JP6330024B2 - 生体吸収性バイオメディカルインプラント - Google Patents
生体吸収性バイオメディカルインプラント Download PDFInfo
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- JP6330024B2 JP6330024B2 JP2016501719A JP2016501719A JP6330024B2 JP 6330024 B2 JP6330024 B2 JP 6330024B2 JP 2016501719 A JP2016501719 A JP 2016501719A JP 2016501719 A JP2016501719 A JP 2016501719A JP 6330024 B2 JP6330024 B2 JP 6330024B2
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- Prior art keywords
- polymer
- rapamycin
- mpa
- tubular scaffold
- average
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- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 description 1
- 229960002066 vinorelbine Drugs 0.000 description 1
- 229960000744 vinpocetine Drugs 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 description 1
- 229960005080 warfarin Drugs 0.000 description 1
- 238000004736 wide-angle X-ray diffraction Methods 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 229910052724 xenon Inorganic materials 0.000 description 1
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 1
- MTZBBNMLMNBNJL-UHFFFAOYSA-N xipamide Chemical compound CC1=CC=CC(C)=C1NC(=O)C1=CC(S(N)(=O)=O)=C(Cl)C=C1O MTZBBNMLMNBNJL-UHFFFAOYSA-N 0.000 description 1
- 229960000537 xipamide Drugs 0.000 description 1
- 229960004764 zafirlukast Drugs 0.000 description 1
- 229960000523 zalcitabine Drugs 0.000 description 1
- HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 description 1
- 229960002555 zidovudine Drugs 0.000 description 1
- UTAZCRNOSWWEFR-ZDUSSCGKSA-N zolmitriptan Chemical compound C=1[C]2C(CCN(C)C)=CN=C2C=CC=1C[C@H]1COC(=O)N1 UTAZCRNOSWWEFR-ZDUSSCGKSA-N 0.000 description 1
- 229960001360 zolmitriptan Drugs 0.000 description 1
- ZAFYATHCZYHLPB-UHFFFAOYSA-N zolpidem Chemical compound N1=C2C=CC(C)=CN2C(CC(=O)N(C)C)=C1C1=CC=C(C)C=C1 ZAFYATHCZYHLPB-UHFFFAOYSA-N 0.000 description 1
- 229960001475 zolpidem Drugs 0.000 description 1
- 229960000820 zopiclone Drugs 0.000 description 1
- HDOZVRUNCMBHFH-UHFFFAOYSA-N zotepine Chemical compound CN(C)CCOC1=CC2=CC=CC=C2SC2=CC=C(Cl)C=C12 HDOZVRUNCMBHFH-UHFFFAOYSA-N 0.000 description 1
- 229960004496 zotepine Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0035—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in release or diffusion time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Surgery (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Transplantation (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polymers & Plastics (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201361777230P | 2013-03-12 | 2013-03-12 | |
US61/777,230 | 2013-03-12 | ||
PCT/US2014/025017 WO2014165264A1 (en) | 2013-03-12 | 2014-03-12 | Bioabsorbable biomedical implants |
Publications (2)
Publication Number | Publication Date |
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JP2016517311A JP2016517311A (ja) | 2016-06-16 |
JP6330024B2 true JP6330024B2 (ja) | 2018-05-23 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016501719A Expired - Fee Related JP6330024B2 (ja) | 2013-03-12 | 2014-03-12 | 生体吸収性バイオメディカルインプラント |
Country Status (10)
Country | Link |
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US (1) | US11039943B2 (zh) |
EP (1) | EP2967803B1 (zh) |
JP (1) | JP6330024B2 (zh) |
KR (1) | KR20150143476A (zh) |
CN (2) | CN105307597A (zh) |
AU (1) | AU2014248508B2 (zh) |
CA (1) | CA2905419C (zh) |
HK (1) | HK1220602A1 (zh) |
IL (1) | IL241421B (zh) |
WO (1) | WO2014165264A1 (zh) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007011708A2 (en) | 2005-07-15 | 2007-01-25 | Micell Technologies, Inc. | Stent with polymer coating containing amorphous rapamycin |
EP1909973B1 (en) | 2005-07-15 | 2018-08-22 | Micell Technologies, Inc. | Polymer coatings containing drug powder of controlled morphology |
US8852625B2 (en) | 2006-04-26 | 2014-10-07 | Micell Technologies, Inc. | Coatings containing multiple drugs |
CN101711137B (zh) | 2007-01-08 | 2014-10-22 | 米歇尔技术公司 | 具有可生物降解层的支架 |
US11426494B2 (en) | 2007-01-08 | 2022-08-30 | MT Acquisition Holdings LLC | Stents having biodegradable layers |
US9433516B2 (en) | 2007-04-17 | 2016-09-06 | Micell Technologies, Inc. | Stents having controlled elution |
CA2721832C (en) | 2008-04-17 | 2018-08-07 | Micell Technologies, Inc. | Stents having bioabsorbable layers |
US9510856B2 (en) | 2008-07-17 | 2016-12-06 | Micell Technologies, Inc. | Drug delivery medical device |
JP2011528275A (ja) | 2008-07-17 | 2011-11-17 | ミセル テクノロジーズ,インク. | 薬物送達医療デバイス |
CN102481195B (zh) | 2009-04-01 | 2015-03-25 | 米歇尔技术公司 | 涂覆支架 |
EP2531140B1 (en) | 2010-02-02 | 2017-11-01 | Micell Technologies, Inc. | Stent and stent delivery system with improved deliverability |
WO2011133655A1 (en) | 2010-04-22 | 2011-10-27 | Micell Technologies, Inc. | Stents and other devices having extracellular matrix coating |
EP2593039B1 (en) | 2010-07-16 | 2022-11-30 | Micell Technologies, Inc. | Drug delivery medical device |
CA2841360A1 (en) | 2011-07-15 | 2013-01-24 | Micell Technologies, Inc. | Drug delivery medical device |
US10188772B2 (en) | 2011-10-18 | 2019-01-29 | Micell Technologies, Inc. | Drug delivery medical device |
WO2014165264A1 (en) | 2013-03-12 | 2014-10-09 | Micell Technologies, Inc. | Bioabsorbable biomedical implants |
KR102079613B1 (ko) | 2013-05-15 | 2020-02-20 | 미셀 테크놀로지즈, 인코포레이티드 | 생흡수성 생체의학적 임플란트 |
DE102015115279A1 (de) | 2015-09-10 | 2017-03-16 | Bentley Innomed Gmbh | Expandierbare Gefäßstütze |
WO2018036434A1 (zh) * | 2016-08-23 | 2018-03-01 | 深圳市信立泰生物医疗工程有限公司 | 一种植入式完全生物可吸收血管聚合物支架 |
WO2018081463A1 (en) * | 2016-10-26 | 2018-05-03 | University Of Pittsburgh -Of The Commonwealth System Of Higher Education | Calcineurin inhibitor and non-steroidal anti-inflammatory drug to reduce risk of post-imaging pancreatitis |
CN106726005B (zh) * | 2017-02-22 | 2018-05-01 | 南京市第一医院 | 一种治疗冠脉介入穿孔的可吸收覆膜支架 |
JP2021074027A (ja) * | 2018-03-13 | 2021-05-20 | テルモ株式会社 | ステントおよびステントの作製方法 |
KR102102660B1 (ko) * | 2019-09-03 | 2020-04-22 | (주)티제이테크 | 말초혈관용 스텐트의 코팅 조성액 제조 및 코팅 방법 |
KR102407468B1 (ko) * | 2021-11-30 | 2022-06-10 | 주식회사 파인트코리아 | 스텐트 제조용 생분해성 복합소재 조성물 및 이의 제조 방법 |
Family Cites Families (610)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3123077A (en) | 1964-03-03 | Surgical suture | ||
US3087860A (en) | 1958-12-19 | 1963-04-30 | Abbott Lab | Method of prolonging release of drug from a precompressed solid carrier |
US3457280A (en) | 1967-06-12 | 1969-07-22 | American Cyanamid Co | Alpha-glycolide and methods for the isolation thereof |
US3597449A (en) | 1967-11-16 | 1971-08-03 | American Cyanamid Co | Stable glycolide and lactide composition |
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
DE2010115A1 (de) | 1970-03-04 | 1971-09-16 | Farbenfabriken Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von Mikrogranulaten |
ZA737247B (en) | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
US4000137A (en) | 1975-06-10 | 1976-12-28 | American Home Products Corporation | Antitumor derivatives of periodate-oxidized nucleosides |
US4188373A (en) | 1976-02-26 | 1980-02-12 | Cooper Laboratories, Inc. | Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes |
US4285987A (en) | 1978-10-23 | 1981-08-25 | Alza Corporation | Process for manufacturing device with dispersion zone |
JPS5668674A (en) | 1979-11-08 | 1981-06-09 | Shionogi & Co Ltd | 5-fluorouracil derivative |
US4326532A (en) | 1980-10-06 | 1982-04-27 | Minnesota Mining And Manufacturing Company | Antithrombogenic articles |
US4389330A (en) | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
US4675189A (en) | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
US4474572A (en) | 1981-09-29 | 1984-10-02 | Syntex (U.S.A.) Inc. | Implanting device and implant magazine |
