JP7497296B2 - ナノエマルジョン及びその製造方法 - Google Patents
ナノエマルジョン及びその製造方法 Download PDFInfo
- Publication number
- JP7497296B2 JP7497296B2 JP2020557160A JP2020557160A JP7497296B2 JP 7497296 B2 JP7497296 B2 JP 7497296B2 JP 2020557160 A JP2020557160 A JP 2020557160A JP 2020557160 A JP2020557160 A JP 2020557160A JP 7497296 B2 JP7497296 B2 JP 7497296B2
- Authority
- JP
- Japan
- Prior art keywords
- nanoemulsion
- macroemulsion
- oil
- nanoemulsions
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000007908 nanoemulsion Substances 0.000 title claims description 86
- 238000004519 manufacturing process Methods 0.000 title claims description 6
- 239000004907 Macro-emulsion Substances 0.000 claims description 63
- 239000000203 mixture Substances 0.000 claims description 61
- 239000003795 chemical substances by application Substances 0.000 claims description 26
- 239000008346 aqueous phase Substances 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 12
- 239000002245 particle Substances 0.000 claims description 9
- 239000012071 phase Substances 0.000 claims description 9
- 229960003067 cystine Drugs 0.000 claims description 8
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 claims description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 6
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- LEVWYRKDKASIDU-IMJSIDKUSA-N cystine group Chemical group C([C@@H](C(=O)O)N)SSC[C@@H](C(=O)O)N LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 claims description 6
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 4
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 4
- QGNJRVVDBSJHIZ-QHLGVNSISA-N retinyl acetate Chemical compound CC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C QGNJRVVDBSJHIZ-QHLGVNSISA-N 0.000 claims description 4
- 239000003002 pH adjusting agent Substances 0.000 claims description 3
- 239000011769 retinyl palmitate Substances 0.000 claims description 3
- 229940108325 retinyl palmitate Drugs 0.000 claims description 3
- 235000019172 retinyl palmitate Nutrition 0.000 claims description 3
- 238000010008 shearing Methods 0.000 claims description 3
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 2
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 2
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims description 2
- 229930003268 Vitamin C Natural products 0.000 claims description 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims description 2
- 229960000342 retinol acetate Drugs 0.000 claims description 2
- 239000011770 retinyl acetate Substances 0.000 claims description 2
- 235000019173 retinyl acetate Nutrition 0.000 claims description 2
- 235000011149 sulphuric acid Nutrition 0.000 claims description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 2
- 239000011708 vitamin B3 Substances 0.000 claims description 2
- 239000011718 vitamin C Substances 0.000 claims description 2
- 235000019154 vitamin C Nutrition 0.000 claims description 2
- LEVWYRKDKASIDU-QWWZWVQMSA-N D-cystine Chemical compound OC(=O)[C@H](N)CSSC[C@@H](N)C(O)=O LEVWYRKDKASIDU-QWWZWVQMSA-N 0.000 claims 2
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 claims 2
- 229930003537 Vitamin B3 Natural products 0.000 claims 1
- CBKLICUQYUTWQL-XWGBWKJCSA-N methyl (3s,4r)-3-methyl-1-(2-phenylethyl)-4-(n-propanoylanilino)piperidine-4-carboxylate;oxalic acid Chemical compound OC(=O)C(O)=O.CCC(=O)N([C@]1([C@H](CN(CCC=2C=CC=CC=2)CC1)C)C(=O)OC)C1=CC=CC=C1 CBKLICUQYUTWQL-XWGBWKJCSA-N 0.000 claims 1
- 229960003512 nicotinic acid Drugs 0.000 claims 1
- 235000019160 vitamin B3 Nutrition 0.000 claims 1
- 239000000839 emulsion Substances 0.000 description 28
- 239000003921 oil Substances 0.000 description 27
- 235000019198 oils Nutrition 0.000 description 27
- -1 serums Substances 0.000 description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 16
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 12
- 239000000194 fatty acid Substances 0.000 description 12
- 239000003755 preservative agent Substances 0.000 description 12
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
- 235000010980 cellulose Nutrition 0.000 description 8
- 229920002678 cellulose Polymers 0.000 description 8
- 239000000463 material Substances 0.000 description 8
- 239000013543 active substance Substances 0.000 description 7
- 235000013399 edible fruits Nutrition 0.000 description 7
- 239000001913 cellulose Substances 0.000 description 6
- 235000014113 dietary fatty acids Nutrition 0.000 description 6
- 229930195729 fatty acid Natural products 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 6
- 230000007935 neutral effect Effects 0.000 description 6
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 5
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 5
- 239000003995 emulsifying agent Substances 0.000 description 5
- 235000011187 glycerol Nutrition 0.000 description 5
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 5
- 230000000699 topical effect Effects 0.000 description 5
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 4
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 4
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 description 4
- 210000002421 cell wall Anatomy 0.000 description 4
- 235000020971 citrus fruits Nutrition 0.000 description 4
- 239000006071 cream Substances 0.000 description 4
- 229960005323 phenoxyethanol Drugs 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 229930002330 retinoic acid Natural products 0.000 description 4
- 229920002545 silicone oil Polymers 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 229960001727 tretinoin Drugs 0.000 description 4
- 229940031723 1,2-octanediol Drugs 0.000 description 3
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 3
- 229920001577 copolymer Polymers 0.000 description 3
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
- 229940008099 dimethicone Drugs 0.000 description 3
- 239000004205 dimethyl polysiloxane Substances 0.000 description 3
- 210000004247 hand Anatomy 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 210000001724 microfibril Anatomy 0.000 description 3
- AEIJTFQOBWATKX-UHFFFAOYSA-N octane-1,2-diol Chemical compound CCCCCCC(O)CO AEIJTFQOBWATKX-UHFFFAOYSA-N 0.000 description 3
- 238000004806 packaging method and process Methods 0.000 description 3
