PL3145517T3 - Funkcjonalne oligodendrocyty pochodzące z pluripotencjalnych komórek macierzystych oraz sposoby ich otrzymywania i stosowania - Google Patents
Funkcjonalne oligodendrocyty pochodzące z pluripotencjalnych komórek macierzystych oraz sposoby ich otrzymywania i stosowaniaInfo
- Publication number
- PL3145517T3 PL3145517T3 PL15796034T PL15796034T PL3145517T3 PL 3145517 T3 PL3145517 T3 PL 3145517T3 PL 15796034 T PL15796034 T PL 15796034T PL 15796034 T PL15796034 T PL 15796034T PL 3145517 T3 PL3145517 T3 PL 3145517T3
- Authority
- PL
- Poland
- Prior art keywords
- making
- methods
- same
- stem cells
- pluripotent stem
- Prior art date
Links
- 210000004248 oligodendroglia Anatomy 0.000 title 1
- 210000001778 pluripotent stem cell Anatomy 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0622—Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/105—Insulin-like growth factors [IGF]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/12—Hepatocyte growth factor [HGF]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/135—Platelet-derived growth factor [PDGF]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases [EC 2.]
- C12N2501/727—Kinases (EC 2.7.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Developmental Biology & Embryology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Virology (AREA)
- Ophthalmology & Optometry (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462002048P | 2014-05-22 | 2014-05-22 | |
| EP15796034.5A EP3145517B1 (en) | 2014-05-22 | 2015-05-22 | Functional oligodendrocytes derived from pluripotent stem cells and methods of making and using the same |
| PCT/US2015/032274 WO2015179822A1 (en) | 2014-05-22 | 2015-05-22 | Functional oligodendrocytes derived from pluripotent stem cells and methods of making and using the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3145517T3 true PL3145517T3 (pl) | 2021-04-06 |
Family
ID=54554868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL15796034T PL3145517T3 (pl) | 2014-05-22 | 2015-05-22 | Funkcjonalne oligodendrocyty pochodzące z pluripotencjalnych komórek macierzystych oraz sposoby ich otrzymywania i stosowania |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US10301592B2 (pl) |
| EP (1) | EP3145517B1 (pl) |
| JP (2) | JP6873705B2 (pl) |
| KR (2) | KR102324714B1 (pl) |
| CN (1) | CN106456672B (pl) |
| AU (1) | AU2015263951B2 (pl) |
| DK (1) | DK3145517T3 (pl) |
| ES (1) | ES2846860T3 (pl) |
| PL (1) | PL3145517T3 (pl) |
| WO (1) | WO2015179822A1 (pl) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6873705B2 (ja) * | 2014-05-22 | 2021-05-19 | ニューヨーク ステム セル ファウンデーション インコーポレイテッド | 多能性幹細胞由来の機能性オリゴデンドロサイト、ならびにその作製方法及び使用方法 |
| CN105567642B (zh) * | 2016-02-01 | 2019-07-12 | 中国科学院生物物理研究所 | 一种着色性干皮病人多能干细胞的制备方法 |
| CN109219657A (zh) * | 2016-03-30 | 2019-01-15 | 阿斯特利亚斯生物治疗股份公司 | 少突胶质细胞祖细胞组合物 |
| BR112019021435A2 (pt) * | 2017-04-13 | 2020-05-05 | Univ Leland Stanford Junior | sistema de cultura neural 3d personalizado para gerar oligodendrócitos humanos e estudar mielinação in vitro |
| CA3069530A1 (en) * | 2017-07-13 | 2019-01-17 | Allele Biotechnology And Pharmaceuticals, Inc. | Induction of neural progenitor cells, oligodendrocyte progenitor cells, and oligodendrocytes by stem cell differentiation using landmark transcription factors |
| WO2019023793A1 (en) * | 2017-08-04 | 2019-02-07 | University Health Network | GENERATION OF OLIGODENDROGENIC NEURON PROGENITOR CELLS |
| CA3006897A1 (en) | 2017-08-04 | 2019-02-04 | University Health Network | Generation of oligodendrogenic neural progenitor cells |
| CN107858331B (zh) * | 2017-11-02 | 2021-01-15 | 北京全式金生物技术有限公司 | 一种诱导人多能性干细胞分化为脊髓运动神经前体细胞的方法 |
