AU2019230497B2 - Crystal form and salt form of pyridoimidazole compound and preparation method therefor - Google Patents

Crystal form and salt form of pyridoimidazole compound and preparation method therefor Download PDF

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Publication number
AU2019230497B2
AU2019230497B2 AU2019230497A AU2019230497A AU2019230497B2 AU 2019230497 B2 AU2019230497 B2 AU 2019230497B2 AU 2019230497 A AU2019230497 A AU 2019230497A AU 2019230497 A AU2019230497 A AU 2019230497A AU 2019230497 B2 AU2019230497 B2 AU 2019230497B2
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AU
Australia
Prior art keywords
compound
crystal form
formula
pattern
xrpd
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AU2019230497A
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AU2019230497A1 (en
Inventor
Kevin X Chen
Shuhui Chen
Xiaoxin Chen
Jian Li
Peng Li
Chengwu Liu
Zhuowei LIU
Chaofeng LONG
Jingjing Wang
Cheng Xie
Jian Xiong
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Guangdong Raynovent Biotech Co Ltd
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Guangdong Raynovent Biotech Co Ltd
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Publication of AU2019230497A1 publication Critical patent/AU2019230497A1/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2019230497A 2018-03-05 2019-03-05 Crystal form and salt form of pyridoimidazole compound and preparation method therefor Active AU2019230497B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201810180641.8 2018-03-05
CN201810180641 2018-03-05
PCT/CN2019/076916 WO2019170067A1 (zh) 2018-03-05 2019-03-05 一种吡啶并咪唑类化合物的晶型、盐型及其制备方法

Publications (2)

Publication Number Publication Date
AU2019230497A1 AU2019230497A1 (en) 2020-09-17
AU2019230497B2 true AU2019230497B2 (en) 2021-08-05

Family

ID=67846865

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2019230497A Active AU2019230497B2 (en) 2018-03-05 2019-03-05 Crystal form and salt form of pyridoimidazole compound and preparation method therefor

Country Status (11)

Country Link
US (1) US11535613B2 (enExample)
EP (1) EP3763713A4 (enExample)
JP (1) JP7031002B2 (enExample)
KR (1) KR102484804B1 (enExample)
CN (1) CN111819177B (enExample)
AU (1) AU2019230497B2 (enExample)
CA (1) CA3092315C (enExample)
NZ (1) NZ767352A (enExample)
RU (1) RU2769050C1 (enExample)
TW (1) TWI794433B (enExample)
WO (1) WO2019170067A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX394277B (es) * 2016-09-05 2025-03-24 Guangdong Raynovent Biotech Co Ltd Derivados de pirimidina contra virus de la influenza
CN114127068B (zh) * 2019-07-22 2024-05-28 广东众生睿创生物科技有限公司 嘧啶衍生物的优势盐型及其晶型
CN114502150B (zh) * 2019-09-10 2023-03-24 广东众生睿创生物科技有限公司 一种用于治疗病毒性感冒的药物组合物及其制剂
CN113116899B (zh) * 2020-03-06 2022-12-20 广东众生睿创生物科技有限公司 一种用于治疗流感的药物组合物及含有该药物组合物的制剂
WO2022089261A1 (zh) * 2020-10-29 2022-05-05 广东众生睿创生物科技有限公司 一种嘧啶衍生物的晶型及其制备方法
EP4286386A4 (en) * 2021-02-03 2025-03-12 Ocumension Therapeutics (Suzhou) Co., Ltd. Salt form and crystal form of a pyrazole-substituted imidazo[1,2-a]quinoxaline derivative
JP2024509939A (ja) * 2021-03-11 2024-03-05 シャンハイ ジェミンケア ファーマシューティカル カンパニー，リミティド ピリジン窒素酸化物の結晶形態およびその使用
WO2025237212A1 (zh) * 2024-05-11 2025-11-20 广东众生睿创生物科技有限公司 一种嘧啶衍生物葡甲胺盐及其晶型

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GEP20207129B (en) * 2009-06-17 2020-07-10 Vertex Pharma Inhibitors of influenza viruses replication
RU2013132681A (ru) * 2010-12-16 2015-01-27 Вертекс Фармасьютикалз Инкорпорейтед Ингибиторы репликации вирусов гриппа
MX341342B (es) * 2011-01-14 2016-08-17 Vertex Pharma Formas solidas del inhibidor de girasa (r)-1-etil-3-[6-fluoro-5-[2 -(1-hidroxi-1-metil-etil) pirimidin-5-il]-7-(tetrahidrofuran-2-il) -1h-benzimidazol-2-il]urea.
EA201790266A1 (ru) 2014-08-08 2017-06-30 Янссен Сайенсиз Айрлэнд Юси Индолы для применения при инфекции, вызванной вирусом гриппа
EP3362451B1 (en) 2015-12-09 2023-04-12 Sunshine Lake Pharma Co., Ltd. Inhibitors of influenza virus replication, application methods and uses thereof
WO2017133670A1 (en) 2016-02-05 2017-08-10 Savira Pharmaceuticals Gmbh Pyridine and pyrimidine derivatives and their use in treatment, amelioration or prevention of influenza
WO2017133667A1 (en) * 2016-02-05 2017-08-10 Savira Pharmaceuticals Gmbh Pyrimidine and pyridine derivatives and use in treatment, amelioration or prevention of influenza thereof
JP7129339B2 (ja) * 2016-03-07 2022-09-01 ハイテック パワー，インコーポレーテッド 内燃エンジン用第２燃料を発生させかつ分配する方法
MX394277B (es) * 2016-09-05 2025-03-24 Guangdong Raynovent Biotech Co Ltd Derivados de pirimidina contra virus de la influenza

Also Published As

Publication number Publication date
AU2019230497A1 (en) 2020-09-17
EP3763713A1 (en) 2021-01-13
KR102484804B1 (ko) 2023-01-04
JP7031002B2 (ja) 2022-03-07
TWI794433B (zh) 2023-03-01
US11535613B2 (en) 2022-12-27
CN111819177B (zh) 2022-03-04
NZ767352A (en) 2023-05-26
WO2019170067A1 (zh) 2019-09-12
CA3092315A1 (en) 2019-09-12
CN111819177A (zh) 2020-10-23
EP3763713A4 (en) 2021-11-24
RU2769050C1 (ru) 2022-03-28
KR20200124710A (ko) 2020-11-03
CA3092315C (en) 2023-08-29
TW201938558A (zh) 2019-10-01
JP2021514967A (ja) 2021-06-17
US20200407354A1 (en) 2020-12-31

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Legal Events

Date Code Title Description
DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE INVENTOR TO READ XIONG, JIAN; CHEN, XIAOXIN; WANG, JINGJING; LIU, ZHUOWEI; CHEN, KEVIN; LIU, CHENGWU; XIE, CHENG; LONG, CHAOFENG; LI, PENG; LI, JIAN AND CHEN, SHUHUI

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE INVENTOR TO READ XIONG, JIAN; CHEN, XIAOXIN; WANG, JINGJING; LIU, ZHUOWEI; CHEN, KEVIN X; LIU, CHENGWU; XIE, CHENG; LONG, CHAOFENG; LI, PENG; LI, JIAN AND CHEN, SHUHUI

FGA Letters patent sealed or granted (standard patent)