記の薄膜層の一つが重合体物質である請求の範囲7の方法。
- 10.前記の重合体物質がポリエチレン、ポリアミド、ポリ塩化ビニルおよびポ リプロピレンからなる群から選ばれる重合体の一種以上から本質的になる請求の 範囲9の方法。
- 11.(a)実質的に類似の熱膨張係数をもつ第一および第二の外層ならびにこ の第一および第二の外層の間に位置しこれらの外層に接着したアルミニウム中間 層を包含する多重積層ブリスターフィルムの凹所に液状投薬部を導入し、 (b)この投薬物を冷凍し、 (c)この投薬物を次いで凍結乾燥し、さらに(d)このブリスターフィルムに 蓋皮シートを付着させて投薬物をブリスターフィルムの凹所に密封することを包 含する、ブリスターパック中に凍結乾燥した投薬物の製造方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/985,040 US5343672A (en) | 1992-12-01 | 1992-12-01 | Method for manufacturing freeze dried dosages in a multilaminate blister pack |
US985,040 | 1992-12-01 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7085912A Division JP2796578B2 (ja) | 1992-12-01 | 1995-03-20 | 多重積層ブリスターフィルム |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH07508676A true JPH07508676A (ja) | 1995-09-28 |
JP2568479B2 JP2568479B2 (ja) | 1997-01-08 |
Family
ID=25531135
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6512933A Expired - Lifetime JP2568479B2 (ja) | 1992-12-01 | 1993-11-30 | 多重積層ブリスターパック中に凍結乾燥した投薬物を製造する改良方法 |
JP7085912A Expired - Fee Related JP2796578B2 (ja) | 1992-12-01 | 1995-03-20 | 多重積層ブリスターフィルム |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7085912A Expired - Fee Related JP2796578B2 (ja) | 1992-12-01 | 1995-03-20 | 多重積層ブリスターフィルム |
Country Status (18)
Country | Link |
---|---|
US (2) | US5343672A (ja) |
EP (2) | EP0646367B1 (ja) |
JP (2) | JP2568479B2 (ja) |
KR (1) | KR100227315B1 (ja) |
CN (1) | CN1066937C (ja) |
AT (2) | ATE153530T1 (ja) |
AU (1) | AU677030B2 (ja) |
BR (1) | BR9305805A (ja) |
CA (1) | CA2129254C (ja) |
DE (2) | DE69311109T2 (ja) |
ES (2) | ES2102143T3 (ja) |
FI (1) | FI105149B (ja) |
GR (1) | GR3023853T3 (ja) |
HK (2) | HK1007489A1 (ja) |
HU (1) | HU216509B (ja) |
NO (1) | NO303161B1 (ja) |
NZ (1) | NZ258600A (ja) |
WO (1) | WO1994012142A1 (ja) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001188475A (ja) * | 1999-10-21 | 2001-07-10 | Knoll Ag | ブリスタパックのためのマルチパートラベル及びその製造及び使用 |
JP2006519187A (ja) * | 2003-02-28 | 2006-08-24 | アルカベロ アクチェセルスカプ | 糖類マトリックスを有する剤形 |
US8012505B2 (en) | 2003-02-28 | 2011-09-06 | Alk-Abello A/S | Dosage form having a saccharide matrix |
US11278501B2 (en) | 2018-10-15 | 2022-03-22 | Aprecia Pharmaceuticals LLC | Method and system for forming a dosage form within a packaging |
US11383440B2 (en) | 2015-08-21 | 2022-07-12 | Aprecia Pharmaceuticals LLC | Three-dimensional printing system and equipment assembly |
Families Citing this family (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5343672A (en) * | 1992-12-01 | 1994-09-06 | Scherer Ltd R P | Method for manufacturing freeze dried dosages in a multilaminate blister pack |
CH684746A5 (de) * | 1993-02-25 | 1994-12-15 | Alusuisse Lonza Services Ag | Laminat. |
US5457895A (en) * | 1993-10-01 | 1995-10-17 | R. P. Scherer Corporation | Method of identifying freeze-dried dosage forms |
US5518892A (en) * | 1994-02-23 | 1996-05-21 | Idexx Laboratories, Inc. | Apparatus and method for quantification of biological material in a liquid sample |
US5488816A (en) * | 1994-07-21 | 1996-02-06 | Boehringer Mannheim Corporation | Method and apparatus for manufacturing a coagulation assay device in a continuous manner |
GB9424535D0 (en) * | 1994-12-05 | 1995-01-25 | Ilett Mary | Animal and insect control |
US5887410A (en) * | 1995-03-01 | 1999-03-30 | International Beauty Network, Inc | Method of molding an packaging of a novelty soap |
EP0845350A1 (de) * | 1996-11-29 | 1998-06-03 | Alusuisse Technology & Management AG | Kalt-verformbare Verbundfolie |
CA2284132C (en) * | 1997-04-01 | 2004-09-07 | Cima Labs Inc. | Blister package and packaged tablet |
EP1001748B1 (en) * | 1997-07-25 | 2006-04-19 | Alpex Pharma S.A. | A process for the preparation of a granulate suitable to the preparation of rapidly disintegrable mouth-soluble tablets |