| US12031153B2 (en) | 2017-12-01 | 2024-07-09 | President And Fellows Of Harvard College | Methods and compositions for the production of oligodendrocyte progenitor cells |
| CN108384755A (zh) * | 2018-02-08 | 2018-08-10 | 北京呈诺医学科技有限公司 | 一种高效、快捷的诱导性多能干细胞向神经干细胞分化的方法 |
| CN112469818A (zh) * | 2018-04-17 | 2021-03-09 | 凯斯西储大学 | 人皮层球体中髓鞘少突胶质细胞的诱导 |
| CN108624560B (zh) * | 2018-06-01 | 2022-04-08 | 南京艾尔普再生医学科技有限公司 | 一种分化培养基及少突胶质前体细胞的制备方法 |
| US12553028B2 (en) | 2018-06-14 | 2026-02-17 | Academia Sinica | Method to generate induced oligodendrocyte-lineage cells and treatment using such cells |
| IL281628B2 (en) | 2018-09-19 | 2025-06-01 | Lineage Cell Therapeutics Inc | Methods for differentiating pluripotent stem cells in dynamic suspension culture |
| EP3660145A1 (en) * | 2018-11-30 | 2020-06-03 | Assistance Publique, Hopitaux De Paris | Use of oligodendrocytes from oral neuroectodermal stem cells in the repair of the nervous system |
| US11603518B2 (en) | 2019-01-23 | 2023-03-14 | Asterias Biotherapeutics, Inc. | Dorsally-derived oligodendrocyte progenitor cells from human pluripotent stem cells |
| WO2020243618A1 (en) * | 2019-05-29 | 2020-12-03 | New York Stem Cell Foundation, Inc. | Functional astrocytes derived from pluripotent stem cells and methods of making and using the same |
| SG11202113095PA (en) * | 2019-05-31 | 2021-12-30 | Harvard College | Sox9-induced oligodendrocyte progenitor cells |
| JP7728747B2 (ja) | 2019-08-23 | 2025-08-25 | サナ バイオテクノロジー，インコーポレイテッド | Ｃｄ２４発現細胞およびそれらの用途 |
| CA3152504A1 (en) * | 2019-09-06 | 2021-03-11 | Keio University | Method for producing cell aggregate including glial progenitor cells |
| CN110716595A (zh) * | 2019-09-11 | 2020-01-21 | 合肥众建翔新能源有限公司 | 一种基于新能源的养殖系统 |
| BR112022019060A2 (pt) | 2020-03-25 | 2022-11-29 | Sana Biotechnology Inc | Células neurais hipoimunogênicas para o tratamento de distúrbios e condições neurológicas |
| KR102657342B1 (ko) * | 2020-05-20 | 2024-04-15 | 고려대학교 산학협력단 | 희소돌기아교세포로 분화가 특화된 신경줄기세포로부터 희소돌기아교세포를 포함하는 오가노이드의 제조방법, 상기 방법으로 제조된 오가노이드 및 이의 용도 |
| IL300516A (en) | 2020-08-13 | 2023-04-01 | Sana Biotechnology Inc | Methods for treating susceptible patients with hypoimmunogenic cells, and related methods and compounds |
| KR102568532B1 (ko) * | 2021-01-13 | 2023-08-18 | 건국대학교 산학협력단 | 3차원 배양을 통한 신경줄기세포 제조 방법 |
| AU2022247250A1 (en) | 2021-03-30 | 2023-11-09 | Trailhead Biosystems Inc. | Methods and compositions for generating oligodendrocyte progenitor cells |
| BR112023024434A2 (pt) | 2021-05-27 | 2024-02-20 | Sana Biotechnology Inc | Células hipoimunogênicas que compreendem hla-e ou hla-g geneticamente modificadas |
| EP4370544A2 (en) | 2021-07-14 | 2024-05-22 | Sana Biotechnology, Inc. | Altered expression of y chromosome-linked antigens in hypoimmunogenic cells |
| CN113564122B (zh) * | 2021-08-05 | 2022-04-08 | 呈诺再生医学科技(珠海横琴新区)有限公司 | 人诱导性多能干细胞向少突胶质细胞分化的方法，试剂盒以及应用 |
| AU2022325955A1 (en) | 2021-08-11 | 2024-02-08 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy to reduce instant blood mediated inflammatory reactions |
| MX2024001443A (es) | 2021-08-11 | 2024-05-15 | Sana Biotechnology Inc | Sistemas inducibles para alterar la expresión génica en células hipoinmunógenas. |
| WO2023019226A1 (en) | 2021-08-11 | 2023-02-16 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy |
| JP2024534771A (ja) | 2021-08-11 | 2024-09-26 | サナ バイオテクノロジー，インコーポレイテッド | 補体媒介性炎症反応を低減するための同種異系細胞療法のための遺伝子改変細胞 |
| CN113699117B (zh) * | 2021-09-03 | 2023-06-30 | 呈诺再生医学科技(北京)有限公司 | 经基因改造的少突胶质祖细胞在多发性硬化症中的应用 |
| CN114262686B (zh) * | 2022-03-02 | 2022-06-24 | 深圳市夏同生物医药科技有限公司 | 一种少突胶质细胞的制备方法及应用 |
| WO2023183313A1 (en) | 2022-03-22 | 2023-09-28 | Sana Biotechnology, Inc. | Engineering cells with a transgene in b2m or ciita locus and associated compositions and methods |
