SG11201700874SA - Method for proliferation of pancreatic progenitor cells - Google Patents

Method for proliferation of pancreatic progenitor cells

Info

Publication number
SG11201700874SA
SG11201700874SA SG11201700874SA SG11201700874SA SG11201700874SA SG 11201700874S A SG11201700874S A SG 11201700874SA SG 11201700874S A SG11201700874S A SG 11201700874SA SG 11201700874S A SG11201700874S A SG 11201700874SA SG 11201700874S A SG11201700874S A SG 11201700874SA
Authority
SG
Singapore
Prior art keywords
proliferation
progenitor cells
pancreatic progenitor
pancreatic
cells
Prior art date
Application number
SG11201700874SA
Inventor
Yuya Kunisada
Original Assignee
Takeda Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Publication of SG11201700874SA publication Critical patent/SG11201700874SA/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C12N5/0678—Stem cells; Progenitor cells; Precursor cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/113—Acidic fibroblast growth factor (aFGF, FGF-1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/415—Wnt; Frizzeled
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases (EC 2.)
    • C12N2501/727—Kinases (EC 2.7.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/998—Proteins not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin
SG11201700874SA 2014-08-04 2015-08-03 Method for proliferation of pancreatic progenitor cells SG11201700874SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2014158470 2014-08-04
PCT/JP2015/072591 WO2016021734A1 (en) 2014-08-04 2015-08-03 Method for proliferation of pancreatic progenitor cells

Publications (1)

Publication Number Publication Date
SG11201700874SA true SG11201700874SA (en) 2017-03-30

Family

ID=55263991

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201700874SA SG11201700874SA (en) 2014-08-04 2015-08-03 Method for proliferation of pancreatic progenitor cells

Country Status (9)

Country Link
US (1) US10655105B2 (en)
EP (1) EP3178924B1 (en)
JP (1) JP6678107B2 (en)
KR (1) KR102416647B1 (en)
CN (1) CN106795487B (en)
AU (1) AU2015300020B2 (en)
CA (1) CA2957000C (en)
SG (1) SG11201700874SA (en)
WO (1) WO2016021734A1 (en)

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MX2015017103A (en) 2013-06-11 2016-11-07 Harvard College Sc-î² cells and compositions and methods for generating the same.
WO2016100898A1 (en) 2014-12-18 2016-06-23 President And Fellows Of Harvard College Serum-free in vitro directed differentiation protocol for generating stem cell-derived b cells and uses thereof
US10253298B2 (en) 2014-12-18 2019-04-09 President And Fellows Of Harvard College Methods for generating stem cell-derived beta cells and methods of use thereof
US10190096B2 (en) 2014-12-18 2019-01-29 President And Fellows Of Harvard College Methods for generating stem cell-derived β cells and uses thereof
CA3022365A1 (en) * 2016-04-28 2017-11-02 Takeda Pharmaceutical Company Limited Purification method for pancreatic precursor cells derived from pluripotent stem cells and amplification method therefor
US20200140826A1 (en) * 2017-01-17 2020-05-07 Agency For Science, Research And Technology Maintenance and Expansion of Pancreatic Progenitor Cells
KR20200087201A (en) 2017-11-15 2020-07-20 셈마 테라퓨틱스, 인크. Islet cell production composition and method of use
JP7451430B2 (en) * 2018-03-02 2024-03-18 バーテックス ファーマシューティカルズ インコーポレイテッド How to promote stem cell differentiation into beta cells
WO2019182157A1 (en) 2018-03-19 2019-09-26 国立大学法人京都大学 Hydrogel capsule
BR112020021802A2 (en) 2018-04-23 2021-02-23 Kyoto University methods to produce a population of insulin-producing cells or a population of pancreatic beta cells and to decrease the number or inhibit the proliferation of ki67 positive cells, and, a population of pancreatic progenitor cells or cells at a later stage of differentiation
CA3101021A1 (en) * 2018-05-31 2019-12-05 University Health Network Methods and compositions comprising tankyrase inhibitors for generating insulin producing cells
EP3831931A4 (en) 2018-08-03 2022-05-18 Kyoto University Cell production method
EP3833365A4 (en) 2018-08-10 2022-05-11 Vertex Pharmaceuticals Incorporated Stem cell derived islet differentiation
US20210353686A1 (en) 2018-09-19 2021-11-18 Takeda Pharmaceutical Company Limited Insulin-producing cells
EP3868870A4 (en) * 2018-10-15 2022-10-19 Evia Life Sciences Inc. Method for producing stem/precursor cells, by using low molecular weight compound, from cells derived from endodermal tissue or organ
CN109749986B (en) * 2019-03-13 2021-04-02 武汉大学 Method for obtaining pancreatic precursor cells and pancreatic beta cells by differentiation of human pluripotent stem cells
KR20210151903A (en) 2019-04-10 2021-12-14 오리즈루 세라퓨틱스 가부시키가이샤 Method for manufacturing a living tissue-type construct
JP7385244B2 (en) * 2019-06-27 2023-11-22 国立大学法人 東京大学 Method for isolating pancreatic progenitor cells
WO2021079874A1 (en) 2019-10-21 2021-04-29 武田薬品工業株式会社 Proliferation inhibitor
JPWO2021241668A1 (en) 2020-05-28 2021-12-02
CN116391028A (en) 2020-11-20 2023-07-04 千纸鹤治疗公司 Ripening agent
WO2022120153A1 (en) * 2020-12-04 2022-06-09 Ocgene Therapeutics Corporation Method for long-term ex vivo maintenance or expansion of human erythroblast, megakaryocyte-erythroid progenitor, or common myeloid progenitor cell
TW202246489A (en) 2021-02-09 2022-12-01 日商千紙鶴治療公司 Maturating agent
CN113234664A (en) * 2021-05-11 2021-08-10 澳门大学 Preparation method and application of pancreatic progenitor cells
WO2024070494A1 (en) * 2022-09-26 2024-04-04 国立大学法人京都大学 Method for producing pancreatic endoderm cells

