JP6677634B2 - SC−β細胞及び組成物並びにその生成方法 - Google Patents
SC−β細胞及び組成物並びにその生成方法 Download PDFInfo
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- JP6677634B2 JP6677634B2 JP2016519628A JP2016519628A JP6677634B2 JP 6677634 B2 JP6677634 B2 JP 6677634B2 JP 2016519628 A JP2016519628 A JP 2016519628A JP 2016519628 A JP2016519628 A JP 2016519628A JP 6677634 B2 JP6677634 B2 JP 6677634B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
- C12N5/0678—Stem cells; Progenitor cells; Precursor cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/39—Pancreas; Islets of Langerhans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/11—Epidermal growth factor [EGF]
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/117—Keratinocyte growth factors (KGF-1, i.e. FGF-7; KGF-2, i.e. FGF-12)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/375—Thyroid stimulating hormone [TSH]
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/395—Thyroid hormones
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases [EC 2.]
- C12N2501/727—Kinases (EC 2.7.)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/03—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from non-embryonic pluripotent stem cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/22—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from pancreatic cells
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
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- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Diabetes (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Developmental Biology & Embryology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Transplantation (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Immunology (AREA)
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020044320A JP7354026B2 (ja) | 2013-06-11 | 2020-03-13 | SC-β細胞及び組成物並びにその生成方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361833898P | 2013-06-11 | 2013-06-11 | |
| US61/833,898 | 2013-06-11 | ||
| US201461972212P | 2014-03-28 | 2014-03-28 | |
| US61/972,212 | 2014-03-28 | ||
| PCT/US2014/041992 WO2014201167A1 (en) | 2013-06-11 | 2014-06-11 | SC-β CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020044320A Division JP7354026B2 (ja) | 2013-06-11 | 2020-03-13 | SC-β細胞及び組成物並びにその生成方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016531087A JP2016531087A (ja) | 2016-10-06 |
| JP2016531087A5 JP2016531087A5 (enExample) | 2017-07-13 |
| JP6677634B2 true JP6677634B2 (ja) | 2020-04-08 |
Family
ID=52022750
Family Applications (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016519628A Active JP6677634B2 (ja) | 2013-06-11 | 2014-06-11 | SC−β細胞及び組成物並びにその生成方法 |
| JP2016519627A Active JP6514689B2 (ja) | 2013-06-11 | 2014-06-11 | SC−β細胞及び組成物並びにその生成方法 |
| JP2019076519A Active JP6893527B2 (ja) | 2013-06-11 | 2019-04-12 | SC−β細胞及び組成物並びにその生成方法 |
| JP2020044320A Active JP7354026B2 (ja) | 2013-06-11 | 2020-03-13 | SC-β細胞及び組成物並びにその生成方法 |
| JP2021091996A Pending JP2021121223A (ja) | 2013-06-11 | 2021-06-01 | SC−β細胞及び組成物並びにその生成方法 |
| JP2023070217A Active JP7766641B2 (ja) | 2013-06-11 | 2023-04-21 | SC-β細胞及び組成物並びにその生成方法 |
| JP2024017609A Pending JP2024054254A (ja) | 2013-06-11 | 2024-02-08 | SC-β細胞及び組成物並びにその生成方法 |
| JP2025009884A Pending JP2025063288A (ja) | 2013-06-11 | 2025-01-23 | SC-β細胞及び組成物並びにその生成方法 |
| JP2026012730A Pending JP2026082908A (ja) | 2013-06-11 | 2026-01-29 | SC-β細胞及び組成物並びにその生成方法 |
Family Applications After (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016519627A Active JP6514689B2 (ja) | 2013-06-11 | 2014-06-11 | SC−β細胞及び組成物並びにその生成方法 |