- 229920001451 polypropylene glycol Polymers 0.000 description 3
- 239000002243 precursor Substances 0.000 description 3
- 230000002335 preservative effect Effects 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- 150000005846 sugar alcohols Polymers 0.000 description 3
- 239000002562 thickening agent Substances 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical class CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- ULQISTXYYBZJSJ-UHFFFAOYSA-N 12-hydroxyoctadecanoic acid Chemical compound CCCCCCC(O)CCCCCCCCCCC(O)=O ULQISTXYYBZJSJ-UHFFFAOYSA-N 0.000 description 2
- BANXPJUEBPWEOT-UHFFFAOYSA-N 2-methyl-Pentadecane Chemical compound CCCCCCCCCCCCCC(C)C BANXPJUEBPWEOT-UHFFFAOYSA-N 0.000 description 2
- 229940099451 3-iodo-2-propynylbutylcarbamate Drugs 0.000 description 2
- WYVVKGNFXHOCQV-UHFFFAOYSA-N 3-iodoprop-2-yn-1-yl butylcarbamate Chemical compound CCCCNC(=O)OCC#CI WYVVKGNFXHOCQV-UHFFFAOYSA-N 0.000 description 2
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 description 2
- VGMJYYDKPUPTID-UHFFFAOYSA-N 4-ethylbenzene-1,3-diol Chemical compound CCC1=CC=C(O)C=C1O VGMJYYDKPUPTID-UHFFFAOYSA-N 0.000 description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 244000007835 Cyamopsis tetragonoloba Species 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- 244000068988 Glycine max Species 0.000 description 2
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 2
- 229920002774 Maltodextrin Polymers 0.000 description 2
- 239000005913 Maltodextrin Substances 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 240000003768 Solanum lycopersicum Species 0.000 description 2
- 229930182558 Sterol Natural products 0.000 description 2
- 235000019486 Sunflower oil Nutrition 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 125000005907 alkyl ester group Chemical group 0.000 description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 2
- 235000015165 citric acid Nutrition 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 150000002191 fatty alcohols Chemical class 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 229940051250 hexylene glycol Drugs 0.000 description 2
- 239000008240 homogeneous mixture Substances 0.000 description 2
- 239000003906 humectant Substances 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 229940035034 maltodextrin Drugs 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- CNVZJPUDSLNTQU-SEYXRHQNSA-N petroselinic acid Chemical compound CCCCCCCCCCC\C=C/CCCCC(O)=O CNVZJPUDSLNTQU-SEYXRHQNSA-N 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 235000019260 propionic acid Nutrition 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- FWFUWXVFYKCSQA-UHFFFAOYSA-M sodium;2-methyl-2-(prop-2-enoylamino)propane-1-sulfonate Chemical compound [Na+].[O-]S(=O)(=O)CC(C)(C)NC(=O)C=C FWFUWXVFYKCSQA-UHFFFAOYSA-M 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 239000003549 soybean oil Substances 0.000 description 2
- 235000012424 soybean oil Nutrition 0.000 description 2
- 235000003702 sterols Nutrition 0.000 description 2
- 239000002600 sunflower oil Substances 0.000 description 2
- 230000000475 sunscreen effect Effects 0.000 description 2
- 239000000516 sunscreening agent Substances 0.000 description 2
- 229920001059 synthetic polymer Polymers 0.000 description 2
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- WWUZIQQURGPMPG-UHFFFAOYSA-N (-)-D-erythro-Sphingosine Natural products CCCCCCCCCCCCCC=CC(O)C(N)CO WWUZIQQURGPMPG-UHFFFAOYSA-N 0.000 description 1
- CRDAMVZIKSXKFV-FBXUGWQNSA-N (2-cis,6-cis)-farnesol Chemical compound CC(C)=CCC\C(C)=C/CC\C(C)=C/CO CRDAMVZIKSXKFV-FBXUGWQNSA-N 0.000 description 1
- 239000000260 (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol Substances 0.000 description 1
- CUNWUEBNSZSNRX-RKGWDQTMSA-N (2r,3r,4r,5s)-hexane-1,2,3,4,5,6-hexol;(z)-octadec-9-enoic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O CUNWUEBNSZSNRX-RKGWDQTMSA-N 0.000 description 1
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
- ZWVMLYRJXORSEP-UHFFFAOYSA-N 1,2,6-Hexanetriol Chemical compound OCCCCC(O)CO ZWVMLYRJXORSEP-UHFFFAOYSA-N 0.000 description 1
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- 150000005207 1,3-dihydroxybenzenes Chemical class 0.000 description 1
- PQUXFUBNSYCQAL-UHFFFAOYSA-N 1-(2,3-difluorophenyl)ethanone Chemical compound CC(=O)C1=CC=CC(F)=C1F PQUXFUBNSYCQAL-UHFFFAOYSA-N 0.000 description 1
- OWEGWHBOCFMBLP-UHFFFAOYSA-N 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one Chemical compound C1=CN=CN1C(C(=O)C(C)(C)C)OC1=CC=C(Cl)C=C1 OWEGWHBOCFMBLP-UHFFFAOYSA-N 0.000 description 1
- JQJSFAJISYZPER-UHFFFAOYSA-N 1-(4-chlorophenyl)-3-(2,3-dihydro-1h-inden-5-ylsulfonyl)urea Chemical compound C1=CC(Cl)=CC=C1NC(=O)NS(=O)(=O)C1=CC=C(CCC2)C2=C1 JQJSFAJISYZPER-UHFFFAOYSA-N 0.000 description 1
- RZRNAYUHWVFMIP-KTKRTIGZSA-N 1-oleoylglycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-KTKRTIGZSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- 229940114072 12-hydroxystearic acid Drugs 0.000 description 1
- OXEDXHIBHVMDST-UHFFFAOYSA-N 12Z-octadecenoic acid Natural products CCCCCC=CCCCCCCCCCCC(O)=O OXEDXHIBHVMDST-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- 229940043268 2,2,4,4,6,8,8-heptamethylnonane Drugs 0.000 description 1
- GOHZKUSWWGUUNR-UHFFFAOYSA-N 2-(4,5-dihydroimidazol-1-yl)ethanol Chemical compound OCCN1CCN=C1 GOHZKUSWWGUUNR-UHFFFAOYSA-N 0.000 description 1
- MGYUQZIGNZFZJS-KTKRTIGZSA-N 2-[2-[(z)-octadec-9-enoxy]ethoxy]ethanol Chemical compound CCCCCCCC\C=C/CCCCCCCCOCCOCCO MGYUQZIGNZFZJS-KTKRTIGZSA-N 0.000 description 1
- NLMKTBGFQGKQEV-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hexadecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO NLMKTBGFQGKQEV-UHFFFAOYSA-N 0.000 description 1
- AMRBZKOCOOPYNY-QXMHVHEDSA-N 2-[dimethyl-[(z)-octadec-9-enyl]azaniumyl]acetate Chemical compound CCCCCCCC\C=C/CCCCCCCC[N+](C)(C)CC([O-])=O AMRBZKOCOOPYNY-QXMHVHEDSA-N 0.000 description 1
- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 description 1
- WSSJONWNBBTCMG-UHFFFAOYSA-N 2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester Chemical compound C1C(C)(C)CC(C)CC1OC(=O)C1=CC=CC=C1O WSSJONWNBBTCMG-UHFFFAOYSA-N 0.000 description 1
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 1
