DK3145517T3 - Funktionelle oligodendrocytter afledt fra pluripotente stamceller og fremgangsmåder til fremstilling og anvendelse deraf - Google Patents
Funktionelle oligodendrocytter afledt fra pluripotente stamceller og fremgangsmåder til fremstilling og anvendelse deraf Download PDFInfo
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- DK3145517T3 DK3145517T3 DK15796034.5T DK15796034T DK3145517T3 DK 3145517 T3 DK3145517 T3 DK 3145517T3 DK 15796034 T DK15796034 T DK 15796034T DK 3145517 T3 DK3145517 T3 DK 3145517T3
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- Prior art keywords
- oligodendrocyts
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- C—CHEMISTRY; METALLURGY
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0622—Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/105—Insulin-like growth factors [IGF]
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/12—Hepatocyte growth factor [HGF]
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/135—Platelet-derived growth factor [PDGF]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases (EC 2.)
- C12N2501/727—Kinases (EC 2.7.)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462002048P | 2014-05-22 | 2014-05-22 | |
PCT/US2015/032274 WO2015179822A1 (en) | 2014-05-22 | 2015-05-22 | Functional oligodendrocytes derived from pluripotent stem cells and methods of making and using the same |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3145517T3 true DK3145517T3 (da) | 2020-11-30 |
Family
ID=54554868
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK15796034.5T DK3145517T3 (da) | 2014-05-22 | 2015-05-22 | Funktionelle oligodendrocytter afledt fra pluripotente stamceller og fremgangsmåder til fremstilling og anvendelse deraf |
Country Status (10)
Country | Link |
---|---|
US (3) | US10301592B2 (da) |
EP (1) | EP3145517B1 (da) |
JP (2) | JP6873705B2 (da) |
KR (2) | KR102324714B1 (da) |
CN (1) | CN106456672B (da) |
AU (1) | AU2015263951B2 (da) |
DK (1) | DK3145517T3 (da) |
ES (1) | ES2846860T3 (da) |
PL (1) | PL3145517T3 (da) |
WO (1) | WO2015179822A1 (da) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL3145517T3 (pl) * | 2014-05-22 | 2021-04-06 | New York Stem Cell Foundation, Inc. | Funkcjonalne oligodendrocyty pochodzące z pluripotencjalnych komórek macierzystych oraz sposoby ich otrzymywania i stosowania |
CN105567642B (zh) * | 2016-02-01 | 2019-07-12 | 中国科学院生物物理研究所 | 一种着色性干皮病人多能干细胞的制备方法 |
EP3436567A4 (en) * | 2016-03-30 | 2019-10-30 | Asterias Biotherapeutics, Inc. | OLIGODENDROCYTE PROGENITOR CELL COMPOSITIONS |
WO2018191656A1 (en) * | 2017-04-13 | 2018-10-18 | The Board Of Trustees Of The Leland Stanford Junior University | Personalized 3d neural culture system for generating human oligodendrocytes and studying myelination in vitro |
KR20200026984A (ko) * | 2017-07-13 | 2020-03-11 | 알렐 바이오테크놀로지 앤 파마슈티칼스, 인크. | 랜드마크 전사 인자를 사용한 줄기 세포 분화에 의한 신경 전구 세포, 핍지교세포 전구 세포, 및 핍지교세포의 유도 |
WO2019023793A1 (en) * | 2017-08-04 | 2019-02-07 | University Health Network | GENERATION OF OLIGODENDROGENIC NEURON PROGENITOR CELLS |
CA3006897A1 (en) * | 2017-08-04 | 2019-02-04 | University Health Network | Generation of oligodendrogenic neural progenitor cells |
CN107858331B (zh) * | 2017-11-02 | 2021-01-15 | 北京全式金生物技术有限公司 | 一种诱导人多能性干细胞分化为脊髓运动神经前体细胞的方法 |
