ES8304954A1 - Un procedimiento para la preparacion de derivados de triazol. - Google Patents

Un procedimiento para la preparacion de derivados de triazol.

Info

Publication number
ES8304954A1
ES8304954A1 ES509669A ES509669A ES8304954A1 ES 8304954 A1 ES8304954 A1 ES 8304954A1 ES 509669 A ES509669 A ES 509669A ES 509669 A ES509669 A ES 509669A ES 8304954 A1 ES8304954 A1 ES 8304954A1
Authority
ES
Spain
Prior art keywords
pharmaceutical compositions
amine compounds
triazole amine
triazole
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES509669A
Other languages
English (en)
Other versions
ES509669A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES8304954A1 publication Critical patent/ES8304954A1/es
Publication of ES509669A0 publication Critical patent/ES509669A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE TRIAZOL Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, HIDRATOS Y BIOPRECURSORES, DE FORMULA (I), EN LA QUE ALQ ES UNA CADENA ALQUILENICA; R , R , R , R , Q, X E Y PUEDEN SER VARIOS TIPOS DE RADICALES; Y M Y N VALEN 2,5 Y 0-3, RESPECTIVAMENTE. CONSISTE EN LA REACCION DE UN COMPUESTO DE AMINOALQUILTRIAZOL DE FORMULA (II), EN LA QUE R PUEDE SER UNO DE VARIOS GRUPOS, Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), CON UN COMPUESTO CAPAZ DE REEMPLAZAR UN HIDROGENO DEL GRUPO R POR UN GRUPO ADECUADO. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE, EVENTUALMENTE EN PRESENCIA DE UNA BASE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD COMO ANTAGONISTAS SELECTIVOS DE LA HISTAMINA H .
ES509669A 1980-02-28 1982-02-16 Un procedimiento para la preparacion de derivados de triazol. Granted ES509669A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8006806 1980-02-28

Publications (2)

Publication Number Publication Date
ES8304954A1 true ES8304954A1 (es) 1983-03-16
ES509669A0 ES509669A0 (es) 1983-03-16

Family

ID=10511754

Family Applications (4)

Application Number Title Priority Date Filing Date
ES499931A Granted ES499931A0 (es) 1980-02-28 1981-02-27 Un procedimiento para la preparacion de derivados de triazol.
ES509669A Granted ES509669A0 (es) 1980-02-28 1982-02-16 Un procedimiento para la preparacion de derivados de triazol.
ES518305A Granted ES518305A0 (es) 1980-02-28 1982-12-16 Un procedimiento para la preparacion de derivados de triazol.
ES530741A Expired ES8506292A1 (es) 1980-02-28 1984-03-16 Un procedimiento para la preparacion de derivados de triazol

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES499931A Granted ES499931A0 (es) 1980-02-28 1981-02-27 Un procedimiento para la preparacion de derivados de triazol.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES518305A Granted ES518305A0 (es) 1980-02-28 1982-12-16 Un procedimiento para la preparacion de derivados de triazol.
ES530741A Expired ES8506292A1 (es) 1980-02-28 1984-03-16 Un procedimiento para la preparacion de derivados de triazol

Country Status (26)

