JPH0257548B2 - - Google Patents

Info

Publication number
JPH0257548B2
JPH0257548B2 JP56029357A JP2935781A JPH0257548B2 JP H0257548 B2 JPH0257548 B2 JP H0257548B2 JP 56029357 A JP56029357 A JP 56029357A JP 2935781 A JP2935781 A JP 2935781A JP H0257548 B2 JPH0257548 B2 JP H0257548B2
Authority
JP
Japan
Prior art keywords
trinor
phenylene
inter
pgi
cis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP56029357A
Other languages
English (en)
Japanese (ja)
Other versions
JPS57144276A (en
Inventor
Kyotaka Oono
Hiroshi Nagase
Mamoru Ishikawa
Kazuhisa Matsumoto
Shintaro Nishio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Priority to JP2935781A priority Critical patent/JPS57144276A/ja
Priority to DK84082A priority patent/DK84082A/da
Priority to EP19820301023 priority patent/EP0060640B1/en
Priority to DE8282301023T priority patent/DE3267350D1/de
Priority to AU81071/82A priority patent/AU560140B2/en
Priority to ZA821403A priority patent/ZA821403B/xx
Publication of JPS57144276A publication Critical patent/JPS57144276A/ja
Priority to US06/567,755 priority patent/US4564620A/en
Priority to US07/102,391 priority patent/US4822804A/en
Publication of JPH0257548B2 publication Critical patent/JPH0257548B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/17—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrogenation of carbon-to-carbon double or triple bonds
    • C07C29/172—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrogenation of carbon-to-carbon double or triple bonds with the obtention of a fully saturated alcohol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)
JP2935781A 1981-03-03 1981-03-03 5,6,7-trinor-4,8-inter-m-phenylene pgi2 derivative Granted JPS57144276A (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP2935781A JPS57144276A (en) 1981-03-03 1981-03-03 5,6,7-trinor-4,8-inter-m-phenylene pgi2 derivative
DK84082A DK84082A (da) 1981-03-03 1982-02-26 Fremgangsmaade til fremstilling af pg12-derivater
EP19820301023 EP0060640B1 (en) 1981-03-03 1982-03-01 5,6,7-trinor-4,8-inter-m-phenylene pgi derivatives and pharmaceutical compositions containing them
DE8282301023T DE3267350D1 (en) 1981-03-03 1982-03-01 5,6,7-trinor-4,8-inter-m-phenylene pgi derivatives and pharmaceutical compositions containing them
AU81071/82A AU560140B2 (en) 1981-03-03 1982-03-03 5,6,7-trinor-4,8-inter-m-phenylene pgi2
ZA821403A ZA821403B (en) 1981-03-03 1982-03-03 5,6,7-trinor-4,8-inter-m-phenylene pgi2 derivatives and pharmaceutical compositions containing them
US06/567,755 US4564620A (en) 1981-03-03 1984-01-03 5,6,7,-Trinor-4,8-inter-m-phenylene PGI2 derivatives and anti-ulcer, anti-thrombotic and anti-hypertensive pharmaceutical compositions containing them
US07/102,391 US4822804A (en) 1981-03-03 1987-09-29 5,6,7,-trinor-4,8-inter-m-phenylene 2-nor PGI2 derivatives and anti-ulcer, anti-thrombotic and anti-hypertensive pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2935781A JPS57144276A (en) 1981-03-03 1981-03-03 5,6,7-trinor-4,8-inter-m-phenylene pgi2 derivative

Publications (2)

Publication Number Publication Date
JPS57144276A JPS57144276A (en) 1982-09-06
JPH0257548B2 true JPH0257548B2 (en, 2012) 1990-12-05

Family

ID=12273939

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2935781A Granted JPS57144276A (en) 1981-03-03 1981-03-03 5,6,7-trinor-4,8-inter-m-phenylene pgi2 derivative

Country Status (7)

