DK3039122T3 - Generering af endokrine progenitorceller fra humane pluripotente stamceller under anvendelse af små molekyler - Google Patents
Generering af endokrine progenitorceller fra humane pluripotente stamceller under anvendelse af små molekyler Download PDFInfo
- Publication number
- DK3039122T3 DK3039122T3 DK14761822.7T DK14761822T DK3039122T3 DK 3039122 T3 DK3039122 T3 DK 3039122T3 DK 14761822 T DK14761822 T DK 14761822T DK 3039122 T3 DK3039122 T3 DK 3039122T3
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- DK
- Denmark
- Prior art keywords
- generation
- small molecules
- pluripotent stem
- human pluripotent
- endocrine progenitor
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0613—Cells from endocrine organs
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
- C12N5/0678—Stem cells; Progenitor cells; Precursor cells
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/38—Vitamins
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases (EC 2.)
- C12N2501/727—Kinases (EC 2.7.)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/22—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from pancreatic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13182440 | 2013-08-30 | ||
US201361875191P | 2013-09-09 | 2013-09-09 | |
PCT/EP2014/068393 WO2015028614A1 (en) | 2013-08-30 | 2014-08-29 | Generation of endocrine progenitor cells from human pluripotent stem cells using small molecules |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3039122T3 true DK3039122T3 (da) | 2019-09-30 |
Family
ID=49080758
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK14761822.7T DK3039122T3 (da) | 2013-08-30 | 2014-08-29 | Generering af endokrine progenitorceller fra humane pluripotente stamceller under anvendelse af små molekyler |
Country Status (6)
Country | Link |
---|---|
US (2) | US20160208215A1 (da) |
EP (1) | EP3039122B1 (da) |
JP (1) | JP6636427B2 (da) |
CN (1) | CN105683361B (da) |
DK (1) | DK3039122T3 (da) |
WO (1) | WO2015028614A1 (da) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102232650B1 (ko) | 2013-06-11 | 2021-03-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | SC-β 세포 및 조성물 그리고 그 생성 방법 |
US10443042B2 (en) | 2014-12-18 | 2019-10-15 | President And Fellows Of Harvard College | Serum-free in vitro directed differentiation protocol for generating stem cell-derived beta cells and uses thereof |
DK3234110T3 (da) | 2014-12-18 | 2024-05-13 | Harvard College | FREMGANGSMÅDER TIL GENERERING AF STAMCELLE-AFLEDTE ß-CELLER OG ANVENDELSER DERAF |
US10253298B2 (en) | 2014-12-18 | 2019-04-09 | President And Fellows Of Harvard College | Methods for generating stem cell-derived beta cells and methods of use thereof |
JP7123802B2 (ja) * | 2016-02-24 | 2022-08-23 | ノヴォ ノルディスク アー/エス | ヒト多能性幹細胞由来内分泌前駆細胞からの機能的ベータ細胞の産生 |
EP3681992A1 (en) | 2017-09-11 | 2020-07-22 | Novo Nordisk A/S | Enrichment of nkx6.1 and c-peptide co-expressing cells derived in vitro from stem cells |
WO2019099725A1 (en) | 2017-11-15 | 2019-05-23 | Semma Therapeutics, Inc. | Islet cell manufacturing compositions and methods of use |
CN108165531A (zh) * | 2017-12-23 | 2018-06-15 | 淮北智淮科技有限公司 | 一种造血干细胞用的脐带血单核细胞培养方法 |
JP7359697B2 (ja) | 2018-01-18 | 2023-10-11 | 第一三共株式会社 | ジヒドロインドリジノン誘導体 |
AU2019320072A1 (en) | 2018-08-10 | 2021-02-25 | Vertex Pharmaceuticals Incorporated | Stem cell derived islet differentiation |
WO2020043292A1 (en) | 2018-08-30 | 2020-03-05 | Novo Nordisk A/S | Generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors |
CN113728090B (zh) | 2019-04-08 | 2024-04-05 | 诺和诺德股份有限公司 | 从干细胞衍生的定形内胚层生成胰腺内胚层 |
TW202115245A (zh) | 2019-06-27 | 2021-04-16 | 丹麥商諾佛 儂迪克股份有限公司 | 安全免疫隱形細胞 |
EP4204542A1 (en) | 2020-08-28 | 2023-07-05 | Novo Nordisk A/S | Method for screening in vitro population of stem cell derived beta like cells and novel markers thereof |
TW202242095A (zh) | 2020-12-18 | 2022-11-01 | 丹麥商諾佛 儂迪克股份有限公司 | 安全免疫隱形細胞 |
WO2022136215A1 (en) | 2020-12-21 | 2022-06-30 | Novo Nordisk A/S | Safe immuno-stealth cells |
WO2024008810A1 (en) * | 2022-07-06 | 2024-01-11 | Novo Nordisk A/S | Differentiation of stem cells to pancreatic endocrine cells |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7695965B2 (en) * | 2006-03-02 | 2010-04-13 | Cythera, Inc. | Methods of producing pancreatic hormones |
AU2007224116B2 (en) * | 2006-03-02 | 2013-11-07 | Viacyte, Inc. | Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production |
US20120021519A1 (en) * | 2008-09-19 | 2012-01-26 | Presidents And Fellows Of Harvard College | Efficient induction of pluripotent stem cells using small molecule compounds |
EP2346988B1 (en) * | 2008-10-31 | 2017-05-31 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells to the pancreatic endocrine lineage |
US20120207744A1 (en) * | 2009-03-19 | 2012-08-16 | Mendlein John D | Reprogramming compositions and methods of using the same |
WO2011008996A2 (en) * | 2009-07-15 | 2011-01-20 | The Regents Of The University Of California | Peptides whose uptake in cells is controllable |
CA2785966C (en) * | 2009-12-29 | 2020-10-27 | Takeda Pharmaceutical Company Limited | Method for manufacturing pancreatic-hormone-producing cells |
CN102093977A (zh) * | 2010-11-29 | 2011-06-15 | 中国人民解放军军事医学科学院基础医学研究所 | 一种诱导iPS细胞向心肌细胞分化的诱导因子及其应用 |
-
2014
- 2014-08-29 WO PCT/EP2014/068393 patent/WO2015028614A1/en active Application Filing
- 2014-08-29 CN CN201480047988.5A patent/CN105683361B/zh active Active
- 2014-08-29 JP JP2016537310A patent/JP6636427B2/ja active Active
- 2014-08-29 DK DK14761822.7T patent/DK3039122T3/da active
- 2014-08-29 US US14/913,604 patent/US20160208215A1/en not_active Abandoned
- 2014-08-29 EP EP14761822.7A patent/EP3039122B1/en active Active
-
2019
- 2019-08-20 US US16/546,018 patent/US20200002670A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20160208215A1 (en) | 2016-07-21 |
JP2016528908A (ja) | 2016-09-23 |
JP6636427B2 (ja) | 2020-01-29 |
US20200002670A1 (en) | 2020-01-02 |
EP3039122B1 (en) | 2019-07-17 |
CN105683361B (zh) | 2021-04-02 |
EP3039122A1 (en) | 2016-07-06 |
WO2015028614A1 (en) | 2015-03-05 |
CN105683361A (zh) | 2016-06-15 |
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