CN108602812B - 可用作哺乳动物组蛋白去乙酰化酶活性的抑制剂的双环异羟肟酸类化合物 - Google Patents
可用作哺乳动物组蛋白去乙酰化酶活性的抑制剂的双环异羟肟酸类化合物 Download PDFInfo
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- CN108602812B CN108602812B CN201680072487.1A CN201680072487A CN108602812B CN 108602812 B CN108602812 B CN 108602812B CN 201680072487 A CN201680072487 A CN 201680072487A CN 108602812 B CN108602812 B CN 108602812B
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- benzoxazole
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- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
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| EP15201841.2 | 2015-12-22 | ||
| EP15201841 | 2015-12-22 | ||
| PCT/EP2016/077914 WO2017108282A1 (en) | 2015-12-22 | 2016-11-16 | Bicyclic hydroxamic acids useful as inhibitors of mammalian histone deacetylase activity |
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| CN108602812A CN108602812A (zh) | 2018-09-28 |
| CN108602812B true CN108602812B (zh) | 2021-11-02 |
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| CN (1) | CN108602812B (cg-RX-API-DMAC7.html) |
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| ZA (1) | ZA201804568B (cg-RX-API-DMAC7.html) |
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| MX2020011959A (es) * | 2018-05-09 | 2021-02-17 | Aprinoia Therapeutics Ltd | Compuestos de heteroarilo y usos de los mismos. |
| WO2020033359A1 (en) * | 2018-08-06 | 2020-02-13 | The Board Of Trustees Of The Leland Stanford Junior University | 2-arylbenzimidazoles as ppargc1a activators for treating neurodegenerative diseases |
| MX2021001565A (es) | 2018-08-08 | 2021-04-19 | Bristol Myers Squibb Co | Inhibidores tipo indol y azaindol de enzimas peptidil arginina deiminasas (pad). |
| WO2020033490A1 (en) | 2018-08-08 | 2020-02-13 | Bristol-Myers Squibb Company | Substituted thienopyrroles as pad4 inhibitors |
| KR102146741B1 (ko) * | 2018-10-31 | 2020-08-21 | 계명대학교 산학협력단 | 항바이러스 조성물 |
| US20220008414A1 (en) * | 2018-11-23 | 2022-01-13 | Chong Kun Dang Pharmaceutical Corp. | Pharmaceutical composition comprising histone deacetylase 6 inhibitors |
| WO2021127643A1 (en) | 2019-12-20 | 2021-06-24 | Tenaya Therapeutics, Inc. | Fluoroalkyl-oxadiazoles and uses thereof |
| TW202140477A (zh) | 2020-02-12 | 2021-11-01 | 美商必治妥美雅史谷比公司 | 雜環pad4抑制劑 |
| JP2023530788A (ja) * | 2020-06-08 | 2023-07-19 | アンジー ファーマシューティカル カンパニー リミテッド | 選択的hdac6阻害剤として有用なキナゾリン誘導体 |
| CN112516142B (zh) * | 2020-12-11 | 2021-10-15 | 北京华氏精恒医药科技有限公司 | 一种具有hdac抑制活性的药物组合物、制备方法及其用途 |
| JP2024514356A (ja) | 2021-04-23 | 2024-04-01 | テナヤ セラピューティクス, インコーポレイテッド | 拡張型心筋症の治療に使用するためのhdac6阻害剤 |
| KR20240016950A (ko) | 2021-05-04 | 2024-02-06 | 테나야 테라퓨틱스, 인코포레이티드 | 대사 질환 및 hfpef의 치료에 사용하기 위한 2-플루오로알킬-1,3,4-옥사디아졸-5-일-티아졸, hdac6 억제제 |
| CN114409638B (zh) * | 2022-02-09 | 2023-02-14 | 深圳大学 | 组蛋白去乙酰化酶8选择性降解剂、制备方法及其在抗肿瘤活性中的应用 |
| WO2023177250A1 (ko) * | 2022-03-17 | 2023-09-21 | 숙명여자대학교산학협력단 | 신규 헤테로고리 히스톤 탈아세틸화 효소 저해제 및 이를 포함하는 약학조성물 |
| WO2025160629A1 (en) * | 2024-01-31 | 2025-08-07 | Certa Therapeutics Pty Ltd | Proton sensing gpcr modulators |
| WO2025215092A1 (en) | 2024-04-10 | 2025-10-16 | Institut National de la Santé et de la Recherche Médicale | Selective hdac6 inhibitors for use in the treatment of myotonic dystrophy type 1 |
| CN118459418B (zh) * | 2024-04-26 | 2025-04-08 | 河北中医药大学 | 一种异羟肟酸类hdac抑制剂及其在制备抗肿瘤药物中的应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005066151A2 (en) * | 2003-12-19 | 2005-07-21 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| CN1860103A (zh) * | 2003-09-22 | 2006-11-08 | S*Bio私人有限公司 | 苯并咪唑衍生物:制备方法及医药应用 |
| WO2015188015A1 (en) * | 2014-06-04 | 2015-12-10 | Haro Pharmaceutical Inc. | 18-20 member bi-polycyclic compounds |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6861533B2 (en) | 2001-11-23 | 2005-03-01 | Irm Llc | Solution phase sythesis of arylbenzoxazoles |
