DE3167442D1 - Improvements in or relating to cell lines - Google Patents

Improvements in or relating to cell lines

Info

Publication number
DE3167442D1
DE3167442D1 DE8181303055T DE3167442T DE3167442D1 DE 3167442 D1 DE3167442 D1 DE 3167442D1 DE 8181303055 T DE8181303055 T DE 8181303055T DE 3167442 T DE3167442 T DE 3167442T DE 3167442 D1 DE3167442 D1 DE 3167442D1
Authority
DE
Germany
Prior art keywords
relating
cell lines
lines
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8181303055T
Other languages
English (en)
Inventor
Cesar Milstein
Bruce William Wright
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BTG International Ltd
Original Assignee
National Research Development Corp UK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Research Development Corp UK filed Critical National Research Development Corp UK
Application granted granted Critical
Publication of DE3167442D1 publication Critical patent/DE3167442D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/14—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from fungi, algea or lichens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/948—Microorganisms using viruses or cell lines
DE8181303055T 1980-07-07 1981-07-03 Improvements in or relating to cell lines Expired DE3167442D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8022206 1980-07-07

Publications (1)

Publication Number Publication Date
DE3167442D1 true DE3167442D1 (en) 1985-01-10

Family

ID=10514589

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8181303055T Expired DE3167442D1 (en) 1980-07-07 1981-07-03 Improvements in or relating to cell lines

Country Status (5)

Country Link
US (1) US4472500A (de)
EP (1) EP0043718B1 (de)
JP (3) JPS5739777A (de)
CA (1) CA1173379A (de)
DE (1) DE3167442D1 (de)