SE445884B (sv) | 1982-04-30 | 1986-07-28 | Medinvent Sa | Anordning for implantation av en rorformig protes |
US4530840A (en) | 1982-07-29 | 1985-07-23 | The Stolle Research And Development Corporation | Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents |
SE435444B (sv) | 1983-02-25 | 1984-10-01 | Hakan Johansson | Fiskeredskap med en fangstlina som utgores av en ljusledare |
US4606347A (en) | 1983-03-25 | 1986-08-19 | Thomas J. Fogarty | Inverted balloon catheter having sealed through lumen |
US4478822A (en) | 1983-05-16 | 1984-10-23 | Merck & Co., Inc. | Drug delivery system utilizing thermosetting gels |
US4474751A (en) | 1983-05-16 | 1984-10-02 | Merck & Co., Inc. | Ophthalmic drug delivery system utilizing thermosetting gels |
US4734227A (en) | 1983-09-01 | 1988-03-29 | Battelle Memorial Institute | Method of making supercritical fluid molecular spray films, powder and fibers |
US4734451A (en) | 1983-09-01 | 1988-03-29 | Battelle Memorial Institute | Supercritical fluid molecular spray thin films and fine powders |
US4582731A (en) | 1983-09-01 | 1986-04-15 | Battelle Memorial Institute | Supercritical fluid molecular spray film deposition and powder formation |
US6309669B1 (en) | 1984-03-16 | 2001-10-30 | The United States Of America As Represented By The Secretary Of The Army | Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix |
US4733665C2 (en) | 1985-11-07 | 2002-01-29 | Expandable Grafts Partnership | Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft |
US5102417A (en) | 1985-11-07 | 1992-04-07 | Expandable Grafts Partnership | Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft |
US4985625A (en) | 1986-03-06 | 1991-01-15 | Finnigan Corporation | Transfer line for mass spectrometer apparatus |
US4762593A (en) | 1986-06-13 | 1988-08-09 | Youngner Philip G | Distilling apparatus |
US4758435A (en) | 1986-08-11 | 1988-07-19 | American Cyanamid Company | Estradiol implant composition and method for preparation |
US5106650A (en) | 1988-07-14 | 1992-04-21 | Union Carbide Chemicals & Plastics Technology Corporation | Electrostatic liquid spray application of coating with supercritical fluids as diluents and spraying from an orifice |
US4950239A (en) | 1988-08-09 | 1990-08-21 | Worldwide Medical Plastics Inc. | Angioplasty balloons and balloon catheters |
EP0431046B1 (en) | 1988-08-24 | 1995-05-03 | SLEPIAN, Marvin J. | Biodegradable polymeric endoluminal sealing |
US4931037A (en) | 1988-10-13 | 1990-06-05 | International Medical, Inc. | In-dwelling ureteral stent and injection stent assembly, and method of using same |
US4958625A (en) | 1989-07-18 | 1990-09-25 | Boston Scientific Corporation | Biopsy needle instrument |
ES2043289T3 (es) | 1989-09-25 | 1993-12-16 | Schneider Usa Inc | La extrusion de capas multiples como procedimiento para hacer balones de angioplastia. |
CA2026604A1 (en) | 1989-10-02 | 1991-04-03 | Rodney G. Wolff | Articulated stent |
US5000519A (en) | 1989-11-24 | 1991-03-19 | John Moore | Towed vehicle emergency brake control system |
US5674192A (en) | 1990-12-28 | 1997-10-07 | Boston Scientific Corporation | Drug delivery |
JP2641781B2 (ja) | 1990-02-23 | 1997-08-20 | シャープ株式会社 | 半導体素子分離領域の形成方法 |
US5545208A (en) | 1990-02-28 | 1996-08-13 | Medtronic, Inc. | Intralumenal drug eluting prosthesis |
US5360403A (en) | 1990-05-16 | 1994-11-01 | Lake Region Manufacturing Co., Inc. | Balloon catheter with lumen occluder |
WO1991017724A1 (en) | 1990-05-17 | 1991-11-28 | Harbor Medical Devices, Inc. | Medical device polymer |
US5320634A (en) | 1990-07-03 | 1994-06-14 | Interventional Technologies, Inc. | Balloon catheter with seated cutting edges |
US5090419A (en) | 1990-08-23 | 1992-02-25 | Aubrey Palestrant | Apparatus for acquiring soft tissue biopsy specimens |
US6248129B1 (en) | 1990-09-14 | 2001-06-19 | Quanam Medical Corporation | Expandable polymeric stent with memory and delivery apparatus and method |
US6524698B1 (en) | 1990-09-27 | 2003-02-25 | Helmuth Schmoock | Fluid impermeable foil |
CA2060635A1 (en) | 1991-02-12 | 1992-08-13 | Keith D'alessio | Bioabsorbable medical implants |
GB2253164B (en) | 1991-02-22 | 1994-10-05 | Hoechst Uk Ltd | Improvements in or relating to electrostatic coating of substrates of medicinal products |
US5158986A (en) | 1991-04-05 | 1992-10-27 | Massachusetts Institute Of Technology | Microcellular thermoplastic foamed with supercritical fluid |
US5195969A (en) | 1991-04-26 | 1993-03-23 | Boston Scientific Corporation | Co-extruded medical balloons and catheter using such balloons |
US5372676A (en) | 1991-05-15 | 1994-12-13 | Lowe; Michael | Method for producing replicated paving stone |
US5185776A (en) | 1991-08-05 | 1993-02-09 | Townsend Boyd E | Cover for an x-ray cassette |
US5356433A (en) | 1991-08-13 | 1994-10-18 | Cordis Corporation | Biocompatible metal surfaces |
US5243023A (en) | 1991-08-28 | 1993-09-07 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Polyimides containing amide and perfluoroisopropylidene connecting groups |
US5366504A (en) | 1992-05-20 | 1994-11-22 | Boston Scientific Corporation | Tubular medical prosthesis |
JPH0698902A (ja) | 1991-11-22 | 1994-04-12 | Janome Sewing Mach Co Ltd | 骨インプラントの製造方法 |
US5125570A (en) | 1991-12-30 | 1992-06-30 | Robert Jones | Delivery box signal device |
US5697882A (en) | 1992-01-07 | 1997-12-16 | Arthrocare Corporation | System and method for electrosurgical cutting and ablation |
US5876452A (en) * | 1992-02-14 | 1999-03-02 | Board Of Regents, University Of Texas System | Biodegradable implant |
WO1993019803A1 (en) | 1992-03-31 | 1993-10-14 | Boston Scientific Corporation | Medical wire |
US5288711A (en) | 1992-04-28 | 1994-02-22 | American Home Products Corporation | Method of treating hyperproliferative vascular disease |
US5342621A (en) | 1992-09-15 | 1994-08-30 | Advanced Cardiovascular Systems, Inc. | Antithrombogenic surface |
US5500180A (en) | 1992-09-30 | 1996-03-19 | C. R. Bard, Inc. | Method of making a distensible dilatation balloon using a block copolymer |
GB9221220D0 (en) | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
US5387313A (en) | 1992-11-09 | 1995-02-07 | Bmc Industries, Inc. | Etchant control system |
US5385776A (en) | 1992-11-16 | 1995-01-31 | Alliedsignal Inc. | Nanocomposites of gamma phase polymers containing inorganic particulate material |
EP0604022A1 (en) | 1992-12-22 | 1994-06-29 | Advanced Cardiovascular Systems, Inc. | Multilayered biodegradable stent and method for its manufacture |
US5324049A (en) | 1992-12-23 | 1994-06-28 | Xerox Corporation | Mandrel with flared, dish shaped disk and process for using mandrel |
CA2152594C (en) | 1993-01-19 | 1998-12-01 | David W. Mayer | Clad composite stent |
US5981568A (en) | 1993-01-28 | 1999-11-09 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5340614A (en) | 1993-02-11 | 1994-08-23 | Minnesota Mining And Manufacturing Company | Methods of polymer impregnation |
US6228879B1 (en) | 1997-10-16 | 2001-05-08 | The Children's Medical Center | Methods and compositions for inhibition of angiogenesis |
ES2113094T3 (es) | 1993-03-09 | 1998-04-16 | Epic Therapeutics Inc | Las microparticulas macromoleculares y metodos de obtencion. |
US5981719A (en) | 1993-03-09 | 1999-11-09 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
US6090925A (en) | 1993-03-09 | 2000-07-18 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
EP0689465A1 (en) | 1993-03-18 | 1996-01-03 | Cedars-Sinai Medical Center | Drug incorporating and releasing polymeric coating for bioprosthesis |
US20020055710A1 (en) | 1998-04-30 | 2002-05-09 | Ronald J. Tuch | Medical device for delivering a therapeutic agent and method of preparation |
