IL249193A0 - גזירת תאי גזע רב-פוטנציאליים מושרי-אנוש עם רנ" א שליח סינטתי ללא מזין - Google Patents

גזירת תאי גזע רב-פוטנציאליים מושרי-אנוש עם רנ" א שליח סינטתי ללא מזין

Info

Publication number
IL249193A0
IL249193A0 IL249193A IL24919316A IL249193A0 IL 249193 A0 IL249193 A0 IL 249193A0 IL 249193 A IL249193 A IL 249193A IL 24919316 A IL24919316 A IL 24919316A IL 249193 A0 IL249193 A0 IL 249193A0
Authority
IL
Israel
Prior art keywords
feeder
human
stem cells
pluripotent stem
messenger rna
Prior art date
Application number
IL249193A
Other languages
English (en)
Other versions
IL249193B (he
Original Assignee
Allele Biotechnology & Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/292,317 external-priority patent/US10119150B2/en
Application filed by Allele Biotechnology & Pharmaceuticals Inc filed Critical Allele Biotechnology & Pharmaceuticals Inc
Publication of IL249193A0 publication Critical patent/IL249193A0/he
Publication of IL249193B publication Critical patent/IL249193B/he

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/98—Xeno-free medium and culture conditions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/602—Sox-2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/603—Oct-3/4
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/604—Klf-4
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/605—Nanog
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1307—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from adult fibroblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
IL249193A 2014-05-30 2016-11-24 גזירת תאי גזע רב–פוטנציאליים מושרי–אנוש עם רנ" א שליח סינטתי ללא מזין IL249193B (he)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14/292,317 US10119150B2 (en) 2012-05-13 2014-05-30 Feeder-free Derivation of human-induced pluripotent stem cells with synthetic messenger RNA
PCT/US2015/033275 WO2015184318A1 (en) 2014-05-30 2015-05-29 Feeder-free derivation of human-induced pluripotent stem cells with synthetic messenger rna

Publications (2)

Publication Number Publication Date
IL249193A0 true IL249193A0 (he) 2017-01-31
IL249193B IL249193B (he) 2020-05-31

Family

ID=54699891

Family Applications (1)

Application Number Title Priority Date Filing Date
IL249193A IL249193B (he) 2014-05-30 2016-11-24 גזירת תאי גזע רב–פוטנציאליים מושרי–אנוש עם רנ" א שליח סינטתי ללא מזין

Country Status (7)

Country Link
KR (1) KR102361849B1 (he)
CA (1) CA2950582C (he)
IL (1) IL249193B (he)
PH (1) PH12016502343A1 (he)
SG (1) SG11201609898WA (he)
TW (1) TWI698526B (he)
WO (1) WO2015184318A1 (he)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109913494A (zh) * 2019-02-12 2019-06-21 北京呈诺医学科技有限公司 一种新的ips细胞的诱导方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120207744A1 (en) * 2009-03-19 2012-08-16 Mendlein John D Reprogramming compositions and methods of using the same
US9580689B2 (en) * 2010-07-22 2017-02-28 Regents Of The University Of Minnesota Induced pluripotent stem cells
AU2013222188A1 (en) * 2012-02-22 2014-09-11 Amgen Inc. Autologous mammalian models derived from induced pluripotent stem cells and related methods
US10155929B2 (en) * 2012-05-13 2018-12-18 Allele Biotechnology & Pharmaceuticals, Inc. Feeder-free derivation of human-induced pluripotent stem cells with synthetic messenger RNA

Also Published As

Publication number Publication date
CA2950582A1 (en) 2015-12-03
TW201600605A (zh) 2016-01-01
CA2950582C (en) 2020-09-22
KR102361849B1 (ko) 2022-02-11
KR20170023014A (ko) 2017-03-02
SG11201609898WA (en) 2016-12-29
WO2015184318A1 (en) 2015-12-03
PH12016502343A1 (en) 2017-02-13
TWI698526B (zh) 2020-07-11
IL249193B (he) 2020-05-31

Similar Documents

Publication Publication Date Title
HK1224335A1 (zh) 使用合成信使 無飼養層衍生人誘導多能幹細胞
SG11201801549VA (en) Pluripotent stem cell production system
IL250689B (he) סידור מחדש של תאי גזע רב–תכליתיים
IL250340A0 (he) מצעי גידול לתרבות של תאי גזע פלוריפוטנטים
EP3510145A4 (en) IMMUNCELLS FROM INDUCED PLURIPOTENT STEM CELLS
EP3334820A4 (en) Induced extended pluripotent stem cells, methods of making and using
PL3145517T3 (pl) Funkcjonalne oligodendrocyty pochodzące z pluripotencjalnych komórek macierzystych oraz sposoby ich otrzymywania i stosowania
SG11201701844YA (en) Methods of differentiating stem cells into liver cell lineages
ZA201704868B (en) Suspension culturing of pluripotent stem cells
HK1204005A1 (en) Feeder-free derivation of human-induced pluripotent stem cells with synthetic messenger rna rna
EP3198004A4 (en) TGFß SIGNALING INDEPENDENT NAÏVE INDUCED PLURIPOTENT STEM CELLS, METHODS OF MAKING AND USE
EP3384007C0 (en) IMPROVED METHODS FOR REPROGRAMMING NON-PLURIPOTENT CELLS INTO PLURIPOTENT STEM CELLS
HK1231553A1 (zh) 功能性細胞狀態的鑒定
IL249813A0 (he) מצע גידול חדש להסרת תאי גזע שלא עברו התמיינות ולטיהור וזיקוק רקמת שריר לב
HK1249862A1 (zh) 多能性幹細胞遷移促進劑
IL247890A0 (he) שיטות קשורות לתאי גזע
EP3194573A4 (en) Mammalian pluripotent stem cells, methods for their production, and uses thereof
SG11201703600YA (en) Method of distinguishing mesenchymal stem cells
IL249193B (he) גזירת תאי גזע רב–פוטנציאליים מושרי–אנוש עם רנ" א שליח סינטתי ללא מזין
HK1252554A1 (zh) 多能性幹細胞製造系統
EP3008174A4 (en) Method of efficiently establishing induced pluripotent stem cells
GB201408753D0 (en) Isolation of adipose derived cells
IL250293A0 (he) שיטה להכנת תא גזע פלוריפוטנטי מושרה מתא גזע מזנכימאלי ושורת תאים המוכנת בשיטה זו
KR101737796B9 (ko) 피더 비의존적 인간 전분화능줄기세포 배양방법
SG11201609269TA (en) Method of culturing cells

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed