JP7030704B2 - 二重特異性シグナル伝達物質およびその使用 - Google Patents

二重特異性シグナル伝達物質およびその使用 Download PDF

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JP7030704B2
JP7030704B2 JP2018541357A JP2018541357A JP7030704B2 JP 7030704 B2 JP7030704 B2 JP 7030704B2 JP 2018541357 A JP2018541357 A JP 2018541357A JP 2018541357 A JP2018541357 A JP 2018541357A JP 7030704 B2 JP7030704 B2 JP 7030704B2
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JP2019506869A (ja
JP2019506869A5 (https=
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クレイ，ニコライ
タベルニエル，ジャン
リント，サンドラ ヴァン
カウウェルズ，アンジェ
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オリオニス バイオサイエンシズ ビーブイ
ブイアイビー ブイゼットダブリュー
ユニバーシテイト ヘント
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2815—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD8
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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JP2018541357A 2016-02-05 2017-02-06 二重特異性シグナル伝達物質およびその使用 Active JP7030704B2 (ja)

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US201662291776P 2016-02-05 2016-02-05
US201662291774P 2016-02-05 2016-02-05
US201662291779P 2016-02-05 2016-02-05
US201662291769P 2016-02-05 2016-02-05
US201662291772P 2016-02-05 2016-02-05
US62/291,776 2016-02-05
US62/291,779 2016-02-05
US62/291,774 2016-02-05
US62/291,769 2016-02-05
US62/291,772 2016-02-05
US201662336030P 2016-05-13 2016-05-13
US201662335979P 2016-05-13 2016-05-13
US201662335880P 2016-05-13 2016-05-13
US201662335968P 2016-05-13 2016-05-13
US201662335965P 2016-05-13 2016-05-13
US62/335,979 2016-05-13
US62/336,030 2016-05-13
US62/335,968 2016-05-13
US62/335,965 2016-05-13
US62/335,880 2016-05-13
US201662353607P 2016-06-23 2016-06-23
US62/353,607 2016-06-23
US201662411805P 2016-10-24 2016-10-24
US62/411,805 2016-10-24
PCT/EP2017/052550 WO2017134305A1 (en) 2016-02-05 2017-02-06 Bispecific signaling agents and uses thereof

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JP2018541289A Active JP7166923B2 (ja) 2016-02-05 2017-02-06 標的療法剤およびその使用
JP2018540141A Active JP6991979B2 (ja) 2016-02-05 2017-02-06 Ｃｄ８結合物質
JP2018541133A Active JP7236273B2 (ja) 2016-02-05 2017-02-06 Ｃｌｅｃ９ａ結合物質
JP2022025686A Active JP7386277B2 (ja) 2016-02-05 2022-02-22 二重特異性シグナル伝達物質およびその使用
JP2022110687A Pending JP2022153437A (ja) 2016-02-05 2022-07-08 標的療法剤およびその使用
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JP2018541133A Active JP7236273B2 (ja) 2016-02-05 2017-02-06 Ｃｌｅｃ９ａ結合物質
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US (7) US11001631B2 (https=)
EP (8) EP3411398B1 (https=)
JP (7) JP7030704B2 (https=)
CN (9) CN109071627B (https=)
CA (4) CA3013554A1 (https=)
DK (3) DK3411065T3 (https=)
ES (3) ES2981745T3 (https=)
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Cited By (1)

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JP2022084614A (ja) * 2016-02-05 2022-06-07 オリオニス バイオサイエンシズ ビーブイ 二重特異性シグナル伝達物質およびその使用

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CN109563141A (zh) * 2016-05-13 2019-04-02 奥里尼斯生物科学公司 对非细胞结构的治疗性靶向
CN110573172A (zh) 2017-02-06 2019-12-13 奥里尼斯生物科学有限公司 靶向的工程化干扰素及其用途
EP3577133A1 (en) * 2017-02-06 2019-12-11 Orionis Biosciences NV Targeted chimeric proteins and uses thereof
BR112019018915A2 (pt) 2017-03-15 2020-04-14 Pandion Therapeutics Inc imunotolerância direcionada
JP2020521452A (ja) 2017-05-24 2020-07-27 パンディオン・セラピューティクス・インコーポレイテッド 標的化免疫寛容
US20210017247A1 (en) 2017-07-03 2021-01-21 Torque Therapeutics, Inc. Fusion Molecules Targeting Immune Regulatory Cells and Uses Thereof
DK3661954T3 (da) 2017-08-03 2022-04-19 Amgen Inc Interleukin-21-muteiner og fremgangsmåder til behandling
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