US5403347A (en) | 1993-05-27 | 1995-04-04 | United States Surgical Corporation | Absorbable block copolymers and surgical articles fabricated therefrom |
US5350627A (en) | 1993-06-11 | 1994-09-27 | Camelot Technologies, Inc. | Coated webs |
US5380299A (en) | 1993-08-30 | 1995-01-10 | Med Institute, Inc. | Thrombolytic treated intravascular medical device |
DE4336209C2 (de) | 1993-09-10 | 1995-09-21 | Michael Dr Simon | Verfahren zur Herstellung einer mit antithrombotischen Agenzien beschichteten Gefäßprothese |
US5632772A (en) | 1993-10-21 | 1997-05-27 | Corvita Corporation | Expandable supportive branched endoluminal grafts |
US5350361A (en) | 1993-11-10 | 1994-09-27 | Medtronic, Inc. | Tri-fold balloon for dilatation catheter and related method |
US5494620A (en) | 1993-11-24 | 1996-02-27 | United States Surgical Corporation | Method of manufacturing a monofilament suture |
US5626611A (en) | 1994-02-10 | 1997-05-06 | United States Surgical Corporation | Composite bioabsorbable materials and surgical articles made therefrom |
ES2141928T5 (es) | 1994-03-02 | 2009-04-16 | Boston Scientific Limited | Balones de elastomero de copolimero en bloques para cateter. |
US6146356A (en) | 1994-03-02 | 2000-11-14 | Scimed Life Systems, Inc. | Block copolymer elastomer catheter balloons |
US5843120A (en) | 1994-03-17 | 1998-12-01 | Medinol Ltd. | Flexible-expandable stent |
US5733303A (en) | 1994-03-17 | 1998-03-31 | Medinol Ltd. | Flexible expandable stent |
US5362718A (en) | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
CA2192821A1 (en) | 1994-06-24 | 1996-01-04 | Wayne R. Gombotz | Controlled release polypeptide compositions and methods of treating inflammatory bowel disease |
HU225964B1 (en) | 1994-07-12 | 2008-01-28 | Berwind Pharma Service | Moisture barrier film coating composition, method, and coated form |
US5626862A (en) | 1994-08-02 | 1997-05-06 | Massachusetts Institute Of Technology | Controlled local delivery of chemotherapeutic agents for treating solid tumors |
NL9401690A (nl) | 1994-10-13 | 1996-05-01 | Industrial Res Bv | In een lichaamsvat implanteerbare stent. |
JPH10510450A (ja) | 1994-12-02 | 1998-10-13 | サイエンス インコーポレイテッド | 薬剤分配装置 |
EP0805678B1 (en) | 1995-01-05 | 2003-10-29 | THE BOARD OF REGENTS acting for and on behalf of THE UNIVERSITY OF MICHIGAN | Surface-modified nanoparticles and method of making and using same |
US5599576A (en) | 1995-02-06 | 1997-02-04 | Surface Solutions Laboratories, Inc. | Medical apparatus with scratch-resistant coating and method of making same |
US6231600B1 (en) | 1995-02-22 | 2001-05-15 | Scimed Life Systems, Inc. | Stents with hybrid coating for medical devices |
US5605696A (en) | 1995-03-30 | 1997-02-25 | Advanced Cardiovascular Systems, Inc. | Drug loaded polymeric material and method of manufacture |
CA2216943C (en) | 1995-04-19 | 2003-06-17 | Schneider (Usa) Inc. | Drug release coated stent |
US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
US6120536A (en) | 1995-04-19 | 2000-09-19 | Schneider (Usa) Inc. | Medical devices with long term non-thrombogenic coatings |
US5837313A (en) | 1995-04-19 | 1998-11-17 | Schneider (Usa) Inc | Drug release stent coating process |
US20020091433A1 (en) | 1995-04-19 | 2002-07-11 | Ni Ding | Drug release coated stent |
US5570537A (en) | 1995-04-27 | 1996-11-05 | Black; Douglas A. | Electronic insecticidal cable |
CN1136922C (zh) | 1995-05-01 | 2004-02-04 | 株式会社三养社 | 可植入的可生物再吸收的膜及其制备方法 |
US6602281B1 (en) | 1995-06-05 | 2003-08-05 | Avantec Vascular Corporation | Radially expansible vessel scaffold having beams and expansion joints |
US5714007A (en) | 1995-06-06 | 1998-02-03 | David Sarnoff Research Center, Inc. | Apparatus for electrostatically depositing a medicament powder upon predefined regions of a substrate |
US5674242A (en) | 1995-06-06 | 1997-10-07 | Quanam Medical Corporation | Endoprosthetic device with therapeutic compound |
CA2178541C (en) | 1995-06-07 | 2009-11-24 | Neal E. Fearnot | Implantable medical device |
US5609629A (en) | 1995-06-07 | 1997-03-11 | Med Institute, Inc. | Coated implantable medical device |
US6774278B1 (en) | 1995-06-07 | 2004-08-10 | Cook Incorporated | Coated implantable medical device |
WO1996041807A1 (en) | 1995-06-09 | 1996-12-27 | Novartis Ag | Rapamycin derivatives |
US6256529B1 (en) | 1995-07-26 | 2001-07-03 | Burdette Medical Systems, Inc. | Virtual reality 3D visualization for surgical procedures |
JP3476604B2 (ja) | 1995-08-22 | 2003-12-10 | 鐘淵化学工業株式会社 | 薬剤を付着・コーティングしたステントの製造方法 |
EP0764675B1 (en) | 1995-09-19 | 1998-05-13 | Mitsubishi Gas Chemical Company, Inc. | Biodegrable water-soluble polymer |
US5607442A (en) | 1995-11-13 | 1997-03-04 | Isostent, Inc. | Stent with improved radiopacity and appearance characteristics |
CA2192520A1 (en) | 1996-03-05 | 1997-09-05 | Ian M. Penn | Expandable stent and method for delivery of same |
US6461644B1 (en) | 1996-03-25 | 2002-10-08 | Richard R. Jackson | Anesthetizing plastics, drug delivery plastics, and related medical products, systems and methods |
NZ331269A (en) | 1996-04-10 | 2000-01-28 | Advanced Cardiovascular System | Expandable stent, its structural strength varying along its length |
US5669932A (en) | 1996-05-29 | 1997-09-23 | Isostent, Inc. | Means for accurately positioning an expandable stent |
KR20000016116A (ko) | 1996-05-31 | 2000-03-25 | 시게후치 마사토시 | 방오성 부재 및 방오성 코팅 조성물 |
US6143037A (en) | 1996-06-12 | 2000-11-07 | The Regents Of The University Of Michigan | Compositions and methods for coating medical devices |
US5876426A (en) | 1996-06-13 | 1999-03-02 | Scimed Life Systems, Inc. | System and method of providing a blood-free interface for intravascular light delivery |
FR2750897B1 (fr) | 1996-07-10 | 1998-09-18 | Sames Sa | Projecteur triboelectrique, installation de projection de produit de revetement et procede de commande d'un tel projecteur |
EP0937082A2 (en) | 1996-07-12 | 1999-08-25 | Ariad Pharmaceuticals, Inc. | Materials and method for treating or preventing pathogenic fungal infection |
JPH1029524A (ja) | 1996-07-15 | 1998-02-03 | Toyota Motor Corp | 車輪スリップ制御装置 |
US5871436A (en) | 1996-07-19 | 1999-02-16 | Advanced Cardiovascular Systems, Inc. | Radiation therapy method and device |
DE69722720T2 (de) | 1996-07-24 | 2004-05-13 | Cordis Corp., Miami Lakes | Ballonkatheter und Methode zur Anwendung |
US6013855A (en) | 1996-08-06 | 2000-01-11 | United States Surgical | Grafting of biocompatible hydrophilic polymers onto inorganic and metal surfaces |
DE19633901A1 (de) | 1996-08-22 | 1998-02-26 | Thomas Prof Dr Med Ischinger | Gefäßstütze in Form einer Schlauchabschnitts-artigen Stützstruktur |
US6884377B1 (en) | 1996-08-27 | 2005-04-26 | Trexel, Inc. | Method and apparatus for microcellular polymer extrusion |
US5807404A (en) | 1996-09-19 | 1998-09-15 | Medinol Ltd. | Stent with variable features to optimize support and method of making such stent |
US6193963B1 (en) | 1996-10-17 | 2001-02-27 | The Regents Of The University Of California | Method of treating tumor-bearing patients with human plasma hyaluronidase |
US6387121B1 (en) | 1996-10-21 | 2002-05-14 | Inflow Dynamics Inc. | Vascular and endoluminal stents with improved coatings |
US6530951B1 (en) | 1996-10-24 | 2003-03-11 | Cook Incorporated | Silver implantable medical device |
GB9623634D0 (en) | 1996-11-13 | 1997-01-08 | Bpsi Holdings Inc | Method and apparatus for the coating of substrates for pharmaceutical use |
US6251980B1 (en) | 1996-12-06 | 2001-06-26 | Amcol International Corporation | Nanocomposites formed by onium ion-intercalated clay and rigid anhydride-cured epoxy resins |
