DK3145517T3 - Funktionelle oligodendrocytter afledt fra pluripotente stamceller og fremgangsmåder til fremstilling og anvendelse deraf - Google Patents
Funktionelle oligodendrocytter afledt fra pluripotente stamceller og fremgangsmåder til fremstilling og anvendelse deraf Download PDFInfo
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- DK3145517T3 DK3145517T3 DK15796034.5T DK15796034T DK3145517T3 DK 3145517 T3 DK3145517 T3 DK 3145517T3 DK 15796034 T DK15796034 T DK 15796034T DK 3145517 T3 DK3145517 T3 DK 3145517T3
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- Prior art keywords
- oligodendrocyts
- derived
- functional
- manufacture
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- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 210000001778 pluripotent stem cell Anatomy 0.000 title 1
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0622—Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A61P25/00—Drugs for disorders of the nervous system
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- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
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- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
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- Zoology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Developmental Biology & Embryology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462002048P | 2014-05-22 | 2014-05-22 | |
| PCT/US2015/032274 WO2015179822A1 (en) | 2014-05-22 | 2015-05-22 | Functional oligodendrocytes derived from pluripotent stem cells and methods of making and using the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3145517T3 true DK3145517T3 (da) | 2020-11-30 |
Family
ID=54554868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15796034.5T DK3145517T3 (da) | 2014-05-22 | 2015-05-22 | Funktionelle oligodendrocytter afledt fra pluripotente stamceller og fremgangsmåder til fremstilling og anvendelse deraf |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US10301592B2 (da) |
| EP (1) | EP3145517B1 (da) |
| JP (2) | JP6873705B2 (da) |
| KR (2) | KR102585909B1 (da) |
| CN (1) | CN106456672B (da) |
| AU (1) | AU2015263951B2 (da) |
| DK (1) | DK3145517T3 (da) |
| ES (1) | ES2846860T3 (da) |
| PL (1) | PL3145517T3 (da) |
| WO (1) | WO2015179822A1 (da) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102585909B1 (ko) * | 2014-05-22 | 2023-10-05 | 뉴욕 스템 셀 파운데이션, 인코포레이티드 | 다능성 줄기 세포로부터 유래된 기능성 희소돌기아교세포 및 이의 제조 및 사용 방법 |
| CN105567642B (zh) * | 2016-02-01 | 2019-07-12 | 中国科学院生物物理研究所 | 一种着色性干皮病人多能干细胞的制备方法 |
| US11920155B2 (en) | 2016-03-30 | 2024-03-05 | Asterias Biotherapeutics, Inc. | Oligodendrocyte progenitor cell compositions |
| JP2020519237A (ja) * | 2017-04-13 | 2020-07-02 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | ヒトオリゴデンドロサイトを作製しインビトロでの髄鞘形成を研究するための個別化された神経系３ｄ培養系 |
| CN110997706B (zh) * | 2017-07-13 | 2024-07-16 | 美国绿阳生物技术及医药公司 | 通过利用地标转录因子的干细胞分化诱导神经祖细胞、寡树突细胞祖细胞及寡树突细胞 |
| WO2019023793A1 (en) * | 2017-08-04 | 2019-02-07 | University Health Network | GENERATION OF OLIGODENDROGENIC NEURON PROGENITOR CELLS |
| CA3006897A1 (en) | 2017-08-04 | 2019-02-04 | University Health Network | Generation of oligodendrogenic neural progenitor cells |
| CN107858331B (zh) * | 2017-11-02 | 2021-01-15 | 北京全式金生物技术有限公司 | 一种诱导人多能性干细胞分化为脊髓运动神经前体细胞的方法 |
| CN108384755A (zh) * | 2018-02-08 | 2018-08-10 | 北京呈诺医学科技有限公司 | 一种高效、快捷的诱导性多能干细胞向神经干细胞分化的方法 |
