JP7219218B2 - 新規のベンジルアミノ置換キナゾリンおよびｓｏｓ１阻害剤としての誘導体 - Google Patents

新規のベンジルアミノ置換キナゾリンおよびｓｏｓ１阻害剤としての誘導体 Download PDF

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JP7219218B2
JP7219218B2 JP2019534303A JP2019534303A JP7219218B2 JP 7219218 B2 JP7219218 B2 JP 7219218B2 JP 2019534303 A JP2019534303 A JP 2019534303A JP 2019534303 A JP2019534303 A JP 2019534303A JP 7219218 B2 JP7219218 B2 JP 7219218B2
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JP2020504742A (ja
JP2020504742A5 (enExample
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ミヒャエル グマッシュ
ミヒャエル サンダーソン
ディルク ケスラー
クリスティアーネ コフィンク
マシュー ラッセル ネザートン
ユルゲン ラムハーター
トビアス ヴンベルク
マルコ ホフマン
ファビオ サバリース
アンケ バウム
ドロテーア ルドルフ
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ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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JP2019534303A 2016-12-22 2017-12-21 新規のベンジルアミノ置換キナゾリンおよびｓｏｓ１阻害剤としての誘導体 Active JP7219218B2 (ja)

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EP16206422.4 2016-12-22
EP16206422 2016-12-22
PCT/EP2017/084265 WO2018115380A1 (en) 2016-12-22 2017-12-21 Novel benzylamino substituted quinazolines and derivatives as sos1 inhibitors

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JP2020504742A JP2020504742A (ja) 2020-02-13
JP2020504742A5 JP2020504742A5 (enExample) 2021-02-04
JP7219218B2 true JP7219218B2 (ja) 2023-02-07

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US (2) US10898487B2 (enExample)
EP (2) EP3558979B1 (enExample)
JP (1) JP7219218B2 (enExample)
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WO (1) WO2018115380A1 (enExample)

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CN109843856B (zh) 2016-05-18 2023-05-02 米拉蒂治疗股份有限公司 Kras g12c抑制剂
US10898487B2 (en) 2016-12-22 2021-01-26 Boehringer Ingelheim International Gmbh Benzylamino substituted quinazolines and derivatives as SOS1 inhibitors
US11104955B2 (en) * 2016-12-30 2021-08-31 Children's Medical Center Corporation MAP2K1 (MEK1) as a therapeutic target for arteriovenous malformations and associated disorders
US20220235013A1 (en) * 2017-03-21 2022-07-28 Bayer Pharma Aktiengesellschaft 2-methyl-quinazolines
KR102861303B1 (ko) 2017-11-15 2025-09-17 미라티 테라퓨틱스, 인크. Ｋｒａｓ ｇ12ｃ 억제제
US10647715B2 (en) 2017-11-15 2020-05-12 Mirati Therapeutics, Inc. KRas G12C inhibitors
ES2944306T3 (es) 2017-12-21 2023-06-20 Boehringer Ingelheim Int Piridopirimidinonas sustituidas por bencilamino y derivados como inhibidores de SOS1
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