US5871437A (en) | 1996-12-10 | 1999-02-16 | Inflow Dynamics, Inc. | Radioactive stent for treating blood vessels to prevent restenosis |
ZA9711732B (en) | 1996-12-31 | 1998-12-28 | Quadrant Holdings Cambridge | Methods and compositions for improvement bioavailability of bioactive agents for mucosal delivery |
FR2758253B1 (fr) | 1997-01-10 | 1999-04-02 | Nycomed Lab Sa | Dispositif implantable pour le traitement d'un conduit corporel |
US6884823B1 (en) | 1997-01-16 | 2005-04-26 | Trexel, Inc. | Injection molding of polymeric material |
DE29702671U1 (de) | 1997-02-17 | 1997-04-10 | Jomed Implantate GmbH, 72414 Rangendingen | Stent |
ATE278397T1 (de) | 1997-03-31 | 2004-10-15 | Boston Scient Ltd | Verwendung von cytoskelettinhibitoren zur vorbeugung der restenose |
US6273913B1 (en) | 1997-04-18 | 2001-08-14 | Cordis Corporation | Modified stent useful for delivery of drugs along stent strut |
IT1292295B1 (it) | 1997-04-29 | 1999-01-29 | Sorin Biomedica Cardio Spa | Stent per angioplastica |
FR2762777B1 (fr) | 1997-05-05 | 1999-10-22 | Patrick Sabaria | Extenseurs vasculaires et coronaires, habituellement designes sous le nom de "stent" |
GB9800936D0 (en) | 1997-05-10 | 1998-03-11 | Univ Nottingham | Biofunctional polymers |
DE19720115C2 (de) | 1997-05-14 | 1999-05-20 | Jomed Implantate Gmbh | Stent-Graft |
CA2308396A1 (en) | 1997-05-14 | 1998-11-19 | Novo Rps Ulc | Expandable stent and method for production of same |
DE29708689U1 (de) | 1997-05-15 | 1997-07-17 | Jomed Implantate GmbH, 72414 Rangendingen | Koronarer Stent |
US5913895A (en) | 1997-06-02 | 1999-06-22 | Isostent, Inc. | Intravascular stent with enhanced rigidity strut members |
US6416779B1 (en) | 1997-06-11 | 2002-07-09 | Umd, Inc. | Device and method for intravaginal or transvaginal treatment of fungal, bacterial, viral or parasitic infections |
US6433154B1 (en) | 1997-06-12 | 2002-08-13 | Bristol-Myers Squibb Company | Functional receptor/kinase chimera in yeast cells |
US6245103B1 (en) | 1997-08-01 | 2001-06-12 | Schneider (Usa) Inc | Bioabsorbable self-expanding stent |
US6077880A (en) | 1997-08-08 | 2000-06-20 | Cordis Corporation | Highly radiopaque polyolefins and method for making the same |
WO1999008729A1 (en) | 1997-08-13 | 1999-02-25 | Boston Scientific Limited | Loading and release of water-insoluble drugs |
JP4352613B2 (ja) | 1997-08-28 | 2009-10-28 | 日産化学工業株式会社 | 血管新生促進剤及び血管新生作用増強剤 |
DE29716476U1 (de) | 1997-09-13 | 1997-12-18 | Convent, Gerd, 47829 Krefeld | Stent zur Stenosebehandlung |
DE29716467U1 (de) | 1997-09-15 | 1998-02-26 | Rittal-Werk Rudolf Loh Gmbh & Co Kg, 35745 Herborn | Gehäuseaufbau für elektrische oder elektronische Einbauten |
US7378105B2 (en) | 1997-09-26 | 2008-05-27 | Abbott Laboratories | Drug delivery systems, kits, and methods for administering zotarolimus and paclitaxel to blood vessel lumens |
US8257725B2 (en) | 1997-09-26 | 2012-09-04 | Abbott Laboratories | Delivery of highly lipophilic agents via medical devices |
TW557297B (en) | 1997-09-26 | 2003-10-11 | Abbott Lab | Rapamycin analogs having immunomodulatory activity, and pharmaceutical compositions containing same |
US6042606A (en) | 1997-09-29 | 2000-03-28 | Cook Incorporated | Radially expandable non-axially contracting surgical stent |
US6071308A (en) | 1997-10-01 | 2000-06-06 | Boston Scientific Corporation | Flexible metal wire stent |
US6127000A (en) | 1997-10-10 | 2000-10-03 | North Carolina State University | Method and compositions for protecting civil infrastructure |
ATE452598T1 (de) | 1997-11-07 | 2010-01-15 | Salviac Ltd | Embolieschutzvorrichtung |
DE59808721D1 (de) | 1997-11-24 | 2003-07-17 | Efmt Entwicklungs Und Forschun | Verfahren zur immobilisierung von mediatormolekülen auf anorganischen und metallischen implantatmaterialien |
US5957975A (en) | 1997-12-15 | 1999-09-28 | The Cleveland Clinic Foundation | Stent having a programmed pattern of in vivo degradation |
CA2314963A1 (en) | 1998-01-06 | 1999-07-15 | Bioamide, Inc. | Bioabsorbable fibers and reinforced composites produced therefrom |
US6129755A (en) | 1998-01-09 | 2000-10-10 | Nitinol Development Corporation | Intravascular stent having an improved strut configuration |
DE69942515D1 (de) | 1998-03-04 | 2010-07-29 | Boston Scient Ltd | Stent mit verbesserter Zellkonfiguration |
US7208010B2 (en) | 2000-10-16 | 2007-04-24 | Conor Medsystems, Inc. | Expandable medical device for delivery of beneficial agent |
SE9801288D0 (sv) | 1998-04-14 | 1998-04-14 | Astra Ab | Vaccine delivery system and metod of production |
US8029561B1 (en) | 2000-05-12 | 2011-10-04 | Cordis Corporation | Drug combination useful for prevention of restenosis |
GB9808052D0 (en) | 1998-04-17 | 1998-06-17 | Secr Defence | Implants for administering substances and methods of producing implants |
US6206914B1 (en) | 1998-04-30 | 2001-03-27 | Medtronic, Inc. | Implantable system with drug-eluting cells for on-demand local drug delivery |
US6190699B1 (en) | 1998-05-08 | 2001-02-20 | Nzl Corporation | Method of incorporating proteins or peptides into a matrix and administration thereof through mucosa |
DE19822157B4 (de) | 1998-05-16 | 2013-01-10 | Abbott Laboratories Vascular Enterprises Ltd. | Radial aufweitbarer Stent zur Implantierung in ein Körpergefäß |
FR2780057B1 (fr) | 1998-06-18 | 2002-09-13 | Sanofi Sa | Phenoxypropanolamines, procede pour leur preparation et compositions pharmaceutiques les contenant |
ATE246522T1 (de) | 1998-06-19 | 2003-08-15 | Oxibio Inc | Implantierbare medizinische vorrichtung mit antiinfektiösen und kontrazeptiven eigenschaften |
US6153252A (en) | 1998-06-30 | 2000-11-28 | Ethicon, Inc. | Process for coating stents |
US6541033B1 (en) | 1998-06-30 | 2003-04-01 | Amgen Inc. | Thermosensitive biodegradable hydrogels for sustained delivery of leptin |
US7967855B2 (en) | 1998-07-27 | 2011-06-28 | Icon Interventional Systems, Inc. | Coated medical device |
US8070796B2 (en) | 1998-07-27 | 2011-12-06 | Icon Interventional Systems, Inc. | Thrombosis inhibiting graft |
US7004962B2 (en) | 1998-07-27 | 2006-02-28 | Schneider (Usa), Inc. | Neuroaneurysm occlusion and delivery device and method of using same |
US6461380B1 (en) | 1998-07-28 | 2002-10-08 | Advanced Cardiovascular Systems, Inc. | Stent configuration |
US6248127B1 (en) | 1998-08-21 | 2001-06-19 | Medtronic Ave, Inc. | Thromboresistant coated medical device |
US6193744B1 (en) | 1998-09-10 | 2001-02-27 | Scimed Life Systems, Inc. | Stent configurations |
US6342062B1 (en) | 1998-09-24 | 2002-01-29 | Scimed Life Systems, Inc. | Retrieval devices for vena cava filter |
US6363104B1 (en) | 1998-10-02 | 2002-03-26 | Ericsson Inc. | Method and apparatus for interference cancellation in a rake receiver |
US6245104B1 (en) | 1999-02-28 | 2001-06-12 | Inflow Dynamics Inc. | Method of fabricating a biocompatible stent |
US6042597A (en) | 1998-10-23 | 2000-03-28 | Scimed Life Systems, Inc. | Helical stent design |
US6143314A (en) | 1998-10-28 | 2000-11-07 | Atrix Laboratories, Inc. | Controlled release liquid delivery compositions with low initial drug burst |
FR2785174A1 (fr) | 1998-11-03 | 2000-05-05 | Jacques Seguin | Extenseur de conduit corporel, notamment vasculaire |
US6355691B1 (en) | 1998-11-12 | 2002-03-12 | Tobias M. Goodman | Urushiol therapy of transitional cell carcinoma of the bladder |
EP1131114B1 (en) | 1998-11-20 | 2004-06-16 | The University of Connecticut | Apparatus and method for control of tissue/implant interactions |
AU1821200A (en) | 1998-12-03 | 2000-06-19 | Scimed Life Systems, Inc. | Stent having drug crystals thereon |
US6372246B1 (en) | 1998-12-16 | 2002-04-16 | Ortho-Mcneil Pharmaceutical, Inc. | Polyethylene glycol coating for electrostatic dry deposition of pharmaceuticals |
