JPH0646943B2 - 生体細胞への物質の微小注入法及びそのための装置 - Google Patents
生体細胞への物質の微小注入法及びそのための装置Info
- Publication number
- JPH0646943B2 JPH0646943B2 JP1063423A JP6342389A JPH0646943B2 JP H0646943 B2 JPH0646943 B2 JP H0646943B2 JP 1063423 A JP1063423 A JP 1063423A JP 6342389 A JP6342389 A JP 6342389A JP H0646943 B2 JPH0646943 B2 JP H0646943B2
- Authority
- JP
- Japan
- Prior art keywords
- cannula
- plane
- drive
- holder
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000126 substance Substances 0.000 title claims abstract description 6
- 238000000034 method Methods 0.000 title claims description 15
- 238000002347 injection Methods 0.000 claims abstract description 10
- 239000007924 injection Substances 0.000 claims abstract description 10
- 239000000725 suspension Substances 0.000 claims abstract description 4
- 239000000463 material Substances 0.000 claims abstract description 3
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 claims description 5
- 239000000243 solution Substances 0.000 claims description 3
- 230000001413 cellular effect Effects 0.000 claims 1
- 238000000520 microinjection Methods 0.000 abstract description 3
- 239000007788 liquid Substances 0.000 abstract description 2
- 210000004027 cell Anatomy 0.000 description 27
- 210000003855 cell nucleus Anatomy 0.000 description 15
- 210000000170 cell membrane Anatomy 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 238000013459 approach Methods 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 210000004940 nucleus Anatomy 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3808531A DE3808531C1 (enExample) | 1988-03-15 | 1988-03-15 | |
| DE3808531.3 | 1988-03-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH02119770A JPH02119770A (ja) | 1990-05-07 |
| JPH0646943B2 true JPH0646943B2 (ja) | 1994-06-22 |
Family
ID=6349731
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1063423A Expired - Lifetime JPH0646943B2 (ja) | 1988-03-15 | 1989-03-15 | 生体細胞への物質の微小注入法及びそのための装置 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5114854A (enExample) |
| EP (1) | EP0332864B1 (enExample) |
| JP (1) | JPH0646943B2 (enExample) |
| AT (1) | ATE85076T1 (enExample) |
| DE (1) | DE3808531C1 (enExample) |
| ES (1) | ES2037889T3 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10136481A1 (de) * | 2001-07-27 | 2003-02-20 | Leica Microsystems | Anordnung zum Mikromanipulieren von biologischen Objekten |
| US5413924A (en) * | 1992-02-13 | 1995-05-09 | Kosak; Kenneth M. | Preparation of wax beads containing a reagent for release by heating |
| US5344610A (en) * | 1993-02-03 | 1994-09-06 | Eastman Kodak Company | Aspirator probe with long pivot arm to minimize tip flick |
| DE4401076C2 (de) * | 1994-01-15 | 1998-12-03 | Eppendorf Geraetebau Netheler | Vorrichtung zur Injektion von Flüssigkeiten in biologische Zellen |
| DE19629141A1 (de) | 1996-07-19 | 1998-04-16 | Bayer Ag | Verfahren und Vorrichtung zum Screening von Molekülen bezüglich ihres individuellen Bindungsverhaltens zu mindestens einem vorgegebenen Ligand |
| DE19714987C1 (de) * | 1997-04-10 | 1998-09-24 | Deutsches Krebsforsch | Vorrichtung zur Isolation von Partikeln, insbesondere von Zellen |
| DE19721084A1 (de) * | 1997-05-20 | 1998-11-26 | Max Planck Gesellschaft | Mikroinjektion |
| US5877008A (en) * | 1997-07-22 | 1999-03-02 | Lockheed Martin Energy Research Corporation | Microinjector for blasocysts |
| US6410057B1 (en) | 1997-12-12 | 2002-06-25 | Samyang Corporation | Biodegradable mixed polymeric micelles for drug delivery |
| AU740342B2 (en) | 1997-12-12 | 2001-11-01 | Samyang Corporation | Biodegradable mixed polymeric micelles for gene delivery |
| US6913934B2 (en) * | 1998-08-13 | 2005-07-05 | Symyx Technologies, Inc. | Apparatus and methods for parallel processing of multiple reaction mixtures |
| US6759014B2 (en) * | 2001-01-26 | 2004-07-06 | Symyx Technologies, Inc. | Apparatus and methods for parallel processing of multiple reaction mixtures |
| EP1204790A4 (en) * | 1999-04-23 | 2004-08-04 | Monica Palacios-Boyce | MICROELECTROMECHANICAL DEVICE FOR HANDLING CELLS OR EMBRYONS, KITS THEREFOR, METHOD FOR THE PRODUCTION THEREOF AND METHOD FOR THE USE THEREOF |
| JP3442357B2 (ja) * | 2000-08-25 | 2003-09-02 | 株式会社日立製作所 | 両生類卵母細胞試料導入装置、両生類卵母細胞試料導入システム、両生類卵母細胞試料導入方法、両生類卵母細胞の製造方法、両生類卵母細胞及びそれを販売又は譲渡する方法、スクリーニング用のセンサーとして用いる方法、容器、及び解析方法 |