| BRPI0414581C1 (pt) * | 2003-09-22 | 2021-05-25 | Mei Pharma Inc | composto, composição farmacêutica compreendendo o referido composto e uso do referido composto |
| ITFI20050041A1 (it) * | 2005-03-15 | 2006-09-16 | Menarini Internat Operations Luxembourg Sa | Idrossammati come inibitori dell'istone deacelitasi, loro preparazione e formulazioni farmaceutiche che li contengono |
| JP5313883B2 (ja) | 2007-04-18 | 2013-10-09 | キッセイ薬品工業株式会社 | 含窒素縮合環誘導体、それを含有する医薬組成物及びその医薬用途 |
| WO2008129276A1 (en) | 2007-04-19 | 2008-10-30 | Boehringer Ingelheim International Gmbh | Disulfonamides useful in the treatment of inflammation |
| CA2703718A1 (en) | 2007-11-02 | 2009-05-07 | Tammy Mallais | Inhibitors of histone deacetylase |
| UA103013C2 (uk) | 2007-12-06 | 2013-09-10 | Тиботек Фармасьютикелз | Амідні сполуки як активатори противірусних препаратів |
| MX2010011168A (es) | 2008-04-15 | 2010-12-21 | Pharmacyclics Inc | Inhibidores selectivos de histona-desacetilasa. |
| WO2010061903A1 (ja) * | 2008-11-27 | 2010-06-03 | 塩野義製薬株式会社 | Pi3k阻害活性を有するピリミジン誘導体およびピリジン誘導体 |
| WO2012012322A1 (en) * | 2010-07-19 | 2012-01-26 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| US8987314B2 (en) | 2012-07-19 | 2015-03-24 | Bristol-Myers Squibb Company | Amide, urea or sulfone amide linked benzothiazole inhibitors of endothelial lipase |
| KR20160055170A (ko) | 2013-08-30 | 2016-05-17 | 암비트 바이오사이언시즈 코포레이션 | 바이아릴 아세트아미드 화합물 및 이의 사용 방법 |
| KR101697518B1 (ko) * | 2014-03-12 | 2017-01-19 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 신규 화합물 및 이를 포함하는 약제학적 조성물 |
| WO2016180472A1 (en) | 2015-05-11 | 2016-11-17 | Kancera Ab | Benzimidazole derivates useful as inhibitors of mammalian histone deacetylase activity |
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2016
- 2016-11-16 AU AU2016375634A patent/AU2016375634B2/en not_active Ceased
- 2016-11-16 CN CN201680072487.1A patent/CN108602812B/zh not_active Expired - Fee Related
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- 2016-11-16 KR KR1020187021065A patent/KR20180098593A/ko not_active Withdrawn
- 2016-11-16 RU RU2018126815A patent/RU2747431C2/ru active
- 2016-11-16 CA CA3007025A patent/CA3007025A1/en not_active Abandoned
- 2016-11-16 EP EP16797555.6A patent/EP3394052B1/en active Active
- 2016-11-16 US US16/063,682 patent/US10654814B2/en not_active Expired - Fee Related
- 2016-11-16 WO PCT/EP2016/077914 patent/WO2017108282A1/en not_active Ceased
- 2016-11-16 JP JP2018532429A patent/JP6927589B2/ja not_active Expired - Fee Related
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2018
- 2018-07-09 ZA ZA2018/04568A patent/ZA201804568B/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1860103A (zh) * | 2003-09-22 | 2006-11-08 | S*Bio私人有限公司 | 苯并咪唑衍生物:制备方法及医药应用 |
| WO2005066151A2 (en) * | 2003-12-19 | 2005-07-21 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| WO2015188015A1 (en) * | 2014-06-04 | 2015-12-10 | Haro Pharmaceutical Inc. | 18-20 member bi-polycyclic compounds |
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| AU2016375634A1 (en) | 2018-07-26 |
| RU2747431C2 (ru) | 2021-05-05 |
| AU2016375634B2 (en) | 2021-03-25 |
| JP6927589B2 (ja) | 2021-09-01 |
| EP3394052B1 (en) | 2021-07-28 |
| CA3007025A1 (en) | 2017-06-29 |
| RU2018126815A (ru) | 2020-01-23 |
| WO2017108282A1 (en) | 2017-06-29 |
| EP3394052A1 (en) | 2018-10-31 |
| US10654814B2 (en) | 2020-05-19 |
| KR20180098593A (ko) | 2018-09-04 |
| CN108602812A (zh) | 2018-09-28 |
| US20190284147A1 (en) | 2019-09-19 |
| ZA201804568B (en) | 2019-09-25 |
| ES2893099T3 (es) | 2022-02-08 |
| RU2018126815A3 (cg-RX-API-DMAC7.html) | 2020-01-31 |
| JP2019505500A (ja) | 2019-02-28 |
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