JP6917144B2 - ベルベリン塩、ウルソデオキシコール酸塩ならびに組み合わせ、その調製および適用方法 - Google Patents

ベルベリン塩、ウルソデオキシコール酸塩ならびに組み合わせ、その調製および適用方法 Download PDF

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JP6917144B2
JP6917144B2 JP2016564633A JP2016564633A JP6917144B2 JP 6917144 B2 JP6917144 B2 JP 6917144B2 JP 2016564633 A JP2016564633 A JP 2016564633A JP 2016564633 A JP2016564633 A JP 2016564633A JP 6917144 B2 JP6917144 B2 JP 6917144B2
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acid
berberine
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liver
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JP2017522264A5 (enExample
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リーピン リュー
リーピン リュー
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シンセン ハイタイド バイオファーマシューティカル リミテッド
シンセン ハイタイド バイオファーマシューティカル リミテッド
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
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    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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JP2016564633A 2014-07-29 2015-07-28 ベルベリン塩、ウルソデオキシコール酸塩ならびに組み合わせ、その調製および適用方法 Active JP6917144B2 (ja)

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Application Number Priority Date Filing Date Title
US201462030140P 2014-07-29 2014-07-29
US201462030147P 2014-07-29 2014-07-29
US62/030,147 2014-07-29
US62/030,140 2014-07-29
US201562128077P 2015-03-04 2015-03-04
US62/128,077 2015-03-04
PCT/CN2015/085350 WO2016015634A1 (en) 2014-07-29 2015-07-28 Berberine salts, ursodeoxycholic salts and combinations, methods of preparation and application thereof

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JP2019237753A Division JP2020073546A (ja) 2014-07-29 2019-12-27 ベルベリン塩、ウルソデオキシコール酸塩ならびに組み合わせ、その調製および適用方法

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JP2017522264A JP2017522264A (ja) 2017-08-10
JP2017522264A5 JP2017522264A5 (enExample) 2018-06-21
JP6917144B2 true JP6917144B2 (ja) 2021-08-11

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JP2019237753A Pending JP2020073546A (ja) 2014-07-29 2019-12-27 ベルベリン塩、ウルソデオキシコール酸塩ならびに組み合わせ、その調製および適用方法
JP2021190958A Active JP7285903B2 (ja) 2014-07-29 2021-11-25 ベルベリン塩、ウルソデオキシコール酸塩ならびに組み合わせ、その調製および適用方法
JP2023084632A Pending JP2023099689A (ja) 2014-07-29 2023-05-23 ベルベリン塩、ウルソデオキシコール酸塩ならびに組み合わせ、その調製および適用方法

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JP2021190958A Active JP7285903B2 (ja) 2014-07-29 2021-11-25 ベルベリン塩、ウルソデオキシコール酸塩ならびに組み合わせ、その調製および適用方法
JP2023084632A Pending JP2023099689A (ja) 2014-07-29 2023-05-23 ベルベリン塩、ウルソデオキシコール酸塩ならびに組み合わせ、その調製および適用方法

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KR (3) KR20250008786A (enExample)
CN (2) CN106687460B (enExample)
AU (2) AU2015296098B2 (enExample)
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WO2011140441A2 (en) 2010-05-06 2011-11-10 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
JP6716468B2 (ja) * 2014-05-05 2020-07-01 ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム 肥満、糖尿病、または癌を治療するためのウルソル酸および／またはレスベラトロールを含む方法および組成物
WO2015183794A1 (en) * 2014-05-27 2015-12-03 City Of Hope Tgr5 agonist complexes for treating diabetes and cancer
EP3712254A1 (en) 2014-05-28 2020-09-23 Children's Hospital Medical Center Methods and systems for converting precursor cells into gastric tissues through directed differentiation
CA3194562C (en) * 2014-07-29 2026-03-17 Shenzhen Hightide Biopharmaceutical, Ltd. Berberine-ursodeoxycholic salt, method of preparation and application therof
CA2963704A1 (en) 2014-10-17 2016-04-21 Children's Hospital Medical Center In vivo model of human small intestine using pluripotent stem cells and methods of making and using same
WO2016161921A1 (en) * 2015-04-06 2016-10-13 Shenzhen Hightide Biopharmaceutical, Ltd. Conjugate compounds of ursodeoxycholic, berberine or l-carnitine, and compositions and methods thereof
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IL282156A (en) 2021-05-31
JP2020073546A (ja) 2020-05-14
EA201790124A1 (ru) 2017-07-31
IL294063B2 (en) 2024-12-01
CA3194562C (en) 2026-03-17
AU2015296098B2 (en) 2019-06-27
EP3174874A1 (en) 2017-06-07
KR20230019267A (ko) 2023-02-08
EP3174874B1 (en) 2020-09-02
CN106687460B (zh) 2019-05-17
IL250317B (en) 2021-04-29
DK3174874T3 (da) 2020-12-07
KR20230134598A (ko) 2023-09-21
SG11201700481YA (en) 2017-02-27
IL250317A0 (en) 2017-03-30
IL294063B1 (en) 2024-08-01
JP2023099689A (ja) 2023-07-13
US20210300915A1 (en) 2021-09-30
JP2017522264A (ja) 2017-08-10
CA3194562A1 (en) 2016-02-04
CA3290585A1 (en) 2026-03-02
US20170037043A1 (en) 2017-02-09
KR20250008786A (ko) 2025-01-15
US20190211007A1 (en) 2019-07-11
EP3174874A4 (en) 2019-03-13

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