| DE10136572B4 (de) * | 2001-07-27 | 2005-11-17 | Eppendorf Ag | Vorrichtung zur optisch kontrollierten Mikromanipulation von biologischen Objekten |
| JP4802319B2 (ja) * | 2002-08-08 | 2011-10-26 | 国立大学法人東京農工大学 | 単一細胞操作支援ロボット |
| KR100475098B1 (ko) * | 2002-11-12 | 2005-03-11 | 한국과학기술연구원 | 단일 셀 조작을 위한 바이오 자동 조작 장치 |
| MXPA06001719A (es) * | 2003-08-11 | 2006-05-19 | Codexis Inc | Polipeptidos de glucosa deshidrogenasa mejorados, y polinucleotidos relacionados. |
| JP4504082B2 (ja) | 2004-04-28 | 2010-07-14 | 富士通株式会社 | 液体注入装置 |
| JP4456429B2 (ja) * | 2004-07-27 | 2010-04-28 | 富士通株式会社 | インジェクション装置 |
| DE102004053596B4 (de) | 2004-11-05 | 2006-10-12 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren und Vorrichtungen zur Bearbeitung einzelner biologischer Zellen |
| JP4894199B2 (ja) * | 2005-02-17 | 2012-03-14 | 富士通株式会社 | 物質注入装置 |
| US20060246571A1 (en) * | 2005-04-29 | 2006-11-02 | Fujitsu Limited | Apparatus and method for automatically producing substance-introduced particles |
| US7491669B2 (en) * | 2006-02-07 | 2009-02-17 | Crystal Clear Technologies, Inc. | Adsorbent with multiple layers |
| JP2007166981A (ja) * | 2005-12-22 | 2007-07-05 | Fujitsu Ltd | 注入装置及び方法 |
| US8497119B1 (en) | 2010-12-15 | 2013-07-30 | Paul J. Taylor | Method and device for performing micro-operations on a vesicular object |
| DE102011012993B3 (de) * | 2011-03-04 | 2012-07-12 | Otto-Von-Guericke-Universität Magdeburg | Integriertes Greif- und Zuführsystem für Anwendungen in der Mikro- und Nanotechnik zur Manipulation von Mikro- und Nano-Objekten und Verfahren zur Durchführung der Manipulation |
| KR101387422B1 (ko) * | 2012-06-13 | 2014-04-21 | 듀라케미 (주) | 관의 내.외부 방식도장에 의해 결합된 패킹 일체형 관 |
| GB2508906A (en) * | 2012-12-14 | 2014-06-18 | Life Science Methods Bv | Frame element for sample injection with optical control means |
| US11680277B2 (en) | 2016-10-31 | 2023-06-20 | Mekonos Limited | Array of needle manipulators for biological cell injection |
| US10702690B2 (en) | 2017-02-03 | 2020-07-07 | Infinitesimal Llc | Electroporation system with micromanipulator and probe |
| CN113950350A (zh) | 2019-06-13 | 2022-01-18 | 梅科诺公司 | 微机电系统结构及其应用 |
| US12233406B2 (en) | 2021-08-04 | 2025-02-25 | City University Of Hong Kong | Automated system for high-throughput microinjection of adherent cells |
| GB202301403D0 (en) * | 2023-01-31 | 2023-03-15 | Francis Crick Institute Ltd | Systems and method for examining biological material |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU675359A1 (en) * | 1977-04-06 | 1979-07-25 | Inst Biologicheskoi Fiz | Method of obtaining sub-cell structures |
| JPS54158945A (en) * | 1978-06-05 | 1979-12-15 | Olympus Optical Co Ltd | Micro-manipulator |
| DE3204040A1 (de) * | 1982-02-05 | 1983-08-11 | Europäisches Laboratorium für Molekularbiologie (EMBL), 6900 Heidelberg | Verfahren und vorrichtung zur injektion von sehr kleinen probenmengen in zellen |
| DE3390499C2 (de) * | 1983-06-30 | 1986-11-06 | Institut Biochimii I Fiziologii Mikroorganizmov Akademii Nauk Sssr | Verfahren zur Durchf}hrung von Mikrooperationen anZelten und Einrichtung zu dessen Verwirklichung |
| JPS60118473A (ja) * | 1983-11-29 | 1985-06-25 | オリンパス光学工業株式会社 | マイクロマニピユレ−タ |
| JPS60205411A (ja) * | 1984-03-29 | 1985-10-17 | Olympus Optical Co Ltd | 倒立型顕微鏡 |
| DE3718066A1 (de) * | 1987-05-29 | 1988-12-08 | Zeiss Carl Fa | Verfahren zur mikroinjektion in zellen bzw. zum absaugen aus einzelnen zellen oder ganzer zellen aus zellkulturen |
-
1988
- 1988-03-15 DE DE3808531A patent/DE3808531C1/de not_active Expired
-
1989
- 1989-02-16 EP EP89102612A patent/EP0332864B1/de not_active Expired - Lifetime
- 1989-02-16 ES ES198989102612T patent/ES2037889T3/es not_active Expired - Lifetime
- 1989-02-16 AT AT89102612T patent/ATE85076T1/de not_active IP Right Cessation
- 1989-02-21 US US07/312,960 patent/US5114854A/en not_active Expired - Lifetime
- 1989-03-15 JP JP1063423A patent/JPH0646943B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH02119770A (ja) | 1990-05-07 |
| US5114854A (en) | 1992-05-19 |
| EP0332864A3 (en) | 1990-07-18 |
| ATE85076T1 (de) | 1993-02-15 |
| EP0332864A2 (de) | 1989-09-20 |
| DE3808531C1 (enExample) | 1989-07-13 |
| EP0332864B1 (de) | 1993-01-27 |
| ES2037889T3 (es) | 1993-07-01 |
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