JPH0338269B2 - - Google Patents
Info
- Publication number
- JPH0338269B2 JPH0338269B2 JP56029293A JP2929381A JPH0338269B2 JP H0338269 B2 JPH0338269 B2 JP H0338269B2 JP 56029293 A JP56029293 A JP 56029293A JP 2929381 A JP2929381 A JP 2929381A JP H0338269 B2 JPH0338269 B2 JP H0338269B2
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- methyl
- compound represented
- free base
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8006806 | 1980-02-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS56147777A JPS56147777A (en) | 1981-11-16 |
| JPH0338269B2 true JPH0338269B2 (en, 2012) | 1991-06-10 |
Family
ID=10511754
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2929381A Granted JPS56147777A (en) | 1980-02-28 | 1981-02-28 | Novel heterocyclic derivative, its manufacture and medicine containing it |
| JP63047352A Pending JPS6452763A (en) | 1980-02-28 | 1988-02-29 | Novel heterocyclic derivative, manufacture and medicinal composition |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63047352A Pending JPS6452763A (en) | 1980-02-28 | 1988-02-29 | Novel heterocyclic derivative, manufacture and medicinal composition |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4670448A (en, 2012) |
| JP (2) | JPS56147777A (en, 2012) |
| KR (3) | KR850000668B1 (en, 2012) |
| AT (2) | AT380240B (en, 2012) |
| AU (1) | AU544357B2 (en, 2012) |
| BE (1) | BE887730A (en, 2012) |
| CA (1) | CA1158649A (en, 2012) |
| CH (1) | CH655104A5 (en, 2012) |
| CY (1) | CY1335A (en, 2012) |
| DE (1) | DE3107628A1 (en, 2012) |
| DK (1) | DK90681A (en, 2012) |
| ES (4) | ES499931A0 (en, 2012) |
| FI (1) | FI76076C (en, 2012) |
| FR (1) | FR2477150A1 (en, 2012) |
| GB (1) | GB2075007B (en, 2012) |
| HK (1) | HK69186A (en, 2012) |
| IE (1) | IE50987B1 (en, 2012) |
| IL (1) | IL62229A (en, 2012) |
| IT (1) | IT1209846B (en, 2012) |
| KE (1) | KE3629A (en, 2012) |
| MY (1) | MY8500428A (en, 2012) |
| NL (2) | NL186812C (en, 2012) |
| NO (1) | NO810681L (en, 2012) |
| NZ (1) | NZ196365A (en, 2012) |
| SE (1) | SE448233B (en, 2012) |
| ZA (1) | ZA811331B (en, 2012) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57169452A (en) * | 1981-04-14 | 1982-10-19 | Teikoku Hormone Mfg Co Ltd | Novel phenoxyalkylamide derivative |
| AU8480982A (en) * | 1981-06-11 | 1983-01-13 | Glaxo Group Limited | 1,2,4-triazole derivatives with histamine h2-blocking activity |
| PT76280A (en) * | 1982-02-24 | 1983-03-01 | Glaxo Group Ltd | Process for preparing heterocyclic derivatives |
| CA1189508A (en) * | 1982-02-25 | 1985-06-25 | Roger Hayes | Heterocyclic derivatives as histamine h.sub.2- antagonists |
| GB8417194D0 (en) * | 1984-07-05 | 1984-08-08 | Boots Co Plc | Therapeutic agents |
| GB8628475D0 (en) * | 1986-11-28 | 1987-01-07 | Glaxo Group Ltd | Medicaments |
| GB8805268D0 (en) * | 1988-03-04 | 1988-04-07 | Glaxo Group Ltd | Medicaments |
| JP3328082B2 (ja) * | 1994-12-13 | 2002-09-24 | 日本カーバイド工業株式会社 | Ｎ−グアニジノチオ尿素塩及び３−アミノ−５−メルカプト−１，２，４−トリアゾールの製造方法 |
| JP2003510359A (ja) * | 1999-10-01 | 2003-03-18 | スミスクライン・ビーチャム・コーポレイション | 化合物および方法 |
| JP4564786B2 (ja) * | 2004-06-07 | 2010-10-20 | 株式会社日本ファインケム | １−置換―１―アミノグアニジン又はその塩、及びこれらの製造方法 |