Country Link
US (2) US4564620A (en, 2012)
EP (1) EP0060640B1 (en, 2012)
JP (1) JPS57144276A (en, 2012)
AU (1) AU560140B2 (en, 2012)
DE (1) DE3267350D1 (en, 2012)
DK (1) DK84082A (en, 2012)
ZA (1) ZA821403B (en, 2012)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57144276A (en) * 1981-03-03 1982-09-06 Toray Ind Inc 5,6,7-trinor-4,8-inter-m-phenylene pgi2 derivative
JPS58124778A (ja) * 1982-01-20 1983-07-25 Toray Ind Inc ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体
JPS59134787A (ja) * 1983-01-19 1984-08-02 Toray Ind Inc ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体の製造法
JPS59161371A (ja) * 1983-03-04 1984-09-12 Toray Ind Inc （−）−〔７−ブロモ−３ａ，８ｂ−シス−ジヒドロ−３Ｈ−シクロペンタ〔ｂ〕ベンゾフラン−５−イル〕ギ酸の製造法
ES2029799T3 (es) * 1986-01-24 1992-10-01 Toray Industries, Inc. Derivados de 2,5,6,7 tetranor-4,8-inter-m-fenilen pg12.
WO1988001613A1 (en) * 1986-08-27 1988-03-10 Pfizer Inc. Crystalline n-(s-3-methylheptanoyl)-d-gamma-glutamyl-glycyl-d-alanine, and processes and intermediates therefor
FI890885A0 (fi) * 1986-08-27 1989-02-24 Pfizer Foerfarande foer framstaellning av n-(s-3-alkylheptanoyl)-d-gamma-glutamyl-glycyl-d-alanin och i foerfarandet anvaendbara mellanprodukter och deras framstaellning.
JPH0662599B1 (en, 2012) * 1987-10-16 1994-08-17 Toray Industries
DE3886936T2 (de) * 1987-10-16 1994-04-28 Toray Industries 2,5,6,7-TETRANOR-4,8-INTER-m-PHENYLEN 2-PGI-DERIVATE, VERFAHREN ZUR HERSTELLUNG UND DEREN VERWENDUNG.
US5248820A (en) * 1989-02-21 1993-09-28 Pfizer Inc. Crystalline N-(S-3-methylheptanoyl)-D-gamma-glutamyl-glycyl-D-alanine, and processes and intermediates therefor
US5136020A (en) * 1989-02-21 1992-08-04 Pfizer Inc. Crystalline n-(s-3-methylheptanoyl)-D-gamma-glutamyl-glycyl-D-alanine, and processes and intermediates therefor
US5185464A (en) * 1989-02-21 1993-02-09 Pfizer Inc. Crystalline N-(S-3-methylheptanoyl)-D-gamma-glutamyl-glycyl-D-alanine, and processes and intermediates therefor
DE69008851T2 (de) * 1989-02-27 1994-08-18 Toray Industries VERFAHREN ZUR HERSTELLUNG VON 5,6,7, -TRINOR- 4,8,-INTER-m-PHENYLEN PGI,2 Abkömmlingen.
CA2012081C (en) * 1989-03-14 2000-08-29 Shigeki Itou 2,5,6,7-tetranor-4,8-inter-m-phenylene pgi 2 derivatives
US5496850A (en) * 1991-04-11 1996-03-05 Toray Industries, Inc. Antimetastasis agent of malignant tumors
JP3230246B2 (ja) * 1991-04-11 2001-11-19 東レ株式会社 悪性腫瘍転移抑制剤
JP3102141B2 (ja) * 1992-05-29 2000-10-23 東レ株式会社 養毛育毛剤
JPH07126161A (ja) * 1993-10-29 1995-05-16 Toray Ind Inc 心不全治療剤
JP3541417B2 (ja) * 1994-02-24 2004-07-14 日産化学工業株式会社 フェニル置換ヒドロキシシクロペンテノン類、ペンタノン類及びフェニル置換プロスタグランジンｉ２類中間体並びにその製造法及び光学分割法
WO1998011899A1 (fr) * 1996-09-17 1998-03-26 Toray Industries, Inc. Agent de potentialisation de la fonction plaquettaire et procede de traitement du dysfonctionnement plaquettaire
KR20000065039A (ko) * 1997-02-27 2000-11-06 히라이 가쯔히꼬 폐순환 개선제
WO1999013880A1 (fr) * 1997-09-16 1999-03-25 Toray Industries, Inc. Inhibiteur de la production de chemokine c-c
JPH11228417A (ja) * 1998-02-06 1999-08-24 Teijin Ltd 神経障害治療剤
US20030092760A1 (en) * 2001-03-12 2003-05-15 Toray Industries, Inc. Therapeutic agent for renal failure
ATE306256T1 (de) 1999-08-05 2005-10-15 Teijin Ltd Mittel zur besserung der neuropathie, die als wirkstoff stickstoffhaltige verbindungen enthalten
EP3461817B1 (en) 2011-06-16 2020-11-04 Lung Biotechnology Inc. Potassium salt of beraprost
CN110452100A (zh) * 2019-07-31 2019-11-15 济南康和医药科技有限公司 一种贝前列素钠中间体的合成方法
CN110746450A (zh) * 2019-09-17 2020-02-04 济南康和医药科技有限公司 一种贝前列素钠关键中间体的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5931510B2 (ja) * 1979-09-03 1984-08-02 東レ株式会社 ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体
JPS5732277A (en) * 1980-08-05 1982-02-20 Toray Ind Inc 5,6,7-trinor-4,8-inter-m-phenylene pgi2 derivative
JPS57144276A (en) * 1981-03-03 1982-09-06 Toray Ind Inc 5,6,7-trinor-4,8-inter-m-phenylene pgi2 derivative

Also Published As

Publication number Publication date
DK84082A (da) 1982-09-04
AU8107182A (en) 1982-09-09
JPS57144276A (en) 1982-09-06
EP0060640A1 (en) 1982-09-22
US4564620A (en) 1986-01-14
EP0060640B1 (en) 1985-11-13
ZA821403B (en) 1983-01-26
AU560140B2 (en) 1987-04-02
US4822804A (en) 1989-04-18
DE3267350D1 (en) 1985-12-19

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