Families Citing this family (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH652145A5 (de) * 1982-01-22 1985-10-31 Sandoz Ag Verfahren zur in vitro-herstellung von hybridomen welche humane monoklonale antikoerper erzeugen.
US4987079A (en) * 1982-07-06 1991-01-22 Wilbur D. Smith Composition and method for in vitro cell culture
JPH0679553B2 (ja) * 1983-01-20 1994-10-12 サントリー株式会社 新規な雑種細胞
GB8318575D0 (en) * 1983-07-08 1983-08-10 Cobbold S P Antibody preparations
US5639639A (en) * 1983-11-02 1997-06-17 Genzyme Corporation Recombinant heterodimeric human fertility hormones, and methods, cells, vectors and DNA for the production thereof
US4634666A (en) * 1984-01-06 1987-01-06 The Board Of Trustees Of The Leland Stanford Junior University Human-murine hybridoma fusion partner
US4562003A (en) * 1984-10-26 1985-12-31 California Biotechnology, Inc. Monoclonal antibodies against alveolar surfactant protein
DE3668186D1 (de) * 1985-04-01 1990-02-15 Celltech Ltd Transformierte myeloma-zell-linie und dieselbe verwendendes verfahren zur expression eines gens, das ein eukaryontisches polypeptid kodiert.
US5981216A (en) * 1985-04-01 1999-11-09 Alusuisse Holdings A.G. Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same
US4808532A (en) * 1985-07-01 1989-02-28 The United States Of America As Represented By The United States Department Of Energy Continuous human cell lines and method of making same
US5292636A (en) * 1986-03-31 1994-03-08 T Cell Diagnostics, Inc. Therapeutic and diagnostic methods using soluble T cell surface molecules
JPS63180059U (de) * 1987-05-11 1988-11-21
EP0329184A3 (de) * 1988-02-19 1990-05-23 Neorx Corporation Antimere und antimere Konjugation
AU623698B2 (en) 1988-09-02 1992-05-21 Chiron Corporation Macrophage-derived inflammatory mediator (mip-2)
CA2002067A1 (en) * 1988-11-09 1990-05-09 Tamotsu Fukuda Parent cell line for producing human hybridomas
JPH0727946Y2 (ja) * 1989-03-14 1995-06-28 トーコー衛材株式会社 簡易マスク
US5567594A (en) * 1991-04-26 1996-10-22 Enteron, L.P. Methods and compositions for the detection and treatment of diseases associated with antigens of microorganisms
US6190864B1 (en) 1991-05-08 2001-02-20 Chiron Corporation HCV genomic sequences for diagnostics and therapeutics
ATE249838T1 (de) 1993-05-12 2003-10-15 Chiron Corp Konserviertes motiv der hepatitis c virus e2/ns1 region
US6471956B1 (en) 1994-08-17 2002-10-29 The Rockefeller University Ob polypeptides, modified forms and compositions thereto
US6124448A (en) * 1994-08-17 2000-09-26 The Rockfeller University Nucleic acid primers and probes for the mammalian OB gene
US6350730B1 (en) 1994-08-17 2002-02-26 The Rockefeller University OB polypeptides and modified forms as modulators of body weight
US6001968A (en) 1994-08-17 1999-12-14 The Rockefeller University OB polypeptides, modified forms and compositions
US6124439A (en) * 1994-08-17 2000-09-26 The Rockefeller University OB polypeptide antibodies and method of making
US6048837A (en) * 1994-08-17 2000-04-11 The Rockefeller University OB polypeptides as modulators of body weight
US6309853B1 (en) 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
US5759776A (en) * 1995-06-05 1998-06-02 California Pacific Medical Center Targets for breast cancer diagnosis and treatment
US5776683A (en) * 1996-07-11 1998-07-07 California Pacific Medical Center Methods for identifying genes amplified in cancer cells
US6893636B2 (en) * 1997-02-20 2005-05-17 Biogen Idec Ma Inc. Gamma-1 and gamma-3 anti-human CD23 monoclonal antibodies and use thereof as therapeutics
US7314711B2 (en) 1997-05-23 2008-01-01 Bioveris Corporation Assays employing electrochemiluminescent labels and electrochemiluminescence quenchers
US6528271B1 (en) 1997-06-05 2003-03-04 Duke University Inhibition of βarrestin mediated effects prolongs and potentiates opioid receptor-mediated analgesia
US5891646A (en) * 1997-06-05 1999-04-06 Duke University Methods of assaying receptor activity and constructs useful in such methods
US7541151B2 (en) 1997-06-05 2009-06-02 Duke University Single-cell biosensor for the measurement of GPCR ligands in a test sample
PT2363488E (pt) 1997-12-11 2015-01-13 Univ Belfast Síndrome multi-sistémica do definhamento pós-desmame de porcos
EP1816200B1 (de) 1997-12-11 2016-03-09 Merial Virus des multisystemischen Kümmersyndroms bei Absatzferkeln
US6087128A (en) 1998-02-12 2000-07-11 Ndsu Research Foundation DNA encoding an avian E. coli iss
US6369201B1 (en) 1998-02-19 2002-04-09 Metamorphix International, Inc. Myostatin multimers
WO2000016804A1 (en) * 1998-09-18 2000-03-30 Dynavax Technologies Corporation METHODS OF TREATING IgE-ASSOCIATED DISORDERS AND COMPOSITIONS FOR USE THEREIN
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