CN108384755A (zh) * | 2018-02-08 | 2018-08-10 | 北京呈诺医学科技有限公司 | 一种高效、快捷的诱导性多能干细胞向神经干细胞分化的方法 |
US20210163888A1 (en) * | 2018-04-17 | 2021-06-03 | Case Western Reserve University | Induction of myelinating oligodendrocytes in human cortical spheroids |
CN108624560B (zh) * | 2018-06-01 | 2022-04-08 | 南京艾尔普再生医学科技有限公司 | 一种分化培养基及少突胶质前体细胞的制备方法 |
WO2019241620A1 (en) * | 2018-06-14 | 2019-12-19 | Academia Sinica | Method to generate induced oligodendrocyte-lineage cells and treatment using such cells |
EP3660145A1 (en) * | 2018-11-30 | 2020-06-03 | Assistance Publique, Hopitaux De Paris | Use of oligodendrocytes from oral neuroectodermal stem cells in the repair of the nervous system |
CA3127213A1 (en) | 2019-01-23 | 2020-07-30 | Asterias Biotherapeutics, Inc. | Dorsally-derived oligodendrocyte progenitor cells from human pluripotent stem cells |
WO2020243618A1 (en) * | 2019-05-29 | 2020-12-03 | New York Stem Cell Foundation, Inc. | Functional astrocytes derived from pluripotent stem cells and methods of making and using the same |
MX2021014681A (es) * | 2019-05-31 | 2022-04-06 | Harvard College | Células progenitoras de oligodendrocitos inducidas por la caja hmg relacionada con sry 9. |
KR20220068222A (ko) | 2019-08-23 | 2022-05-25 | 사나 바이오테크놀로지, 인크. | Cd24 발현 세포 및 이의 용도 |
JPWO2021045217A1 (da) | 2019-09-06 | 2021-03-11 | ||
CN110716595A (zh) * | 2019-09-11 | 2020-01-21 | 合肥众建翔新能源有限公司 | 一种基于新能源的养殖系统 |
US20230293593A1 (en) | 2020-03-25 | 2023-09-21 | Sana Biotechnology, Inc. | Hypoimmunogenic neural cells for the treatment of neurological disorders and conditions |
WO2021235848A1 (ko) * | 2020-05-20 | 2021-11-25 | 고려대학교 산학협력단 | 희소돌기아교세포로 분화가 특화된 신경줄기세포로부터 희소돌기아교세포를 포함하는 오가노이드의 제조방법, 상기 방법으로 제조된 오가노이드 및 이의 용도 |
IL300516A (en) | 2020-08-13 | 2023-04-01 | Sana Biotechnology Inc | Methods for treating susceptible patients with hypoimmunogenic cells, and related methods and compounds |
KR102568532B1 (ko) * | 2021-01-13 | 2023-08-18 | 건국대학교 산학협력단 | 3차원 배양을 통한 신경줄기세포 제조 방법 |
AU2022247250A1 (en) * | 2021-03-30 | 2023-11-09 | Trailhead Biosystems Inc. | Methods and compositions for generating oligodendrocyte progenitor cells |
AU2022283291A1 (en) | 2021-05-27 | 2023-11-02 | Sana Biotechnology, Inc. | Hypoimmunogenic cells comprising engineered hla-e or hla-g |
IL310089A (en) | 2021-07-14 | 2024-03-01 | Sana Biotechnology Inc | Differential expression of Y-linked antigens in hypoimmunogenic cells |
CN113564122B (zh) * | 2021-08-05 | 2022-04-08 | 呈诺再生医学科技(珠海横琴新区)有限公司 | 人诱导性多能干细胞向少突胶质细胞分化的方法,试剂盒以及应用 |
WO2023019226A1 (en) | 2021-08-11 | 2023-02-16 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy |
AU2022325955A1 (en) | 2021-08-11 | 2024-02-08 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy to reduce instant blood mediated inflammatory reactions |
CA3227613A1 (en) | 2021-08-11 | 2023-02-16 | William Dowdle | Inducible systems for altering gene expression in hypoimmunogenic cells |
WO2023019227A1 (en) | 2021-08-11 | 2023-02-16 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy to reduce complement-mediated inflammatory reactions |
CN113699117B (zh) * | 2021-09-03 | 2023-06-30 | 呈诺再生医学科技(北京)有限公司 | 经基因改造的少突胶质祖细胞在多发性硬化症中的应用 |
CN114262686B (zh) * | 2022-03-02 | 2022-06-24 | 深圳市夏同生物医药科技有限公司 | 一种少突胶质细胞的制备方法及应用 |