US6858598B1 (en) | 1998-12-23 | 2005-02-22 | G. D. Searle & Co. | Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
US6147135A (en) | 1998-12-31 | 2000-11-14 | Ethicon, Inc. | Fabrication of biocompatible polymeric composites |
US6638727B1 (en) | 1999-01-26 | 2003-10-28 | Cytyc Health Corporation | Methods for identifying treating or monitoring asymptomatic patients for risk reduction or therapeutic treatment of breast cancer |
US6706283B1 (en) | 1999-02-10 | 2004-03-16 | Pfizer Inc | Controlled release by extrusion of solid amorphous dispersions of drugs |
SE9900519D0 (sv) | 1999-02-17 | 1999-02-17 | Lars Lidgren | A method for the preparation of UHMWPE doped with an antioxidant and an implant made thereof |
US6171327B1 (en) | 1999-02-24 | 2001-01-09 | Scimed Life Systems, Inc. | Intravascular filter and method |
US6620192B1 (en) | 1999-03-16 | 2003-09-16 | Advanced Cardiovascular Systems, Inc. | Multilayer stent |
SE9901002D0 (sv) | 1999-03-19 | 1999-03-19 | Electrolux Ab | Anordning för rengöring av textilföremål med en förtätad vätskeformig behandlingsgas |
US6364903B2 (en) | 1999-03-19 | 2002-04-02 | Meadox Medicals, Inc. | Polymer coated stent |
US6368658B1 (en) | 1999-04-19 | 2002-04-09 | Scimed Life Systems, Inc. | Coating medical devices using air suspension |
US6923979B2 (en) | 1999-04-27 | 2005-08-02 | Microdose Technologies, Inc. | Method for depositing particles onto a substrate using an alternating electric field |
US8016873B1 (en) | 1999-05-03 | 2011-09-13 | Drasler William J | Intravascular hinge stent |
US6726712B1 (en) | 1999-05-14 | 2004-04-27 | Boston Scientific Scimed | Prosthesis deployment device with translucent distal end |
JP2000316981A (ja) | 1999-05-14 | 2000-11-21 | Kawasumi Lab Inc | ステント |
US6815218B1 (en) | 1999-06-09 | 2004-11-09 | Massachusetts Institute Of Technology | Methods for manufacturing bioelectronic devices |
CN1390126B (zh) | 1999-07-06 | 2012-06-13 | 恩多研究公司 | 选择性雌激素受体调节剂在制备用于治疗或降低肥胖症发展危险性的药物中的用途 |
AU783158B2 (en) | 1999-08-24 | 2005-09-29 | Ariad Pharmaceuticals, Inc. | 28-epirapalogs |
US6146404A (en) | 1999-09-03 | 2000-11-14 | Scimed Life Systems, Inc. | Removable thrombus filter |
US20070032853A1 (en) | 2002-03-27 | 2007-02-08 | Hossainy Syed F | 40-O-(2-hydroxy)ethyl-rapamycin coated stent |
US6358557B1 (en) | 1999-09-10 | 2002-03-19 | Sts Biopolymers, Inc. | Graft polymerization of substrate surfaces |
US6610013B1 (en) | 1999-10-01 | 2003-08-26 | Life Imaging Systems, Inc. | 3D ultrasound-guided intraoperative prostate brachytherapy |
US6755871B2 (en) | 1999-10-15 | 2004-06-29 | R.R. Street & Co. Inc. | Cleaning system utilizing an organic cleaning solvent and a pressurized fluid solvent |
US6458387B1 (en) | 1999-10-18 | 2002-10-01 | Epic Therapeutics, Inc. | Sustained release microspheres |
US7537785B2 (en) | 1999-10-29 | 2009-05-26 | Nitromed, Inc. | Composition for treating vascular diseases characterized by nitric oxide insufficiency |
US6537310B1 (en) | 1999-11-19 | 2003-03-25 | Advanced Bio Prosthetic Surfaces, Ltd. | Endoluminal implantable devices and method of making same |
US6908624B2 (en) | 1999-12-23 | 2005-06-21 | Advanced Cardiovascular Systems, Inc. | Coating for implantable devices and a method of forming the same |
US6572813B1 (en) | 2000-01-13 | 2003-06-03 | Advanced Cardiovascular Systems, Inc. | Balloon forming process |
TWI284048B (en) | 2000-01-27 | 2007-07-21 | Zentaris Ag | Compressed microparticles for dry injection |
EP1132058A1 (en) | 2000-03-06 | 2001-09-12 | Advanced Laser Applications Holding S.A. | Intravascular prothesis |
EP1145719A3 (en) | 2000-03-10 | 2001-11-14 | Pfizer Products Inc. | Use a ferrous salt for inhibiting oxidative degradation of pharmaceutical formulations |
US8088060B2 (en) | 2000-03-15 | 2012-01-03 | Orbusneich Medical, Inc. | Progenitor endothelial cell capturing with a drug eluting implantable medical device |
CN2423899Y (zh) | 2000-05-08 | 2001-03-21 | 微创医疗器械(上海)有限公司 | 冠状动脉支架 |
AU6145501A (en) | 2000-05-12 | 2001-11-26 | Advanced Bio Prosthetic Surfac | Self-supporting laminated films, structural materials and medical devices manufactured therefrom and methods of making same |
MXPA02011427A (es) | 2000-05-16 | 2004-09-10 | Johnson & Johnson | Procedimiento para revestir dispositivos medicos utilizando dioxido de carbono supercritico. |
US7217770B2 (en) | 2000-05-17 | 2007-05-15 | Samyang Corporation | Stable polymeric micelle-type drug composition and method for the preparation thereof |
US20020144757A1 (en) | 2000-07-07 | 2002-10-10 | Craig Charles Horace | Stainless steel alloy with improved radiopaque characteristics |
US20030077200A1 (en) | 2000-07-07 | 2003-04-24 | Craig Charles H. | Enhanced radiopaque alloy stent |
EP1317304B1 (en) | 2000-09-01 | 2011-04-27 | Palmaya Pty Ltd. | Slow release pharmaceutical preparation and method of administering same |
US7332242B2 (en) | 2000-09-01 | 2008-02-19 | Itochu Corporation | Lithium-based battery having extensible, ion-impermeable polymer covering on the battery container |
US6362718B1 (en) | 2000-09-06 | 2002-03-26 | Stephen L. Patrick | Motionless electromagnetic generator |
US6506213B1 (en) | 2000-09-08 | 2003-01-14 | Ferro Corporation | Manufacturing orthopedic parts using supercritical fluid processing techniques |
US6521258B1 (en) | 2000-09-08 | 2003-02-18 | Ferro Corporation | Polymer matrices prepared by supercritical fluid processing techniques |
US6953560B1 (en) | 2000-09-28 | 2005-10-11 | Advanced Cardiovascular Systems, Inc. | Barriers for polymer-coated implantable medical devices and methods for making the same |
AU1129902A (en) | 2000-09-29 | 2002-04-08 | Cordis Corp | Coated medical devices |
US20060222756A1 (en) | 2000-09-29 | 2006-10-05 | Cordis Corporation | Medical devices, drug coatings and methods of maintaining the drug coatings thereon |
US20020111590A1 (en) | 2000-09-29 | 2002-08-15 | Davila Luis A. | Medical devices, drug coatings and methods for maintaining the drug coatings thereon |
JP2004537495A (ja) | 2000-11-03 | 2004-12-16 | コントロール・デリバリー・システムズ | 関節疾患を治療するための改善された装置及び方法 |
US20040018228A1 (en) | 2000-11-06 | 2004-01-29 | Afmedica, Inc. | Compositions and methods for reducing scar tissue formation |
US20050084514A1 (en) | 2000-11-06 | 2005-04-21 | Afmedica, Inc. | Combination drug therapy for reducing scar tissue formation |
WO2002040702A2 (en) | 2000-11-09 | 2002-05-23 | Vanderbilt University | Methods for the treatment of cancer and other diseases and methods of developing the same |
US6682757B1 (en) | 2000-11-16 | 2004-01-27 | Euro-Celtique, S.A. | Titratable dosage transdermal delivery system |
JP4868565B2 (ja) | 2000-11-30 | 2012-02-01 | 株式会社 京都医療設計 | 血管用ステント |
US6913617B1 (en) | 2000-12-27 | 2005-07-05 | Advanced Cardiovascular Systems, Inc. | Method for creating a textured surface on an implantable medical device |
GB0100760D0 (en) | 2001-01-11 | 2001-02-21 | Biocompatibles Ltd | Drug delivery from stents |
GB0100761D0 (en) | 2001-01-11 | 2001-02-21 | Biocompatibles Ltd | Drug delivery from stents |
TWI246524B (en) | 2001-01-19 | 2006-01-01 | Shearwater Corp | Multi-arm block copolymers as drug delivery vehicles |
US6660176B2 (en) | 2001-01-24 | 2003-12-09 | Virginia Commonwealth University | Molecular imprinting of small particles, and production of small particles from solid state reactants |
IL151150A0 (en) | 2001-01-31 | 2003-04-10 | Roehm Gmbh | Multiparticulate drug form comprising at least two differently coated pellet forms |
US20040220660A1 (en) | 2001-02-05 | 2004-11-04 | Shanley John F. | Bioresorbable stent with beneficial agent reservoirs |