- BJRXGOFKVBOFCO-UHFFFAOYSA-N 2-hydroxypropyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(C)O BJRXGOFKVBOFCO-UHFFFAOYSA-N 0.000 description 1
- KUJRLICPLXLHNV-UHFFFAOYSA-N 3,4-diethyl-2-hexylphenol;2-methoxyphenol;triazine Chemical compound C1=CN=NN=C1.COC1=CC=CC=C1O.CCCCCCC1=C(O)C=CC(CC)=C1CC KUJRLICPLXLHNV-UHFFFAOYSA-N 0.000 description 1
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 description 1
- PLSHDRPUKROXKW-UHFFFAOYSA-N 3-(2-ethylhexyl)-2-hydroxybenzoic acid Chemical compound CCCCC(CC)CC1=CC=CC(C(O)=O)=C1O PLSHDRPUKROXKW-UHFFFAOYSA-N 0.000 description 1
- XPFCZYUVICHKDS-UHFFFAOYSA-N 3-methylbutane-1,3-diol Chemical compound CC(C)(O)CCO XPFCZYUVICHKDS-UHFFFAOYSA-N 0.000 description 1
- XTQUSEDRZLDHRC-UHFFFAOYSA-N 3-octadecanoyloxybutyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCC(C)OC(=O)CCCCCCCCCCCCCCCCC XTQUSEDRZLDHRC-UHFFFAOYSA-N 0.000 description 1
- ANTLBIMVNRRJNP-UHFFFAOYSA-N 4-(2-phenylethyl)benzene-1,3-diol Chemical compound OC1=CC(O)=CC=C1CCC1=CC=CC=C1 ANTLBIMVNRRJNP-UHFFFAOYSA-N 0.000 description 1
- 239000004101 4-Hexylresorcinol Substances 0.000 description 1
- NZXZINXFUSKTPH-UHFFFAOYSA-N 4-[4-(4-butylcyclohexyl)cyclohexyl]-1,2-difluorobenzene Chemical compound C1CC(CCCC)CCC1C1CCC(C=2C=C(F)C(F)=CC=2)CC1 NZXZINXFUSKTPH-UHFFFAOYSA-N 0.000 description 1
- NZLWYNBRWDATJO-UHFFFAOYSA-N 4-cyclohexyl-5-methylbenzene-1,3-diol Chemical compound CC1=CC(O)=CC(O)=C1C1CCCCC1 NZLWYNBRWDATJO-UHFFFAOYSA-N 0.000 description 1
- IXMNGROEFGBSGO-UHFFFAOYSA-N 4-cyclopentylbenzene-1,3-diol Chemical compound OC1=CC(O)=CC=C1C1CCCC1 IXMNGROEFGBSGO-UHFFFAOYSA-N 0.000 description 1
- WFJIVOKAWHGMBH-UHFFFAOYSA-N 4-hexylbenzene-1,3-diol Chemical compound CCCCCCC1=CC=C(O)C=C1O WFJIVOKAWHGMBH-UHFFFAOYSA-N 0.000 description 1
- 235000019360 4-hexylresorcinol Nutrition 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- 229940090248 4-hydroxybenzoic acid Drugs 0.000 description 1
- FBSIDCYWGKQYRW-UHFFFAOYSA-N 5-methyl-4-propan-2-ylbenzene-1,3-diol Chemical compound CC(C)C1=C(C)C=C(O)C=C1O FBSIDCYWGKQYRW-UHFFFAOYSA-N 0.000 description 1
- JBYXPOFIGCOSSB-GOJKSUSPSA-N 9-cis,11-trans-octadecadienoic acid Chemical compound CCCCCC\C=C\C=C/CCCCCCCC(O)=O JBYXPOFIGCOSSB-GOJKSUSPSA-N 0.000 description 1
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 235000006491 Acacia senegal Nutrition 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- 235000009436 Actinidia deliciosa Nutrition 0.000 description 1
- 244000298697 Actinidia deliciosa Species 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 235000002961 Aloe barbadensis Nutrition 0.000 description 1
- 244000144927 Aloe barbadensis Species 0.000 description 1
- 244000144730 Amygdalus persica Species 0.000 description 1
- 244000075850 Avena orientalis Species 0.000 description 1
- 235000007319 Avena orientalis Nutrition 0.000 description 1
- 235000000832 Ayote Nutrition 0.000 description 1
- 229920002749 Bacterial cellulose Polymers 0.000 description 1
- 235000021537 Beetroot Nutrition 0.000 description 1
- 241000219310 Beta vulgaris subsp. vulgaris Species 0.000 description 1
- 240000002791 Brassica napus Species 0.000 description 1
- 235000011293 Brassica napus Nutrition 0.000 description 1
- 235000000540 Brassica rapa subsp rapa Nutrition 0.000 description 1
- 235000004936 Bromus mango Nutrition 0.000 description 1
- 241000195940 Bryophyta Species 0.000 description 1
- UPXUUCBQSRQWMJ-UHFFFAOYSA-N CC(C)c1ccc(O)cc1O.Oc1ccc(C2CCCCC2)c(O)c1 Chemical compound CC(C)c1ccc(O)cc1O.Oc1ccc(C2CCCCC2)c(O)c1 UPXUUCBQSRQWMJ-UHFFFAOYSA-N 0.000 description 1
- 240000003538 Chamaemelum nobile Species 0.000 description 1
- 235000007866 Chamaemelum nobile Nutrition 0.000 description 1
- QMBJSIBWORFWQT-DFXBJWIESA-N Chlormadinone acetate Chemical compound C1=C(Cl)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 QMBJSIBWORFWQT-DFXBJWIESA-N 0.000 description 1
- 241000207199 Citrus Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 240000004244 Cucurbita moschata Species 0.000 description 1
- 235000009854 Cucurbita moschata Nutrition 0.000 description 1
- 235000009804 Cucurbita pepo subsp pepo Nutrition 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- FPVVYTCTZKCSOJ-UHFFFAOYSA-N Ethylene glycol distearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCOC(=O)CCCCCCCCCCCCCCCCC FPVVYTCTZKCSOJ-UHFFFAOYSA-N 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 235000011430 Malus pumila Nutrition 0.000 description 1
- 235000015103 Malus silvestris Nutrition 0.000 description 1
- 235000014826 Mangifera indica Nutrition 0.000 description 1
- 240000007228 Mangifera indica Species 0.000 description 1
- 240000003183 Manihot esculenta Species 0.000 description 1
- 235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 description 1
- 235000007232 Matricaria chamomilla Nutrition 0.000 description 1
- 235000010654 Melissa officinalis Nutrition 0.000 description 1
- 244000062730 Melissa officinalis Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- CNVZJPUDSLNTQU-UHFFFAOYSA-N Petroselaidic acid Natural products CCCCCCCCCCCC=CCCCCC(O)=O CNVZJPUDSLNTQU-UHFFFAOYSA-N 0.000 description 1
- 235000010582 Pisum sativum Nutrition 0.000 description 1
- 240000004713 Pisum sativum Species 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000004721 Polyphenylene oxide Substances 0.000 description 1
- CMCJFUXWBBHIIL-UHFFFAOYSA-N Propylene glycol stearate Chemical class CC(O)CO.CCCCCCCCCCCCCCCCCC(O)=O CMCJFUXWBBHIIL-UHFFFAOYSA-N 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- 229920001131 Pulp (paper) Polymers 0.000 description 1
- 235000019484 Rapeseed oil Nutrition 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- 235000019485 Safflower oil Nutrition 0.000 description 1
- 241001558929 Sclerotium <basidiomycota> Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical group [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 239000004288 Sodium dehydroacetate Substances 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- IYFATESGLOUGBX-YVNJGZBMSA-N Sorbitan monopalmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O IYFATESGLOUGBX-YVNJGZBMSA-N 0.000 description 1
- 239000004147 Sorbitan trioleate Substances 0.000 description 1
- PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 description 1
- 235000009184 Spondias indica Nutrition 0.000 description 1