| MA52540A (fr) * | 2018-04-17 | 2021-02-24 | Univ Case Western Reserve | Induction d'oligodendrocytes myélinisants dans des sphéroïdes corticaux humains |
| CN108624560B (zh) * | 2018-06-01 | 2022-04-08 | 南京艾尔普再生医学科技有限公司 | 一种分化培养基及少突胶质前体细胞的制备方法 |
| CN112513257A (zh) * | 2018-06-14 | 2021-03-16 | 中央研究院 | 产生诱导式少突胶质谱系细胞的方法及使用所述细胞的治疗 |
| EP3660145A1 (en) * | 2018-11-30 | 2020-06-03 | Assistance Publique, Hopitaux De Paris | Use of oligodendrocytes from oral neuroectodermal stem cells in the repair of the nervous system |
| EP3914264A4 (en) | 2019-01-23 | 2022-11-23 | Asterias Biotherapeutics, Inc. | DORSAL DERIVATIVE OLIGODENDROCYTE PROGENITORS FROM HUMAN PLURIPOTENTIC STEM CELLS |
| WO2020243618A1 (en) * | 2019-05-29 | 2020-12-03 | New York Stem Cell Foundation, Inc. | Functional astrocytes derived from pluripotent stem cells and methods of making and using the same |
| MX2021014681A (es) * | 2019-05-31 | 2022-04-06 | Harvard College | Células progenitoras de oligodendrocitos inducidas por la caja hmg relacionada con sry 9. |
| AU2020336302A1 (en) | 2019-08-23 | 2022-03-03 | Sana Biotechnology, Inc. | CD24 expressing cells and uses thereof |
| WO2021045217A1 (ja) | 2019-09-06 | 2021-03-11 | 学校法人慶應義塾 | グリア前駆細胞を含む細胞凝集体の製造方法 |
| CN110716595A (zh) * | 2019-09-11 | 2020-01-21 | 合肥众建翔新能源有限公司 | 一种基于新能源的养殖系统 |
| CA3173096A1 (en) | 2020-03-25 | 2021-09-30 | Sonja SCHREPFER | Hypoimmunogenic neural cells for the treatment of neurological disorders and conditions |
| WO2021235848A1 (ko) * | 2020-05-20 | 2021-11-25 | 고려대학교 산학협력단 | 희소돌기아교세포로 분화가 특화된 신경줄기세포로부터 희소돌기아교세포를 포함하는 오가노이드의 제조방법, 상기 방법으로 제조된 오가노이드 및 이의 용도 |
| IL300516A (en) | 2020-08-13 | 2023-04-01 | Sana Biotechnology Inc | Methods for treating susceptible patients with hypoimmunogenic cells, and related methods and compounds |
| KR102568532B1 (ko) * | 2021-01-13 | 2023-08-18 | 건국대학교 산학협력단 | 3차원 배양을 통한 신경줄기세포 제조 방법 |
| EP4314256A1 (en) * | 2021-03-30 | 2024-02-07 | Trailhead Biosystems Inc. | Methods and compositions for generating oligodendrocyte progenitor cells |
| KR20240013135A (ko) | 2021-05-27 | 2024-01-30 | 사나 바이오테크놀로지, 인크. | 조작된 hla-e 또는 hla-g를 포함하는 저면역원성 세포 |
| EP4370544A2 (en) | 2021-07-14 | 2024-05-22 | Sana Biotechnology, Inc. | Altered expression of y chromosome-linked antigens in hypoimmunogenic cells |
| CN113564122B (zh) * | 2021-08-05 | 2022-04-08 | 呈诺再生医学科技(珠海横琴新区)有限公司 | 人诱导性多能干细胞向少突胶质细胞分化的方法，试剂盒以及应用 |
| JP2024534772A (ja) | 2021-08-11 | 2024-09-26 | サナ バイオテクノロジー，インコーポレイテッド | 同種異系細胞療法用の遺伝子改変細胞 |
| WO2023019227A1 (en) | 2021-08-11 | 2023-02-16 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy to reduce complement-mediated inflammatory reactions |
| MX2024001443A (es) | 2021-08-11 | 2024-05-15 | Sana Biotechnology Inc | Sistemas inducibles para alterar la expresión génica en células hipoinmunógenas. |
| AU2022325955A1 (en) | 2021-08-11 | 2024-02-08 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy to reduce instant blood mediated inflammatory reactions |
| CN113699117B (zh) * | 2021-09-03 | 2023-06-30 | 呈诺再生医学科技(北京)有限公司 | 经基因改造的少突胶质祖细胞在多发性硬化症中的应用 |
| CN114262686B (zh) * | 2022-03-02 | 2022-06-24 | 深圳市夏同生物医药科技有限公司 | 一种少突胶质细胞的制备方法及应用 |
| WO2023183313A1 (en) | 2022-03-22 | 2023-09-28 | Sana Biotechnology, Inc. | Engineering cells with a transgene in b2m or ciita locus and associated compositions and methods |