DE10106810A1 (de) | 2001-02-14 | 2002-09-05 | Siemens Ag | Netzunabhängige Stromversorgungseinheit |
US6905555B2 (en) | 2001-02-15 | 2005-06-14 | Micell Technologies, Inc. | Methods for transferring supercritical fluids in microelectronic and other industrial processes |
US6720003B2 (en) | 2001-02-16 | 2004-04-13 | Andrx Corporation | Serotonin reuptake inhibitor formulations |
US6811549B2 (en) | 2001-02-16 | 2004-11-02 | William H. Fleming | Administration of therapeutic or diagnostic agents using interlabial pad |
US6949251B2 (en) | 2001-03-02 | 2005-09-27 | Stryker Corporation | Porous β-tricalcium phosphate granules for regeneration of bone tissue |
US7771468B2 (en) | 2001-03-16 | 2010-08-10 | Angiotech Biocoatings Corp. | Medicated stent having multi-layer polymer coating |
JP2004526499A (ja) | 2001-03-16 | 2004-09-02 | エスティーエス バイオポリマーズ,インコーポレイティド | 複数層ポリマーコーティングを有する薬物添加ステント |
WO2002085188A2 (en) | 2001-04-24 | 2002-10-31 | Kaplan Edward J | Deflectable implantation device and method for use |
US20040022853A1 (en) | 2001-04-26 | 2004-02-05 | Control Delivery Systems, Inc. | Polymer-based, sustained release drug delivery system |
US7247338B2 (en) | 2001-05-16 | 2007-07-24 | Regents Of The University Of Minnesota | Coating medical devices |
US6973718B2 (en) | 2001-05-30 | 2005-12-13 | Microchips, Inc. | Methods for conformal coating and sealing microchip reservoir devices |
US7201940B1 (en) | 2001-06-12 | 2007-04-10 | Advanced Cardiovascular Systems, Inc. | Method and apparatus for thermal spray processing of medical devices |
US20030044514A1 (en) | 2001-06-13 | 2003-03-06 | Richard Robert E. | Using supercritical fluids to infuse therapeutic on a medical device |
US7485113B2 (en) | 2001-06-22 | 2009-02-03 | Johns Hopkins University | Method for drug delivery through the vitreous humor |
US7501157B2 (en) | 2001-06-26 | 2009-03-10 | Accelr8 Technology Corporation | Hydroxyl functional surface coating |
US6585755B2 (en) | 2001-06-29 | 2003-07-01 | Advanced Cardiovascular | Polymeric stent suitable for imaging by MRI and fluoroscopy |
US6967234B2 (en) | 2002-12-18 | 2005-11-22 | Ethicon, Inc. | Alkyd-lactone copolymers for medical applications |
US7015875B2 (en) | 2001-06-29 | 2006-03-21 | Novus Partners Llc | Dynamic device for billboard advertising |
US6743505B2 (en) | 2001-07-27 | 2004-06-01 | Ethicon, Inc. | Bioabsorbable multifilament yarn and methods of manufacture |
US6723913B1 (en) | 2001-08-23 | 2004-04-20 | Anthony T. Barbetta | Fan cooling of active speakers |
US6669980B2 (en) | 2001-09-18 | 2003-12-30 | Scimed Life Systems, Inc. | Method for spray-coating medical devices |
WO2003034944A1 (de) | 2001-10-15 | 2003-05-01 | Hemoteq Gmbh | Beschichtung von stents zur verhinderung von restenose |
US20030088307A1 (en) | 2001-11-05 | 2003-05-08 | Shulze John E. | Potent coatings for stents |
US6939376B2 (en) | 2001-11-05 | 2005-09-06 | Sun Biomedical, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
CA2466336A1 (en) | 2001-11-09 | 2003-05-15 | Ebrahim Versi | Anti-muscarinic agent and estrogen-agonist for treating unstable or overactive bladder |
US6517889B1 (en) | 2001-11-26 | 2003-02-11 | Swaminathan Jayaraman | Process for coating a surface of a stent |
US7488313B2 (en) | 2001-11-29 | 2009-02-10 | Boston Scientific Scimed, Inc. | Mechanical apparatus and method for dilating and delivering a therapeutic agent to a site of treatment |
US6868123B2 (en) | 2001-12-07 | 2005-03-15 | Motorola, Inc. | Programmable motion estimation module with vector array unit |
TW497494U (en) | 2001-12-28 | 2002-08-01 | Metal Ind Redearch & Amp Dev C | Fluid driven stirring device for compressing gas cleaning system |
DE10200388A1 (de) | 2002-01-08 | 2003-07-24 | Translumina Gmbh | Beschichtungssystem |
KR20040076278A (ko) | 2002-01-10 | 2004-08-31 | 노파르티스 아게 | 라파마이신 및 그의 유도체를 포함하는, 혈관 질환의 예방및 치료를 위한 약물 전달 시스템 |
US20030135256A1 (en) | 2002-01-14 | 2003-07-17 | Gallagher Brendan P. | Stent delivery system |
HUP0402591A2 (hu) | 2002-02-15 | 2005-09-28 | Cv Therapeutics, Inc. | Polimer bevonat orvosi eszközök számára |
US20060093771A1 (en) | 2002-02-15 | 2006-05-04 | Frantisek Rypacek | Polymer coating for medical devices |
PL371466A1 (en) | 2002-02-28 | 2005-06-13 | Novartis Ag | N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine coated stents |
WO2003074992A2 (en) | 2002-03-01 | 2003-09-12 | Mds Proteomics Inc. | Phosphorylated proteins and uses related thereto |
GB0205868D0 (en) | 2002-03-13 | 2002-04-24 | Univ Nottingham | Polymer composite with internally distributed deposition matter |
US7919075B1 (en) | 2002-03-20 | 2011-04-05 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable medical devices |
US6743463B2 (en) | 2002-03-28 | 2004-06-01 | Scimed Life Systems, Inc. | Method for spray-coating a medical device having a tubular wall such as a stent |
US7470281B2 (en) | 2002-04-26 | 2008-12-30 | Medtronic Vascular, Inc. | Coated stent with crimpable coating |
US7270675B2 (en) | 2002-05-10 | 2007-09-18 | Cordis Corporation | Method of forming a tubular membrane on a structural frame |
US6669785B2 (en) | 2002-05-15 | 2003-12-30 | Micell Technologies, Inc. | Methods and compositions for etch cleaning microelectronic substrates in carbon dioxide |
ATE460994T1 (de) | 2002-05-28 | 2010-04-15 | Battelle Memorial Institute | Elektrostatische abscheidung von durch schnelle entspannung überkritischer lösungen (ress) erhaltene partikel |
US6756084B2 (en) | 2002-05-28 | 2004-06-29 | Battelle Memorial Institute | Electrostatic deposition of particles generated from rapid expansion of supercritical fluid solutions |
US6749902B2 (en) | 2002-05-28 | 2004-06-15 | Battelle Memorial Institute | Methods for producing films using supercritical fluid |
US6780475B2 (en) | 2002-05-28 | 2004-08-24 | Battelle Memorial Institute | Electrostatic deposition of particles generated from rapid expansion of supercritical fluid solutions |
US7229837B2 (en) | 2002-05-30 | 2007-06-12 | Uchicago Argonne, Llc | Enhanced photophysics of conjugated polymers |
TW200403065A (en) | 2002-05-30 | 2004-03-01 | Akzo Nobel Nv | New etonogestrel esters |
CN100369593C (zh) | 2002-06-05 | 2008-02-20 | 佛罗里达大学研究基金会有限公司 | 眼科给药体系 |
CA2489362A1 (en) | 2002-06-13 | 2003-12-24 | Kappler, Inc. | Microporous membrane with adsorbent multi-functional filler |
US6794902B2 (en) | 2002-06-14 | 2004-09-21 | Sun Microsystems, Inc. | Virtual ground circuit |
US7033602B1 (en) | 2002-06-21 | 2006-04-25 | Advanced Cardiovascular Systems, Inc. | Polycationic peptide coatings and methods of coating implantable medical devices |
US7217426B1 (en) | 2002-06-21 | 2007-05-15 | Advanced Cardiovascular Systems, Inc. | Coatings containing polycationic peptides for cardiovascular therapy |
US6839913B2 (en) | 2002-06-25 | 2005-01-11 | Noble Ideas, Inc. | Adjustable garment waistband and method of manufacture |
WO2004002367A1 (fr) | 2002-06-27 | 2004-01-08 | Microport Medical (Shanghai) Co., Ltd. | Stent eluant des medicaments |
CN100471469C (zh) | 2002-06-27 | 2009-03-25 | 微创医疗器械(上海)有限公司 | 一种具有多层涂层的药物洗脱支架 |
US20040013792A1 (en) | 2002-07-19 | 2004-01-22 | Samuel Epstein | Stent coating holders |
US7491233B1 (en) | 2002-07-19 | 2009-02-17 | Advanced Cardiovascular Systems Inc. | Purified polymers for coatings of implantable medical devices |
JP2004058431A (ja) | 2002-07-29 | 2004-02-26 | Nitto Denko Corp | 粘着テープ又はシート |
GB2391439B (en) | 2002-07-30 | 2006-06-21 | Wolfson Ltd | Bass compressor |
US20050019747A1 (en) | 2002-08-07 | 2005-01-27 | Anderson Daniel G. | Nanoliter-scale synthesis of arrayed biomaterials and screening thereof |
US7029495B2 (en) | 2002-08-28 | 2006-04-18 | Scimed Life Systems, Inc. | Medical devices and methods of making the same |