| US20230349922A1 (en) | 2020-08-11 | 2023-11-02 | Université De Strasbourg | H2 Blockers Targeting Liver Macrophages for the Prevention and Treatment of Liver Disease and Cancer |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1419994A (en) * | 1973-05-03 | 1976-01-07 | Smith Kline French Lab | Heterocyclicalkylaminotheterocyclic compounds methods for their preparation and compositions comprising them |
| DE2835695A1 (de) * | 1977-08-29 | 1979-03-15 | Yamanouchi Pharma Co Ltd | Neue heterocyclische verbindungen, verfahren zu ihrer herstellung und arzneimittel, die diese enthalten |
| AR228941A1 (es) * | 1978-04-26 | 1983-05-13 | Glaxo Group Ltd | Procedimiento para preparar nuevos derivados de 3,5-diamino-1,2,4-triazol que son activos contra receptores histaminicos |
| GB2023133B (en) * | 1978-04-26 | 1982-09-08 | Glaxo Group Ltd | Heterocyclic derivatives |
| GB2047238B (en) * | 1979-03-02 | 1983-09-14 | Glaxo Group Ltd | Triazole derivatives processes for their production and pharmaceutical compositions containing them |
-
1981
- 1981-02-26 FR FR8103847A patent/FR2477150A1/fr active Granted
- 1981-02-26 CH CH1288/81A patent/CH655104A5/fr not_active IP Right Cessation
- 1981-02-27 DE DE19813107628 patent/DE3107628A1/de active Granted
- 1981-02-27 NL NLAANVRAGE8100979,A patent/NL186812C/xx not_active IP Right Cessation
- 1981-02-27 AT AT0093981A patent/AT380240B/de not_active IP Right Cessation
- 1981-02-27 ES ES499931A patent/ES499931A0/es active Granted
- 1981-02-27 DK DK90681A patent/DK90681A/da not_active Application Discontinuation
- 1981-02-27 SE SE8101311A patent/SE448233B/sv not_active IP Right Cessation
- 1981-02-27 AU AU67933/81A patent/AU544357B2/en not_active Ceased
- 1981-02-27 ZA ZA00811331A patent/ZA811331B/xx unknown
- 1981-02-27 IT IT8147905A patent/IT1209846B/it active
- 1981-02-27 IL IL62229A patent/IL62229A/xx unknown
- 1981-02-27 IE IE431/81A patent/IE50987B1/en unknown
- 1981-02-27 CA CA000371889A patent/CA1158649A/en not_active Expired
- 1981-02-27 FI FI810619A patent/FI76076C/fi not_active IP Right Cessation
- 1981-02-27 NO NO810681A patent/NO810681L/no unknown
- 1981-02-27 BE BE0/203963A patent/BE887730A/fr unknown
- 1981-02-27 CY CY133581A patent/CY1335A/en unknown
- 1981-02-27 NZ NZ196365A patent/NZ196365A/en unknown
- 1981-02-27 GB GB8106314A patent/GB2075007B/en not_active Expired
- 1981-02-28 KR KR1019810000669A patent/KR850000668B1/ko not_active Expired
- 1981-02-28 JP JP2929381A patent/JPS56147777A/ja active Granted
-
1982
- 1982-02-16 ES ES509669A patent/ES8304954A1/es not_active Expired
- 1982-12-16 ES ES518305A patent/ES8405775A1/es not_active Expired
-
1983
- 1983-02-10 US US06/465,616 patent/US4670448A/en not_active Expired - Fee Related
-
1984
- 1984-03-16 ES ES530741A patent/ES8506292A1/es not_active Expired
- 1984-05-08 AT AT0151084A patent/AT387774B/de not_active IP Right Cessation
- 1984-08-18 KR KR1019840004976A patent/KR850000682B1/ko not_active Expired
- 1984-08-20 KR KR1019840004977A patent/KR850000676B1/ko not_active Expired
-
1985
- 1985-12-30 MY MY428/85A patent/MY8500428A/xx unknown
-
1986
- 1986-04-16 KE KE3629A patent/KE3629A/xx unknown
- 1986-09-18 HK HK691/86A patent/HK69186A/xx unknown
-
1988
- 1988-02-29 JP JP63047352A patent/JPS6452763A/ja active Pending
- 1988-09-09 NL NL8802221A patent/NL8802221A/nl not_active Application Discontinuation
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