| KR20230171226A (ko) * | 2022-06-13 | 2023-12-20 | 고려대학교 산학협력단 | 키나아제 저해제를 유효성분으로 포함하는 탈수초성 질환 예방 또는 치료용 약학적 조성물 |
| US20240043798A1 (en) * | 2022-08-08 | 2024-02-08 | Trailhead Biosystems Inc. | Methods and compositions for generating oligodendrocyte progenitor cells |
| US20240052321A1 (en) * | 2022-08-15 | 2024-02-15 | Cellino Biotech, Inc. | Systems and methods for cell manufacturing |
| CN115322965B (zh) * | 2022-08-19 | 2024-01-30 | 同济大学 | 一种体外获得后脑底板细胞的方法、成套培养基及应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004052389A2 (en) * | 2002-12-06 | 2004-06-24 | Singapore General Hospital Pte Ltd. | Nogo, caspr, f3 nb-3 useful in the treatment of injury and disease to the central nervous system |
| EP2064319B1 (en) * | 2006-08-28 | 2017-02-22 | Yeda Research and Development Co. Ltd. | Methods of generating glial and neuronal cells and use of same for the treatment of medical conditions of the cns |
| US8227247B2 (en) * | 2007-12-20 | 2012-07-24 | Wisconsin Alumni Research Foundation | Method of generating myelinating oligodendrocytes |
| WO2015124725A1 (en) | 2014-02-21 | 2015-08-27 | Johan Ericson | Late born central nervous system cell types |
| KR102585909B1 (ko) | 2014-05-22 | 2023-10-05 | 뉴욕 스템 셀 파운데이션, 인코포레이티드 | 다능성 줄기 세포로부터 유래된 기능성 희소돌기아교세포 및 이의 제조 및 사용 방법 |
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2015
- 2015-05-22 KR KR1020217036151A patent/KR102585909B1/ko active IP Right Grant
- 2015-05-22 CN CN201580033959.8A patent/CN106456672B/zh active Active
- 2015-05-22 JP JP2016568940A patent/JP6873705B2/ja active Active
- 2015-05-22 EP EP15796034.5A patent/EP3145517B1/en active Active
- 2015-05-22 AU AU2015263951A patent/AU2015263951B2/en active Active
- 2015-05-22 KR KR1020167034668A patent/KR102324714B1/ko active IP Right Grant
- 2015-05-22 US US15/313,079 patent/US10301592B2/en active Active
- 2015-05-22 PL PL15796034T patent/PL3145517T3/pl unknown
- 2015-05-22 ES ES15796034T patent/ES2846860T3/es active Active
- 2015-05-22 DK DK15796034.5T patent/DK3145517T3/da active
- 2015-05-22 WO PCT/US2015/032274 patent/WO2015179822A1/en active Application Filing
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2019
- 2019-05-06 US US16/404,502 patent/US10676716B2/en active Active
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2020
- 2020-06-03 US US16/892,181 patent/US11814648B2/en active Active
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- 2021-04-21 JP JP2021071974A patent/JP7410903B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP6873705B2 (ja) | 2021-05-19 |
| US20190256820A1 (en) | 2019-08-22 |
| US20200399595A1 (en) | 2020-12-24 |
| JP2017524340A (ja) | 2017-08-31 |
| JP7410903B2 (ja) | 2024-01-10 |
| US10676716B2 (en) | 2020-06-09 |
| US20170183627A1 (en) | 2017-06-29 |
| ES2846860T3 (es) | 2021-07-29 |
| KR102585909B1 (ko) | 2023-10-05 |
| AU2015263951A1 (en) | 2016-12-01 |
| AU2015263951B2 (en) | 2020-07-02 |
| KR20170005844A (ko) | 2017-01-16 |
| KR102324714B1 (ko) | 2021-11-11 |
| WO2015179822A1 (en) | 2015-11-26 |
| JP2021118718A (ja) | 2021-08-12 |
| US11814648B2 (en) | 2023-11-14 |
| EP3145517A1 (en) | 2017-03-29 |
| CN106456672B (zh) | 2020-03-13 |
| EP3145517B1 (en) | 2020-08-26 |
| CN106456672A (zh) | 2017-02-22 |
| KR20210138783A (ko) | 2021-11-19 |
| EP3145517A4 (en) | 2017-11-15 |
| PL3145517T3 (pl) | 2021-04-06 |
| US10301592B2 (en) | 2019-05-28 |
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