HK1257187B - 包含非天然胰腺β细胞的装置以及在治疗疾病如糖尿病中的用途 - Google Patents
包含非天然胰腺β细胞的装置以及在治疗疾病如糖尿病中的用途 Download PDFInfo
- Publication number
- HK1257187B HK1257187B HK18116147.8A HK18116147A HK1257187B HK 1257187 B HK1257187 B HK 1257187B HK 18116147 A HK18116147 A HK 18116147A HK 1257187 B HK1257187 B HK 1257187B
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- Prior art keywords
- cells
- diabetes
- treating diseases
- native pancreatic
- pancreatic
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
- C12N5/0678—Stem cells; Progenitor cells; Precursor cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/39—Pancreas; Islets of Langerhans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
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- C12N2501/38—Hormones with nuclear receptors
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- Health & Medical Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Developmental Biology & Embryology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Transplantation (AREA)
- Nutrition Science (AREA)
- Hematology (AREA)
- Physiology (AREA)
- Immunology (AREA)
- Virology (AREA)
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- Emergency Medicine (AREA)
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361833898P | 2013-06-11 | 2013-06-11 | |
| US61/833898 | 2013-06-11 | ||
| US201461972212P | 2014-03-28 | 2014-03-28 | |
| US61/972212 | 2014-03-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HK1257187A1 HK1257187A1 (en) | 2019-10-18 |
| HK1257187B true HK1257187B (zh) | 2020-06-12 |
Family
ID=52022750
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK18116147.8A HK1257187B (zh) | 2013-06-11 | 2018-12-17 | 包含非天然胰腺β细胞的装置以及在治疗疾病如糖尿病中的用途 |
Country Status (17)
| Country | Link |
|---|---|
| US (16) | US20170029778A1 (enExample) |
| EP (4) | EP4461806A3 (enExample) |
| JP (8) | JP6677634B2 (enExample) |
| KR (12) | KR102361924B1 (enExample) |
| CN (5) | CN120796168A (enExample) |
| AU (6) | AU2014284677B2 (enExample) |
| BR (2) | BR112015030946A8 (enExample) |
| CA (2) | CA2915088A1 (enExample) |
| DE (2) | DE112014002780B4 (enExample) |
| DK (1) | DK3008168T3 (enExample) |
| GB (3) | GB2557508B (enExample) |
| HK (1) | HK1257187B (enExample) |
| MX (2) | MX2015017103A (enExample) |
| PH (1) | PH12015502767A1 (enExample) |
| RU (2) | RU2016100219A (enExample) |
| SG (3) | SG10201710218RA (enExample) |
| WO (2) | WO2014201167A1 (enExample) |
Families Citing this family (101)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3207103A1 (en) | 2007-07-31 | 2009-02-05 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells to pancreatic endocrine |
| CN107574142B (zh) | 2007-11-27 | 2021-07-06 | 生命扫描有限公司 | 人胚胎干细胞的分化 |
| US9388386B2 (en) | 2011-12-22 | 2016-07-12 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells into single hormonal insulin positive cells |
| EP2938723B1 (en) | 2012-12-31 | 2023-02-01 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells into pancreatic endocrine cells using hb9 regulators |
| ES2924479T3 (es) * | 2013-04-08 | 2022-10-07 | Harvard College | Composiciones para rejuvenecer las células madre del músculo esquelético |
| BR112015030946A8 (pt) | 2013-06-11 | 2020-01-28 | Harvard College | composição compreendendo uma célula ß pancreática não-nativa, método de diferenciação de células progenitoras em células ß pancreáticas in vitro e uso de uma célula ß pancreática não-nativa |
| WO2015175307A1 (en) | 2014-05-16 | 2015-11-19 | Janssen Biotech, Inc. | Use of small molecules to enhance mafa expression in pancreatic endocrine cells |
| WO2016100898A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | Serum-free in vitro directed differentiation protocol for generating stem cell-derived b cells and uses thereof |
| WO2016100921A1 (en) * | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | METHODS FOR GENERATING STEM CELL-DERIVED β CELLS AND USES THEREOF |
| CN113234661A (zh) | 2014-12-18 | 2021-08-10 | 哈佛学院校长同事会 | 干细胞来源的β细胞的产生方法及其使用方法 |
