IL249193A0 - Feeder-free derivation of human-induced pluripotent stem cells with synthetic messenger rna - Google Patents
Feeder-free derivation of human-induced pluripotent stem cells with synthetic messenger rnaInfo
- Publication number
- IL249193A0 IL249193A0 IL249193A IL24919316A IL249193A0 IL 249193 A0 IL249193 A0 IL 249193A0 IL 249193 A IL249193 A IL 249193A IL 24919316 A IL24919316 A IL 24919316A IL 249193 A0 IL249193 A0 IL 249193A0
- Authority
- IL
- Israel
- Prior art keywords
- feeder
- human
- stem cells
- pluripotent stem
- messenger rna
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
- A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/98—Xeno-free medium and culture conditions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/602—Sox-2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/603—Oct-3/4
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/604—Klf-4
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/605—Nanog
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
- C12N2506/1307—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from adult fibroblasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14/292,317 US10119150B2 (en) | 2012-05-13 | 2014-05-30 | Feeder-free Derivation of human-induced pluripotent stem cells with synthetic messenger RNA |
PCT/US2015/033275 WO2015184318A1 (en) | 2014-05-30 | 2015-05-29 | Feeder-free derivation of human-induced pluripotent stem cells with synthetic messenger rna |
Publications (2)
Publication Number | Publication Date |
---|---|
IL249193A0 true IL249193A0 (en) | 2017-01-31 |
IL249193B IL249193B (en) | 2020-05-31 |
Family
ID=54699891
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL249193A IL249193B (en) | 2014-05-30 | 2016-11-24 | Feeder-free derivation of human-induced pluripotent stem cells with synthetic messenger rna |
Country Status (7)
Country | Link |
---|---|
KR (1) | KR102361849B1 (en) |
CA (1) | CA2950582C (en) |
IL (1) | IL249193B (en) |
PH (1) | PH12016502343A1 (en) |
SG (1) | SG11201609898WA (en) |
TW (1) | TWI698526B (en) |
WO (1) | WO2015184318A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109913494A (en) * | 2019-02-12 | 2019-06-21 | 北京呈诺医学科技有限公司 | A kind of abductive approach of new ips cell |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010108126A2 (en) * | 2009-03-19 | 2010-09-23 | Fate Therapeutics, Inc. | Reprogramming compositions and methods of using the same |
WO2012012708A1 (en) * | 2010-07-22 | 2012-01-26 | Regents Of The University Of Minnesota | Induced pluripotent stem cells |
CA2864702A1 (en) * | 2012-02-22 | 2013-08-29 | Amgen Inc. | Autologous mammalian models derived from induced pluripotent stem cells and related methods |
US10155929B2 (en) * | 2012-05-13 | 2018-12-18 | Allele Biotechnology & Pharmaceuticals, Inc. | Feeder-free derivation of human-induced pluripotent stem cells with synthetic messenger RNA |
-
2015
- 2015-05-29 KR KR1020167036491A patent/KR102361849B1/en active IP Right Grant
- 2015-05-29 SG SG11201609898WA patent/SG11201609898WA/en unknown
- 2015-05-29 WO PCT/US2015/033275 patent/WO2015184318A1/en active Application Filing
- 2015-05-29 CA CA2950582A patent/CA2950582C/en active Active
- 2015-05-29 TW TW104117573A patent/TWI698526B/en active
-
2016
- 2016-11-24 IL IL249193A patent/IL249193B/en active IP Right Grant
- 2016-11-25 PH PH12016502343A patent/PH12016502343A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
TWI698526B (en) | 2020-07-11 |
IL249193B (en) | 2020-05-31 |
TW201600605A (en) | 2016-01-01 |
PH12016502343A1 (en) | 2017-02-13 |
CA2950582C (en) | 2020-09-22 |
SG11201609898WA (en) | 2016-12-29 |
CA2950582A1 (en) | 2015-12-03 |
WO2015184318A1 (en) | 2015-12-03 |
KR102361849B1 (en) | 2022-02-11 |
KR20170023014A (en) | 2017-03-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1224335A1 (en) | Feeder-free derivation of human-induced pluripotent stem cells with synthetic messenger rna rna | |
SG11201801549VA (en) | Pluripotent stem cell production system | |
IL250689B (en) | Resetting pluripotent stem cells | |
IL250340A0 (en) | Media for culturing pluripotent stem cells | |
EP3334820A4 (en) | Induced extended pluripotent stem cells, methods of making and using | |
EP3510145A4 (en) | Immune cells derived from induced pluripotent stem cell | |
PL3145517T3 (en) | Functional oligodendrocytes derived from pluripotent stem cells and methods of making and using the same | |
SG11201701844YA (en) | Methods of differentiating stem cells into liver cell lineages | |
ZA201704868B (en) | Suspension culturing of pluripotent stem cells | |
HK1204005A1 (en) | Feeder-free derivation of human-induced pluripotent stem cells with synthetic messenger rna rna | |
EP3198004A4 (en) | TGFß SIGNALING INDEPENDENT NAÏVE INDUCED PLURIPOTENT STEM CELLS, METHODS OF MAKING AND USE | |
HK1231553A1 (en) | Identification of functional cell states | |
IL249813A0 (en) | New undifferentiated stem cell removal and myocardial purification and refinement culture medium | |
HK1249862A1 (en) | Pluripotent stem cell migration promoter | |
IL247890A0 (en) | Methods relating to pluripotent cells | |
EP3194573A4 (en) | Mammalian pluripotent stem cells, methods for their production, and uses thereof | |
IL249193B (en) | Feeder-free derivation of human-induced pluripotent stem cells with synthetic messenger rna | |
SG11201703600YA (en) | Method of distinguishing mesenchymal stem cells | |
EP3008174A4 (en) | Method of efficiently establishing induced pluripotent stem cells | |
GB201408753D0 (en) | Isolation of adipose derived cells | |
IL250293A0 (en) | Method for preparing induced pluripotent stem cell line from mesenchymal stem cells, and cell line obtained thereby | |
KR101737796B9 (en) | Feeder-free culture system for human pluripotent stem cells | |
SG11201609269TA (en) | Method of culturing cells | |
HK1252554A1 (en) | Pluripotent stem cell production system | |
SG10201403640XA (en) | Stem cells |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed |