JP6883045B2 - オレキシン受容体調節因子としてのハロ置換ピペリジン - Google Patents

オレキシン受容体調節因子としてのハロ置換ピペリジン Download PDF

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JP6883045B2
JP6883045B2 JP2018542231A JP2018542231A JP6883045B2 JP 6883045 B2 JP6883045 B2 JP 6883045B2 JP 2018542231 A JP2018542231 A JP 2018542231A JP 2018542231 A JP2018542231 A JP 2018542231A JP 6883045 B2 JP6883045 B2 JP 6883045B2
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methyl
alkyl
compound
disorders
pharmaceutically acceptable
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JP2019511466A5 (enExample
JP2019511466A (ja
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セオドア・エム・カメネッカ
イェルク・ホーレンツ
スティーヴン・ウェソロゥスキー
ユァンヂィン・フゥー
ローランド・ビュルリ
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AstraZeneca AB
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
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  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2018542231A 2016-02-12 2017-02-10 オレキシン受容体調節因子としてのハロ置換ピペリジン Active JP6883045B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662294940P 2016-02-12 2016-02-12
US62/294,940 2016-02-12
US201662336102P 2016-05-13 2016-05-13
US62/336,102 2016-05-13
PCT/US2017/017408 WO2017139603A1 (en) 2016-02-12 2017-02-10 Halo-substituted piperidines as orexin receptor modulators

Publications (3)

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JP2019511466A JP2019511466A (ja) 2019-04-25
JP2019511466A5 JP2019511466A5 (enExample) 2020-03-19
JP6883045B2 true JP6883045B2 (ja) 2021-06-02

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US (4) US10894789B2 (enExample)
EP (1) EP3414241B1 (enExample)
JP (1) JP6883045B2 (enExample)
KR (1) KR102738491B1 (enExample)
CN (1) CN109219606B (enExample)
AU (1) AU2017217931B2 (enExample)
BR (1) BR112018016446B1 (enExample)
CA (1) CA3013927C (enExample)
CL (1) CL2018002121A1 (enExample)
CO (1) CO2018009290A2 (enExample)
CR (1) CR20180429A (enExample)
CY (1) CY1125461T1 (enExample)
DK (1) DK3414241T3 (enExample)
DO (1) DOP2018000179A (enExample)
EA (1) EA036542B9 (enExample)
ES (1) ES2923790T3 (enExample)
HR (1) HRP20220906T1 (enExample)
HU (1) HUE059280T2 (enExample)
IL (1) IL260788B (enExample)
LT (1) LT3414241T (enExample)
MX (1) MX2018009656A (enExample)
MY (1) MY195239A (enExample)
PE (1) PE20181718A1 (enExample)
PH (1) PH12018501708A1 (enExample)
PL (1) PL3414241T3 (enExample)
PT (1) PT3414241T (enExample)
RS (1) RS63471B1 (enExample)
SG (1) SG11201806368VA (enExample)
SI (1) SI3414241T1 (enExample)
SM (1) SMT202200323T1 (enExample)
SV (1) SV2018005731A (enExample)
TN (1) TN2018000280A1 (enExample)
TW (1) TWI710557B (enExample)
WO (1) WO2017139603A1 (enExample)
ZA (1) ZA201805839B (enExample)

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CN111132975B (zh) * 2017-09-28 2023-05-23 勃林格殷格翰国际有限公司 N-(2,2-二氟乙基)-n-[(嘧啶基氨基)丙基]芳基甲酰胺
WO2020023723A1 (en) * 2018-07-27 2020-01-30 Icahn School Of Medicine At Mount Sinai Method of treating aggression with orexin receptor antagonists
CN114502551B (zh) 2019-11-01 2023-08-22 优迈特株式会社 含氟嘧啶化合物及其制备方法
WO2022207935A1 (en) 2021-04-02 2022-10-06 Orexia Therapeutics Limited 2-(3-ethynylbenzyl)-substituted heterocycle derivatives as orexin-2 agonists
GB202311281D0 (en) 2023-07-21 2023-09-06 Bial Portela & Ca Sa Orexin receptor antagonists
GB202311280D0 (en) 2023-07-21 2023-09-06 Bial Portela & Ca Sa Orexin receptor antagonists

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