US7060051B2 (en) | 2002-09-24 | 2006-06-13 | Scimed Life Systems, Inc. | Multi-balloon catheter with hydrogel coating |
JP2006500996A (ja) | 2002-09-26 | 2006-01-12 | エンドバスキュラー デバイセス インコーポレイテッド | 溶出性生体適合性移植可能医療器具を介してマイトマイシンを送達するための装置および方法 |
US6702850B1 (en) | 2002-09-30 | 2004-03-09 | Mediplex Corporation Korea | Multi-coated drug-eluting stent for antithrombosis and antirestenosis |
US6770729B2 (en) | 2002-09-30 | 2004-08-03 | Medtronic Minimed, Inc. | Polymer compositions containing bioactive agents and methods for their use |
US20050010275A1 (en) | 2002-10-11 | 2005-01-13 | Sahatjian Ronald A. | Implantable medical devices |
US6800663B2 (en) | 2002-10-18 | 2004-10-05 | Alkermes Controlled Therapeutics Inc. Ii, | Crosslinked hydrogel copolymers |
KR100511030B1 (ko) | 2002-10-21 | 2005-08-31 | 한국과학기술연구원 | 혈액적합성 의료용 금속 재료 및 이의 제조 방법 |
WO2004043383A2 (en) | 2002-11-07 | 2004-05-27 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | A new target for angiogenesis and anti-angiogenesis therapy |
US20050070989A1 (en) | 2002-11-13 | 2005-03-31 | Whye-Kei Lye | Medical devices having porous layers and methods for making the same |
US20060121080A1 (en) | 2002-11-13 | 2006-06-08 | Lye Whye K | Medical devices having nanoporous layers and methods for making the same |
US20040098106A1 (en) | 2002-11-14 | 2004-05-20 | Williams Michael S. | Intraluminal prostheses and carbon dioxide-assisted methods of impregnating same with pharmacological agents |
CA2503388C (en) | 2002-11-15 | 2012-05-15 | Synecor, Llc | Improved endoprostheses and methods of manufacture |
CA2506319C (en) | 2002-11-18 | 2012-08-28 | Polymerix Corporation | Stents comprising biodegradable polymers associated with therapeutic agents |
JP4371653B2 (ja) | 2002-11-25 | 2009-11-25 | テルモ株式会社 | 体内埋込医療器具 |
US6790483B2 (en) | 2002-12-06 | 2004-09-14 | Eastman Kodak Company | Method for producing patterned deposition from compressed fluid |
US7094256B1 (en) | 2002-12-16 | 2006-08-22 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable medical device containing polycationic peptides |
EP1578193A4 (en) | 2002-12-23 | 2011-06-15 | Vical Inc | FREEZING PROCESS FOR NUCLEIC ACID / BLOCK COPOLYMER / CATION SIDE COMPLEXES |
US7152452B2 (en) | 2002-12-26 | 2006-12-26 | Advanced Cardiovascular Systems, Inc. | Assembly for crimping an intraluminal device and method of use |
US20040143317A1 (en) | 2003-01-17 | 2004-07-22 | Stinson Jonathan S. | Medical devices |
US7309349B2 (en) | 2003-01-23 | 2007-12-18 | Cordis Corporation | Friction reducing lubricant for stent loading and stent delivery systems |
JP2004225126A (ja) | 2003-01-24 | 2004-08-12 | Pioneer Electronic Corp | 成膜用マスクとその製造方法 |
US20050079199A1 (en) | 2003-02-18 | 2005-04-14 | Medtronic, Inc. | Porous coatings for drug release from medical devices |
US20080051866A1 (en) | 2003-02-26 | 2008-02-28 | Chao Chin Chen | Drug delivery devices and methods |
EP1603485A4 (en) | 2003-02-26 | 2011-03-30 | Medivas Llc | BIOACTIVE STENTS AND METHOD OF USE THEREOF |
US7871607B2 (en) | 2003-03-05 | 2011-01-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases |
US20040193262A1 (en) | 2003-03-29 | 2004-09-30 | Shadduck John H. | Implants for treating ocular hypertension, methods of use and methods of fabrication |
US7527632B2 (en) | 2003-03-31 | 2009-05-05 | Cordis Corporation | Modified delivery device for coated medical devices |
US7326734B2 (en) | 2003-04-01 | 2008-02-05 | The Regents Of The University Of California | Treatment of bladder and urinary tract cancers |
US20050216075A1 (en) | 2003-04-08 | 2005-09-29 | Xingwu Wang | Materials and devices of enhanced electromagnetic transparency |
US20060102871A1 (en) | 2003-04-08 | 2006-05-18 | Xingwu Wang | Novel composition |
WO2004091571A2 (en) | 2003-04-08 | 2004-10-28 | New Jersey Institute Of Technology (Njit) | Polymer coating/encapsulation of nanoparticles using a supercritical antisolvent process |
US20050208102A1 (en) | 2003-04-09 | 2005-09-22 | Schultz Clyde L | Hydrogels used to deliver medicaments to the eye for the treatment of posterior segment diseases |
US20050038498A1 (en) | 2003-04-17 | 2005-02-17 | Nanosys, Inc. | Medical device applications of nanostructured surfaces |
US8246974B2 (en) | 2003-05-02 | 2012-08-21 | Surmodics, Inc. | Medical devices and methods for producing the same |
GB0310300D0 (en) | 2003-05-06 | 2003-06-11 | Univ Belfast | Nanocomposite drug delivery composition |
US7279174B2 (en) | 2003-05-08 | 2007-10-09 | Advanced Cardiovascular Systems, Inc. | Stent coatings comprising hydrophilic additives |
US7553827B2 (en) | 2003-08-13 | 2009-06-30 | Depuy Spine, Inc. | Transdiscal administration of cycline compounds |
US7429378B2 (en) | 2003-05-13 | 2008-09-30 | Depuy Spine, Inc. | Transdiscal administration of high affinity anti-MMP inhibitors |
CA2519742A1 (en) | 2003-05-16 | 2004-11-25 | Blue Membranes Gmbh | Medical implants comprising biocompatible coatings |
US7524527B2 (en) | 2003-05-19 | 2009-04-28 | Boston Scientific Scimed, Inc. | Electrostatic coating of a device |
US20040236416A1 (en) | 2003-05-20 | 2004-11-25 | Robert Falotico | Increased biocompatibility of implantable medical devices |
US7662864B2 (en) | 2003-06-04 | 2010-02-16 | Rutgers, The State University Of New Jersey | Solution polymerization processes to prepare a polymer that degrades to release a physiologically active agent |
WO2004108274A1 (ja) | 2003-06-06 | 2004-12-16 | Mitsubishi Chemical Corporation | 吸水性物品およびその製造方法 |
WO2004113429A2 (en) | 2003-06-23 | 2004-12-29 | The University Of Chicago | Polyolefin nanocomposites |
US8399013B2 (en) | 2003-06-26 | 2013-03-19 | Poly-Med, Inc. | Partially absorbable fiber-reinforced composites for controlled drug delivery |
US7318945B2 (en) | 2003-07-09 | 2008-01-15 | Medtronic Vascular, Inc. | Laminated drug-polymer coated stent having dipped layers |
US8025637B2 (en) | 2003-07-18 | 2011-09-27 | Boston Scientific Scimed, Inc. | Medical balloons and processes for preparing same |
US7128277B2 (en) | 2003-07-29 | 2006-10-31 | Illinois Tool Works Inc. | Powder bell with secondary charging electrode |
US7169404B2 (en) | 2003-07-30 | 2007-01-30 | Advanced Cardiovasular Systems, Inc. | Biologically absorbable coatings for implantable devices and methods for fabricating the same |
US7056591B1 (en) | 2003-07-30 | 2006-06-06 | Advanced Cardiovascular Systems, Inc. | Hydrophobic biologically absorbable coatings for drug delivery devices and methods for fabricating the same |
US20050033417A1 (en) | 2003-07-31 | 2005-02-10 | John Borges | Coating for controlled release of a therapeutic agent |
KR20060052722A (ko) | 2003-08-05 | 2006-05-19 | 가부시키가이샤 가네카 | 생체유치용 스텐트 |
US7318944B2 (en) | 2003-08-07 | 2008-01-15 | Medtronic Vascular, Inc. | Extrusion process for coating stents |
EP1575565B1 (en) | 2003-08-08 | 2010-01-06 | Biovail Laboratories International Srl | Modified-release tablet of bupropion hydrochloride |
CA2535345A1 (en) | 2003-08-13 | 2005-03-03 | Medtronic, Inc. | Active agent delivery systems including a miscible polymer blend, medical devices, and methods |
US7204560B2 (en) | 2003-08-15 | 2007-04-17 | Sandvik Intellectual Property Ab | Rotary cutting bit with material-deflecting ledge |
JP4732346B2 (ja) | 2003-08-19 | 2011-07-27 | バイエル・マテリアルサイエンス・アクチェンゲゼルシャフト | 医療機器用の高分子薬剤溶出システム |
CN101094622A (zh) | 2003-09-18 | 2007-12-26 | 先进生物假体表面有限公司 | 具有MEMs功能的医疗装置及其制造方法 |
US7785653B2 (en) | 2003-09-22 | 2010-08-31 | Innovational Holdings Llc | Method and apparatus for loading a beneficial agent into an expandable medical device |
