JP7303126B2 - 抗ｂｃｍａ重鎖のみ抗体 - Google Patents

抗ｂｃｍａ重鎖のみ抗体 Download PDF

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JP7303126B2
JP7303126B2 JP2019570103A JP2019570103A JP7303126B2 JP 7303126 B2 JP7303126 B2 JP 7303126B2 JP 2019570103 A JP2019570103 A JP 2019570103A JP 2019570103 A JP2019570103 A JP 2019570103A JP 7303126 B2 JP7303126 B2 JP 7303126B2
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antibody
heavy chain
seq
bcma
sequence
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JP2020524506A5 (enExample
JP2020524506A (ja
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ネイサン トリンクライン，
シェリー フォース オルドレッド，
キャサリン ハリス，
ショーテン， ウィム ヴァン
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テネオバイオ， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2019570103A 2017-06-20 2018-06-20 抗ｂｃｍａ重鎖のみ抗体 Active JP7303126B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022141179A JP2022174169A (ja) 2017-06-20 2022-09-06 抗ｂｃｍａ重鎖のみ抗体
JP2024107254A JP2024127941A (ja) 2017-06-20 2024-07-03 抗ｂｃｍａ重鎖のみ抗体

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762522355P 2017-06-20 2017-06-20
US62/522,355 2017-06-20
PCT/US2018/038549 WO2018237037A2 (en) 2017-06-20 2018-06-20 Anti-bcma heavy chain-only antibodies

Related Child Applications (1)

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JP2022141179A Division JP2022174169A (ja) 2017-06-20 2022-09-06 抗ｂｃｍａ重鎖のみ抗体

Publications (3)

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JP2020524506A JP2020524506A (ja) 2020-08-20
JP2020524506A5 JP2020524506A5 (enExample) 2021-07-29
JP7303126B2 true JP7303126B2 (ja) 2023-07-04

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JP2019570103A Active JP7303126B2 (ja) 2017-06-20 2018-06-20 抗ｂｃｍａ重鎖のみ抗体
JP2022141179A Withdrawn JP2022174169A (ja) 2017-06-20 2022-09-06 抗ｂｃｍａ重鎖のみ抗体
JP2024107254A Pending JP2024127941A (ja) 2017-06-20 2024-07-03 抗ｂｃｍａ重鎖のみ抗体

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JP2022141179A Withdrawn JP2022174169A (ja) 2017-06-20 2022-09-06 抗ｂｃｍａ重鎖のみ抗体
JP2024107254A Pending JP2024127941A (ja) 2017-06-20 2024-07-03 抗ｂｃｍａ重鎖のみ抗体

Country Status (13)

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US (2) US11970540B2 (enExample)
EP (1) EP3642237A2 (enExample)
JP (3) JP7303126B2 (enExample)
KR (2) KR102742528B1 (enExample)
CN (2) CN117866097A (enExample)
AU (1) AU2018289515B2 (enExample)
BR (1) BR112019026907A2 (enExample)
CA (1) CA3067584A1 (enExample)
IL (2) IL312322A (enExample)
MX (1) MX2024001394A (enExample)
SG (1) SG11201912774RA (enExample)
WO (1) WO2018237037A2 (enExample)
ZA (2) ZA201908214B (enExample)

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EP3559035A1 (en) 2016-12-21 2019-10-30 TeneoBio, Inc. Anti-bcma heavy chain-only antibodies
CA3067584A1 (en) 2017-06-20 2018-12-27 Teneobio, Inc. Anti-bcma heavy chain-only antibodies
CN118146370A (zh) 2017-06-20 2024-06-07 特纳奥尼股份有限公司 仅有重链的抗bcma抗体
CN111094345B (zh) * 2017-06-30 2023-10-27 美国卫生和人力服务部 具有人结构域的抗b细胞成熟抗原嵌合抗原受体
WO2019126756A1 (en) 2017-12-22 2019-06-27 Teneobio, Inc. Heavy chain antibodies binding to cd22
EP3802611A2 (en) 2018-06-01 2021-04-14 Novartis AG Binding molecules against bcma and uses thereof
TWI838389B (zh) 2018-07-19 2024-04-11 美商再生元醫藥公司 雙特異性抗-BCMAｘ抗-CD3抗體及其用途
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CN116769032A (zh) 2018-07-20 2023-09-19 坦尼奥第二公司 与cd19结合的重链抗体
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PH12021553145A1 (en) 2019-06-14 2022-07-25 Teneobio Inc Multispecific heavy chain antibodies binding to cd22 and cd3
AU2021237570A1 (en) 2020-03-16 2022-09-08 Angeles Therapeutics, Inc. Novel antigen binding domains and synthetic antigen receptors incorporating the same
KR20250007022A (ko) 2020-04-29 2025-01-13 테네오원, 인코포레이티드 변형된 중쇄 불변 영역을 갖는 다중특이적 중쇄 항체
CA3214992A1 (en) 2020-04-29 2021-11-04 Teneobio, Inc. Multispecific heavy chain antibodies with modified heavy chain constant regions
PE20230464A1 (es) * 2020-06-30 2023-03-14 Teneobio Inc Union de anticuerpos multiespecificos a bcma
JP2023539453A (ja) * 2020-08-20 2023-09-14 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド Ｂｃｍａと結合する単一可変ドメイン及び抗原結合分子
CA3214012A1 (en) * 2021-04-15 2022-10-20 Bing Zhang Multi-specific antibody targeting bcma
CN119552243B (zh) * 2025-01-24 2025-04-15 安徽农业大学 一种高稳定性prssv-gp5纳米抗体及其制备方法和应用

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