- 235000015125 Sterculia urens Nutrition 0.000 description 1
- 240000001058 Sterculia urens Species 0.000 description 1
- 235000021536 Sugar beet Nutrition 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 239000005844 Thymol Substances 0.000 description 1
- 235000007303 Thymus vulgaris Nutrition 0.000 description 1
- 240000002657 Thymus vulgaris Species 0.000 description 1
- PHYFQTYBJUILEZ-UHFFFAOYSA-N Trioleoylglycerol Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCCCCCCCC)COC(=O)CCCCCCCC=CCCCCCCCC PHYFQTYBJUILEZ-UHFFFAOYSA-N 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- IJCWFDPJFXGQBN-RYNSOKOISA-N [(2R)-2-[(2R,3R,4S)-4-hydroxy-3-octadecanoyloxyoxolan-2-yl]-2-octadecanoyloxyethyl] octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCCCCCCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCCCCCCCCCCCC IJCWFDPJFXGQBN-RYNSOKOISA-N 0.000 description 1
- OEWBEINAQKIQLZ-CMRBMDBWSA-N [(2s)-2-[(2r)-3,4-bis(2-hexyldecanoyloxy)-5-oxo-2h-furan-2-yl]-2-(2-hexyldecanoyloxy)ethyl] 2-hexyldecanoate Chemical compound CCCCCCCCC(CCCCCC)C(=O)OC[C@H](OC(=O)C(CCCCCC)CCCCCCCC)[C@H]1OC(=O)C(OC(=O)C(CCCCCC)CCCCCCCC)=C1OC(=O)C(CCCCCC)CCCCCCCC OEWBEINAQKIQLZ-CMRBMDBWSA-N 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 229940048053 acrylate Drugs 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Natural products OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 235000011399 aloe vera Nutrition 0.000 description 1
- WUOACPNHFRMFPN-UHFFFAOYSA-N alpha-terpineol Chemical compound CC1=CCC(C(C)(C)O)CC1 WUOACPNHFRMFPN-UHFFFAOYSA-N 0.000 description 1
- 229940099583 aluminum starch octenylsuccinate Drugs 0.000 description 1
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000001166 anti-perspirative effect Effects 0.000 description 1
- 229940053195 antiepileptics hydantoin derivative Drugs 0.000 description 1
- 239000003213 antiperspirant Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000005016 bacterial cellulose Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000019445 benzyl alcohol Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- NZIKRHKSEITLPS-UHFFFAOYSA-N butane-1,3-diol;octadecanoic acid Chemical compound CC(O)CCO.CCCCCCCCCCCCCCCCCC(O)=O NZIKRHKSEITLPS-UHFFFAOYSA-N 0.000 description 1
- 210000001217 buttock Anatomy 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 229940105329 carboxymethylcellulose Drugs 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 229940081620 ceteth-2 Drugs 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Natural products C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 1
- 229960003344 climbazole Drugs 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 229940108924 conjugated linoleic acid Drugs 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- SQIFACVGCPWBQZ-UHFFFAOYSA-N delta-terpineol Natural products CC(C)(O)C1CCC(=C)CC1 SQIFACVGCPWBQZ-UHFFFAOYSA-N 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- HUVYTMDMDZRHBN-UHFFFAOYSA-N drometrizole trisiloxane Chemical compound C[Si](C)(C)O[Si](C)(O[Si](C)(C)C)CC(C)CC1=CC(C)=CC(N2N=C3C=CC=CC3=N2)=C1O HUVYTMDMDZRHBN-UHFFFAOYSA-N 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- UVCJGUGAGLDPAA-UHFFFAOYSA-N ensulizole Chemical compound N1C2=CC(S(=O)(=O)O)=CC=C2N=C1C1=CC=CC=C1 UVCJGUGAGLDPAA-UHFFFAOYSA-N 0.000 description 1
- 229960000655 ensulizole Drugs 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 229940100524 ethylhexylglycerin Drugs 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 229940043259 farnesol Drugs 0.000 description 1
- 229930002886 farnesol Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 235000021323 fish oil Nutrition 0.000 description 1
- 239000000834 fixative Substances 0.000 description 1
- 210000002683 foot Anatomy 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 229910021485 fumed silica Inorganic materials 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 150000002314 glycerols Chemical class 0.000 description 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
- 229940075529 glyceryl stearate Drugs 0.000 description 1
- 229940100608 glycol distearate Drugs 0.000 description 1
- 229940100242 glycol stearate Drugs 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 229940087559 grape seed Drugs 0.000 description 1
- 239000008169 grapeseed oil Substances 0.000 description 1
- 235000009569 green tea Nutrition 0.000 description 1
- 229960003258 hexylresorcinol Drugs 0.000 description 1
- 150000001469 hydantoins Chemical class 0.000 description 1
- 239000001341 hydroxy propyl starch Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 235000013828 hydroxypropyl starch Nutrition 0.000 description 1
- ZCTXEAQXZGPWFG-UHFFFAOYSA-N imidurea Chemical compound O=C1NC(=O)N(CO)C1NC(=O)NCNC(=O)NC1C(=O)NC(=O)N1CO ZCTXEAQXZGPWFG-UHFFFAOYSA-N 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- KUVMKLCGXIYSNH-UHFFFAOYSA-N isopentadecane Natural products CCCCCCCCCCCCC(C)C KUVMKLCGXIYSNH-UHFFFAOYSA-N 0.000 description 1
- 229940093629 isopropyl isostearate Drugs 0.000 description 1
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 210000002414 leg Anatomy 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 1
- 229940078752 magnesium ascorbyl phosphate Drugs 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 235000011929 mousse Nutrition 0.000 description 1
- 239000002159 nanocrystal Substances 0.000 description 1
- 210000003739 neck Anatomy 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 1
- 229960001679 octinoxate Drugs 0.000 description 1
- BARWIPMJPCRCTP-UHFFFAOYSA-N oleic acid oleyl ester Natural products CCCCCCCCC=CCCCCCCCCOC(=O)CCCCCCCC=CCCCCCCCC BARWIPMJPCRCTP-UHFFFAOYSA-N 0.000 description 1
- 229940099570 oleth-2 Drugs 0.000 description 1
- BARWIPMJPCRCTP-CLFAGFIQSA-N oleyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC BARWIPMJPCRCTP-CLFAGFIQSA-N 0.000 description 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 description 1
- 229940012843 omega-3 fatty acid Drugs 0.000 description 1
- 239000006014 omega-3 oil Substances 0.000 description 1
- 229940033080 omega-6 fatty acid Drugs 0.000 description 1
- 235000020665 omega-6 fatty acid Nutrition 0.000 description 1
- 239000003346 palm kernel oil Substances 0.000 description 1
