JP7308034B2 - 最適化二重ヌクレアーゼ融合物および方法 - Google Patents

最適化二重ヌクレアーゼ融合物および方法 Download PDF

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JP7308034B2
JP7308034B2 JP2018569138A JP2018569138A JP7308034B2 JP 7308034 B2 JP7308034 B2 JP 7308034B2 JP 2018569138 A JP2018569138 A JP 2018569138A JP 2018569138 A JP2018569138 A JP 2018569138A JP 7308034 B2 JP7308034 B2 JP 7308034B2
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polypeptide
amino acid
domain
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acid sequence
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JP2019530430A (ja
JP2019530430A5 (enExample
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ジェイムズ アーサー ポサダ，
サンジェイ パテル，
ウェイホン ユー，
クリス ガベル，
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リゾルブ セラピューティクス， エルエルシー
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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JP2018569138A 2016-07-01 2017-06-30 最適化二重ヌクレアーゼ融合物および方法 Active JP7308034B2 (ja)

Priority Applications (3)

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JP2022122570A JP7817106B2 (ja) 2016-07-01 2022-08-01 最適化二重ヌクレアーゼ融合物および方法
JP2023208402A JP2024026334A (ja) 2016-07-01 2023-12-11 最適化二重ヌクレアーゼ融合物および方法
JP2026003402A JP2026063077A (ja) 2016-07-01 2026-01-13 最適化二重ヌクレアーゼ融合物および方法

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US201662357756P 2016-07-01 2016-07-01
US62/357,756 2016-07-01
PCT/US2017/040267 WO2018005954A2 (en) 2016-07-01 2017-06-30 Optimized binuclease fusions and methods

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JP2022122570A Active JP7817106B2 (ja) 2016-07-01 2022-08-01 最適化二重ヌクレアーゼ融合物および方法
JP2023208402A Pending JP2024026334A (ja) 2016-07-01 2023-12-11 最適化二重ヌクレアーゼ融合物および方法
JP2026003402A Pending JP2026063077A (ja) 2016-07-01 2026-01-13 最適化二重ヌクレアーゼ融合物および方法

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JP2023208402A Pending JP2024026334A (ja) 2016-07-01 2023-12-11 最適化二重ヌクレアーゼ融合物および方法
JP2026003402A Pending JP2026063077A (ja) 2016-07-01 2026-01-13 最適化二重ヌクレアーゼ融合物および方法

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EP (2) EP3478830B1 (enExample)
JP (4) JP7308034B2 (enExample)
CN (2) CN109790526A (enExample)
AU (2) AU2017290389B2 (enExample)
CA (1) CA3029627A1 (enExample)
DK (1) DK3478830T3 (enExample)
HR (1) HRP20240603T1 (enExample)
MA (1) MA45554A (enExample)
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HUE041426T2 (hu) 2009-11-02 2019-05-28 Univ Washington Terápiás nukleáz-készítmények és eljárások
CA2834626A1 (en) 2011-04-29 2012-11-01 University Of Washington Therapeutic nuclease compositions and methods
SI3063275T1 (sl) 2013-10-31 2020-02-28 Resolve Therapeutics, Llc Terapevtske fuzije nukleaza-albumin in postopki
MA45554A (fr) 2016-07-01 2019-05-08 Resolve Therapeutics Llc Fusions de binucléase optimisées.
CN111315767B (zh) 2017-08-22 2025-03-18 萨纳生物有限责任公司 可溶性干扰素受体及其用途
CA3124352A1 (en) * 2019-01-04 2020-07-09 Resolve Therapeutics, Llc Treatment of sjogren's disease with nuclease fusion proteins
CA3166299A1 (en) * 2020-01-11 2021-07-15 Paul STABACH Compositions and methods for treating, ameliorating, and/or preventing diseases or disorders caused by or associated with dnase1 and/or dnase1l3 deficiency
CA3181572A1 (en) * 2020-06-08 2021-12-16 Paul STABACH Compositions and methods for treating and/or preventing coagulopathy and/or sepsis in patients suffering from bacterial and/or viral infections
EP4182455A1 (en) * 2020-07-15 2023-05-24 University of Rochester Targeted rna cleavage with dcasl3-rnase fusion proteins
CN112322607B (zh) * 2020-11-20 2023-03-28 江南大学 一种融合型腈水合酶及其应用
EP4294916A2 (en) 2021-02-19 2023-12-27 Theripion, Inc. Dnase fusion polypeptides and related compositions and methods
WO2025147696A1 (en) * 2024-01-05 2025-07-10 Resolve Therapeutics, Llc Treatment of symptoms associated with sars-cov viral infection or a prior sars-cov viral infection with nuclease agents
US12416020B2 (en) 2024-02-20 2025-09-16 Wyvern Pharmaceuticals Inc. Plasmid encoding a TLR3 and Fc fusion protein

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