ES8506292A1 - Un procedimiento para la preparacion de derivados de triazol - Google Patents

Un procedimiento para la preparacion de derivados de triazol

Info

Publication number
ES8506292A1
ES8506292A1 ES530741A ES530741A ES8506292A1 ES 8506292 A1 ES8506292 A1 ES 8506292A1 ES 530741 A ES530741 A ES 530741A ES 530741 A ES530741 A ES 530741A ES 8506292 A1 ES8506292 A1 ES 8506292A1
Authority
ES
Spain
Prior art keywords
pharmaceutical compositions
amine compounds
triazole amine
triazole
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES530741A
Other languages
English (en)
Other versions
ES530741A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES530741A0 publication Critical patent/ES530741A0/es
Publication of ES8506292A1 publication Critical patent/ES8506292A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE TRIAZOL.CONSISTE EN OXIDAR EL COMPUESTO DE FORMULA (I) DONDE R4 ES EL GRUPO (CH2)Q-CHR11OH, (CH2)QCHO, (CH2)QSR8 (DONDE R8 ES DISTINTO DE HIDROXI) O (CH2)QSH; Y CUANDO EL COMPUESTO DE FORMULA (I) SE PRODUCE EN FORMA DE BASE LIBRE CONVERTIRLO EN UNA SAL; DONDE R1 ES H, ALQUILO C 1 A 14 Y OTROS; ALQ REPRESENTA UNA CADENA ALQUILENICA LINEAL O RAMIFICADA DE C 1 A 6; QREPRESENTA UN ANILLO FURANO O DE TIOFENO Y OTROS; X REPRESENTA OXIGENO, AZUFRE, -NH-, METILENO O UN ENLACE; Y REPRESENTA OXIGENO, AZUFRE, METILENO O UN ENLACE; N REPRESENTA 0, 1, 2 O 3 Y M ES UN NUMERO ENTERO DE 2 A 5, PUDIENDO SER OTROS; R3 REPRESENTA H, ALQUILO, ALQUENILO Y OTROS; R4 ES EL GRUPO (CH2)R7 DONDE Q ES 0, 1, 2, 3, 4, 5 O 6 Y LA CADENA ALQUILENICA (CH2)Q PUEDE SER LINEAL O RAMIFICADA.
ES530741A 1980-02-28 1984-03-16 Un procedimiento para la preparacion de derivados de triazol Expired ES8506292A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8006806 1980-02-28

Publications (2)

Publication Number Publication Date
ES530741A0 ES530741A0 (es) 1985-07-01
ES8506292A1 true ES8506292A1 (es) 1985-07-01

Family

ID=10511754

Family Applications (4)

Application Number Title Priority Date Filing Date
ES499931A Granted ES499931A0 (es) 1980-02-28 1981-02-27 Un procedimiento para la preparacion de derivados de triazol.
ES509669A Granted ES509669A0 (es) 1980-02-28 1982-02-16 Un procedimiento para la preparacion de derivados de triazol.
ES518305A Granted ES518305A0 (es) 1980-02-28 1982-12-16 Un procedimiento para la preparacion de derivados de triazol.
ES530741A Expired ES8506292A1 (es) 1980-02-28 1984-03-16 Un procedimiento para la preparacion de derivados de triazol

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES499931A Granted ES499931A0 (es) 1980-02-28 1981-02-27 Un procedimiento para la preparacion de derivados de triazol.
ES509669A Granted ES509669A0 (es) 1980-02-28 1982-02-16 Un procedimiento para la preparacion de derivados de triazol.
ES518305A Granted ES518305A0 (es) 1980-02-28 1982-12-16 Un procedimiento para la preparacion de derivados de triazol.

Country Status (26)

