DK2970903T3 - Fotoreceptorer og fotoreceptor-progenitorer fremstillet fra pluripotente stamceller - Google Patents
Fotoreceptorer og fotoreceptor-progenitorer fremstillet fra pluripotente stamceller Download PDFInfo
- Publication number
- DK2970903T3 DK2970903T3 DK14764825.7T DK14764825T DK2970903T3 DK 2970903 T3 DK2970903 T3 DK 2970903T3 DK 14764825 T DK14764825 T DK 14764825T DK 2970903 T3 DK2970903 T3 DK 2970903T3
- Authority
- DK
- Denmark
- Prior art keywords
- photoreceptors
- stem cells
- pluripotent stem
- photoreceptor progenitors
- progenitors produced
- Prior art date
Links
- 108091008695 photoreceptors Proteins 0.000 title 2
- 210000001778 pluripotent stem cell Anatomy 0.000 title 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/062—Sensory transducers, e.g. photoreceptors; Sensory neurons, e.g. for hearing, taste, smell, pH, touch, temperature, pain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
- A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0623—Stem cells
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
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- C12N2501/10—Growth factors
- C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/235—Leukemia inhibitory factor [LIF]
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/33—Insulin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Developmental Biology & Embryology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Ophthalmology & Optometry (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Gynecology & Obstetrics (AREA)
- Immunology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Acoustics & Sound (AREA)
- Physics & Mathematics (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361793168P | 2013-03-15 | 2013-03-15 | |
PCT/US2014/029790 WO2014145108A1 (en) | 2013-03-15 | 2014-03-14 | Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2970903T3 true DK2970903T3 (da) | 2024-02-19 |
Family
ID=51537881
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK14764825.7T DK2970903T3 (da) | 2013-03-15 | 2014-03-14 | Fotoreceptorer og fotoreceptor-progenitorer fremstillet fra pluripotente stamceller |
Country Status (13)
Country | Link |
---|---|
US (5) | US10307444B2 (da) |
EP (2) | EP4292600A3 (da) |
JP (4) | JP6581966B2 (da) |
KR (3) | KR102527507B1 (da) |
CN (1) | CN105378070A (da) |
AU (3) | AU2014233403B2 (da) |
CA (2) | CA2906815A1 (da) |
DK (1) | DK2970903T3 (da) |
FI (1) | FI2970903T3 (da) |
HK (2) | HK1218931A1 (da) |
IL (5) | IL294897B2 (da) |
PT (1) | PT2970903T (da) |
WO (1) | WO2014145108A1 (da) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102527507B1 (ko) | 2013-03-15 | 2023-04-28 | 아스텔라스 인스티튜트 포 리제너러티브 메디슨 | 만능 줄기 세포로부터 제조된 광수용기 및 광수용기 전구체 |
US11241460B2 (en) | 2013-03-15 | 2022-02-08 | Astellas Institute For Regenerative Medicine | Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells |
HUE054946T2 (hu) * | 2015-03-23 | 2021-10-28 | Astellas Inst For Regenerative Medicine | Javított eljárás humán retinai pigment epitélium (RPE) sejtek és fotoreceptor progenitorok hatásosságának vizsgálatára |
US20160331867A1 (en) * | 2015-05-13 | 2016-11-17 | Taipei Veterans General Hospital | Multilayered retinal cell implant |
KR102411018B1 (ko) | 2015-08-18 | 2022-06-20 | 아스텔라스 인스티튜트 포 리제너러티브 메디슨 | 임상 제제 |
JP6792844B6 (ja) | 2015-09-08 | 2021-02-03 | 大日本住友製薬株式会社 | 網膜色素上皮細胞の製造方法 |
