PL3145517T3 - Funkcjonalne oligodendrocyty pochodzące z pluripotencjalnych komórek macierzystych oraz sposoby ich otrzymywania i stosowania - Google Patents
Funkcjonalne oligodendrocyty pochodzące z pluripotencjalnych komórek macierzystych oraz sposoby ich otrzymywania i stosowaniaInfo
- Publication number
- PL3145517T3 PL3145517T3 PL15796034T PL15796034T PL3145517T3 PL 3145517 T3 PL3145517 T3 PL 3145517T3 PL 15796034 T PL15796034 T PL 15796034T PL 15796034 T PL15796034 T PL 15796034T PL 3145517 T3 PL3145517 T3 PL 3145517T3
- Authority
- PL
- Poland
- Prior art keywords
- making
- methods
- same
- stem cells
- pluripotent stem
- Prior art date
Links
- 210000004248 oligodendroglia Anatomy 0.000 title 1
- 210000001778 pluripotent stem cell Anatomy 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0622—Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/105—Insulin-like growth factors [IGF]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/12—Hepatocyte growth factor [HGF]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/135—Platelet-derived growth factor [PDGF]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases [EC 2.]
- C12N2501/727—Kinases (EC 2.7.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Developmental Biology & Embryology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Virology (AREA)
- Ophthalmology & Optometry (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462002048P | 2014-05-22 | 2014-05-22 | |
| EP15796034.5A EP3145517B1 (en) | 2014-05-22 | 2015-05-22 | Functional oligodendrocytes derived from pluripotent stem cells and methods of making and using the same |
| PCT/US2015/032274 WO2015179822A1 (en) | 2014-05-22 | 2015-05-22 | Functional oligodendrocytes derived from pluripotent stem cells and methods of making and using the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3145517T3 true PL3145517T3 (pl) | 2021-04-06 |
Family
ID=54554868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL15796034T PL3145517T3 (pl) | 2014-05-22 | 2015-05-22 | Funkcjonalne oligodendrocyty pochodzące z pluripotencjalnych komórek macierzystych oraz sposoby ich otrzymywania i stosowania |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US10301592B2 (pl) |
| EP (1) | EP3145517B1 (pl) |
| JP (2) | JP6873705B2 (pl) |
| KR (2) | KR102324714B1 (pl) |
| CN (1) | CN106456672B (pl) |
| AU (1) | AU2015263951B2 (pl) |
| DK (1) | DK3145517T3 (pl) |
| ES (1) | ES2846860T3 (pl) |
| PL (1) | PL3145517T3 (pl) |
| WO (1) | WO2015179822A1 (pl) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106456672B (zh) * | 2014-05-22 | 2020-03-13 | 纽约干细胞基金会有限公司 | 源于多能干细胞的功能性少突胶质细胞及其制备和使用方法 |
| CN105567642B (zh) * | 2016-02-01 | 2019-07-12 | 中国科学院生物物理研究所 | 一种着色性干皮病人多能干细胞的制备方法 |
| AU2017240591B2 (en) * | 2016-03-30 | 2023-08-24 | Asterias Biotherapeutics, Inc. | Oligodendrocyte progenitor cell compositions |
| SG11201909501TA (en) * | 2017-04-13 | 2019-11-28 | Univ Leland Stanford Junior | Personalized 3d neural culture system for generating human oligodendrocytes and studying myelination in vitro |
| CA3069530A1 (en) * | 2017-07-13 | 2019-01-17 | Allele Biotechnology And Pharmaceuticals, Inc. | Induction of neural progenitor cells, oligodendrocyte progenitor cells, and oligodendrocytes by stem cell differentiation using landmark transcription factors |
| CA3006897A1 (en) | 2017-08-04 | 2019-02-04 | University Health Network | Generation of oligodendrogenic neural progenitor cells |
| WO2019023793A1 (en) * | 2017-08-04 | 2019-02-07 | University Health Network | GENERATION OF OLIGODENDROGENIC NEURON PROGENITOR CELLS |
