JPH0538B2 - - Google Patents
Info
- Publication number
- JPH0538B2 JPH0538B2 JP2047125A JP4712590A JPH0538B2 JP H0538 B2 JPH0538 B2 JP H0538B2 JP 2047125 A JP2047125 A JP 2047125A JP 4712590 A JP4712590 A JP 4712590A JP H0538 B2 JPH0538 B2 JP H0538B2
- Authority
- JP
- Japan
- Prior art keywords
- cells
- cell line
- medium
- rats
- hybrid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000000153 supplemental effect Effects 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 238000004114 suspension culture Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/14—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from fungi, algea or lichens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
- C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/948—Microorganisms using viruses or cell lines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8022206 | 1980-07-07 | ||
| GB8022206 | 1980-07-07 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56106817A Division JPS5739777A (en) | 1980-07-07 | 1981-07-07 | Cell line |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4051415A Division JPH05304979A (ja) | 1980-07-07 | 1992-03-10 | モノクローナル抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH02291298A JPH02291298A (ja) | 1990-12-03 |
| JPH0538B2 true JPH0538B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1993-01-05 |
Family
ID=10514589
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56106817A Granted JPS5739777A (en) | 1980-07-07 | 1981-07-07 | Cell line |
| JP2047125A Granted JPH02291298A (ja) | 1980-07-07 | 1990-02-27 | 抗体の生産方法 |
| JP4051415A Pending JPH05304979A (ja) | 1980-07-07 | 1992-03-10 | モノクローナル抗体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56106817A Granted JPS5739777A (en) | 1980-07-07 | 1981-07-07 | Cell line |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4051415A Pending JPH05304979A (ja) | 1980-07-07 | 1992-03-10 | モノクローナル抗体 |
Country Status (5)
Families Citing this family (109)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH652145A5 (de) * | 1982-01-22 | 1985-10-31 | Sandoz Ag | Verfahren zur in vitro-herstellung von hybridomen welche humane monoklonale antikoerper erzeugen. |
| US4987079A (en) * | 1982-07-06 | 1991-01-22 | Wilbur D. Smith | Composition and method for in vitro cell culture |
| JPH0679553B2 (ja) * | 1983-01-20 | 1994-10-12 | サントリー株式会社 | 新規な雑種細胞 |
| GB8318575D0 (en) * | 1983-07-08 | 1983-08-10 | Cobbold S P | Antibody preparations |
| US5639639A (en) * | 1983-11-02 | 1997-06-17 | Genzyme Corporation | Recombinant heterodimeric human fertility hormones, and methods, cells, vectors and DNA for the production thereof |
| US4634666A (en) * | 1984-01-06 | 1987-01-06 | The Board Of Trustees Of The Leland Stanford Junior University | Human-murine hybridoma fusion partner |
| US4562003A (en) * | 1984-10-26 | 1985-12-31 | California Biotechnology, Inc. | Monoclonal antibodies against alveolar surfactant protein |
| US5981216A (en) * | 1985-04-01 | 1999-11-09 | Alusuisse Holdings A.G. | Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same |
| EP0216846B2 (en) * | 1985-04-01 | 1995-04-26 | Celltech Limited | Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same |
| US4808532A (en) * | 1985-07-01 | 1989-02-28 | The United States Of America As Represented By The United States Department Of Energy | Continuous human cell lines and method of making same |
| US5292636A (en) * | 1986-03-31 | 1994-03-08 | T Cell Diagnostics, Inc. | Therapeutic and diagnostic methods using soluble T cell surface molecules |
| JPS63180059U (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1987-05-11 | 1988-11-21 | ||