Country Link
US (1) US4670448A (es)
JP (2) JPS56147777A (es)
KR (3) KR850000668B1 (es)
AT (2) AT380240B (es)
AU (1) AU544357B2 (es)
BE (1) BE887730A (es)
CA (1) CA1158649A (es)
CH (1) CH655104A5 (es)
CY (1) CY1335A (es)
DE (1) DE3107628A1 (es)
DK (1) DK90681A (es)
ES (4) ES499931A0 (es)
FI (1) FI76076C (es)
FR (1) FR2477150A1 (es)
GB (1) GB2075007B (es)
HK (1) HK69186A (es)
IE (1) IE50987B1 (es)
IL (1) IL62229A (es)
IT (1) IT1209846B (es)
KE (1) KE3629A (es)
MY (1) MY8500428A (es)
NL (2) NL186812C (es)
NO (1) NO810681L (es)
NZ (1) NZ196365A (es)
SE (1) SE448233B (es)
ZA (1) ZA811331B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57169452A (en) * 1981-04-14 1982-10-19 Teikoku Hormone Mfg Co Ltd Novel phenoxyalkylamide derivative
US4476126A (en) * 1981-06-11 1984-10-09 Glaxo Group Limited 1,2,4 Triazoze amines and their pharmaceutical use
ES8407030A1 (es) * 1982-02-24 1984-04-01 Glaxo Group Ltd Un procedimiento para prepararacion de derivados del triazol.
CA1189508A (en) * 1982-02-25 1985-06-25 Roger Hayes Heterocyclic derivatives as histamine h.sub.2- antagonists
GB8417194D0 (en) * 1984-07-05 1984-08-08 Boots Co Plc Therapeutic agents
GB8628475D0 (en) * 1986-11-28 1987-01-07 Glaxo Group Ltd Medicaments
GB8805268D0 (en) * 1988-03-04 1988-04-07 Glaxo Group Ltd Medicaments
JP3328082B2 (ja) * 1994-12-13 2002-09-24 日本カーバイド工業株式会社 Ｎ−グアニジノチオ尿素塩及び３−アミノ−５−メルカプト−１，２，４−トリアゾールの製造方法
EP1223932A4 (en) 1999-10-01 2003-01-15 Smithkline Beecham Corp COMPOUNDS AND METHODS
JP4564786B2 (ja) * 2004-06-07 2010-10-20 株式会社日本ファインケム １−置換―１―アミノグアニジン又はその塩、及びこれらの製造方法
EP4196793A1 (en) 2020-08-11 2023-06-21 Université de Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1419994A (en) * 1973-05-03 1976-01-07 Smith Kline French Lab Heterocyclicalkylaminotheterocyclic compounds methods for their preparation and compositions comprising them
DE2835695A1 (de) * 1977-08-29 1979-03-15 Yamanouchi Pharma Co Ltd Neue heterocyclische verbindungen, verfahren zu ihrer herstellung und arzneimittel, die diese enthalten
AR228941A1 (es) * 1978-04-26 1983-05-13 Glaxo Group Ltd Procedimiento para preparar nuevos derivados de 3,5-diamino-1,2,4-triazol que son activos contra receptores histaminicos
GB2023133B (en) * 1978-04-26 1982-09-08 Glaxo Group Ltd Heterocyclic derivatives
DE3067920D1 (en) * 1979-03-02 1984-06-28 Glaxo Group Ltd 1,2,4-triazole derivatives, processes for their production and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
KR850000676B1 (ko) 1985-05-10
IE50987B1 (en) 1986-09-03
AU6793381A (en) 1981-09-03
KR850000682B1 (ko) 1985-05-14
ES8304954A1 (es) 1983-03-16
FI810619L (fi) 1981-08-29
KE3629A (en) 1986-05-16
NZ196365A (en) 1984-07-31
AT387774B (de) 1989-03-10
SE448233B (sv) 1987-02-02
DE3107628A1 (de) 1982-04-01
ES509669A0 (es) 1983-03-16
ES530741A0 (es) 1985-07-01
GB2075007A (en) 1981-11-11
KR830005164A (ko) 1983-08-03
AU544357B2 (en) 1985-05-23
FR2477150A1 (fr) 1981-09-04
CH655104A5 (fr) 1986-03-27
FI76076B (fi) 1988-05-31
HK69186A (en) 1986-09-26
NL186812B (nl) 1990-10-01
IL62229A0 (en) 1981-03-31
ATA151084A (de) 1988-08-15
KR850002011A (ko) 1985-04-10
DK90681A (da) 1981-08-29
MY8500428A (en) 1985-12-31
FI76076C (fi) 1988-09-09
SE8101311L (sv) 1981-08-29
ES8205208A1 (es) 1982-06-01
ES8405775A1 (es) 1984-06-16
JPS6452763A (en) 1989-02-28
FR2477150B1 (es) 1984-03-16
GB2075007B (en) 1983-07-13
ZA811331B (en) 1982-10-27
KR850000668B1 (ko) 1985-05-09
NL8802221A (nl) 1989-01-02
ES518305A0 (es) 1984-06-16
NO810681L (no) 1981-08-31
IE810431L (en) 1981-08-28
IT1209846B (it) 1989-08-30
US4670448A (en) 1987-06-02
CA1158649A (en) 1983-12-13
KR850002010A (ko) 1985-04-10
ES499931A0 (es) 1982-06-01
IL62229A (en) 1987-10-30
AT380240B (de) 1986-04-25
IT8147905A0 (it) 1981-02-27
CY1335A (en) 1986-10-24
NL186812C (nl) 1991-03-01
JPS56147777A (en) 1981-11-16
DE3107628C2 (es) 1991-03-14
NL8100979A (nl) 1981-10-01
BE887730A (fr) 1981-08-27
JPH0338269B2 (es) 1991-06-10
ATA93981A (de) 1985-09-15

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