| CN107858331B (zh) * | 2017-11-02 | 2021-01-15 | 北京全式金生物技术有限公司 | 一种诱导人多能性干细胞分化为脊髓运动神经前体细胞的方法 |
| WO2019108894A1 (en) | 2017-12-01 | 2019-06-06 | President And Fellows Of Harvard College | Methods and compositions for the production of oligodendrocyte progenitor cells |
| CN108384755A (zh) * | 2018-02-08 | 2018-08-10 | 北京呈诺医学科技有限公司 | 一种高效、快捷的诱导性多能干细胞向神经干细胞分化的方法 |
| CN112469818A (zh) * | 2018-04-17 | 2021-03-09 | 凯斯西储大学 | 人皮层球体中髓鞘少突胶质细胞的诱导 |
| CN108624560B (zh) * | 2018-06-01 | 2022-04-08 | 南京艾尔普再生医学科技有限公司 | 一种分化培养基及少突胶质前体细胞的制备方法 |
| TWI833764B (zh) * | 2018-06-14 | 2024-03-01 | 中央研究院 | 產生誘導式少突膠質譜系細胞之方法及使用該等細胞的治療 |
| CN113646422B (zh) | 2018-09-19 | 2025-03-11 | 谱系细胞疗法股份有限公司 | 用于在动态悬浮培养中分化多能干细胞的方法 |
| EP3660145A1 (en) * | 2018-11-30 | 2020-06-03 | Assistance Publique, Hopitaux De Paris | Use of oligodendrocytes from oral neuroectodermal stem cells in the repair of the nervous system |
| CN120060141A (zh) | 2019-01-23 | 2025-05-30 | 阿斯特里亚斯生物疗法股份有限公司 | 来自人多能干细胞的背源性少突胶质祖细胞 |
| WO2020243618A1 (en) * | 2019-05-29 | 2020-12-03 | New York Stem Cell Foundation, Inc. | Functional astrocytes derived from pluripotent stem cells and methods of making and using the same |
| CN114466933B (zh) * | 2019-05-31 | 2024-08-02 | 哈佛学院院长及董事 | Sox9-诱导的少突胶质细胞祖细胞 |
| WO2021041316A1 (en) | 2019-08-23 | 2021-03-04 | Sana Biotechnology, Inc. | Cd24 expressing cells and uses thereof |
| CN114375328B (zh) * | 2019-09-06 | 2024-12-27 | 学校法人庆应义塾 | 包含胶质前体细胞的细胞聚集体的制备方法 |
| CN110716595A (zh) * | 2019-09-11 | 2020-01-21 | 合肥众建翔新能源有限公司 | 一种基于新能源的养殖系统 |
| IL296665A (en) | 2020-03-25 | 2022-11-01 | Sana Biotechnology Inc | Hypoimmune neural cells for the treatment of disorders and conditions of the nervous system |
| WO2021235848A1 (ko) * | 2020-05-20 | 2021-11-25 | 고려대학교 산학협력단 | 희소돌기아교세포로 분화가 특화된 신경줄기세포로부터 희소돌기아교세포를 포함하는 오가노이드의 제조방법, 상기 방법으로 제조된 오가노이드 및 이의 용도 |
| US20220049226A1 (en) | 2020-08-13 | 2022-02-17 | Sana Biotechnology, Inc. | Methods of treating sensitized patients with hypoimmunogenic cells, and associated methods and compositions |
| KR102568532B1 (ko) * | 2021-01-13 | 2023-08-18 | 건국대학교 산학협력단 | 3차원 배양을 통한 신경줄기세포 제조 방법 |
| IL305671A (en) | 2021-03-30 | 2023-11-01 | Trailhead Biosystems Inc | Methods and preparations for the production of oligodendrocyte progenitor cells |
| KR20240013135A (ko) | 2021-05-27 | 2024-01-30 | 사나 바이오테크놀로지, 인크. | 조작된 hla-e 또는 hla-g를 포함하는 저면역원성 세포 |
| KR20240046319A (ko) | 2021-07-14 | 2024-04-08 | 사나 바이오테크놀로지, 인크. | 저면역원성 세포에서의 y 염색체-연결 항원의 변경된 발현 |
| CN113564122B (zh) * | 2021-08-05 | 2022-04-08 | 呈诺再生医学科技(珠海横琴新区)有限公司 | 人诱导性多能干细胞向少突胶质细胞分化的方法，试剂盒以及应用 |
| EP4384544A1 (en) | 2021-08-11 | 2024-06-19 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy |
| AU2022325955A1 (en) | 2021-08-11 | 2024-02-08 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy to reduce instant blood mediated inflammatory reactions |
| US20260053851A1 (en) | 2021-08-11 | 2026-02-26 | Sana Biotechnology, Inc. | Inducible systems for altering gene expression in hypoimmunogenic cells |
| US20240425820A1 (en) | 2021-08-11 | 2024-12-26 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy to reduce complement-mediated inflammatory reactions |
| CN113699117B (zh) * | 2021-09-03 | 2023-06-30 | 呈诺再生医学科技(北京)有限公司 | 经基因改造的少突胶质祖细胞在多发性硬化症中的应用 |
| CN114262686B (zh) * | 2022-03-02 | 2022-06-24 | 深圳市夏同生物医药科技有限公司 | 一种少突胶质细胞的制备方法及应用 |
| WO2023183313A1 (en) | 2022-03-22 | 2023-09-28 | Sana Biotechnology, Inc. | Engineering cells with a transgene in b2m or ciita locus and associated compositions and methods |