CN105567635A (zh) * | 2016-02-21 | 2016-05-11 | 中国医科大学附属第一医院 | 一种改良的Neurobasal B27培养基、制备方法及应用 |
JP2019509744A (ja) | 2016-03-30 | 2019-04-11 | アステリアス バイオセラピューティクス インコーポレイテッド | オリゴデンドロサイト前駆細胞組成物 |
EP3583204A1 (en) * | 2017-02-17 | 2019-12-25 | Sorbonne Universite | Feeder-free methods for obtaining retinal progenitors, retinal pigmented epithelial cells and neural retinal cells |
GB201703058D0 (en) * | 2017-02-24 | 2017-04-12 | Ucl Business Plc | Biomarkers |
JP7007686B2 (ja) | 2017-03-08 | 2022-01-25 | 大日本住友製薬株式会社 | 網膜色素上皮細胞の製造方法 |
US20200277571A1 (en) * | 2017-09-14 | 2020-09-03 | Riken | Method for amplifying cone photoreceptors or rod photoreceptors using dorsalization signal transmitter or ventralization signal transmitter |
JP7360583B2 (ja) * | 2017-09-14 | 2023-10-13 | 国立研究開発法人理化学研究所 | 網膜組織の製造方法 |
WO2019078781A1 (en) * | 2017-10-17 | 2019-04-25 | National University Of Singapore | SYSTEMS AND METHODS FOR PRODUCING PHOTORECEPTOR PROGENITORS |
CN108795864B (zh) * | 2018-05-24 | 2021-08-24 | 中山大学中山眼科中心 | 一种利用人诱导多能干细胞获得富含视锥及视杆细胞的类视网膜组织的方法 |
CN113272422A (zh) * | 2018-09-07 | 2021-08-17 | 赫贝细胞股份有限公司 | 用于无载体3d球体悬浮培养中视网膜神经元生成的方法和组合物 |
AU2019342741A1 (en) * | 2018-09-19 | 2021-04-15 | Lineage Cell Therapeutics, Inc. | Methods for differentiating pluripotent stem cells in dynamic suspension culture |
CN109486766B (zh) * | 2018-11-26 | 2021-05-07 | 中山大学 | 一种泪腺干细胞、泪腺干细胞的培养体系和培养方法 |
SG11202107732XA (en) | 2019-01-23 | 2021-08-30 | Asterias Biotherapeutics Inc | Dorsally-derived oligodendrocyte progenitor cells from human pluripotent stem cells |
CA3178949A1 (en) * | 2020-05-29 | 2021-12-02 | Andrew DIAS | Retinal pigmented epithelium and photoreceptor dual cell aggregates and methods of use thereof |
KR20230017876A (ko) * | 2020-05-29 | 2023-02-06 | 후지필름 셀룰러 다이내믹스, 인코포레이티드 | 망막 색소 상피 및 광수용체의 이중층 및 이의 용도 |
EP4269564A1 (en) * | 2020-12-25 | 2023-11-01 | Iregene Therapeutics Ltd | Chemical induction method for photoreceptor neuron cells |
CN112608883B (zh) * | 2020-12-25 | 2023-02-24 | 武汉睿健医药科技有限公司 | 一种光感受器神经元细胞的化学诱导方法 |
KR102525093B1 (ko) * | 2021-04-16 | 2023-04-27 | 가톨릭대학교 산학협력단 | 사람 신경능 유래 코 하비갑개 줄기세포를 유효성분으로 포함하는 망막변성질환 예방 또는 치료용 약학적 조성물 |
CN113388582A (zh) * | 2021-06-21 | 2021-09-14 | 香港再生医学有限公司 | 促使iPSC分化为外周神经干细胞的方法及培养基和系统 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7794704B2 (en) | 2004-01-23 | 2010-09-14 | Advanced Cell Technology, Inc. | Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration |
EP4248751A3 (en) * | 2004-01-23 | 2023-11-01 | President and Fellows of Harvard College | Improved modalities for the treatment of degenerative diseases of the retina |
WO2006044204A2 (en) * | 2004-10-05 | 2006-04-27 | University Of Georgia Research Foundation, Inc. | Neuronal progenitors from feeder-free human embryonic stem cell culture |
US7541186B2 (en) | 2006-02-22 | 2009-06-02 | University Of Washington | Method of generating human retinal progenitors from embryonic stem cells |
US20100136537A1 (en) | 2006-10-10 | 2010-06-03 | The Regents Of The University Of Michigan | Photoreceptor precursor cells |
WO2008087917A1 (ja) * | 2007-01-18 | 2008-07-24 | Riken | 視細胞への分化誘導方法 |
EP2470645B1 (en) * | 2009-08-24 | 2019-06-26 | Wisconsin Alumni Research Foundation | Substantially pure human retinal progenitor, forebrain progenitor, and retinal pigment epithelium cell cultures and methods of making the same |
