JP6927589B2 - 哺乳類ヒストンデアセチラーゼ活性の阻害剤として有用な二環式ヒドロキサム酸 - Google Patents
哺乳類ヒストンデアセチラーゼ活性の阻害剤として有用な二環式ヒドロキサム酸 Download PDFInfo
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- JP6927589B2 JP6927589B2 JP2018532429A JP2018532429A JP6927589B2 JP 6927589 B2 JP6927589 B2 JP 6927589B2 JP 2018532429 A JP2018532429 A JP 2018532429A JP 2018532429 A JP2018532429 A JP 2018532429A JP 6927589 B2 JP6927589 B2 JP 6927589B2
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- Prior art keywords
- hydroxy
- carboxamide
- benzoxazole
- phenyl
- alkyl
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- 0 CC(C)CN(*)C(C)C Chemical compound CC(C)CN(*)C(C)C 0.000 description 6
- NEUPKMUVAZVNEL-UHFFFAOYSA-N CC(C)CN(C)C(C)C Chemical compound CC(C)CN(C)C(C)C NEUPKMUVAZVNEL-UHFFFAOYSA-N 0.000 description 1
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- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
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- A61K31/42—Oxazoles
- A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
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- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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- C07D498/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Furan Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
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| EP15201841.2 | 2015-12-22 | ||
| EP15201841 | 2015-12-22 | ||
| PCT/EP2016/077914 WO2017108282A1 (en) | 2015-12-22 | 2016-11-16 | Bicyclic hydroxamic acids useful as inhibitors of mammalian histone deacetylase activity |
Publications (3)
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| JP2019505500A JP2019505500A (ja) | 2019-02-28 |
| JP2019505500A5 JP2019505500A5 (cg-RX-API-DMAC7.html) | 2019-12-19 |
| JP6927589B2 true JP6927589B2 (ja) | 2021-09-01 |
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| CN (1) | CN108602812B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2016375634B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3007025A1 (cg-RX-API-DMAC7.html) |
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| WO (1) | WO2017108282A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201804568B (cg-RX-API-DMAC7.html) |
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| MX2020011959A (es) * | 2018-05-09 | 2021-02-17 | Aprinoia Therapeutics Ltd | Compuestos de heteroarilo y usos de los mismos. |
| WO2020033359A1 (en) * | 2018-08-06 | 2020-02-13 | The Board Of Trustees Of The Leland Stanford Junior University | 2-arylbenzimidazoles as ppargc1a activators for treating neurodegenerative diseases |
| MX2021001565A (es) | 2018-08-08 | 2021-04-19 | Bristol Myers Squibb Co | Inhibidores tipo indol y azaindol de enzimas peptidil arginina deiminasas (pad). |
| WO2020033490A1 (en) | 2018-08-08 | 2020-02-13 | Bristol-Myers Squibb Company | Substituted thienopyrroles as pad4 inhibitors |
| KR102146741B1 (ko) * | 2018-10-31 | 2020-08-21 | 계명대학교 산학협력단 | 항바이러스 조성물 |
| US20220008414A1 (en) * | 2018-11-23 | 2022-01-13 | Chong Kun Dang Pharmaceutical Corp. | Pharmaceutical composition comprising histone deacetylase 6 inhibitors |
| WO2021127643A1 (en) | 2019-12-20 | 2021-06-24 | Tenaya Therapeutics, Inc. | Fluoroalkyl-oxadiazoles and uses thereof |
| TW202140477A (zh) | 2020-02-12 | 2021-11-01 | 美商必治妥美雅史谷比公司 | 雜環pad4抑制劑 |
| JP2023530788A (ja) * | 2020-06-08 | 2023-07-19 | アンジー ファーマシューティカル カンパニー リミテッド | 選択的hdac6阻害剤として有用なキナゾリン誘導体 |
| CN112516142B (zh) * | 2020-12-11 | 2021-10-15 | 北京华氏精恒医药科技有限公司 | 一种具有hdac抑制活性的药物组合物、制备方法及其用途 |
| JP2024514356A (ja) | 2021-04-23 | 2024-04-01 | テナヤ セラピューティクス, インコーポレイテッド | 拡張型心筋症の治療に使用するためのhdac6阻害剤 |
| KR20240016950A (ko) | 2021-05-04 | 2024-02-06 | 테나야 테라퓨틱스, 인코포레이티드 | 대사 질환 및 hfpef의 치료에 사용하기 위한 2-플루오로알킬-1,3,4-옥사디아졸-5-일-티아졸, hdac6 억제제 |
| CN114409638B (zh) * | 2022-02-09 | 2023-02-14 | 深圳大学 | 组蛋白去乙酰化酶8选择性降解剂、制备方法及其在抗肿瘤活性中的应用 |
| WO2023177250A1 (ko) * | 2022-03-17 | 2023-09-21 | 숙명여자대학교산학협력단 | 신규 헤테로고리 히스톤 탈아세틸화 효소 저해제 및 이를 포함하는 약학조성물 |
| WO2025160629A1 (en) * | 2024-01-31 | 2025-08-07 | Certa Therapeutics Pty Ltd | Proton sensing gpcr modulators |
