JP6728186B2 - 脂質カプセル化ガスマイクロスフェア組成物および関連方法 - Google Patents

脂質カプセル化ガスマイクロスフェア組成物および関連方法 Download PDF

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JP6728186B2
JP6728186B2 JP2017535077A JP2017535077A JP6728186B2 JP 6728186 B2 JP6728186 B2 JP 6728186B2 JP 2017535077 A JP2017535077 A JP 2017535077A JP 2017535077 A JP2017535077 A JP 2017535077A JP 6728186 B2 JP6728186 B2 JP 6728186B2
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lipid
glycerol
dppe
dppa
propylene glycol
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JP2018503629A (ja
JP2018503629A5 (enExample
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サイモン・ピー・ロビンソン
ロバート・ダブリュー・シーグラー
デイビッド・シー・オンサンク
ニュン・トゥエ・グエン
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ランセウス メディカル イメージング， インコーポレイテッド
ランセウス メディカル イメージング， インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/225—Microparticles, microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
JP2017535077A 2014-12-31 2015-12-28 脂質カプセル化ガスマイクロスフェア組成物および関連方法 Expired - Fee Related JP6728186B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462098453P 2014-12-31 2014-12-31
US62/098,453 2014-12-31
PCT/US2015/067615 WO2016109400A2 (en) 2014-12-31 2015-12-28 Lipid-encapsulated gas microsphere compositions and related methods

Related Child Applications (1)

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JP2020113906A Division JP2020172507A (ja) 2014-12-31 2020-07-01 脂質カプセル化ガスマイクロスフェア組成物および関連方法

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JP2018503629A JP2018503629A (ja) 2018-02-08
JP2018503629A5 JP2018503629A5 (enExample) 2019-02-14
JP6728186B2 true JP6728186B2 (ja) 2020-07-22

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JP2017535077A Expired - Fee Related JP6728186B2 (ja) 2014-12-31 2015-12-28 脂質カプセル化ガスマイクロスフェア組成物および関連方法
JP2020113906A Withdrawn JP2020172507A (ja) 2014-12-31 2020-07-01 脂質カプセル化ガスマイクロスフェア組成物および関連方法
JP2023064692A Withdrawn JP2023089124A (ja) 2014-12-31 2023-04-12 脂質カプセル化ガスマイクロスフェア組成物および関連方法

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JP2023064692A Withdrawn JP2023089124A (ja) 2014-12-31 2023-04-12 脂質カプセル化ガスマイクロスフェア組成物および関連方法

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US (5) US10583207B2 (enExample)
EP (2) EP4154915A1 (enExample)
JP (3) JP6728186B2 (enExample)
KR (2) KR20240005184A (enExample)
CN (2) CN107206111B (enExample)
AU (2) AU2015374286B2 (enExample)
BR (1) BR112017013787A2 (enExample)
CA (1) CA2972423A1 (enExample)
EA (1) EA201791437A1 (enExample)
ES (1) ES2928401T3 (enExample)
IL (2) IL296875A (enExample)
MX (3) MX2017008721A (enExample)
NZ (1) NZ733010A (enExample)
TW (2) TWI821755B (enExample)
WO (1) WO2016109400A2 (enExample)
ZA (1) ZA201704426B (enExample)

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Publication number Priority date Publication date Assignee Title
IL296875A (en) 2014-12-31 2022-12-01 Lantheus Medical Imaging Inc Fat-wrapped gas microsphere preparations and related methods
CA3022698A1 (en) * 2016-05-04 2017-11-09 Lantheus Medical Imaging, Inc. Methods and devices for preparation of ultrasound contrast agents
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
WO2022139583A1 (en) * 2020-12-27 2022-06-30 Solstice Pharmaceuticals B.V. A cartridge for mixing a phospholipid composition intended for intracorporeal use

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