| EP0329184A3 (en) * | 1988-02-19 | 1990-05-23 | Neorx Corporation | Antimers and antimeric conjugation |
| DE68928124T2 (de) | 1988-09-02 | 1997-10-16 | Chiron Corp., Emeryville, Calif. | Makrophagenabgeleiteter entzündungsmediator(mip-2) |
| CA2002067A1 (en) * | 1988-11-09 | 1990-05-09 | Tamotsu Fukuda | Parent cell line for producing human hybridomas |
| JPH0727946Y2 (ja) * | 1989-03-14 | 1995-06-28 | トーコー衛材株式会社 | 簡易マスク |
| US5567594A (en) * | 1991-04-26 | 1996-10-22 | Enteron, L.P. | Methods and compositions for the detection and treatment of diseases associated with antigens of microorganisms |
| US6190864B1 (en) | 1991-05-08 | 2001-02-20 | Chiron Corporation | HCV genomic sequences for diagnostics and therapeutics |
| JPH08510240A (ja) | 1993-05-12 | 1996-10-29 | カイロン コーポレイション | Ｃ型肝炎ウイルスｅ２／ｎｓ１領域の保存モチーフ |
| US6124439A (en) * | 1994-08-17 | 2000-09-26 | The Rockefeller University | OB polypeptide antibodies and method of making |
| US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| US6001968A (en) | 1994-08-17 | 1999-12-14 | The Rockefeller University | OB polypeptides, modified forms and compositions |
| US6350730B1 (en) | 1994-08-17 | 2002-02-26 | The Rockefeller University | OB polypeptides and modified forms as modulators of body weight |
| US6048837A (en) * | 1994-08-17 | 2000-04-11 | The Rockefeller University | OB polypeptides as modulators of body weight |
| US6471956B1 (en) | 1994-08-17 | 2002-10-29 | The Rockefeller University | Ob polypeptides, modified forms and compositions thereto |
| US6124448A (en) * | 1994-08-17 | 2000-09-26 | The Rockfeller University | Nucleic acid primers and probes for the mammalian OB gene |
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| AU766492B2 (en) * | 1998-09-18 | 2003-10-16 | Dynavax Technologies Corporation | Methods of treating IgE-associated disorders and compositions for use therein |
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| US6773911B1 (en) * | 1998-11-23 | 2004-08-10 | Amgen Canada Inc. | Apoptosis-inducing factor |
| US6156514A (en) * | 1998-12-03 | 2000-12-05 | Sunol Molecular Corporation | Methods for making recombinant cells |
| WO2000050078A1 (en) | 1999-02-26 | 2000-08-31 | Chiron Corporation | Use of bioadhesives and adjuvants for the mucosal delivery of antigens |
| US6399759B1 (en) | 1999-05-27 | 2002-06-04 | University Of Georgia Research Foundation, Inc. | Ant proteases and methods of inhibition |
| US6262265B1 (en) | 1999-06-18 | 2001-07-17 | Microgenics Corporation | Non-hydrolyzable analogs of heroin metabolites suitable for use in immunoassay |
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| DE19957065B4 (de) | 1999-11-26 | 2005-01-05 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Screening-Verfahren für Arzneistoffe |
| AU2001230912A1 (en) * | 2000-01-11 | 2001-07-24 | The Board Of Regents Of The University Of Nebraska | Identification of virulence determinants |
| AU2016204535C1 (en) * | 2000-04-12 | 2017-02-23 | Laboratoire Français Du Fractionnement Et Des Biotechnologies | Anti-D monoclonal antibodies |
| FR2807767B1 (fr) | 2000-04-12 | 2005-01-14 | Lab Francais Du Fractionnement | Anticorps monoclonaux anti-d |
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| EP1734050A3 (en) | 2000-06-12 | 2012-12-05 | University Of Saskatchewan | Immunization of dairy cattle with GapC protein against streptococcus infection |
| US7018812B2 (en) * | 2000-11-03 | 2006-03-28 | Duke University | Modified G-protein coupled receptors |
| US7163800B2 (en) * | 2000-11-03 | 2007-01-16 | Molecular Devices Corporation | Methods of screening compositions for G protein-coupled receptor desensitization inhibitory activity |