| WO2025215092A1 (en) | 2024-04-10 | 2025-10-16 | Institut National de la Santé et de la Recherche Médicale | Selective hdac6 inhibitors for use in the treatment of myotonic dystrophy type 1 |
| CN118459418B (zh) * | 2024-04-26 | 2025-04-08 | 河北中医药大学 | 一种异羟肟酸类hdac抑制剂及其在制备抗肿瘤药物中的应用 |
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| US6861533B2 (en) | 2001-11-23 | 2005-03-01 | Irm Llc | Solution phase sythesis of arylbenzoxazoles |
| BRPI0414581C1 (pt) * | 2003-09-22 | 2021-05-25 | Mei Pharma Inc | composto, composição farmacêutica compreendendo o referido composto e uso do referido composto |
| ES2348360T3 (es) * | 2003-09-22 | 2010-12-03 | S*Bio Pte Ltd | Derivados de bencimidazol: preparación y aplicaciones farmacéuticas. |
| US20050137234A1 (en) * | 2003-12-19 | 2005-06-23 | Syrrx, Inc. | Histone deacetylase inhibitors |
| ITFI20050041A1 (it) * | 2005-03-15 | 2006-09-16 | Menarini Internat Operations Luxembourg Sa | Idrossammati come inibitori dell'istone deacelitasi, loro preparazione e formulazioni farmaceutiche che li contengono |
| JP5313883B2 (ja) | 2007-04-18 | 2013-10-09 | キッセイ薬品工業株式会社 | 含窒素縮合環誘導体、それを含有する医薬組成物及びその医薬用途 |
| WO2008129276A1 (en) | 2007-04-19 | 2008-10-30 | Boehringer Ingelheim International Gmbh | Disulfonamides useful in the treatment of inflammation |
| CA2703718A1 (en) | 2007-11-02 | 2009-05-07 | Tammy Mallais | Inhibitors of histone deacetylase |
| UA103013C2 (uk) | 2007-12-06 | 2013-09-10 | Тиботек Фармасьютикелз | Амідні сполуки як активатори противірусних препаратів |
| MX2010011168A (es) | 2008-04-15 | 2010-12-21 | Pharmacyclics Inc | Inhibidores selectivos de histona-desacetilasa. |
| WO2010061903A1 (ja) * | 2008-11-27 | 2010-06-03 | 塩野義製薬株式会社 | Pi3k阻害活性を有するピリミジン誘導体およびピリジン誘導体 |
| WO2012012322A1 (en) * | 2010-07-19 | 2012-01-26 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| US8987314B2 (en) | 2012-07-19 | 2015-03-24 | Bristol-Myers Squibb Company | Amide, urea or sulfone amide linked benzothiazole inhibitors of endothelial lipase |
| KR20160055170A (ko) | 2013-08-30 | 2016-05-17 | 암비트 바이오사이언시즈 코포레이션 | 바이아릴 아세트아미드 화합물 및 이의 사용 방법 |
| KR101697518B1 (ko) * | 2014-03-12 | 2017-01-19 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 신규 화합물 및 이를 포함하는 약제학적 조성물 |
| US20170114019A1 (en) * | 2014-06-04 | 2017-04-27 | Haro Pharmaceutical Inc. | 18-20 member bi-polycyclic compounds |
| WO2016180472A1 (en) | 2015-05-11 | 2016-11-17 | Kancera Ab | Benzimidazole derivates useful as inhibitors of mammalian histone deacetylase activity |
-
2016
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- 2016-11-16 CN CN201680072487.1A patent/CN108602812B/zh not_active Expired - Fee Related
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- 2016-11-16 KR KR1020187021065A patent/KR20180098593A/ko not_active Withdrawn
- 2016-11-16 RU RU2018126815A patent/RU2747431C2/ru active
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- 2016-11-16 EP EP16797555.6A patent/EP3394052B1/en active Active
- 2016-11-16 US US16/063,682 patent/US10654814B2/en not_active Expired - Fee Related
- 2016-11-16 WO PCT/EP2016/077914 patent/WO2017108282A1/en not_active Ceased
- 2016-11-16 JP JP2018532429A patent/JP6927589B2/ja not_active Expired - Fee Related
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2018
- 2018-07-09 ZA ZA2018/04568A patent/ZA201804568B/en unknown
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| AU2016375634A1 (en) | 2018-07-26 |
| RU2747431C2 (ru) | 2021-05-05 |
| AU2016375634B2 (en) | 2021-03-25 |
| EP3394052B1 (en) | 2021-07-28 |
| CA3007025A1 (en) | 2017-06-29 |
| RU2018126815A (ru) | 2020-01-23 |
| WO2017108282A1 (en) | 2017-06-29 |
| EP3394052A1 (en) | 2018-10-31 |
| US10654814B2 (en) | 2020-05-19 |
| KR20180098593A (ko) | 2018-09-04 |
| CN108602812A (zh) | 2018-09-28 |
| US20190284147A1 (en) | 2019-09-19 |
| ZA201804568B (en) | 2019-09-25 |
| ES2893099T3 (es) | 2022-02-08 |
| RU2018126815A3 (cg-RX-API-DMAC7.html) | 2020-01-31 |
| CN108602812B (zh) | 2021-11-02 |
| JP2019505500A (ja) | 2019-02-28 |
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