JP7031002B2 - ピリジノイミダゾール系化合物の結晶型、塩型及びその製造方法 - Google Patents
ピリジノイミダゾール系化合物の結晶型、塩型及びその製造方法 Download PDFInfo
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- JP7031002B2 JP7031002B2 JP2020544744A JP2020544744A JP7031002B2 JP 7031002 B2 JP7031002 B2 JP 7031002B2 JP 2020544744 A JP2020544744 A JP 2020544744A JP 2020544744 A JP2020544744 A JP 2020544744A JP 7031002 B2 JP7031002 B2 JP 7031002B2
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- JCHDJLSIYWBAHI-ZWHBIUKWSA-N OC([C@@H](C1CCC2CC1)[C@H]2Nc1nc(-c(c2c3)n[nH]c2ncc3F)nc(C2CC2)c1F)=O Chemical compound OC([C@@H](C1CCC2CC1)[C@H]2Nc1nc(-c(c2c3)n[nH]c2ncc3F)nc(C2CC2)c1F)=O JCHDJLSIYWBAHI-ZWHBIUKWSA-N 0.000 description 5
- JCHDJLSIYWBAHI-ZWHBIUKWSA-M [O-]C([C@@H](C1CCC2CC1)[C@H]2Nc1nc(-c(c2c3)n[nH]c2ncc3F)nc(C2CC2)c1F)=O Chemical compound [O-]C([C@@H](C1CCC2CC1)[C@H]2Nc1nc(-c(c2c3)n[nH]c2ncc3F)nc(C2CC2)c1F)=O JCHDJLSIYWBAHI-ZWHBIUKWSA-M 0.000 description 4
- 0 CCOC([C@](C1CCC2CC1)[C@]2Nc1nc(-c(c2c3)n[n](*)c2ncc3F)nc(C2CC2)c1F)=O Chemical compound CCOC([C@](C1CCC2CC1)[C@]2Nc1nc(-c(c2c3)n[n](*)c2ncc3F)nc(C2CC2)c1F)=O 0.000 description 2
- LWUKBLLDUOGHON-XCLBFWBUSA-N CCOC([C@@H](C1CCC2CC1)[C@H]2Nc1nc(-c(c2c3)n[nH]c2ncc3F)nc(C2CC2)c1F)=O Chemical compound CCOC([C@@H](C1CCC2CC1)[C@H]2Nc1nc(-c(c2c3)n[nH]c2ncc3F)nc(C2CC2)c1F)=O LWUKBLLDUOGHON-XCLBFWBUSA-N 0.000 description 1
- VWLHFPYDMKSVGD-UHFFFAOYSA-N Cc1nc(C)ncc1F Chemical compound Cc1nc(C)ncc1F VWLHFPYDMKSVGD-UHFFFAOYSA-N 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
- C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810180641.8 | 2018-03-05 | ||
| CN201810180641 | 2018-03-05 | ||
| PCT/CN2019/076916 WO2019170067A1 (zh) | 2018-03-05 | 2019-03-05 | 一种吡啶并咪唑类化合物的晶型、盐型及其制备方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021514967A JP2021514967A (ja) | 2021-06-17 |
| JP2021514967A5 JP2021514967A5 (enExample) | 2021-07-29 |
| JP7031002B2 true JP7031002B2 (ja) | 2022-03-07 |
Family
ID=67846865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020544744A Active JP7031002B2 (ja) | 2018-03-05 | 2019-03-05 | ピリジノイミダゾール系化合物の結晶型、塩型及びその製造方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11535613B2 (enExample) |
| EP (1) | EP3763713A4 (enExample) |
| JP (1) | JP7031002B2 (enExample) |
| KR (1) | KR102484804B1 (enExample) |
| CN (1) | CN111819177B (enExample) |
| AU (1) | AU2019230497B2 (enExample) |
| CA (1) | CA3092315C (enExample) |
| NZ (1) | NZ767352A (enExample) |
| RU (1) | RU2769050C1 (enExample) |
| TW (1) | TWI794433B (enExample) |
| WO (1) | WO2019170067A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX394277B (es) * | 2016-09-05 | 2025-03-24 | Guangdong Raynovent Biotech Co Ltd | Derivados de pirimidina contra virus de la influenza |
| CN114127068B (zh) * | 2019-07-22 | 2024-05-28 | 广东众生睿创生物科技有限公司 | 嘧啶衍生物的优势盐型及其晶型 |
| CN114502150B (zh) * | 2019-09-10 | 2023-03-24 | 广东众生睿创生物科技有限公司 | 一种用于治疗病毒性感冒的药物组合物及其制剂 |
| CN113116899B (zh) * | 2020-03-06 | 2022-12-20 | 广东众生睿创生物科技有限公司 | 一种用于治疗流感的药物组合物及含有该药物组合物的制剂 |
| WO2022089261A1 (zh) * | 2020-10-29 | 2022-05-05 | 广东众生睿创生物科技有限公司 | 一种嘧啶衍生物的晶型及其制备方法 |
| EP4286386A4 (en) * | 2021-02-03 | 2025-03-12 | Ocumension Therapeutics (Suzhou) Co., Ltd. | Salt form and crystal form of a pyrazole-substituted imidazo[1,2-a]quinoxaline derivative |