| US20050136431A1 (en) * | 2000-11-03 | 2005-06-23 | Oakley Robert H. | Methods of screening compositions for G protein-coupled receptor desensitization inhibitory activity |
| FR2817875B1 (fr) * | 2000-12-07 | 2005-03-18 | Technopharm | Procede de preparation d'un anticorps monoclonal humain, de fragments de celui-ci ou d'anticorps comprenant de tels fragments, les anticorps ainsi obtenus et leur utilisation |
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| US20090324612A1 (en) * | 2001-06-05 | 2009-12-31 | Kaufman Daniel L | Modulating neuronal outgrowth via the major histocompatibility complex class i (mhc i) molecule |
| AU2002312329A1 (en) * | 2001-06-05 | 2002-12-16 | The Regents Of The University Of California | Modulating neuronal outgrowth via the major histocompatibility complex class i (mhc i) molecule |
| AU2003201159A1 (en) | 2002-01-08 | 2003-07-24 | Bayer Healthcare Ag | Single nucleotide polymorphisms predicting cardiovascular disease and medication efficacy |
| US20030182669A1 (en) * | 2002-03-19 | 2003-09-25 | Rockman Howard A. | Phosphoinositide 3-kinase mediated inhibition of GPCRs |
| AU2003228348A1 (en) * | 2002-03-20 | 2003-10-08 | John T. Fassett | Induction of hepatocyte proliferation in vitro by inhibition of cell cycle inhibitors |
| US7290215B2 (en) * | 2002-06-03 | 2007-10-30 | Microsoft Corporation | Dynamic wizard interface system and method |
| AU2003273633A1 (en) | 2002-09-26 | 2004-04-19 | K.U.Leuven Research And Development | Integrase cofactor |
| AU2002953431A0 (en) * | 2002-12-19 | 2003-01-09 | Murdoch University | BmpB Novel Nucleotide and Amino Acid Sequences and Diagnostic and Therapeutic Uses Thereof |
| CA2514179A1 (en) * | 2003-01-24 | 2004-08-12 | Duke University | Modified trafficking patterns for arrestin and g-protein-coupled receptors via arrestin-ubiquitin chimera |
| AU2004247021A1 (en) * | 2003-05-16 | 2004-12-23 | Acorda Therapeutics | Compositions and methods including a recombinant human MAB that promotes CNS remyelination |
| US20060035242A1 (en) | 2004-08-13 | 2006-02-16 | Michelitsch Melissa D | Prion-specific peptide reagents |
| US7767792B2 (en) | 2004-02-20 | 2010-08-03 | Ludwig Institute For Cancer Research Ltd. | Antibodies to EGF receptor epitope peptides |
| US7138504B2 (en) * | 2004-08-12 | 2006-11-21 | Microgenics Corporation | Reagents and methods for mycophenolic acid immunoassay |
| US20060240496A1 (en) * | 2005-04-21 | 2006-10-26 | Lakshmi Anne | Immunogens, derivatives and immunoassay for ethyl glucuronide |
| AR053385A1 (es) | 2005-05-12 | 2007-05-02 | Novartis Ag | Genes y proteinas novedosos de brachyspira hyodysenteriae y uso de los mismos para diagnostico y terapia |
| KR20130099253A (ko) | 2005-06-22 | 2013-09-05 | 제론 코포레이션 | 영장류 다능성 줄기 세포의 심근세포 계통 세포로의 분화 |
| US7780969B2 (en) * | 2005-07-15 | 2010-08-24 | University Of Georgia Research Foundation, Inc. | Trypanosoma cruzi proteome compositions and methods |
| CN101627111A (zh) * | 2005-08-31 | 2010-01-13 | 森托科尔公司 | 用于生产具有增强的效应子功能的抗体恒定区的宿主细胞系 |
| MX2008003054A (es) * | 2005-08-31 | 2008-03-25 | Centocor Inc | Lineas de celulas hospederas para la produccion de la region constante de anticuerpos, con fusion efectora mejorada. |
| EP2759307B1 (en) | 2006-03-29 | 2016-11-09 | Merial Limited | Vaccine against Streptococci |
| ES2530716T3 (es) | 2006-04-21 | 2015-03-04 | Intervet Int Bv | Especies de pestivirus |
| EP2676678A1 (en) | 2007-07-17 | 2013-12-25 | The General Hospital Corporation | Methods to identify and enrich populations of ovarian cancer stem cells and somatic stem cells and uses thereof |
