JP6490055B2 - ３−（５−アミノ−２−メチル−４−オキソキナゾリン−３（４ｈ）−イル）ピペリジン−２，６−ジオンの合成 - Google Patents

３−（５−アミノ−２−メチル−４−オキソキナゾリン−３（４ｈ）−イル）ピペリジン−２，６−ジオンの合成 Download PDF

Info

Publication number
JP6490055B2
JP6490055B2 JP2016511825A JP2016511825A JP6490055B2 JP 6490055 B2 JP6490055 B2 JP 6490055B2 JP 2016511825 A JP2016511825 A JP 2016511825A JP 2016511825 A JP2016511825 A JP 2016511825A JP 6490055 B2 JP6490055 B2 JP 6490055B2
Authority
JP
Japan
Prior art keywords
methyl
dione
nitro
certain embodiments
benzo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2016511825A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016517886A (ja
JP2016517886A5 (enExample
Inventor
エル．ルチェルマン アレクサンダー
エル．ルチェルマン アレクサンダー
エム．コーエン ベンジャミン
エム．コーエン ベンジャミン
チョウウドフリ アヌスヤ
チョウウドフリ アヌスヤ
エム．クレイレイン マシュウ
エム．クレイレイン マシュウ
ダブリュー．レオング ウイリアム
ダブリュー．レオング ウイリアム
マン ホン‐ワー
マン ホン‐ワー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Celgene Corp
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of JP2016517886A publication Critical patent/JP2016517886A/ja
Publication of JP2016517886A5 publication Critical patent/JP2016517886A5/ja
Application granted granted Critical
Publication of JP6490055B2 publication Critical patent/JP6490055B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2016511825A 2013-05-01 2014-04-30 ３−（５−アミノ−２−メチル−４−オキソキナゾリン−３（４ｈ）−イル）ピペリジン−２，６−ジオンの合成 Expired - Fee Related JP6490055B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361818254P 2013-05-01 2013-05-01
US61/818,254 2013-05-01
PCT/US2014/036083 WO2014179416A1 (en) 2013-05-01 2014-04-30 Synthesis of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4h)-yl) piperidine-2,6-dione

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018229189A Division JP2019069958A (ja) 2013-05-01 2018-12-06 ３−（５−アミノ−２−メチル−４−オキソキナゾリン−３（４ｈ）−イル）ピペリジン−２，６−ジオンの合成

Publications (3)

Publication Number Publication Date
JP2016517886A JP2016517886A (ja) 2016-06-20
JP2016517886A5 JP2016517886A5 (enExample) 2017-06-15
JP6490055B2 true JP6490055B2 (ja) 2019-03-27

Family

ID=50885008

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016511825A Expired - Fee Related JP6490055B2 (ja) 2013-05-01 2014-04-30 ３−（５−アミノ−２−メチル−４−オキソキナゾリン−３（４ｈ）−イル）ピペリジン−２，６−ジオンの合成
JP2018229189A Pending JP2019069958A (ja) 2013-05-01 2018-12-06 ３−（５−アミノ−２−メチル−４−オキソキナゾリン−３（４ｈ）−イル）ピペリジン−２，６−ジオンの合成

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2018229189A Pending JP2019069958A (ja) 2013-05-01 2018-12-06 ３−（５−アミノ−２−メチル−４−オキソキナゾリン−３（４ｈ）−イル）ピペリジン−２，６−ジオンの合成

Country Status (26)