- 235000019865 palm kernel oil Nutrition 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 229940031709 peg-30-dipolyhydroxystearate Drugs 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920013639 polyalphaolefin Polymers 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 229920000059 polyethylene glycol stearate Polymers 0.000 description 1
- 229920000223 polyglycerol Polymers 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- NEOZOXKVMDBOSG-UHFFFAOYSA-N propan-2-yl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OC(C)C NEOZOXKVMDBOSG-UHFFFAOYSA-N 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 229940095574 propionic acid Drugs 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 235000021251 pulses Nutrition 0.000 description 1
- 235000015136 pumpkin Nutrition 0.000 description 1
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 230000002207 retinal effect Effects 0.000 description 1
- NCYCYZXNIZJOKI-OVSJKPMPSA-N retinal group Chemical group C\C(=C/C=O)\C=C\C=C(\C=C\C1=C(CCCC1(C)C)C)/C NCYCYZXNIZJOKI-OVSJKPMPSA-N 0.000 description 1
- 229960003471 retinol Drugs 0.000 description 1
- 235000020944 retinol Nutrition 0.000 description 1
- 239000011607 retinol Substances 0.000 description 1
- 125000002523 retinol group Chemical group 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 235000020748 rosemary extract Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229940047670 sodium acrylate Drugs 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 235000019259 sodium dehydroacetate Nutrition 0.000 description 1
- 229940079839 sodium dehydroacetate Drugs 0.000 description 1
- DSOWAKKSGYUMTF-GZOLSCHFSA-M sodium;(1e)-1-(6-methyl-2,4-dioxopyran-3-ylidene)ethanolate Chemical compound [Na+].C\C([O-])=C1/C(=O)OC(C)=CC1=O DSOWAKKSGYUMTF-GZOLSCHFSA-M 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 235000011071 sorbitan monopalmitate Nutrition 0.000 description 1
- 239000001570 sorbitan monopalmitate Substances 0.000 description 1
- 229940031953 sorbitan monopalmitate Drugs 0.000 description 1
- 229960005078 sorbitan sesquioleate Drugs 0.000 description 1
- 235000019337 sorbitan trioleate Nutrition 0.000 description 1
- 229960000391 sorbitan trioleate Drugs 0.000 description 1
- 235000011078 sorbitan tristearate Nutrition 0.000 description 1
- 239000001589 sorbitan tristearate Substances 0.000 description 1
- 229960004129 sorbitan tristearate Drugs 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229940104261 taurate Drugs 0.000 description 1
- 229940116411 terpineol Drugs 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- 239000001585 thymus vulgaris Substances 0.000 description 1
- CRDAMVZIKSXKFV-UHFFFAOYSA-N trans-Farnesol Natural products CC(C)=CCCC(C)=CCCC(C)=CCO CRDAMVZIKSXKFV-UHFFFAOYSA-N 0.000 description 1
- AQWHMKSIVLSRNY-UHFFFAOYSA-N trans-Octadec-5-ensaeure Natural products CCCCCCCCCCCCC=CCCCC(O)=O AQWHMKSIVLSRNY-UHFFFAOYSA-N 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 1
- HTJNEBVCZXHBNJ-XCTPRCOBSA-H trimagnesium;(2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;diphosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.OC[C@H](O)[C@H]1OC(=O)C(O)=C1O HTJNEBVCZXHBNJ-XCTPRCOBSA-H 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 150000003700 vitamin C derivatives Chemical class 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/068—Microemulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/064—Water-in-oil emulsions, e.g. Water-in-silicone emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/447—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
- A61K8/492—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid having condensed rings, e.g. indol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/21—Emulsions characterized by droplet sizes below 1 micron
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Colloid Chemistry (AREA)
- Detergent Compositions (AREA)
Description
本発明は、ナノエマルジョン、および、当該ナノエマルジョンを製造し、使用する方法を対象とする。より詳細には、本発明は、油で連続し、かつ、その水相において25℃および中性pHで水に溶けない高濃度の有益剤を有するナノエマルジョンを対象とする。
ナノエマルジョンは、パーソナルケア組成物に使用するためにますます普及しつつある。ナノエマルジョンは安定しており、その単位体積からみて高い表面積を有する。ナノエマルジョンは、その水相および油相において活性剤を運ぶことができ、皮膚を通して活性剤の浸透を増強するとともに、エマルジョンによって製剤化された最終使用組成物を使用する消費者にもたらされる局所的な利益を増強するため、望ましい。
ナノエマルジョンを作製するための試みが開示されている。米国公開出願第2017/0112764A1号において、可逆的な連続相及び分散相を有するナノエマルジョンが記載されている。
第1の態様において、本発明は、以下の工程を含む油連続ナノエマルジョンの製造方法を対象とする:
(a)特に順序なく、pH10~14の第1の油連続マクロエマルジョンおよびその水相中の皮膚有益剤を、pH2~5の第2の油連続マクロエマルジョンと組み合わせる工程;
(b)第1のマクロエマルジョンと第2のマクロエマルジョンとを混合してマクロエマルジョンの混合物を作製する工程(ここで、該混合物は、pHが10~14およびpHが2~5の両方を有するマクロエマルジョンを有する);
(c)マクロエマルジョンの混合物を剪断して、150~900nmの粒径を有するナノエマルジョンを生成する工程(ここで、ナノエマルジョンはその水相において0.15~5重量%の皮膚有益剤を含む)。
本発明のナノエマルジョンを調製するのに使用される油連続マクロエマルジョンに関して、当該マクロエマルジョンは、典型的には、マクロエマルジョンの総重量に基づいて、30~70重量%、好ましくは35~65重量%、最も好ましくは40~60重量%の水を含み、そこに含まれる全ての範囲を含む。
本明細書で有用なこのような本質的に不揮発性のポリアルキルシロキサンは、例えば、25℃で5~100,000センチストークスの粘度を有するポリジメチルシロキサン(ジメチコンのようである)を含む。
(1)パルミチン酸イソプロピル、イソステアリン酸イソプロピル、イソノノイン酸イソノニル、ミリスチン酸オレイル、ミリスチン酸イソプロピル、ステアリン酸オレイル、オレイルオレイン酸オレイルのような炭素原子を10~20個有する脂肪酸のアルケニルまたはアルキルエステル;
(2)エトキシル化脂肪アルコールの脂肪酸エステルのようなエーテル-エステル;
(3)エチレングリコールモノ-及びジ-脂肪酸エステル、ジエチレングリコールモノ-及びジ-脂肪酸エステル、ポリエチレングリコール(200-6000)モノ-及びジ-脂肪酸エステル、プロピレングリコールモノ-及びジ-脂肪酸エステル、ポリプロピレングリコール2000モノオレエート、ポリプロピレングリコール2000モノオレエート、エトキシル化プロピレングリコールモノステアレート、グリセリルモノ-及びジ-脂肪酸エステル、ポリグリセロールポリ-脂肪酸エステル、エトキシル化グリセリルモノ-ステアレート、1,3-ブチレングリコールモノステアレート、1,3-ブチレングリコールジステアリン酸、ポリオキシエチレンポリオール脂肪酸エステル、ソルビタン脂肪酸エステル、及びポリオキシ-エチレンソルビタン脂肪酸エステル等の多価アルコールエステル;
(4)ステロールエステル(この大豆ステロール及びコレステロール脂肪酸エステルがその例である。)。
特に好ましい態様において、本発明において使用される任意の油溶性活性物質は、レチノイン酸前駆物質である。
高pH(pH12)マクロエマルジョンと低pH(pH2.5)マクロエマルジョンを別々に調製した。高pHマクロエマルジョン(表1a)を調製する際には、水相の全成分を混合容器に入れ、磁気攪拌棒と混合(室温および適度なせん断)した結果、透明な混合物が得られた。オーバーヘッド・スターラーを備えた別個の混合容器に成分(適度なせん断および室温も)を組み合わせて混合して調製した油相。得られた混合物が透明になった時点で混合を終了した。続いて、水溶液を油相と混合容器に徐々に加え、一方、撹拌/撹拌を提供して、2つの相を混合した。均一な混合物を得た後、攪拌を停止し、油連続マクロエマルジョンの粒径は約10ミクロンであった。
実施例2の試料は、実施例1に記載したものと同様の方法で調製した。
Claims (11)
- 油連続ナノエマルジョンの製造方法であって、以下の工程:
(a)特に順序なく、pH10~14の第1の油連続マクロエマルジョンおよびその水相中の皮膚有益剤を、pH2~5の第2の油連続マクロエマルジョンと組み合わせる工程;
(b)前記第1の油連続マクロエマルジョンと前記第2の油連続マクロエマルジョンとを混合してマクロエマルジョンの混合物を作製する工程(ここで、該混合物は、pHが10~14の第1の油連続マクロエマルジョンと、pHが2~5の第2の油連続マクロエマルジョンとを有する);
(c)マクロエマルジョンの混合物を剪断して150~900nmの粒径を有するナノエマルジョンを生成する工程(ここで、該ナノエマルジョンは、0.15~5重量%の皮膚有益剤をその水相中に含む)
を含み、
前記皮膚有益剤がシスチンである、製造方法。 - 前記皮膚有益剤が、フェニルアラニン、チロシン、トリプトファンまたはそれらの混合物をさらに含む、請求項1記載の製造方法。