WO2023183313A1 (en) | 2022-03-22 | 2023-09-28 | Sana Biotechnology, Inc. | Engineering cells with a transgene in b2m or ciita locus and associated compositions and methods |
KR20230171226A (ko) * | 2022-06-13 | 2023-12-20 | 고려대학교 산학협력단 | 키나아제 저해제를 유효성분으로 포함하는 탈수초성 질환 예방 또는 치료용 약학적 조성물 |
CN115322965B (zh) * | 2022-08-19 | 2024-01-30 | 同济大学 | 一种体外获得后脑底板细胞的方法、成套培养基及应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1567186A2 (en) * | 2002-12-06 | 2005-08-31 | Singapore General Hospital Pte. Ltd. | Nogo, caspr, f3 and nb-3 useful in the treatment of injury and disease to the central nervous system |
WO2008026198A2 (en) * | 2006-08-28 | 2008-03-06 | Yeda Research And Development Co. Ltd. | Methods of generating glial and neuronal cells and use of same for the treatment of medical conditions of the cns |
US8227247B2 (en) * | 2007-12-20 | 2012-07-24 | Wisconsin Alumni Research Foundation | Method of generating myelinating oligodendrocytes |
WO2015124725A1 (en) * | 2014-02-21 | 2015-08-27 | Johan Ericson | Late born central nervous system cell types |
PL3145517T3 (pl) | 2014-05-22 | 2021-04-06 | New York Stem Cell Foundation, Inc. | Funkcjonalne oligodendrocyty pochodzące z pluripotencjalnych komórek macierzystych oraz sposoby ich otrzymywania i stosowania |
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2015
- 2015-05-22 PL PL15796034T patent/PL3145517T3/pl unknown
- 2015-05-22 JP JP2016568940A patent/JP6873705B2/ja active Active
- 2015-05-22 CN CN201580033959.8A patent/CN106456672B/zh active Active
- 2015-05-22 WO PCT/US2015/032274 patent/WO2015179822A1/en active Application Filing
- 2015-05-22 KR KR1020167034668A patent/KR102324714B1/ko active IP Right Grant
- 2015-05-22 ES ES15796034T patent/ES2846860T3/es active Active
- 2015-05-22 US US15/313,079 patent/US10301592B2/en active Active
- 2015-05-22 DK DK15796034.5T patent/DK3145517T3/da active
- 2015-05-22 EP EP15796034.5A patent/EP3145517B1/en active Active
- 2015-05-22 KR KR1020217036151A patent/KR102585909B1/ko active IP Right Grant
- 2015-05-22 AU AU2015263951A patent/AU2015263951B2/en active Active
-
2019
- 2019-05-06 US US16/404,502 patent/US10676716B2/en active Active
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2020
- 2020-06-03 US US16/892,181 patent/US11814648B2/en active Active
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2021
- 2021-04-21 JP JP2021071974A patent/JP7410903B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
US10301592B2 (en) | 2019-05-28 |
EP3145517A1 (en) | 2017-03-29 |
KR20210138783A (ko) | 2021-11-19 |
JP2017524340A (ja) | 2017-08-31 |
CN106456672B (zh) | 2020-03-13 |
AU2015263951B2 (en) | 2020-07-02 |
KR20170005844A (ko) | 2017-01-16 |
KR102585909B1 (ko) | 2023-10-05 |
US20200399595A1 (en) | 2020-12-24 |
AU2015263951A1 (en) | 2016-12-01 |
US11814648B2 (en) | 2023-11-14 |
CN106456672A (zh) | 2017-02-22 |
EP3145517A4 (en) | 2017-11-15 |
ES2846860T3 (es) | 2021-07-29 |
US10676716B2 (en) | 2020-06-09 |
JP7410903B2 (ja) | 2024-01-10 |
PL3145517T3 (pl) | 2021-04-06 |
WO2015179822A1 (en) | 2015-11-26 |
US20170183627A1 (en) | 2017-06-29 |
JP6873705B2 (ja) | 2021-05-19 |
US20190256820A1 (en) | 2019-08-22 |
EP3145517B1 (en) | 2020-08-26 |
JP2021118718A (ja) | 2021-08-12 |
KR102324714B1 (ko) | 2021-11-11 |
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