Country Link
US (3) US9067912B2 (enExample)
EP (2) EP3199532A1 (enExample)
JP (2) JP6490055B2 (enExample)
KR (1) KR20160003228A (enExample)
CN (2) CN105377831B (enExample)
AR (1) AR096165A1 (enExample)
AU (2) AU2014260011A1 (enExample)
CA (1) CA2910971A1 (enExample)
CY (1) CY1119525T1 (enExample)
DK (1) DK2991976T3 (enExample)
ES (1) ES2645944T3 (enExample)
HR (1) HRP20171535T1 (enExample)
HU (1) HUE034770T2 (enExample)
LT (1) LT2991976T (enExample)
MX (1) MX363652B (enExample)
NZ (1) NZ628322A (enExample)
PH (1) PH12015502477A1 (enExample)
PL (1) PL2991976T3 (enExample)
PT (1) PT2991976T (enExample)
RS (1) RS56565B1 (enExample)
RU (1) RU2015151359A (enExample)
SG (1) SG11201508836XA (enExample)
SI (1) SI2991976T1 (enExample)
SM (1) SMT201700513T1 (enExample)
TW (1) TW201536766A (enExample)
WO (1) WO2014179416A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS52349B (sr) 2006-09-26 2012-12-31 Celgene Corporation 5-supstituisani derivati hinazolinona kao antitumorski agensi
CA2829570C (en) 2011-03-11 2019-05-07 Celgene Corporation Solid forms of 3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione, and their pharmaceutical compositions and uses
EP2892887B1 (en) 2012-09-04 2020-07-15 Celgene Corporation Isotopologues of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4h)-yl) piperidine-2-6-dione and methods of preparation thereof
US10973822B2 (en) 2015-07-02 2021-04-13 Celgene Corporation Combination therapy for treatment of hematological cancers and solid tumors
CN106083622B (zh) * 2016-06-16 2018-06-19 常州齐晖药业有限公司 一种甲苯咪唑中间体3,4-二氨基二苯甲酮的制备方法
US20180258064A1 (en) * 2017-03-07 2018-09-13 Celgene Corporation Solid forms of 3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione, and their pharmaceutical compositions and uses
CN113101295A (zh) * 2020-03-20 2021-07-13 上海疆云医疗健康科技有限公司 二苯乙烯类似物在治疗糖尿病肾脏疾病中的用途
KR20240055046A (ko) * 2021-09-02 2024-04-26 신톤 비.브이. 오시머티닙을 제조하는 방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2032538A2 (en) * 2006-06-08 2009-03-11 Array Biopharma, Inc. Quinoline compounds and methods of use
RS52349B (sr) * 2006-09-26 2012-12-31 Celgene Corporation 5-supstituisani derivati hinazolinona kao antitumorski agensi
RU2017120977A (ru) * 2011-03-11 2018-11-15 Селджин Корпорейшн Способ лечения рака с использованием 3-(5-амино-2-метил-4-оксо-4h-хиназолин-3-ил)пиперидин-2,6-диона
CA2829570C (en) * 2011-03-11 2019-05-07 Celgene Corporation Solid forms of 3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione, and their pharmaceutical compositions and uses
EP2892887B1 (en) * 2012-09-04 2020-07-15 Celgene Corporation Isotopologues of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4h)-yl) piperidine-2-6-dione and methods of preparation thereof
EP2943201B2 (en) * 2013-01-14 2020-07-29 Deuterx, LLC 3-(5-substituted-4-oxoquinazolin-3(4h)-yl)-3-deutero-piperidine-2,6-dione derivatives

