JP6400082B2 - 「インターフェロン遺伝子の刺激因子」依存性シグナル伝達を抑制するための組成物および方法 - Google Patents

「インターフェロン遺伝子の刺激因子」依存性シグナル伝達を抑制するための組成物および方法 Download PDF

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JP6400082B2
JP6400082B2 JP2016514152A JP2016514152A JP6400082B2 JP 6400082 B2 JP6400082 B2 JP 6400082B2 JP 2016514152 A JP2016514152 A JP 2016514152A JP 2016514152 A JP2016514152 A JP 2016514152A JP 6400082 B2 JP6400082 B2 JP 6400082B2
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cyclic
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JP2016531842A (ja
JP2016531842A5 (enExample
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ドゥベンスキー，トーマス，ダブリュー．，ジュニア
カンヌ，デイビッド，ビー．
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Chinook Therapeutics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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JP2016514152A 2013-05-18 2014-05-18 「インターフェロン遺伝子の刺激因子」依存性シグナル伝達を抑制するための組成物および方法 Expired - Fee Related JP6400082B2 (ja)

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US201361825009P 2013-05-18 2013-05-18
US61/825,009 2013-05-18
PCT/US2014/038526 WO2014189806A1 (en) 2013-05-18 2014-05-18 Compositions and methods for inhibiting "stimulator of interferon gene" dependent signalling

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JP2016531842A JP2016531842A (ja) 2016-10-13
JP2016531842A5 JP2016531842A5 (enExample) 2017-06-22
JP6400082B2 true JP6400082B2 (ja) 2018-10-03

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EP (1) EP2996472B1 (enExample)
JP (1) JP6400082B2 (enExample)
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WO (1) WO2014189806A1 (enExample)

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CN105188373A (zh) 2015-12-23
HK1217606A1 (zh) 2017-01-20
EP2996472A4 (en) 2016-12-28
CN105188373B (zh) 2017-09-22
EP2996472A1 (en) 2016-03-23
JP2016531842A (ja) 2016-10-13
WO2014189806A1 (en) 2014-11-27
EP2996472B1 (en) 2019-03-27

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