| JP2019076519A Active JP6893527B2 (ja) | 2013-06-11 | 2019-04-12 | SC−β細胞及び組成物並びにその生成方法 |
| JP2020044320A Active JP7354026B2 (ja) | 2013-06-11 | 2020-03-13 | SC-β細胞及び組成物並びにその生成方法 |
| JP2021091996A Pending JP2021121223A (ja) | 2013-06-11 | 2021-06-01 | SC−β細胞及び組成物並びにその生成方法 |
| JP2023070217A Active JP7766641B2 (ja) | 2013-06-11 | 2023-04-21 | SC-β細胞及び組成物並びにその生成方法 |
| JP2024017609A Pending JP2024054254A (ja) | 2013-06-11 | 2024-02-08 | SC-β細胞及び組成物並びにその生成方法 |
| JP2025009884A Pending JP2025063288A (ja) | 2013-06-11 | 2025-01-23 | SC-β細胞及び組成物並びにその生成方法 |
| JP2026012730A Pending JP2026082908A (ja) | 2013-06-11 | 2026-01-29 | SC-β細胞及び組成物並びにその生成方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (16) | US20170029778A1 (enExample) |
| EP (4) | EP3008170A4 (enExample) |
| JP (9) | JP6677634B2 (enExample) |
| KR (12) | KR102341674B1 (enExample) |
| CN (6) | CN120796168A (enExample) |
| AU (7) | AU2014278178B2 (enExample) |
| BR (2) | BR112015030972A8 (enExample) |
| CA (3) | CA3311831A1 (enExample) |
| DE (2) | DE112014002780B4 (enExample) |
| DK (1) | DK3008168T3 (enExample) |
| GB (3) | GB2557508B (enExample) |
| HK (1) | HK1257187B (enExample) |
| MX (2) | MX2015017103A (enExample) |
| PH (1) | PH12015502767A1 (enExample) |
| RU (2) | RU2016100219A (enExample) |
| SG (3) | SG11201510176VA (enExample) |
| WO (2) | WO2015002724A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023093654A (ja) * | 2013-06-11 | 2023-07-04 | プレジデント アンド フェローズ オブ ハーバード カレッジ | SC-β細胞及び組成物並びにその生成方法 |
Families Citing this family (106)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2473685C2 (ru) | 2007-07-31 | 2013-01-27 | Лайфскен, Инк. | Дифференцировка человеческих эмбриональных стволовых клеток |
| CN107574142B (zh) | 2007-11-27 | 2021-07-06 | 生命扫描有限公司 | 人胚胎干细胞的分化 |
| RU2705001C2 (ru) | 2011-12-22 | 2019-11-01 | Янссен Байотек, Инк. | Дифференцировка эмбриональных стволовых клеток человека в одногормональные инсулинположительные клетки |
| MX2015008578A (es) | 2012-12-31 | 2015-09-07 | Janssen Biotech Inc | Diferenciacion de celulas madre embrionarias humanas en celulas endocrinas pancreaticas mediante el uso de relugadores de hb9. |
| EP2983694B1 (en) * | 2013-04-08 | 2022-06-22 | President and Fellows of Harvard College | Compositions for rejuvenating skeletal muscle stem cells |
| SG11201609473XA (en) | 2014-05-16 | 2016-12-29 | Janssen Biotech Inc | Use of small molecules to enhance mafa expression in pancreatic endocrine cells |
| ES2985135T3 (es) | 2014-12-18 | 2024-11-04 | Harvard College | Procedimientos para generar células ß derivadas de células madre y usos de las mismas |
| US10443042B2 (en) | 2014-12-18 | 2019-10-15 | President And Fellows Of Harvard College | Serum-free in vitro directed differentiation protocol for generating stem cell-derived beta cells and uses thereof |
| CN107614678B (zh) | 2014-12-18 | 2021-04-30 | 哈佛学院校长同事会 | 干细胞来源的β细胞的产生方法及其使用方法 |
| WO2016100921A1 (en) * | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | METHODS FOR GENERATING STEM CELL-DERIVED β CELLS AND USES THEREOF |
| WO2016100857A1 (en) * | 2014-12-19 | 2016-06-23 | Regeneron Pharmaceuticals, Inc. | Stem cells for modeling type 2 diabetes |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2023093654A (ja) * | 2013-06-11 | 2023-07-04 | プレジデント アンド フェローズ オブ ハーバード カレッジ | SC-β細胞及び組成物並びにその生成方法 |
| JP7766641B2 (ja) | 2013-06-11 | 2025-11-10 | プレジデント アンド フェローズ オブ ハーバード カレッジ | SC-β細胞及び組成物並びにその生成方法 |
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