US9359592B2 (en) * | 2009-10-06 | 2016-06-07 | Snu R&Db Foundation | Method for differentiation into retinal cells from stem cells |
CN105349492B (zh) | 2011-05-18 | 2019-04-16 | 加利福尼亚大学董事会 | 用于治疗视网膜疾病的组合物及方法 |
US9458428B2 (en) * | 2012-06-05 | 2016-10-04 | The Regents Of The University Of California | Methods and compositions for the rapid production of retinal pigmented epithelial cells from pluripotent cells |
US20160175362A1 (en) | 2014-03-14 | 2016-06-23 | Ocata Therapeutics, Inc. | Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells |
US20160175361A1 (en) | 2014-03-14 | 2016-06-23 | Advanced Cell Technology, Inc. | Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells |
KR102527507B1 (ko) | 2013-03-15 | 2023-04-28 | 아스텔라스 인스티튜트 포 리제너러티브 메디슨 | 만능 줄기 세포로부터 제조된 광수용기 및 광수용기 전구체 |
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2014
- 2014-03-14 KR KR1020217017223A patent/KR102527507B1/ko active IP Right Grant
- 2014-03-14 IL IL294897A patent/IL294897B2/en unknown
- 2014-03-14 US US14/214,598 patent/US10307444B2/en active Active
- 2014-03-14 FI FIEP14764825.7T patent/FI2970903T3/fi active
- 2014-03-14 EP EP23192245.1A patent/EP4292600A3/en active Pending
- 2014-03-14 KR KR1020157029814A patent/KR102263956B1/ko active IP Right Grant
- 2014-03-14 WO PCT/US2014/029790 patent/WO2014145108A1/en active Application Filing
- 2014-03-14 JP JP2016503223A patent/JP6581966B2/ja active Active
- 2014-03-14 AU AU2014233403A patent/AU2014233403B2/en active Active
- 2014-03-14 EP EP14764825.7A patent/EP2970903B1/en active Active
- 2014-03-14 PT PT147648257T patent/PT2970903T/pt unknown
- 2014-03-14 CN CN201480022584.0A patent/CN105378070A/zh active Pending
- 2014-03-14 US US14/774,771 patent/US20160030490A1/en not_active Abandoned
- 2014-03-14 IL IL307568A patent/IL307568A/en unknown
- 2014-03-14 CA CA2906815A patent/CA2906815A1/en active Pending
- 2014-03-14 CA CA3177943A patent/CA3177943A1/en active Pending
- 2014-03-14 KR KR1020237013967A patent/KR20230058556A/ko not_active Application Discontinuation
- 2014-03-14 DK DK14764825.7T patent/DK2970903T3/da active
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2015
- 2015-09-03 IL IL241177A patent/IL241177B/en active IP Right Grant
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2016
- 2016-06-16 HK HK16106950.7A patent/HK1218931A1/zh unknown
- 2016-09-02 HK HK16110477.3A patent/HK1222205A1/zh unknown
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2019
- 2019-02-25 US US16/284,565 patent/US20190290701A1/en not_active Abandoned
- 2019-03-27 US US16/367,045 patent/US20190321414A1/en not_active Abandoned
- 2019-05-21 IL IL266775A patent/IL266775B/en active IP Right Grant
- 2019-09-02 JP JP2019159491A patent/JP7245752B2/ja active Active
- 2019-10-24 AU AU2019253874A patent/AU2019253874A1/en not_active Abandoned
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2020
- 2020-07-20 IL IL276173A patent/IL276173B2/en unknown
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2021
- 2021-10-01 JP JP2021162946A patent/JP2022023092A/ja active Pending
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2022
- 2022-03-22 AU AU2022201986A patent/AU2022201986A1/en active Pending
- 2022-04-13 US US17/719,473 patent/US20220347228A1/en active Pending
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2023
- 2023-12-01 JP JP2023203590A patent/JP2024053564A/ja active Pending
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