| KR102898110B1 (ko) * | 2022-06-13 | 2025-12-12 | 고려대학교 산학협력단 | 키나아제 저해제를 유효성분으로 포함하는 탈수초성 질환 예방 또는 치료용 약학적 조성물 |
| IL318362A (en) * | 2022-08-08 | 2025-03-01 | Trailhead Biosystems Inc | Methods and compositions for producing oligodendrocyte progenitor cells |
| US20240052321A1 (en) * | 2022-08-15 | 2024-02-15 | Cellino Biotech, Inc. | Systems and methods for cell manufacturing |
| CN115322965B (zh) * | 2022-08-19 | 2024-01-30 | 同济大学 | 一种体外获得后脑底板细胞的方法、成套培养基及应用 |
| WO2025054202A1 (en) | 2023-09-05 | 2025-03-13 | Sana Biotechnology, Inc. | Method of screening a sample comprising a transgene with a unique barcode |
| US20250230470A1 (en) | 2024-01-12 | 2025-07-17 | Sana Biotechnology, Inc. | Safety switches to control in vitro and in vivo proliferation of cell therapy products |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG169231A1 (en) * | 2002-12-06 | 2011-03-30 | Singapore General Hospital Pte Ltd | Nogo, caspr, f3 nb-3 useful in the treatment of injury and disease to the central nervous system |
| US8809052B2 (en) * | 2006-08-28 | 2014-08-19 | Yeda Research And Development Co. Ltd. | Methods of generating mature oligodendrocytes |
| US8227247B2 (en) | 2007-12-20 | 2012-07-24 | Wisconsin Alumni Research Foundation | Method of generating myelinating oligodendrocytes |
| WO2015124725A1 (en) | 2014-02-21 | 2015-08-27 | Johan Ericson | Late born central nervous system cell types |
| CN106456672B (zh) * | 2014-05-22 | 2020-03-13 | 纽约干细胞基金会有限公司 | 源于多能干细胞的功能性少突胶质细胞及其制备和使用方法 |
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2015
- 2015-05-22 CN CN201580033959.8A patent/CN106456672B/zh active Active
- 2015-05-22 DK DK15796034.5T patent/DK3145517T3/da active
- 2015-05-22 AU AU2015263951A patent/AU2015263951B2/en active Active
- 2015-05-22 WO PCT/US2015/032274 patent/WO2015179822A1/en not_active Ceased
- 2015-05-22 PL PL15796034T patent/PL3145517T3/pl unknown
- 2015-05-22 EP EP15796034.5A patent/EP3145517B1/en active Active
- 2015-05-22 US US15/313,079 patent/US10301592B2/en active Active
- 2015-05-22 ES ES15796034T patent/ES2846860T3/es active Active
- 2015-05-22 JP JP2016568940A patent/JP6873705B2/ja active Active
- 2015-05-22 KR KR1020167034668A patent/KR102324714B1/ko active Active
- 2015-05-22 KR KR1020217036151A patent/KR102585909B1/ko active Active
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2019
- 2019-05-06 US US16/404,502 patent/US10676716B2/en active Active
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2020
- 2020-06-03 US US16/892,181 patent/US11814648B2/en active Active
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2021
- 2021-04-21 JP JP2021071974A patent/JP7410903B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2021118718A (ja) | 2021-08-12 |
| JP7410903B2 (ja) | 2024-01-10 |
| US10301592B2 (en) | 2019-05-28 |
| KR20210138783A (ko) | 2021-11-19 |
| JP2017524340A (ja) | 2017-08-31 |
| EP3145517B1 (en) | 2020-08-26 |
| DK3145517T3 (da) | 2020-11-30 |
| KR102324714B1 (ko) | 2021-11-11 |
| AU2015263951A1 (en) | 2016-12-01 |
| ES2846860T3 (es) | 2021-07-29 |
| AU2015263951B2 (en) | 2020-07-02 |
| US20200399595A1 (en) | 2020-12-24 |
| KR102585909B1 (ko) | 2023-10-05 |
| US10676716B2 (en) | 2020-06-09 |
| KR20170005844A (ko) | 2017-01-16 |
| US20170183627A1 (en) | 2017-06-29 |
| CN106456672B (zh) | 2020-03-13 |
| US20190256820A1 (en) | 2019-08-22 |
| JP6873705B2 (ja) | 2021-05-19 |
| US11814648B2 (en) | 2023-11-14 |
| EP3145517A4 (en) | 2017-11-15 |
| CN106456672A (zh) | 2017-02-22 |
| WO2015179822A1 (en) | 2015-11-26 |
| EP3145517A1 (en) | 2017-03-29 |
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