EP1005413B1 (en) * | 1997-08-18 | 2002-05-08 | R.P. Scherer Corporation | The formation of indicia in the base of a blister pack for transference to a body cast therein |
EP0905042A1 (de) * | 1997-09-17 | 1999-03-31 | Alusuisse Technology & Management AG | Blister- oder Durchdrückpackung |
US6416257B1 (en) | 1998-03-27 | 2002-07-09 | Anchor Wall Systems, Inc. | Segmental retaining wall system |
CA2334950C (en) | 1998-06-22 | 2007-12-04 | Astrazeneca Ab | Device for emptying powder-containing cavities by suction |
GB9817793D0 (en) | 1998-08-14 | 1998-10-14 | Scherer Corp R P | The formation of indicia in the base of a blister pack for transference to a body cast therein |
GB9827292D0 (en) | 1998-12-12 | 1999-02-03 | Univ Strathclyde | Freeze drying |
US6318934B1 (en) * | 1999-06-24 | 2001-11-20 | Anchor Wall Systems, Inc. | Segmental retaining wall system |
CN1232423C (zh) * | 1999-09-09 | 2005-12-21 | 戴里戈德技术有限公司 | 用于包装食品的方法 |
EP1157682A1 (en) † | 2000-05-25 | 2001-11-28 | Cilag AG | Blister package for topiramate tablets |
JP4149803B2 (ja) | 2000-06-27 | 2008-09-17 | エフ.ホフマン−ラ ロシュ アーゲー | 組成物の調製方法 |
AU2001284772A1 (en) * | 2000-08-10 | 2002-02-25 | Delsys Pharmaceutical Corporation | Improved solid pharmaceutical dosage formulation of hydrophobic drugs |
US6869059B2 (en) * | 2000-11-30 | 2005-03-22 | The Pillsbury Company | Bakeable muffin pan, and use thereof |
US6814978B2 (en) * | 2000-12-29 | 2004-11-09 | Mcneil-Ppc, Inc. | Process for preparing a soft tablet |
US6588180B2 (en) * | 2001-02-02 | 2003-07-08 | R. P. Scherer Technologies, Inc. | Constricted neck blister pack and apparatus and method for making the same |
EP1399057B8 (en) * | 2001-06-08 | 2012-05-02 | Roche Diagnostics GmbH | Control solution packets and methods for calibrating body fluid sampling devices |
WO2003015783A1 (en) * | 2001-08-14 | 2003-02-27 | Biotie Therapies Corporation | Method of treating alcoholism or alcohol abuse |
JP4731767B2 (ja) * | 2001-09-19 | 2011-07-27 | 株式会社ミューチュアル | ブリスター包装機のフィルム加熱成形方法及びその装置 |
ES2266568T3 (es) * | 2001-10-08 | 2007-03-01 | THE PROCTER & GAMBLE COMPANY | Procedimiento para la produccion de bolsas hidrosolubles asi como las bolsas asi obtenidas. |
US20050051453A1 (en) * | 2001-12-21 | 2005-03-10 | Inhale Therapeutic Systems, Inc. | Sealing a pharmaceutical formulation in a package |
ATE516799T1 (de) * | 2002-02-13 | 2011-08-15 | Michael K Weibel | Arzneimitteldosenform und -herstellungsverfahren |
GB0210397D0 (en) | 2002-05-07 | 2002-06-12 | Ferring Bv | Pharmaceutical formulations |
US6887709B2 (en) * | 2002-05-09 | 2005-05-03 | Lifescan, Inc. | Devices, systems and methods for the containment and use of liquid solutions |
AU2003256284A1 (en) * | 2002-06-20 | 2004-01-06 | Orapharma, Inc. | Rapidly disintegrating formulations for treating or preventing mucositis |
GB0225621D0 (en) * | 2002-11-02 | 2002-12-11 | Glaxo Group Ltd | Medicament carrier |
WO2004047793A1 (en) | 2002-11-26 | 2004-06-10 | Alk-Abelló A/S | Pharmaceutical allergen product |
US20040224024A1 (en) * | 2003-04-23 | 2004-11-11 | Massachusetts Institute Of Technology | Controlled drug release formulations containing polyion complexes |
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JP2001188475A (ja) * | 1999-10-21 | 2001-07-10 | Knoll Ag | ブリスタパックのためのマルチパートラベル及びその製造及び使用 |
JP2006519187A (ja) * | 2003-02-28 | 2006-08-24 | アルカベロ アクチェセルスカプ | 糖類マトリックスを有する剤形 |
JP4688787B2 (ja) * | 2003-02-28 | 2011-05-25 | アルカベロ アクチェセルスカプ | 糖類マトリックスを有する剤形 |
US8012505B2 (en) | 2003-02-28 | 2011-09-06 | Alk-Abello A/S | Dosage form having a saccharide matrix |
US11383440B2 (en) | 2015-08-21 | 2022-07-12 | Aprecia Pharmaceuticals LLC | Three-dimensional printing system and equipment assembly |
US11278501B2 (en) | 2018-10-15 | 2022-03-22 | Aprecia Pharmaceuticals LLC | Method and system for forming a dosage form within a packaging |
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