JP7134628B2 - 癌治療のためのｆｇｆｒ／ｐｄ－１併用療法 - Google Patents

癌治療のためのｆｇｆｒ／ｐｄ－１併用療法 Download PDF

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JP7134628B2
JP7134628B2 JP2017551655A JP2017551655A JP7134628B2 JP 7134628 B2 JP7134628 B2 JP 7134628B2 JP 2017551655 A JP2017551655 A JP 2017551655A JP 2017551655 A JP2017551655 A JP 2017551655A JP 7134628 B2 JP7134628 B2 JP 7134628B2
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pharmaceutical composition
antibody
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JP2018511611A (ja
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マシュー、ブイ．ロレンツィ
スーゾ、イエス、プラテロ
ラルカ、ベローナ
ジャヤプラカッシュ、カーケラ
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Astex Therapeutics Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q2600/00—Oligonucleotides characterized by their use
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Animal Behavior & Ethology (AREA)
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  • Cell Biology (AREA)
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  • Biophysics (AREA)
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  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
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  • Hospice & Palliative Care (AREA)
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  • Mycology (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
JP2017551655A 2015-04-03 2016-04-01 癌治療のためのｆｇｆｒ／ｐｄ－１併用療法 Active JP7134628B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562142569P 2015-04-03 2015-04-03
US62/142,569 2015-04-03
US15/079,136 US10478494B2 (en) 2015-04-03 2016-03-24 FGFR/PD-1 combination therapy for the treatment of cancer
US15/079,136 2016-03-24
PCT/US2016/025482 WO2016161239A1 (en) 2015-04-03 2016-04-01 Fgfr/pd-1 combination therapy for the treatment of cancer

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JP2018511611A JP2018511611A (ja) 2018-04-26
JP2018511611A5 JP2018511611A5 (cg-RX-API-DMAC7.html) 2019-05-16
JP7134628B2 true JP7134628B2 (ja) 2022-09-12

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US (3) US10478494B2 (cg-RX-API-DMAC7.html)
EP (1) EP3277319A1 (cg-RX-API-DMAC7.html)
JP (1) JP7134628B2 (cg-RX-API-DMAC7.html)
KR (1) KR102722130B1 (cg-RX-API-DMAC7.html)
CN (1) CN107889462A (cg-RX-API-DMAC7.html)
AU (3) AU2016243917A1 (cg-RX-API-DMAC7.html)
BR (1) BR112017020973A2 (cg-RX-API-DMAC7.html)
CA (1) CA2981603A1 (cg-RX-API-DMAC7.html)
CL (1) CL2017002481A1 (cg-RX-API-DMAC7.html)
CO (1) CO2017011197A2 (cg-RX-API-DMAC7.html)
CR (1) CR20170477A (cg-RX-API-DMAC7.html)
EA (1) EA201792191A1 (cg-RX-API-DMAC7.html)
EC (1) ECSP17072756A (cg-RX-API-DMAC7.html)
IL (1) IL254673B2 (cg-RX-API-DMAC7.html)
MA (1) MA41858A (cg-RX-API-DMAC7.html)
MX (1) MX2017012552A (cg-RX-API-DMAC7.html)
MY (2) MY205639A (cg-RX-API-DMAC7.html)
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PH (1) PH12017501818A1 (cg-RX-API-DMAC7.html)
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KR20250115414A (ko) * 2022-12-07 2025-07-30 이뮨원코 바이오파마슈티컬즈 (상하이) 인크. 항-cd24 항체 및 pd-1-pd-l1 경로 차단 항체를 사용한 암 조합 치료법
WO2025046898A1 (ja) * 2023-08-31 2025-03-06 大鵬薬品工業株式会社 ３，５－二置換ベンゼンアルキニル化合物と免疫チェックポイント阻害薬を含む癌治療法

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