- 前記マクロエマルジョンの混合物の50~90重量%のpHが10~14であり、
前記ナノエマルジョンの水相がシスチンを含む、請求項1に記載の製造方法。 - 前記第1の油連続マクロエマルジョンのpHが11~12.5であり、
前記第2の油連続マクロエマルジョンのpHが2~3である、請求項1記載の製造方法。 - 前記第1および第2の油連続マクロエマルジョンが、1~30ミクロンの粒径を有し、
前記ナノエマルジョンが275~825nmの粒径を有する、請求項1記載の製造方法。 - 前記マクロエマルジョンが、トリエチルアミン、NaOH、KOH、H2SO4、HCL、クエン酸およびそれらの混合物からなる群から選択されるpH調整剤をさらに含む、請求項1に記載の製造方法。
- 請求項1~6のいずれか1項に記載の製造方法により得ることができるナノエマルジョン。
- 前記シスチンが前記水相に存在し、前記ナノエマルジョンの0.5~3.5重量%を構成する、請求項7に記載のナノエマルジョン。
- 前記ナノエマルジョンが、その水相中にビタミンB3および/またはビタミンCを、ならびに、その油相中にレゾルシノール、レチニルプロピオン酸、レチニルパルミテート、レチニル酢酸またはその混合物をさらに含む、請求項7または8に記載のナノエマルジョン。
- 250~800nmの粒径を有する、請求項7~9のいずれか1項に記載のナノエマルジョン。
- 最終使用組成物のブースターとしての、請求項7~10のいずれか1項に記載のナノエマルジョンの使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18173916 | 2018-05-23 | ||
EP18173916.0 | 2018-05-23 | ||
PCT/EP2019/062300 WO2019224048A1 (en) | 2018-05-23 | 2019-05-14 | Nanoemulsions and a method for making the same |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2021526127A JP2021526127A (ja) | 2021-09-30 |
JP7497296B2 true JP7497296B2 (ja) | 2024-06-10 |
Family
ID=62567224
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2020557160A Active JP7497296B2 (ja) | 2018-05-23 | 2019-05-14 | ナノエマルジョン及びその製造方法 |
Country Status (9)
Country | Link |
---|---|
US (1) | US11540984B2 (ja) |
EP (1) | EP3773422B1 (ja) |
JP (1) | JP7497296B2 (ja) |
CN (1) | CN112165927B (ja) |
CA (1) | CA3098981A1 (ja) |
EA (1) | EA202092461A1 (ja) |
MX (1) | MX2020012410A (ja) |
WO (1) | WO2019224048A1 (ja) |
ZA (1) | ZA202006323B (ja) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020200979A1 (en) * | 2019-04-01 | 2020-10-08 | Unilever Plc | Multiple emulsion comprising an oil continuous nanoemulsion and a method for using the same |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011502952A (ja) | 2006-12-01 | 2011-01-27 | アンテリオス, インコーポレイテッド | ペプチドナノ粒子およびその使用 |
WO2018113636A1 (en) | 2016-12-21 | 2018-06-28 | Unilever Plc | Topical skin lightening additive and composition with amino acids and ppar activating fatty acids |
Family Cites Families (112)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB720561A (en) | 1952-04-17 | 1954-12-22 | Frederick Victor Wells | Improvements in preparations for application to the hair and scalp |
GB874368A (en) | 1957-12-09 | 1961-08-02 | Irwin Irville Lubowe | Improvements in anti-seborrheic and scalp preparations |
NL241476A (ja) | 1958-07-24 | |||
GB987800A (en) | 1962-02-13 | 1965-03-31 | Shiseido Co Ltd | Improvements in or relating to toilet preparations containing amino acids |
GB1050756A (ja) | 1964-09-10 | 1900-01-01 | ||
US3786076A (en) | 1966-10-13 | 1974-01-15 | J Morelle | Lipoaminoacids |
GB1235667A (en) | 1967-07-19 | 1971-06-16 | Nat Res Dev | Improvements in or relating to sustained release preparations |
JPS5032533B1 (ja) | 1969-02-27 | 1975-10-22 | ||
BE793930A (fr) | 1972-01-12 | 1973-05-02 | Athlon Corp | Composition pour le conditionnement de la peau |
US4201235A (en) | 1978-01-03 | 1980-05-06 | Mare Corporation | Amino acid-vitamin formulations for skin, hair and scalp conditioners |
JPS61227515A (ja) | 1985-04-01 | 1986-10-09 | Shiseido Co Ltd | 皮膚外用剤 |
US4826828A (en) | 1985-04-22 | 1989-05-02 | Avon Products, Inc. | Composition and method for reducing wrinkles |
US4707354A (en) | 1985-06-17 | 1987-11-17 | Alpen Tau, Inc. | Mature skin treatment and protectant compositions and methods of using same |
FR2608424B1 (fr) | 1986-12-17 | 1989-06-16 | Cazacou Cecilia | Accelerateur de bronzage sans ecran solaire utilisant un complexe naturel favorisant la melanogenese |
US4885157A (en) | 1987-02-13 | 1989-12-05 | Fiaschetti Mary G | Dermal cosmetic composition and applications therefor |
GB2212722B (en) | 1987-11-25 | 1991-12-11 | Theravit Limited | Vitamin compositions |
US5133958A (en) | 1989-04-20 | 1992-07-28 | Erwin Stuckler | Agent for nail, skin and hair care |
FR2660196A1 (fr) | 1990-03-28 | 1991-10-04 | Courmontagne Albert | Procede de fabrication d'extrait cellulaire hydrosoluble d'embryons d'óoeuf et produit obtenu. |
US5198465A (en) | 1991-06-19 | 1993-03-30 | Dioguardi Francesco S | Compositions based on amino acids for preventing and treating precursor deficiencies in the synthesis of collagen |
WO1993000156A1 (en) | 1991-06-29 | 1993-01-07 | Miyazaki-Ken | Monodisperse single and double emulsions and production thereof |
US5254331A (en) | 1991-09-12 | 1993-10-19 | Chanel, Inc. | Skin cream composition |
TW233264B (ja) | 1992-02-03 | 1994-11-01 | Otsuka Pharma Co Ltd | |
IL101007A (en) | 1992-02-18 | 1997-08-14 | Pharmos Ltd | Dry stable compositions prepared by lyophilization |
DE4328871A1 (de) | 1993-08-27 | 1995-03-02 | Beiersdorf Ag | Mittel gegen empfindliche, hyperreaktive Hautzustände, atopische Dermatiden, Pruritus, Psoriasis Prurigo, Photodermatosen und Ichthyosis |
US5416075A (en) | 1993-11-30 | 1995-05-16 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Biospecific emulsions |
FR2718637A1 (fr) | 1994-04-15 | 1995-10-20 | Oreal | Composition cosmétique à appliquer sur l'ongle. |
DE19509354A1 (de) | 1994-12-08 | 1996-06-13 | Klett Loch Lore M | Kombinationspräparat zur Förderung des Haarwachstums und ggf. des Haut- und Nagelwachstums sowie zur Verhinderung bzw. zur Beseitigung von Haarausfall |
DE19510732C1 (de) | 1995-03-24 | 1996-05-23 | Tscheulin Rothal Gmbh | Verfahren zum Verschließen einer Behälteröffnung, Behälter mit einem Behälterverschluß sowie Deckelmaterial zur Herstellung eines solchen Behälterverschlusses |
US5738051A (en) | 1996-03-06 | 1998-04-14 | Outboard Marine Corporation | Four-cycle marine engine |
TW592713B (en) | 1998-05-11 | 2004-06-21 | Ciba Sc Holding Ag | Use of nanodispersions in cosmetic end formulations |
US7381423B2 (en) | 1998-05-11 | 2008-06-03 | Ciba Specialty Chemicals Corp. | Use of nanodispersions in cosmetic end formulations |
DE19831798A1 (de) | 1998-07-15 | 2000-01-27 | Mandorlo Investment Gmbh Luxem | Mittel zur Pflege und/oder Behandlung von Haut und Gewebe |
CA2346700A1 (en) | 1998-10-09 | 2000-04-20 | Ajinomoto Co., Inc. | Cysteine derivatives |
US6149925A (en) | 1998-11-05 | 2000-11-21 | Color Access, Inc. | Topical compositions for enhancing glutathione production |
AU7789800A (en) | 1999-10-22 | 2001-04-30 | Unilever Plc | Stable multiple emulsion composition |