US6773911B1 (en) * 1998-11-23 2004-08-10 Amgen Canada Inc. Apoptosis-inducing factor
US6156514A (en) * 1998-12-03 2000-12-05 Sunol Molecular Corporation Methods for making recombinant cells
ES2350306T3 (es) 1999-02-26 2011-01-20 Novartis Vaccines And Diagnostics, Inc. Uso de bioadhesivos y adyuvantes para la administración de antígenos por vía mucosa.
US6399759B1 (en) 1999-05-27 2002-06-04 University Of Georgia Research Foundation, Inc. Ant proteases and methods of inhibition
US6262265B1 (en) 1999-06-18 2001-07-17 Microgenics Corporation Non-hydrolyzable analogs of heroin metabolites suitable for use in immunoassay
ATE426016T1 (de) 1999-09-24 2009-04-15 Cybios Llc Pluripotent embryonale stammzellen-ahnliche zellen, zusammensetzungen und ihre vervendungen
DE19957065B4 (de) 1999-11-26 2005-01-05 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Screening-Verfahren für Arzneistoffe
AU2001230912A1 (en) * 2000-01-11 2001-07-24 The Board Of Regents Of The University Of Nebraska Identification of virulence determinants
AU2016204535C1 (en) * 2000-04-12 2017-02-23 Laboratoire Français Du Fractionnement Et Des Biotechnologies Anti-D monoclonal antibodies
FR2807767B1 (fr) 2000-04-12 2005-01-14 Lab Francais Du Fractionnement Anticorps monoclonaux anti-d
US6458589B1 (en) 2000-04-27 2002-10-01 Geron Corporation Hepatocyte lineage cells derived from pluripotent stem cells
CA2409515C (en) 2000-05-10 2015-11-24 Mayo Foundation For Medical Education & Research Human igm antibodies with the capability of inducing remyelination, and diagnostic and therapeutic uses thereof particularly in the central nervous system
US7250294B2 (en) 2000-05-17 2007-07-31 Geron Corporation Screening small molecule drugs using neural cells differentiated from human embryonic stem cells
EP1734050A3 (de) 2000-06-12 2012-12-05 University Of Saskatchewan Immunisation von Milchvieh mit GapC Protein gegen Streptococcusinfektion
US7163800B2 (en) * 2000-11-03 2007-01-16 Molecular Devices Corporation Methods of screening compositions for G protein-coupled receptor desensitization inhibitory activity
US20050136431A1 (en) * 2000-11-03 2005-06-23 Oakley Robert H. Methods of screening compositions for G protein-coupled receptor desensitization inhibitory activity
US7018812B2 (en) * 2000-11-03 2006-03-28 Duke University Modified G-protein coupled receptors
FR2817875B1 (fr) * 2000-12-07 2005-03-18 Technopharm Procede de preparation d'un anticorps monoclonal humain, de fragments de celui-ci ou d'anticorps comprenant de tels fragments, les anticorps ainsi obtenus et leur utilisation
PT2163256E (pt) 2001-05-11 2015-11-20 Ludwig Inst For Cancer Res Ltd Proteínas de ligação específica e suas utilizações
US20110313230A1 (en) 2001-05-11 2011-12-22 Terrance Grant Johns Specific binding proteins and uses thereof
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
WO2002099069A2 (en) * 2001-06-05 2002-12-12 The Regents Of The University Of California Modulating neuronal outgrowth via the major histocompatibility complex class i (mhc i) molecule
US20090324612A1 (en) * 2001-06-05 2009-12-31 Kaufman Daniel L Modulating neuronal outgrowth via the major histocompatibility complex class i (mhc i) molecule
EP1978108A3 (de) 2002-01-08 2009-01-07 Siemens Healthcare Diagnostics GmbH Einzelnukleotidpolymorphismen zur Vorhersage kardiovaskulärer Erkrankungen und Medikationswirkung
US20030182669A1 (en) * 2002-03-19 2003-09-25 Rockman Howard A. Phosphoinositide 3-kinase mediated inhibition of GPCRs
WO2003080649A2 (en) * 2002-03-20 2003-10-02 Regents Of The University Of Minnesota Induction of hepatocyte proliferation in vitro by inhibition of cell cycle inhibitors
US7290215B2 (en) * 2002-06-03 2007-10-30 Microsoft Corporation Dynamic wizard interface system and method
US7514233B2 (en) 2002-09-26 2009-04-07 K.U. Leuven Research & Development Integrase cofactor
AU2002953431A0 (en) * 2002-12-19 2003-01-09 Murdoch University BmpB Novel Nucleotide and Amino Acid Sequences and Diagnostic and Therapeutic Uses Thereof
EP1590438A2 (de) * 2003-01-24 2005-11-02 Duke University Modifizierte transportmuster für arrestin und g-protein-gekoppelte rezeptoren über arrestin-ubiquitin-chimäre
EP1648427B1 (de) 2003-05-16 2013-12-18 Mayo Foundation For Medical Education And Research Niederdosis Behandlung demyelinisierender Erkrankungen mit IgM Antikörpern
US20060035242A1 (en) 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
US7767792B2 (en) 2004-02-20 2010-08-03 Ludwig Institute For Cancer Research Ltd. Antibodies to EGF receptor epitope peptides
US7138504B2 (en) * 2004-08-12 2006-11-21 Microgenics Corporation Reagents and methods for mycophenolic acid immunoassay
US20060240496A1 (en) * 2005-04-21 2006-10-26 Lakshmi Anne Immunogens, derivatives and immunoassay for ethyl glucuronide