| KR102898110B1 (ko) * | 2022-06-13 | 2025-12-12 | 고려대학교 산학협력단 | 키나아제 저해제를 유효성분으로 포함하는 탈수초성 질환 예방 또는 치료용 약학적 조성물 |
| IL318362A (en) * | 2022-08-08 | 2025-03-01 | Trailhead Biosystems Inc | Methods and compositions for producing oligodendrocyte progenitor cells |
| JP2025529816A (ja) * | 2022-08-15 | 2025-09-09 | セリーノ バイオテック， インコーポレイテッド | 細胞を製造するめのシステム及び方法 |
| CN115322965B (zh) * | 2022-08-19 | 2024-01-30 | 同济大学 | 一种体外获得后脑底板细胞的方法、成套培养基及应用 |
| WO2025054202A1 (en) | 2023-09-05 | 2025-03-13 | Sana Biotechnology, Inc. | Method of screening a sample comprising a transgene with a unique barcode |
| WO2025151838A1 (en) | 2024-01-12 | 2025-07-17 | Sana Biotechnology, Inc. | Safety switches to control in vitro and in vivo proliferation of cell therapy products |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20050094400A (ko) * | 2002-12-06 | 2005-09-27 | 싱가포르 제너럴 하스피털 피티이 엘티디. | 중추신경계에 대한 손상 및 질병 치료에 유용한 ｎｏｇｏ,ｃａｓｐｒ, ｆ３, ｎｂ３ |
| EP2064319B1 (en) * | 2006-08-28 | 2017-02-22 | Yeda Research and Development Co. Ltd. | Methods of generating glial and neuronal cells and use of same for the treatment of medical conditions of the cns |
| US8227247B2 (en) * | 2007-12-20 | 2012-07-24 | Wisconsin Alumni Research Foundation | Method of generating myelinating oligodendrocytes |
| WO2015124725A1 (en) * | 2014-02-21 | 2015-08-27 | Johan Ericson | Late born central nervous system cell types |
| JP6873705B2 (ja) | 2014-05-22 | 2021-05-19 | ニューヨーク ステム セル ファウンデーション インコーポレイテッド | 多能性幹細胞由来の機能性オリゴデンドロサイト、ならびにその作製方法及び使用方法 |
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2015
- 2015-05-22 JP JP2016568940A patent/JP6873705B2/ja active Active
- 2015-05-22 US US15/313,079 patent/US10301592B2/en active Active
- 2015-05-22 KR KR1020167034668A patent/KR102324714B1/ko active Active
- 2015-05-22 ES ES15796034T patent/ES2846860T3/es active Active
- 2015-05-22 AU AU2015263951A patent/AU2015263951B2/en active Active
- 2015-05-22 KR KR1020217036151A patent/KR102585909B1/ko active Active
- 2015-05-22 PL PL15796034T patent/PL3145517T3/pl unknown
- 2015-05-22 WO PCT/US2015/032274 patent/WO2015179822A1/en not_active Ceased
- 2015-05-22 DK DK15796034.5T patent/DK3145517T3/da active
- 2015-05-22 CN CN201580033959.8A patent/CN106456672B/zh active Active
- 2015-05-22 EP EP15796034.5A patent/EP3145517B1/en active Active
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2019
- 2019-05-06 US US16/404,502 patent/US10676716B2/en active Active
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2020
- 2020-06-03 US US16/892,181 patent/US11814648B2/en active Active
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2021
- 2021-04-21 JP JP2021071974A patent/JP7410903B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US10301592B2 (en) | 2019-05-28 |
| US20190256820A1 (en) | 2019-08-22 |
| JP7410903B2 (ja) | 2024-01-10 |
| US10676716B2 (en) | 2020-06-09 |
| US20200399595A1 (en) | 2020-12-24 |
| EP3145517B1 (en) | 2020-08-26 |
| US20170183627A1 (en) | 2017-06-29 |
| AU2015263951B2 (en) | 2020-07-02 |
| KR102324714B1 (ko) | 2021-11-11 |
| JP2021118718A (ja) | 2021-08-12 |
| CN106456672B (zh) | 2020-03-13 |
| CN106456672A (zh) | 2017-02-22 |
| AU2015263951A1 (en) | 2016-12-01 |
| JP6873705B2 (ja) | 2021-05-19 |
| ES2846860T3 (es) | 2021-07-29 |
| EP3145517A4 (en) | 2017-11-15 |
| DK3145517T3 (da) | 2020-11-30 |
| KR20170005844A (ko) | 2017-01-16 |
| KR102585909B1 (ko) | 2023-10-05 |
| EP3145517A1 (en) | 2017-03-29 |
| JP2017524340A (ja) | 2017-08-31 |
| WO2015179822A1 (en) | 2015-11-26 |
| KR20210138783A (ko) | 2021-11-19 |
| US11814648B2 (en) | 2023-11-14 |
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