AU6349501A (en) | 2000-05-31 | 2001-12-11 | Encelle Inc | Method of treating chronic ulcers |
DE10130963A1 (de) | 2001-06-27 | 2003-01-16 | Beiersdorf Ag | Verwendung von Bis-Resorcinyltriazinderivaten zur Verbesserung der Wirksamkeit von lipophilen Wirkstoffen in kosmetischen oder dermatologischen Zubereitungen |
US7740831B2 (en) | 2001-10-09 | 2010-06-22 | Fancl Corporation | Compositions for potentiating glutathione |
FR2832074B1 (fr) | 2001-11-09 | 2004-08-27 | Rhodia Chimie Sa | Emulsions multiples comprenant des particules de dimensions nanometriques de surface modifie a titre d'agents stabilisants |
US6858217B2 (en) | 2002-03-22 | 2005-02-22 | Unilever Home & Personal Care Usa Division Of Conopco, Inc. | Stabilization of terpenoids in cosmetic compositions |
US6863897B2 (en) | 2002-03-22 | 2005-03-08 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Stabilization of resorcinol derivatives in cosmetic compositions |
US6869598B2 (en) | 2002-03-22 | 2005-03-22 | Unilever Home & Personal Care Usa Division Of Conopco, Inc. | Stabilization of sunscreens in cosmetic compositions |
US20030232091A1 (en) | 2002-06-17 | 2003-12-18 | Adi Shefer | Stabilized retinol for cosmetic dermatological, and pharmaceutical compositions, and use thereof |
US6592908B1 (en) | 2002-09-23 | 2003-07-15 | Albert Crum | Nutritional or therapeutic compositions |
EP1680070B1 (en) | 2003-05-07 | 2008-04-23 | The Lubrizol Corporation | Emulsifiers for multiple emulsions |
KR101002433B1 (ko) | 2003-09-19 | 2010-12-17 | 주식회사 엘지생활건강 | 비타민 a 및 그의 유도체, 및 펩타이드를 포함하는 나노에멀젼, 및 이를 포함하는 주름 개선용 화장료 조성물 |
DE10351644A1 (de) | 2003-11-05 | 2005-06-09 | Bayer Technology Services Gmbh | Verfahren zur Herstellung von lagerstabilen multiplen Emulsionen |
JP4099716B2 (ja) | 2004-02-09 | 2008-06-11 | 住友電装株式会社 | 高圧コネクタ |
US20050192229A1 (en) | 2004-02-27 | 2005-09-01 | Perricone Nicholas V. | Topical glutathione treatments |
EP1598060A1 (en) | 2004-05-18 | 2005-11-23 | Nestec S.A. | Oil-in-water emulsion for delivery |
US20050271726A1 (en) | 2004-06-02 | 2005-12-08 | Albert Crum | Immune enhancing compositions and methods of use thereof |
KR100623013B1 (ko) | 2004-09-04 | 2006-09-19 | 김영대 | 나노에멀션, 그의 용도 및 제조방법 |
KR100638602B1 (ko) | 2004-09-16 | 2006-10-26 | 한국콜마 주식회사 | 친유형으로 변형된 폴리프록토스계 고분자 유화제를이용한 수중유중수형 다중에멀젼 상의 화장료 및 그제조방법 |
US7300649B2 (en) | 2005-02-11 | 2007-11-27 | Genepharm, Inc. | Cosmetic and cosmeceutical compositions for restoration of skin barrier function |
US9039273B2 (en) | 2005-03-04 | 2015-05-26 | President And Fellows Of Harvard College | Method and apparatus for forming multiple emulsions |
BRPI0609905B1 (pt) | 2005-04-28 | 2018-04-03 | Ciba Specialty Chemicals Holding Inc. | Uso de derivados de benzotriazol para fotoestabilização e composição cosmética ou dermatológica para melhorar a fotoestabilidade de sistemas absorvedores de UV |
US8241681B2 (en) | 2005-10-14 | 2012-08-14 | Symrise Ag | Synergistic mixtures of bisabolol and ginger extract |
DE602006016328D1 (de) | 2005-11-22 | 2010-09-30 | Nestec Sa | Öl-in-wasser-emulsion und ihre verwendung zur abgabe einer funktionalität |
JP2009523061A (ja) | 2005-11-22 | 2009-06-18 | ネステク ソシエテ アノニム | 容易に分散できる脂質相 |
US8147815B2 (en) | 2005-12-16 | 2012-04-03 | Celmatrix Corporation | Topical administration carrier composition and therapeutic formulations comprising same |
ITMI20060618A1 (it) | 2006-03-31 | 2007-10-01 | Enitecnologie Spa | Procedimento per la preparazione di nanoemulsioni acqua ion olio e olio in acqua |
WO2008082524A1 (en) | 2006-12-19 | 2008-07-10 | National Stem Cell Inc. | Embryonic germ cell secreted product derived topical compositions and methods of use thereof |
US20080311058A1 (en) | 2007-06-18 | 2008-12-18 | Connopco, Inc., D/B/A Unilever | Stable high internal phase emulsions and compositions comprising the same |
ES2398478T5 (es) | 2007-07-09 | 2016-02-25 | Symrise Ag | Sales solubles estables de ácido fenilbencimidazolsulfónico de pH 6,0 a menos de 6,8 |
BRPI0814745A2 (pt) | 2007-08-03 | 2014-10-07 | Aminotech As | Composição de produto. |
US20100322876A1 (en) | 2007-09-14 | 2010-12-23 | L'oreal | Compositions and methods for treating keratinous substrates |
US8236332B2 (en) | 2007-09-28 | 2012-08-07 | Conopco Inc. | Particle stabilised emulsion composition |
FR2924033B1 (fr) | 2007-11-22 | 2013-07-05 | Nat Inov | Procede d'obtention d'une dispersion d'au moins une huile essentielle dans l'eau. |
US9649275B2 (en) | 2007-11-28 | 2017-05-16 | Commonwealth Scientific And Industrial Research Organisation | Nanoemulsions |
CN101214199B (zh) | 2007-12-29 | 2010-06-16 | 广东拉芳日化有限公司 | 纳米活性祛痘化妆品组合物 |
JP2009242321A (ja) | 2008-03-31 | 2009-10-22 | Shiseido Co Ltd | 皮膚外用剤 |
US8425882B2 (en) | 2008-04-01 | 2013-04-23 | Conopco, Inc. | In-shower and bath compositions |
US20090263513A1 (en) | 2008-04-18 | 2009-10-22 | Jan Marini | Cosmetic skin lightening formulation |
DK2337627T3 (da) | 2008-09-18 | 2013-09-08 | Univ Eindhoven Tech | Fremgangsmåde til fremstilling af monodispergerede emulsioner |
NL2002046C (en) | 2008-10-01 | 2010-04-02 | Friesland Brands Bv | Double emulsion and method to produce such. |
CN101401775B (zh) | 2008-11-18 | 2010-08-25 | 董萍 | 被动靶向夜用和日用皮肤美白功效纳米乳及其制备方法 |
US8299127B2 (en) | 2009-03-11 | 2012-10-30 | Conopco, Inc. | Method and composition for evenly applying water soluble actives |
CN101530377B (zh) | 2009-03-11 | 2011-04-20 | 董萍 | 皮肤外用祛斑功效纳米乳组合产品及其制备方法 |
US20100305169A1 (en) | 2009-03-23 | 2010-12-02 | Larry Rich Robinson | Personal-care composition comprising a cationic active |
JP5032533B2 (ja) | 2009-06-09 | 2012-09-26 | 富士通テレコムネットワークス株式会社 | フレーム伝送装置及びフレーム廃棄数測定方法 |
CN102597205B (zh) | 2009-11-06 | 2015-11-25 | 宝洁公司 | 递送颗粒 |
CN101721930B (zh) | 2009-12-15 | 2011-11-30 | 山东大学 | 一种正电纳米乳液的低能制备方法 |
BRPI0905347C1 (pt) | 2009-12-15 | 2021-05-25 | Univ Federal Rio Grande Sul | nanocápsulas poliméricas deformáveis no encapsulamento de bioativos |
CN102150866B (zh) | 2010-02-12 | 2014-10-15 | 悠哈味觉糖有限公司 | 含胱氨酸复合体及其制造方法 |
CN201799243U (zh) | 2010-06-13 | 2011-04-20 | 中国人民解放军第三军医大学 | 一种用一步法和低能乳化法制备纳米乳的搅拌机 |
US8895628B2 (en) | 2010-10-25 | 2014-11-25 | Johnson & Johnson Consumer Companies, Inc. | Compositions comprising a retinoid and an NFkB-inhibitor and their methods of use |