| JP2024509939A (ja) * | 2021-03-11 | 2024-03-05 | シャンハイ ジェミンケア ファーマシューティカル カンパニー，リミティド | ピリジン窒素酸化物の結晶形態およびその使用 |
| WO2025237212A1 (zh) * | 2024-05-11 | 2025-11-20 | 广东众生睿创生物科技有限公司 | 一种嘧啶衍生物葡甲胺盐及其晶型 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012530713A (ja) | 2009-06-17 | 2012-12-06 | バーテックス ファーマシューティカルズ インコーポレイテッド | インフルエンザウイルス複製の阻害剤 |
| JP2013545816A (ja) | 2010-12-16 | 2013-12-26 | バーテックス ファーマシューティカルズ インコーポレイテッド | インフルエンザウイルス複製阻害物質 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX341342B (es) * | 2011-01-14 | 2016-08-17 | Vertex Pharma | Formas solidas del inhibidor de girasa (r)-1-etil-3-[6-fluoro-5-[2 -(1-hidroxi-1-metil-etil) pirimidin-5-il]-7-(tetrahidrofuran-2-il) -1h-benzimidazol-2-il]urea. |
| EA201790266A1 (ru) | 2014-08-08 | 2017-06-30 | Янссен Сайенсиз Айрлэнд Юси | Индолы для применения при инфекции, вызванной вирусом гриппа |
| EP3362451B1 (en) | 2015-12-09 | 2023-04-12 | Sunshine Lake Pharma Co., Ltd. | Inhibitors of influenza virus replication, application methods and uses thereof |
| WO2017133670A1 (en) | 2016-02-05 | 2017-08-10 | Savira Pharmaceuticals Gmbh | Pyridine and pyrimidine derivatives and their use in treatment, amelioration or prevention of influenza |
| WO2017133667A1 (en) * | 2016-02-05 | 2017-08-10 | Savira Pharmaceuticals Gmbh | Pyrimidine and pyridine derivatives and use in treatment, amelioration or prevention of influenza thereof |
| JP7129339B2 (ja) * | 2016-03-07 | 2022-09-01 | ハイテック パワー，インコーポレーテッド | 内燃エンジン用第２燃料を発生させかつ分配する方法 |
| MX394277B (es) * | 2016-09-05 | 2025-03-24 | Guangdong Raynovent Biotech Co Ltd | Derivados de pirimidina contra virus de la influenza |
-
2019
- 2019-03-05 NZ NZ767352A patent/NZ767352A/en unknown
- 2019-03-05 JP JP2020544744A patent/JP7031002B2/ja active Active
- 2019-03-05 CN CN201980013553.1A patent/CN111819177B/zh active Active
- 2019-03-05 WO PCT/CN2019/076916 patent/WO2019170067A1/zh not_active Ceased
- 2019-03-05 US US16/975,600 patent/US11535613B2/en active Active
- 2019-03-05 TW TW108107240A patent/TWI794433B/zh active
- 2019-03-05 RU RU2020131044A patent/RU2769050C1/ru active
- 2019-03-05 KR KR1020207027160A patent/KR102484804B1/ko active Active
- 2019-03-05 AU AU2019230497A patent/AU2019230497B2/en active Active
- 2019-03-05 EP EP19763994.1A patent/EP3763713A4/en active Pending
- 2019-03-05 CA CA3092315A patent/CA3092315C/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012530713A (ja) | 2009-06-17 | 2012-12-06 | バーテックス ファーマシューティカルズ インコーポレイテッド | インフルエンザウイルス複製の阻害剤 |
| JP2013545816A (ja) | 2010-12-16 | 2013-12-26 | バーテックス ファーマシューティカルズ インコーポレイテッド | インフルエンザウイルス複製阻害物質 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2019230497A1 (en) | 2020-09-17 |
| EP3763713A1 (en) | 2021-01-13 |
| KR102484804B1 (ko) | 2023-01-04 |
| TWI794433B (zh) | 2023-03-01 |
| US11535613B2 (en) | 2022-12-27 |
| CN111819177B (zh) | 2022-03-04 |
| NZ767352A (en) | 2023-05-26 |
| WO2019170067A1 (zh) | 2019-09-12 |
| CA3092315A1 (en) | 2019-09-12 |
| CN111819177A (zh) | 2020-10-23 |
| EP3763713A4 (en) | 2021-11-24 |
| RU2769050C1 (ru) | 2022-03-28 |
| KR20200124710A (ko) | 2020-11-03 |
| AU2019230497B2 (en) | 2021-08-05 |
| CA3092315C (en) | 2023-08-29 |
| TW201938558A (zh) | 2019-10-01 |
| JP2021514967A (ja) | 2021-06-17 |
| US20200407354A1 (en) | 2020-12-31 |
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