Country Link
US (1) US4670448A (es)
JP (2) JPS56147777A (es)
KR (3) KR850000668B1 (es)
AT (2) AT380240B (es)
AU (1) AU544357B2 (es)
BE (1) BE887730A (es)
CA (1) CA1158649A (es)
CH (1) CH655104A5 (es)
CY (1) CY1335A (es)
DE (1) DE3107628A1 (es)
DK (1) DK90681A (es)
ES (4) ES499931A0 (es)
FI (1) FI76076C (es)
FR (1) FR2477150A1 (es)
GB (1) GB2075007B (es)
HK (1) HK69186A (es)
IE (1) IE50987B1 (es)
IL (1) IL62229A (es)
IT (1) IT1209846B (es)
KE (1) KE3629A (es)
MY (1) MY8500428A (es)
NL (2) NL186812C (es)
NO (1) NO810681L (es)
NZ (1) NZ196365A (es)
SE (1) SE448233B (es)
ZA (1) ZA811331B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57169452A (en) * 1981-04-14 1982-10-19 Teikoku Hormone Mfg Co Ltd Novel phenoxyalkylamide derivative
EP0070097A1 (en) * 1981-06-11 1983-01-19 Glaxo Group Limited 1,2,4-Triazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
PT76280A (en) * 1982-02-24 1983-03-01 Glaxo Group Ltd Process for preparing heterocyclic derivatives
CA1189508A (en) * 1982-02-25 1985-06-25 Roger Hayes Heterocyclic derivatives as histamine h.sub.2- antagonists
GB8417194D0 (en) * 1984-07-05 1984-08-08 Boots Co Plc Therapeutic agents
GB8628475D0 (en) * 1986-11-28 1987-01-07 Glaxo Group Ltd Medicaments
GB8805268D0 (en) * 1988-03-04 1988-04-07 Glaxo Group Ltd Medicaments
JP3328082B2 (ja) * 1994-12-13 2002-09-24 日本カーバイド工業株式会社 Ｎ−グアニジノチオ尿素塩及び３−アミノ−５−メルカプト−１，２，４−トリアゾールの製造方法
JP2003510359A (ja) * 1999-10-01 2003-03-18 スミスクライン・ビーチャム・コーポレイション 化合物および方法
JP4564786B2 (ja) * 2004-06-07 2010-10-20 株式会社日本ファインケム １−置換―１―アミノグアニジン又はその塩、及びこれらの製造方法
EP4196793A1 (en) 2020-08-11 2023-06-21 Université de Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1419994A (en) * 1973-05-03 1976-01-07 Smith Kline French Lab Heterocyclicalkylaminotheterocyclic compounds methods for their preparation and compositions comprising them
DE2835695A1 (de) * 1977-08-29 1979-03-15 Yamanouchi Pharma Co Ltd Neue heterocyclische verbindungen, verfahren zu ihrer herstellung und arzneimittel, die diese enthalten
AR228941A1 (es) * 1978-04-26 1983-05-13 Glaxo Group Ltd Procedimiento para preparar nuevos derivados de 3,5-diamino-1,2,4-triazol que son activos contra receptores histaminicos
GB2023133B (en) * 1978-04-26 1982-09-08 Glaxo Group Ltd Heterocyclic derivatives
YU56680A (en) * 1979-03-02 1983-04-30 Glaxo Group Ltd Process for obtaining new 1,2,4-triazole derivatives

Also Published As

Publication number Publication date
JPH0338269B2 (es) 1991-06-10
KE3629A (en) 1986-05-16
KR850000676B1 (ko) 1985-05-10
FR2477150A1 (fr) 1981-09-04
AT380240B (de) 1986-04-25
NL186812B (nl) 1990-10-01
JPS56147777A (en) 1981-11-16
AT387774B (de) 1989-03-10
IL62229A (en) 1987-10-30
NL8100979A (nl) 1981-10-01
ZA811331B (en) 1982-10-27
IT8147905A0 (it) 1981-02-27
DK90681A (da) 1981-08-29
ES530741A0 (es) 1985-07-01
CY1335A (en) 1986-10-24
ES8205208A1 (es) 1982-06-01
ES8405775A1 (es) 1984-06-16
FR2477150B1 (es) 1984-03-16
ES518305A0 (es) 1984-06-16
KR830005164A (ko) 1983-08-03
IL62229A0 (en) 1981-03-31
KR850002011A (ko) 1985-04-10
US4670448A (en) 1987-06-02
IE810431L (en) 1981-08-28
NL186812C (nl) 1991-03-01
BE887730A (fr) 1981-08-27
KR850002010A (ko) 1985-04-10
ES509669A0 (es) 1983-03-16
GB2075007A (en) 1981-11-11
KR850000682B1 (ko) 1985-05-14
ES499931A0 (es) 1982-06-01
ATA151084A (de) 1988-08-15
KR850000668B1 (ko) 1985-05-09
NL8802221A (nl) 1989-01-02
HK69186A (en) 1986-09-26
DE3107628C2 (es) 1991-03-14
ES8506292A1 (es) 1985-07-01
AU544357B2 (en) 1985-05-23
GB2075007B (en) 1983-07-13
FI810619L (fi) 1981-08-29
IT1209846B (it) 1989-08-30
NO810681L (no) 1981-08-31
CA1158649A (en) 1983-12-13
AU6793381A (en) 1981-09-03
FI76076C (fi) 1988-09-09
SE448233B (sv) 1987-02-02
ATA93981A (de) 1985-09-15
SE8101311L (sv) 1981-08-29
IE50987B1 (en) 1986-09-03
NZ196365A (en) 1984-07-31
CH655104A5 (fr) 1986-03-27
JPS6452763A (en) 1989-02-28
FI76076B (fi) 1988-05-31
MY8500428A (en) 1985-12-31
DE3107628A1 (de) 1982-04-01

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