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL144654A0 (en) * 1999-02-10 2002-05-23 Curis Inc Pancreatic progenitor cells, methods and uses related thereto
US7625753B2 (en) 2003-12-23 2009-12-01 Cythera, Inc. Expansion of definitive endoderm cells
CA2637843C (en) 2006-01-20 2014-12-30 Reneuron, Inc. Method of improving cell proliferation of pancreatic progenitor cells in a pancreatic cell culture
CA2907326A1 (en) 2008-11-04 2010-05-14 Chad Green Stem cell aggregate suspension compositions and methods for differentiation thereof
US8008075B2 (en) * 2008-11-04 2011-08-30 Viacyte, Inc. Stem cell aggregate suspension compositions and methods of differentiation thereof
US9109245B2 (en) * 2009-04-22 2015-08-18 Viacyte, Inc. Cell compositions derived from dedifferentiated reprogrammed cells
CA2785966C (en) 2009-12-29 2020-10-27 Takeda Pharmaceutical Company Limited Method for manufacturing pancreatic-hormone-producing cells
JP6494515B2 (en) * 2012-10-19 2019-04-03 エージェンシー フォー サイエンス， テクノロジー アンド リサーチ Method for differentiating stem cells into one or more cell lineages
CA2898431C (en) 2013-02-06 2023-10-17 Viacyte, Inc. Cell compositions derived from dedifferentiated reprogrammed cells
JPWO2015125926A1 (en) * 2014-02-21 2017-03-30 国立研究開発法人理化学研究所 Method for establishing and maintaining trophoblast stem cells

Also Published As

Publication number Publication date
EP3178924A4 (en) 2018-01-24
US20170233700A1 (en) 2017-08-17
JPWO2016021734A1 (en) 2017-05-18
US10655105B2 (en) 2020-05-19
EP3178924B1 (en) 2019-12-25
JP6678107B2 (en) 2020-04-08
AU2015300020A1 (en) 2017-02-23
CA2957000A1 (en) 2016-02-11
KR102416647B1 (en) 2022-07-05
CN106795487B (en) 2021-11-19
WO2016021734A1 (en) 2016-02-11
KR20170031254A (en) 2017-03-20
EP3178924A1 (en) 2017-06-14
CN106795487A (en) 2017-05-31
AU2015300020B2 (en) 2021-04-08
CA2957000C (en) 2023-08-01

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