CA2932130C (en) | 2011-01-07 | 2019-07-09 | Allergan, Inc. | Compositions comprising substituted benzaldehydes and use thereof for lightening skin or treating hyperpigmenation and hypermelanosis disorders |
HUE042252T2 (hu) | 2011-03-21 | 2019-06-28 | Broda Tech Co Ltd | Fordítottan hõ-reverzibilis hidrogél kompozíciók |
US8795643B1 (en) | 2011-04-29 | 2014-08-05 | Michael Mark Anthony | Method of preparing a hair treatment formulation comprising nanoparticles in solution and method of hair treatment utilizing a treatment formulation comprising nanoparticles in solution |
US9345773B2 (en) | 2011-06-23 | 2016-05-24 | Indian Institute Of Technology Kanpur | PVA-boronic acid containing copolymer compositions for protein delivery |
US10639252B2 (en) | 2011-09-23 | 2020-05-05 | Allergan, Inc. | Compositions for skin exfoliation and use thereof |
CN104302271A (zh) | 2011-12-20 | 2015-01-21 | 荷兰联合利华有限公司 | 包含氨基肽混合物的保湿组合物 |
CN102755847B (zh) | 2012-07-17 | 2014-08-06 | 山东大学 | 一种油包水型纳米乳液的低能耗制备方法 |
JP6115086B2 (ja) | 2012-11-13 | 2017-04-19 | 味の素株式会社 | アミノ酸化合物の酢酸塩を含有する化粧料組成物 |
WO2014131871A2 (en) | 2013-02-28 | 2014-09-04 | L'oreal | Cosmetic composition in the form of an oil-in-water nanoemulsion for the oxidation dyeing of keratin fibres, and process for the same |
CN105142603B (zh) | 2013-03-08 | 2018-10-19 | 荷兰联合利华有限公司 | 用于皮肤病用途的间苯二酚化合物 |
JP6039484B2 (ja) | 2013-03-29 | 2016-12-07 | 富士フイルム株式会社 | 組成物及び化粧料 |
CN105283173B (zh) | 2013-06-03 | 2018-07-31 | 刘慧文 | 化合物包覆的纳米颗粒和纳米乳剂的制备及其用途 |
US20140375562A1 (en) | 2013-06-21 | 2014-12-25 | Daniel Robert Pereira | System and Process for Human-Computer Interaction Using a Ballistic Projectile as an Input Indicator |
JP6212320B2 (ja) | 2013-08-01 | 2017-10-11 | ポーラ化成工業株式会社 | 皮膚外用剤 |
WO2015066777A1 (en) | 2013-11-08 | 2015-05-14 | L'oreal | Cosmetic compositions in the form of oil-in-water nanoemulsions, comprising solid fatty alcohol(s), liquid fatty ester(s), other oil(s) and non-ionic surfactant(s) |
JP6510177B2 (ja) | 2014-04-01 | 2019-05-08 | ロレアル | ナノ又はマイクロエマルションの形態の組成物 |
JP2016056111A (ja) | 2014-09-05 | 2016-04-21 | ロレアル | ナノエマルションを調製するための方法 |
WO2016085739A1 (en) | 2014-11-24 | 2016-06-02 | President And Fellows Of Harvard College | Systems and methods for encapsulation of actives in compartments or sub-compartments |
WO2016123002A1 (en) | 2015-01-28 | 2016-08-04 | The Procter & Gamble Company | Silicone nanoemulsion comprising c3-c6 alkylene glycol alkyl ether |
KR20160123753A (ko) | 2015-04-17 | 2016-10-26 | (주)제이준코스메틱 | 피부미백용 조성물 |
CN104874305A (zh) | 2015-04-28 | 2015-09-02 | 扬州大学 | 一种o/w纳米乳液及其低能制备方法 |
CN105148758B (zh) | 2015-08-20 | 2017-11-14 | 扬州大学 | 一种快速制备纳米乳液的方法 |
US9872832B2 (en) * | 2015-10-23 | 2018-01-23 | LG Bionano, LLC | Nanoemulsions having reversible continuous and dispersed phases |
CN105919827A (zh) | 2016-06-01 | 2016-09-07 | 北京希诺赛尔健康科技推广有限公司 | 一种具有保湿抗皱作用的护肤组合物 |
CN109199878A (zh) | 2018-09-26 | 2019-01-15 | 华南理工大学 | 一种美白防晒w/o/w多重乳液及其制备方法 |
CN109276515B (zh) | 2018-10-30 | 2021-07-06 | 广州瑾洋化妆品有限公司 | 一种含有生物活性胶原肽的组合物及其制备方法与应用 |
-
2019
- 2019-05-14 CN CN201980034399.6A patent/CN112165927B/zh active Active
- 2019-05-14 US US17/056,583 patent/US11540984B2/en active Active
- 2019-05-14 MX MX2020012410A patent/MX2020012410A/es unknown
- 2019-05-14 WO PCT/EP2019/062300 patent/WO2019224048A1/en active Search and Examination
- 2019-05-14 CA CA3098981A patent/CA3098981A1/en active Pending
- 2019-05-14 JP JP2020557160A patent/JP7497296B2/ja active Active
- 2019-05-14 EA EA202092461A patent/EA202092461A1/ru unknown
- 2019-05-14 EP EP19722920.6A patent/EP3773422B1/en active Active
-
2020
- 2020-10-12 ZA ZA2020/06323A patent/ZA202006323B/en unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011502952A (ja) | 2006-12-01 | 2011-01-27 | アンテリオス, インコーポレイテッド | ペプチドナノ粒子およびその使用 |
WO2018113636A1 (en) | 2016-12-21 | 2018-06-28 | Unilever Plc | Topical skin lightening additive and composition with amino acids and ppar activating fatty acids |
Also Published As
Publication number | Publication date |
---|---|
CA3098981A1 (en) | 2019-11-28 |
EP3773422B1 (en) | 2021-11-10 |
ZA202006323B (en) | 2022-01-26 |
EA202092461A1 (ru) | 2021-02-20 |
JP2021526127A (ja) | 2021-09-30 |
US11540984B2 (en) | 2023-01-03 |
EP3773422A1 (en) | 2021-02-17 |
US20210205186A1 (en) | 2021-07-08 |
CN112165927A (zh) | 2021-01-01 |
CN112165927B (zh) | 2024-01-30 |
WO2019224048A1 (en) | 2019-11-28 |
MX2020012410A (es) | 2022-03-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20190209446A1 (en) | Oil-in-wateroil-in-water type emulsion having excellent stability and cosmetic composition comprising same | |
JP2010527332A (ja) | 界面活性剤不含泡沫処方物 | |
JP2015007115A (ja) | 泡沫状クリームにおけるdms(真皮膜構造) | |
CA2624356A1 (en) | Skincare products | |
JP7194483B2 (ja) | 皮膚組成物ブースターオイル | |
KR20160117111A (ko) | 식물 유래 계면활성제를 포함하는 화장료 조성물 | |
JP7497296B2 (ja) | ナノエマルジョン及びその製造方法 | |
JP7358243B2 (ja) | 色安定化された活性物質を有するナノエマルジョン | |
EP3946221B1 (en) | Multiple emulsion comprising an oil continuous nanoemulsion and a method for using the same | |
CN113056254B (zh) | 不含胭脂虫红的红色着色剂和包含其的组合物 | |
JP2005179320A (ja) | 水中油型乳化組成物 | |
WO2023073590A1 (en) | Compositions suitable for use in skin care | |
CN117695159A (zh) | 高密度超细颗粒组合物的制备方法及化妆品组合物 | |
JP6232285B2 (ja) | 化粧料 | |
JP2023045208A (ja) | 水中油型乳化組成物 | |
JP2024506121A (ja) | 水系乳化物 | |
WO2013148436A2 (en) | Cosmetic composition in the form of an oil-in-water emulsion | |
WO2007099757A1 (ja) | 乳化組成物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A529 | Written submission of copy of amendment under article 34 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A529 Effective date: 20201016 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20220314 |
|
A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20220406 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20230207 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20230501 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20230801 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20230912 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20231206 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20240312 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20240430 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20240529 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 7497296 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |