TWI794433B - 吡啶并吡唑類化合物的晶型、鹽型及其製備方法 - Google Patents

吡啶并吡唑類化合物的晶型、鹽型及其製備方法 Download PDF

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TWI794433B
TWI794433B TW108107240A TW108107240A TWI794433B TW I794433 B TWI794433 B TW I794433B TW 108107240 A TW108107240 A TW 108107240A TW 108107240 A TW108107240 A TW 108107240A TW I794433 B TWI794433 B TW I794433B
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compound
crystal form
chemical formula
spectrum
formula
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TW108107240A
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TW201938558A (zh
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熊劍
王晶晶
新海 陳
謝程
李鵬
健 黎
曙輝 陳
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大陸商廣東衆生睿創生物科技有限公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
TW108107240A 2018-03-05 2019-03-05 吡啶并吡唑類化合物的晶型、鹽型及其製備方法 TWI794433B (zh)

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CN201810180641.8 2018-03-05
??201810180641.8 2018-03-05
CN201810180641 2018-03-05

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TW201938558A TW201938558A (zh) 2019-10-01
TWI794433B true TWI794433B (zh) 2023-03-01

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US (1) US11535613B2 (enExample)
EP (1) EP3763713A4 (enExample)
JP (1) JP7031002B2 (enExample)
KR (1) KR102484804B1 (enExample)
CN (1) CN111819177B (enExample)
AU (1) AU2019230497B2 (enExample)
CA (1) CA3092315C (enExample)
NZ (1) NZ767352A (enExample)
RU (1) RU2769050C1 (enExample)
TW (1) TWI794433B (enExample)
WO (1) WO2019170067A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX394277B (es) * 2016-09-05 2025-03-24 Guangdong Raynovent Biotech Co Ltd Derivados de pirimidina contra virus de la influenza
CN114127068B (zh) * 2019-07-22 2024-05-28 广东众生睿创生物科技有限公司 嘧啶衍生物的优势盐型及其晶型
CN114502150B (zh) * 2019-09-10 2023-03-24 广东众生睿创生物科技有限公司 一种用于治疗病毒性感冒的药物组合物及其制剂
CN113116899B (zh) * 2020-03-06 2022-12-20 广东众生睿创生物科技有限公司 一种用于治疗流感的药物组合物及含有该药物组合物的制剂
WO2022089261A1 (zh) * 2020-10-29 2022-05-05 广东众生睿创生物科技有限公司 一种嘧啶衍生物的晶型及其制备方法
EP4286386A4 (en) * 2021-02-03 2025-03-12 Ocumension Therapeutics (Suzhou) Co., Ltd. Salt form and crystal form of a pyrazole-substituted imidazo[1,2-a]quinoxaline derivative
JP2024509939A (ja) * 2021-03-11 2024-03-05 シャンハイ ジェミンケア ファーマシューティカル カンパニー，リミティド ピリジン窒素酸化物の結晶形態およびその使用
WO2025237212A1 (zh) * 2024-05-11 2025-11-20 广东众生睿创生物科技有限公司 一种嘧啶衍生物葡甲胺盐及其晶型

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103492381A (zh) * 2010-12-16 2014-01-01 沃泰克斯药物股份有限公司 流感病毒复制的抑制剂
TWI535714B (zh) * 2011-01-14 2016-06-01 維泰克斯製藥公司 旋轉酶抑制劑（ｒ）－１－乙基－３－［６－氟－５－［２－（１－羥基－１－甲基－乙基）嘧啶－５－基］－７－（四氫呋喃－２－基）－１ｈ－苯并咪唑－２－基］脲之固體形式
CN106573920A (zh) * 2014-08-08 2017-04-19 爱尔兰詹森科学公司 用于在流感病毒感染中使用的吲哚
WO2018041263A1 (zh) * 2016-09-05 2018-03-08 广东众生药业股份有限公司 抗流感病毒嘧啶衍生物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GEP20207129B (en) * 2009-06-17 2020-07-10 Vertex Pharma Inhibitors of influenza viruses replication
EP3362451B1 (en) 2015-12-09 2023-04-12 Sunshine Lake Pharma Co., Ltd. Inhibitors of influenza virus replication, application methods and uses thereof
WO2017133670A1 (en) 2016-02-05 2017-08-10 Savira Pharmaceuticals Gmbh Pyridine and pyrimidine derivatives and their use in treatment, amelioration or prevention of influenza
WO2017133667A1 (en) * 2016-02-05 2017-08-10 Savira Pharmaceuticals Gmbh Pyrimidine and pyridine derivatives and use in treatment, amelioration or prevention of influenza thereof
JP7129339B2 (ja) * 2016-03-07 2022-09-01 ハイテック パワー，インコーポレーテッド 内燃エンジン用第２燃料を発生させかつ分配する方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103492381A (zh) * 2010-12-16 2014-01-01 沃泰克斯药物股份有限公司 流感病毒复制的抑制剂
TWI535714B (zh) * 2011-01-14 2016-06-01 維泰克斯製藥公司 旋轉酶抑制劑（ｒ）－１－乙基－３－［６－氟－５－［２－（１－羥基－１－甲基－乙基）嘧啶－５－基］－７－（四氫呋喃－２－基）－１ｈ－苯并咪唑－２－基］脲之固體形式
CN106573920A (zh) * 2014-08-08 2017-04-19 爱尔兰詹森科学公司 用于在流感病毒感染中使用的吲哚
WO2018041263A1 (zh) * 2016-09-05 2018-03-08 广东众生药业股份有限公司 抗流感病毒嘧啶衍生物

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Publication number Publication date
AU2019230497A1 (en) 2020-09-17
EP3763713A1 (en) 2021-01-13
KR102484804B1 (ko) 2023-01-04
JP7031002B2 (ja) 2022-03-07
US11535613B2 (en) 2022-12-27
CN111819177B (zh) 2022-03-04
NZ767352A (en) 2023-05-26
WO2019170067A1 (zh) 2019-09-12
CA3092315A1 (en) 2019-09-12
CN111819177A (zh) 2020-10-23
EP3763713A4 (en) 2021-11-24
RU2769050C1 (ru) 2022-03-28
KR20200124710A (ko) 2020-11-03
AU2019230497B2 (en) 2021-08-05
CA3092315C (en) 2023-08-29
TW201938558A (zh) 2019-10-01
JP2021514967A (ja) 2021-06-17
US20200407354A1 (en) 2020-12-31

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