| BRPI0721908A2 (pt) | 2007-08-03 | 2014-02-25 | Spirogene Pty Ltd | Genes e proteínas de brachyspira hyodysenteriae e usos dos mesmos |
| EP2363407A1 (en) | 2008-02-28 | 2011-09-07 | Murdoch University | Novel sequences of Brachyspira, immunogenic compositions, methods for preparation and use thereof |
| EP2530087B1 (en) | 2008-03-27 | 2018-05-02 | Murdoch University | Sequences of brachyspira, immunogenic composition, methods for preparation and use thereof |
| US8093049B2 (en) | 2008-03-27 | 2012-01-10 | Geron Corporation | Differentiation of primate pluripotent stem cells to hematopoietic lineage cells |
| JP5822822B2 (ja) | 2009-04-17 | 2015-11-24 | ニューヨーク ユニバーシティ | Ｔｎｆファミリー受容体を標的とし、ｔｎｆ作用を拮抗するペプチド、その組成物、方法および使用 |
| US20110076232A1 (en) | 2009-09-29 | 2011-03-31 | Ludwig Institute For Cancer Research | Specific binding proteins and uses thereof |
| US9005579B2 (en) | 2010-01-05 | 2015-04-14 | Contrafect Corporation | Methods and compositions for enhanced immunological therapy and targeting of gram-positive bacteria |
| WO2011113118A1 (en) | 2010-03-19 | 2011-09-22 | Katholieke Universiteit Leuven | Drug tolerance/persistence of fungal biofilms |
| US9169329B2 (en) | 2010-06-01 | 2015-10-27 | Ludwig Institute For Cancer Research | Antibodies directed to the receptor tyrosine kinase c-Met |
| SG190793A1 (en) | 2010-11-11 | 2013-07-31 | Agency Science Tech & Res | Targeting metabolic enzymes in human cancer |
| CA2829804A1 (en) | 2011-03-29 | 2012-10-04 | Geron Corporation | Enriched populations of cardiomyocyte lineage cells from pluripotent stem cells |
| GB201107467D0 (en) | 2011-05-05 | 2011-06-15 | Univ Leuven Kath | Novel treatment of pain |
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| WO2014080251A1 (en) | 2012-11-24 | 2014-05-30 | Hangzhou Dac Biotech Co., Ltd. | Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules |
| US10221239B2 (en) | 2013-06-28 | 2019-03-05 | Singapore Health Services Pte Ltd | TRPM4 channel inhibitors for stroke treatment |
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| WO2015042125A2 (en) | 2013-09-19 | 2015-03-26 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for producing hepatocyte-like cells |
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| CN115397848A (zh) | 2020-02-05 | 2022-11-25 | 拉利玛生物医药公司 | Tat肽结合蛋白及其用途 |
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| CN117980327A (zh) | 2021-11-03 | 2024-05-03 | 杭州多禧生物科技有限公司 | 抗体的特异性偶联 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1142466A (en) * | 1979-01-09 | 1983-03-08 | Cesar Milstein | Cell lines |
-
1981
- 1981-07-03 DE DE8181303055T patent/DE3167442D1/de not_active Expired
- 1981-07-03 EP EP81303055A patent/EP0043718B1/en not_active Expired
- 1981-07-06 CA CA000381131A patent/CA1173379A/en not_active Expired
- 1981-07-07 US US06/281,038 patent/US4472500A/en not_active Expired - Lifetime
- 1981-07-07 JP JP56106817A patent/JPS5739777A/ja active Granted
-
1990
- 1990-02-27 JP JP2047125A patent/JPH02291298A/ja active Granted
-
1992
- 1992-03-10 JP JP4051415A patent/JPH05304979A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JPH05304979A (ja) | 1993-11-19 |
| JPS5739777A (en) | 1982-03-05 |
| EP0043718A2 (en) | 1982-01-13 |
| US4472500A (en) | 1984-09-18 |
| EP0043718A3 (en) | 1982-01-20 |
| DE3167442D1 (en) | 1985-01-10 |
| JPH0372271B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1991-11-18 |
| EP0043718B1 (en) | 1984-11-28 |
| JPH02291298A (ja) | 1990-12-03 |
| CA1173379A (en) | 1984-08-28 |
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