Also Published As

Publication number Publication date
RS56565B1 (sr) 2018-02-28
NZ628322A (en) 2017-06-30
CN107935994A (zh) 2018-04-20
US9303014B2 (en) 2016-04-05
CN105377831B (zh) 2018-02-02
KR20160003228A (ko) 2016-01-08
RU2015151359A (ru) 2017-06-06
MX2015015073A (es) 2016-03-03
EP2991976A1 (en) 2016-03-09
SI2991976T1 (sl) 2017-11-30
LT2991976T (lt) 2017-10-25
CA2910971A1 (en) 2014-11-06
CN105377831A (zh) 2016-03-02
JP2019069958A (ja) 2019-05-09
SMT201700513T1 (it) 2018-01-11
US20150274694A1 (en) 2015-10-01
US9067912B2 (en) 2015-06-30
US9266858B2 (en) 2016-02-23
PH12015502477A1 (en) 2016-02-22
MX363652B (es) 2019-03-28
AR096165A1 (es) 2015-12-09
ES2645944T3 (es) 2017-12-11
WO2014179416A1 (en) 2014-11-06
US20140330016A1 (en) 2014-11-06
EP3199532A1 (en) 2017-08-02
HUE034770T2 (hu) 2018-02-28
PT2991976T (pt) 2017-11-14
CY1119525T1 (el) 2018-03-07
HRP20171535T1 (hr) 2017-11-17
EP2991976B1 (en) 2017-09-20
PL2991976T3 (pl) 2018-01-31
SG11201508836XA (en) 2015-11-27
US20160009685A1 (en) 2016-01-14
JP2016517886A (ja) 2016-06-20
TW201536766A (zh) 2015-10-01
AU2017200965A1 (en) 2017-03-02
DK2991976T3 (da) 2017-11-06
AU2014260011A1 (en) 2015-11-12

Similar Documents

Publication Publication Date Title
JP6490055B2 (ja) ３−（５−アミノ−２−メチル−４−オキソキナゾリン−３（４ｈ）−イル）ピペリジン−２，６−ジオンの合成
CN108925135A (zh) 制备(S)-(2R,3R,11bR)-3-异丁基-9,10-二甲氧基-2,3,4,6,7,11b-六氢-1H-吡啶并[2,1-a]异喹啉-2-基2-氨基-3-甲基丁酸酯二(4-甲基苯磺酸盐)的合成方法
CN101253163A (zh) 4-氨基-2-(2,6-二氧哌啶-3-基)异吲哚啉-1,3-二酮化合物的制备方法
CN107108507A (zh) 制备二芳基硫代乙内酰脲化合物的方法
EP2707367B1 (en) Methods for preparing naphthyridines
CN111961034A (zh) 用作ret激酶抑制剂的化合物及其应用
CN105294536A (zh) 一种制备3-亚氨基异吲哚啉酮类化合物的方法
WO2020050241A1 (ja) ４環性化合物の製造方法
JP2015017101A (ja) ホスフィナートルテニウム錯体
CN112979529B (zh) 一种芳香胺吲哚萘醌衍生物及其制备方法
TWI762527B (zh) 色氨酸羥化酶-１抑製劑製備方法
CN114907315B (zh) Selitrectinib中间体的合成方法
CN110139853A (zh) 用于制备杀有害生物化合物的方法
JP6997769B2 (ja) ２－（６－ニトロピリジン－３－イル）－９Ｈ－ジピリド［２，３－ｂ；３’，４’－ｄ］ピロールの製造方法
HK40051429B (zh) 四环化合物的制备方法
CN108473510B (zh) 制备2-吡唑并[1,5-a]吡嗪-2-基吡啶并[1,2-a]嘧啶-4-酮的方法
KR20250117368A (ko) (z)-3-(2-(5-브로모-1h-인돌-3-일)-2-시아노비닐)-4-메톡시벤조니트릴의제조 방법
JP2025100323A (ja) 新規な３置換ビニルスルホキシイミン誘導体、およびその製造方法、ならびにそれを用いる３置換アルケンの立体選択的な製造方法
CN104788370A (zh) 一种构型可控地合成2-(4-硝基)丁酰基吡啶氮-氧化合物的方法
CN117682985A (zh) 盐酸倍他司汀的制备方法
CN109982997A (zh) 3-(吡啶基-2-氨基)丙腈及其类似物的制造方法
HK1215809A1 (zh) 制备三环化合物的方法以及可通过所述制备方法制备的三环化合物

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170428

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20170428

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20180228

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180313

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180613

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20180807

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20181206

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20181221

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20190205

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20190226

R150 Certificate of patent or registration of utility model

Ref document number: 6490055

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

LAPS Cancellation because of no payment of annual fees