| ES2985135T3 (es) | 2014-12-18 | 2024-11-04 | Harvard College | Procedimientos para generar células ß derivadas de células madre y usos de las mismas |
| WO2016100857A1 (en) * | 2014-12-19 | 2016-06-23 | Regeneron Pharmaceuticals, Inc. | Stem cells for modeling type 2 diabetes |
| US10975355B2 (en) | 2015-04-23 | 2021-04-13 | The Regents Of The University Of California | Controlled induction of human pancreatic progenitors produces functional beta-like cells |
| PT3286300T (pt) * | 2015-04-24 | 2020-12-28 | Univ Copenhagen | Isolamento de células progenitoras pancreáticas genuínas |
| ES2856872T3 (es) * | 2015-04-24 | 2021-09-28 | Univ Copenhagen | Procedimiento para la producción de células productoras de insulina |
| US11332716B2 (en) | 2015-07-27 | 2022-05-17 | The Regents Of The University Of California | Methods and compositions for producing pancreatic beta cells |
| US11499140B2 (en) * | 2015-10-29 | 2022-11-15 | Juntendo Educational Foundation | Method for producing pancreatic endocrine cells, and transdifferentiation agent |
| EP3932414A1 (en) | 2015-11-10 | 2022-01-05 | City of Hope | Conditioning regimens and methods for inducing mixed chimerism |
| US20190000889A1 (en) * | 2015-12-31 | 2019-01-03 | City Of Hope | Methods for treating diabetes |
| EP3949979A1 (en) | 2016-01-06 | 2022-02-09 | President and Fellows of Harvard College | Treatment with gdf11 prevents weight gain, improves glucose tolerance and reduces hepatosteatosis |
| WO2017123806A1 (en) | 2016-01-12 | 2017-07-20 | Cedars-Sinai Medical Center | A method of non destructive monitoring of biological processes in microfluidic tissue culture systems |
| CA3013357A1 (en) | 2016-02-01 | 2017-08-10 | Cedars-Sinai Medical Center | Systems and methods for growth of intestinal cells in microfluidic devices |
| WO2017144695A1 (en) * | 2016-02-24 | 2017-08-31 | Novo Nordisk A/S | Generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors |
| US10201540B2 (en) | 2016-03-02 | 2019-02-12 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I |
| US20190060371A1 (en) * | 2016-03-02 | 2019-02-28 | Frequency Therapeutics, Inc. | Methods for controlled proliferation of vestibular stem cells / generating inner ear hair cells using wnt and tgfbeta-inhibition |
| US10213511B2 (en) | 2016-03-02 | 2019-02-26 | Frequency Therapeutics, Inc. | Thermoreversible compositions for administration of therapeutic agents |
| MA45329A (fr) | 2016-04-08 | 2019-02-13 | Univ California | Production de cellules bêta matures pleinement fonctionnelles à partir de progénitrices pancréatiques humaines |
| WO2017214465A1 (en) * | 2016-06-09 | 2017-12-14 | Georgetown University | Process for continuous cell culture of islet cells |
| MA45502A (fr) * | 2016-06-21 | 2019-04-24 | Janssen Biotech Inc | Génération de cellules bêta fonctionnelles dérivées de cellules souches pluripotentes humaines ayant une respiration mitochondriale glucose-dépendante et une réponse en sécrétion d'insuline en deux phases |
| AU2017363145B2 (en) * | 2016-11-16 | 2024-02-15 | Allele Biotechnology & Pharmaceuticals, Inc. | Induction of pancreatic beta cells by stem cell differentiation with RNA |
| WO2018140647A1 (en) | 2017-01-25 | 2018-08-02 | Cedars-Sinai Medical Center | In vitro induction of mammary-like differentiation from human pluripotent stem cells |
| KR101745297B1 (ko) * | 2017-02-02 | 2017-06-09 | 경북대학교 산학협력단 | 비만 진단용 조성물 및 이의 용도 |
| US11767513B2 (en) | 2017-03-14 | 2023-09-26 | Cedars-Sinai Medical Center | Neuromuscular junction |
| US11414648B2 (en) | 2017-03-24 | 2022-08-16 | Cedars-Sinai Medical Center | Methods and compositions for production of fallopian tube epithelium |
| US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
| NZ800904A (en) | 2017-06-14 | 2025-08-29 | Vertex Pharma | Devices and methods for delivering therapeutics |
| US20210355448A1 (en) * | 2017-06-26 | 2021-11-18 | City Of Hope | Methods of islet cell culture |
| US10391156B2 (en) | 2017-07-12 | 2019-08-27 | Viacyte, Inc. | University donor cells and related methods |
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