CN101175856A (zh) 2005-05-12 2008-05-07 诺瓦提斯公司 猪痢疾短螺旋体的基因和蛋白质及其用于诊断和治疗的用途
KR101529317B1 (ko) 2005-06-22 2015-06-16 아스테리아스 바이오세라퓨틱스, 인크. 영장류 다능성 줄기 세포의 심근세포 계통 세포로의 분화
US7780969B2 (en) * 2005-07-15 2010-08-24 University Of Georgia Research Foundation, Inc. Trypanosoma cruzi proteome compositions and methods
CA2621236A1 (en) 2005-08-31 2007-03-08 Centocor, Inc. Host cell lines for production of antibody constant region with enhanced effector function
CN101627111A (zh) * 2005-08-31 2010-01-13 森托科尔公司 用于生产具有增强的效应子功能的抗体恒定区的宿主细胞系
WO2007115059A2 (en) 2006-03-29 2007-10-11 Merial Limited Vaccine against streptococci
EP3147365B1 (de) 2006-04-21 2019-12-04 Intervet International B.V. Pestivirusspezies
EP2190481B1 (de) 2007-07-17 2014-12-24 The General Hospital Corporation Verfahren zur identifizierung und anreicherung von populationen von eierstockkrebs-stammzellen und somatischen eierstock-stammzellen und ihre verwendungen
CN101821284B (zh) 2007-08-03 2014-11-19 贝林格尔·英格海姆维特梅迪卡有限公司 猪痢疾短螺旋体的基因和蛋白质及其用途
EP2363407A1 (de) 2008-02-28 2011-09-07 Murdoch University Neuartige Brachyspira-Sequenzen, immunogene Zusammensetzungen, Herstellungsverfahren dafür und Verwendung davon
WO2009117773A1 (en) 2008-03-27 2009-10-01 Murdoch University Novel sequences of brachyspira, immunogenic compositions, methods for preparation and use thereof
US8093049B2 (en) 2008-03-27 2012-01-10 Geron Corporation Differentiation of primate pluripotent stem cells to hematopoietic lineage cells
WO2010120374A2 (en) 2009-04-17 2010-10-21 New York University Peptides targeting tnf family receptors and antagonizing tnf action, compositions, methods and uses thereof
US20110076232A1 (en) 2009-09-29 2011-03-31 Ludwig Institute For Cancer Research Specific binding proteins and uses thereof
US9005579B2 (en) 2010-01-05 2015-04-14 Contrafect Corporation Methods and compositions for enhanced immunological therapy and targeting of gram-positive bacteria
WO2011113118A1 (en) 2010-03-19 2011-09-22 Katholieke Universiteit Leuven Drug tolerance/persistence of fungal biofilms
EP2576622A4 (de) 2010-06-01 2013-11-27 Univ Monash Auf die unverarbeitete rezeptor-tyrosin-kinase c-met zielende antikörper
US9297813B2 (en) 2010-11-11 2016-03-29 Agency For Science, Technology And Research Targeting metabolic enzymes in human cancer
EP2691512B1 (de) 2011-03-29 2019-05-01 Asterias Biotherapeutics, Inc. Angereicherte populationen von herzmuskelzellen aus pluripotenten stammzellen
GB201107467D0 (en) 2011-05-05 2011-06-15 Univ Leuven Kath Novel treatment of pain
AU2012385228B2 (en) 2012-07-12 2016-10-06 Hangzhou Dac Biotech Co., Ltd Conjugates of cell binding molecules with cytotoxic agents
AU2012395148B2 (en) 2012-11-24 2016-10-27 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
EP3013857B1 (de) 2013-06-28 2021-06-23 Singapore Health Services Pte Ltd Trpm4-kanalinhibitoren für die behandlung von schlaganfall
WO2015028850A1 (en) 2013-09-02 2015-03-05 Hangzhou Dac Biotech Co., Ltd Novel cytotoxic agents for conjugation of drugs to cell binding molecule
CA2959117C (en) 2013-09-19 2023-08-22 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for producing hepatocyte-like cells
FI3122757T3 (fi) 2014-02-28 2023-10-10 Hangzhou Dac Biotech Co Ltd Varautuneita linkkereitä ja niiden konjugointikäyttötapoja
WO2016140799A1 (en) 2015-03-03 2016-09-09 Ark Diagnostics, Inc. Pregabalin immunoassays
WO2015151081A2 (en) 2015-07-12 2015-10-08 Suzhou M-Conj Biotech Co., Ltd Bridge linkers for conjugation of a cell-binding molecule
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
KR102459468B1 (ko) 2016-11-14 2022-10-26 항저우 디에이씨 바이오테크 씨오, 엘티디 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용
US11578140B2 (en) 2019-03-26 2023-02-14 Microgenics Corporation Immunoassay for mitragynine
BR112021025984A2 (pt) 2019-06-29 2022-04-12 Hangzhou Dac Biotech Co Ltd Conjugado de anticorpo-derivado de tubulisina b (análogo), composto, composição farmacêutica, e, usos do conjugado, dos compostos e das composições farmacêuticas
EP3862023A1 (de) 2020-02-05 2021-08-11 Hangzhou DAC Biotech Co, Ltd Konjugate aus zellbindenden molekülen mit zytotoxika
CN115397848A (zh) 2020-02-05 2022-11-25 拉利玛生物医药公司 Tat肽结合蛋白及其用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1142466A (en) * 1979-01-09 1983-03-08 Cesar Milstein Cell lines

Also Published As

Publication number Publication date
EP0043718A3 (en) 1982-01-20
JPH02291298A (ja) 1990-12-03
EP0043718A2 (de) 1982-01-13
CA1173379A (en) 1984-08-28
JPH0372271B2 (de) 1991-11-18
EP0043718B1 (de) 1984-11-28
US4472500A (en) 1984-09-18
JPH0538B2 (de) 1993-01-05
JPH05304979A (ja) 1993-11-19
JPS5739777A (en) 1982-03-05

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: BRITISH TECHNOLOGY GROUP LTD., LONDON, GB