US8801692B2 (en) | 2003-09-24 | 2014-08-12 | Medtronic Vascular, Inc. | Gradient coated stent and method of fabrication |
US20050070990A1 (en) | 2003-09-26 | 2005-03-31 | Stinson Jonathan S. | Medical devices and methods of making same |
US7744645B2 (en) | 2003-09-29 | 2010-06-29 | Medtronic Vascular, Inc. | Laminated drug-polymer coated stent with dipped and cured layers |
US7198675B2 (en) | 2003-09-30 | 2007-04-03 | Advanced Cardiovascular Systems | Stent mandrel fixture and method for selectively coating surfaces of a stent |
US7618647B2 (en) | 2003-10-03 | 2009-11-17 | Boston Scientific Scimed, Inc. | Using bucky paper as a therapeutic aid in medical applications |
US6984411B2 (en) | 2003-10-14 | 2006-01-10 | Boston Scientific Scimed, Inc. | Method for roll coating multiple stents |
US7329383B2 (en) | 2003-10-22 | 2008-02-12 | Boston Scientific Scimed, Inc. | Alloy compositions and devices including the compositions |
JP2007509220A (ja) | 2003-10-23 | 2007-04-12 | ユニバーシテイ・オブ・ノツテインガム | 活性ポリマー押出物の調製 |
US7220755B2 (en) * | 2003-11-12 | 2007-05-22 | Biosensors International Group, Ltd. | 42-O-alkoxyalkyl rapamycin derivatives and compositions comprising same |
ES2293368T3 (es) | 2003-12-16 | 2008-03-16 | Cytec Surface Specialties, S.A. | Proceso para aplicar un recubrimiento a una banda metalica enrollada. |
US20050131513A1 (en) | 2003-12-16 | 2005-06-16 | Cook Incorporated | Stent catheter with a permanently affixed conductor |
JP4796506B2 (ja) | 2003-12-24 | 2011-10-19 | ノバルティス アーゲー | 医薬組成物 |
US20050147734A1 (en) | 2004-01-07 | 2005-07-07 | Jan Seppala | Method and system for coating tubular medical devices |
US20050268573A1 (en) | 2004-01-20 | 2005-12-08 | Avantec Vascular Corporation | Package of sensitive articles |
US7306677B2 (en) | 2004-01-30 | 2007-12-11 | Boston Scientific Corporation | Clamping fixture for coating stents, system using the fixture, and method of using the fixture |
GB2411078B (en) | 2004-02-10 | 2009-02-04 | Samsung Electronics Co Ltd | Mobile communications |
US7241344B2 (en) | 2004-02-10 | 2007-07-10 | Boston Scientific Scimed, Inc. | Apparatus and method for electrostatic spray coating of medical devices |
US8551512B2 (en) | 2004-03-22 | 2013-10-08 | Advanced Cardiovascular Systems, Inc. | Polyethylene glycol/poly(butylene terephthalate) copolymer coated devices including EVEROLIMUS |
WO2005097223A1 (en) | 2004-03-26 | 2005-10-20 | Surmodics, Inc. | Composition and method for preparing biocompatible surfaces |
US7335264B2 (en) | 2004-04-22 | 2008-02-26 | Boston Scientific Scimed, Inc. | Differentially coated medical devices, system for differentially coating medical devices, and coating method |
US7820732B2 (en) | 2004-04-30 | 2010-10-26 | Advanced Cardiovascular Systems, Inc. | Methods for modulating thermal and mechanical properties of coatings on implantable devices |
US20050288481A1 (en) | 2004-04-30 | 2005-12-29 | Desnoyer Jessica R | Design of poly(ester amides) for the control of agent-release from polymeric compositions |
JP5042820B2 (ja) | 2004-05-14 | 2012-10-03 | ベクトン・ディキンソン・アンド・カンパニー | 生物活性表面を有する物品およびそれらの無溶媒調製法 |
WO2005117942A2 (en) | 2004-05-14 | 2005-12-15 | The Regents Of The University Of Michigan | Methods for encapsulation of biomacromolecules in polymers |
US7758892B1 (en) | 2004-05-20 | 2010-07-20 | Boston Scientific Scimed, Inc. | Medical devices having multiple layers |
US7682656B2 (en) | 2004-06-14 | 2010-03-23 | Agruim Inc. | Process and apparatus for producing a coated product |
US7976557B2 (en) | 2004-06-23 | 2011-07-12 | Boston Scientific Scimed, Inc. | Cutting balloon and process |
CA2511212A1 (en) | 2004-07-02 | 2006-01-02 | Henkel Kommanditgesellschaft Auf Aktien | Surface conditioner for powder coating systems |
EP1773375A1 (en) | 2004-07-14 | 2007-04-18 | University of Utah Research Foundation | Netrin-related compositions and uses |
US20060020325A1 (en) | 2004-07-26 | 2006-01-26 | Robert Burgermeister | Material for high strength, controlled recoil stent |
US8597716B2 (en) * | 2009-06-23 | 2013-12-03 | Abbott Cardiovascular Systems Inc. | Methods to increase fracture resistance of a drug-eluting medical device |
US8541078B2 (en) | 2004-08-06 | 2013-09-24 | Societe Bic | Fuel supplies for fuel cells |
US7425368B2 (en) * | 2004-08-20 | 2008-09-16 | Massachusetts Institute Of Technology | Filler-enhanced polymeric fibers with improved mechanical properties and method for making |
US8119153B2 (en) | 2004-08-26 | 2012-02-21 | Boston Scientific Scimed, Inc. | Stents with drug eluting coatings |
EP1787676A4 (en) | 2004-09-08 | 2012-06-20 | Kaneka Corp | VASCULAR ENDOPROTHESIS PLACING IN THE BODY |
JP2008514706A (ja) | 2004-09-29 | 2008-05-08 | コーディス・コーポレイション | 安定非晶質ラパマイシン様化合物の薬学的投与形態 |
US8313763B2 (en) | 2004-10-04 | 2012-11-20 | Tolmar Therapeutics, Inc. | Sustained delivery formulations of rapamycin compounds |
US20060093643A1 (en) | 2004-11-04 | 2006-05-04 | Stenzel Eric B | Medical device for delivering therapeutic agents over different time periods |
US7455658B2 (en) | 2004-11-10 | 2008-11-25 | Samw Hong Jen Wang | Fluid dispensing or feeding device |
US7455688B2 (en) | 2004-11-12 | 2008-11-25 | Con Interventional Systems, Inc. | Ostial stent |
EP1819373A2 (en) | 2004-12-07 | 2007-08-22 | SurModics, Inc. | Coatings with crystallized active agent(s) |
US20070059350A1 (en) | 2004-12-13 | 2007-03-15 | Kennedy John P | Agents for controlling biological fluids and methods of use thereof |
WO2006063430A1 (en) | 2004-12-16 | 2006-06-22 | Miv Therapeutics Inc. | Multi-layer drug delivery device and method of manufacturing same |
US7632307B2 (en) | 2004-12-16 | 2009-12-15 | Advanced Cardiovascular Systems, Inc. | Abluminal, multilayer coating constructs for drug-delivery stents |
US8292944B2 (en) | 2004-12-17 | 2012-10-23 | Reva Medical, Inc. | Slide-and-lock stent |
US20060198868A1 (en) | 2005-01-05 | 2006-09-07 | Dewitt David M | Biodegradable coating compositions comprising blends |
US7727273B2 (en) | 2005-01-13 | 2010-06-01 | Boston Scientific Scimed, Inc. | Medical devices and methods of making the same |
US7772352B2 (en) | 2005-01-28 | 2010-08-10 | Bezwada Biomedical Llc | Bioabsorbable and biocompatible polyurethanes and polyamides for medical devices |
WO2006110197A2 (en) | 2005-03-03 | 2006-10-19 | Icon Medical Corp. | Polymer biodegradable medical device |
US7837726B2 (en) | 2005-03-14 | 2010-11-23 | Abbott Laboratories | Visible endoprosthesis |
KR20070116821A (ko) | 2005-03-14 | 2007-12-11 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 의약 제제용 생체적합성 중합체 화합물 |
WO2006101972A2 (en) | 2005-03-17 | 2006-09-28 | Elan Pharma International Limited | Injectable compositions of nanoparticulate immunosuppressive compounds |
JP5271697B2 (ja) | 2005-03-23 | 2013-08-21 | アボット ラボラトリーズ | 医療装置を介する高親油性薬剤の送達 |
US8628565B2 (en) | 2005-04-13 | 2014-01-14 | Abbott Cardiovascular Systems Inc. | Intravascular stent |
US20110118827A1 (en) * | 2005-06-06 | 2011-05-19 | Dr. Tim Wu | Biodegradable stent formed with polymer-bioceramic nanoparticle composite and method of making the same |
US20070009564A1 (en) | 2005-06-22 | 2007-01-11 | Mcclain James B | Drug/polymer composite materials and methods of making the same |
WO2007011708A2 (en) | 2005-07-15 | 2007-01-25 | Micell Technologies, Inc. | Stent with polymer coating containing amorphous rapamycin |
EP1909973B1 (en) | 2005-07-15 | 2018-08-22 | Micell Technologies, Inc. | Polymer coatings containing drug powder of controlled morphology |
US8377462B2 (en) | 2005-07-29 | 2013-02-19 | Advanced Cardiovascular Systems, Inc. | PEA-TEMPO/PEA-BZ coatings for controlled delivery of drug from implantable medical devices |
US20070026042A1 (en) | 2005-07-29 | 2007-02-01 | Narayanan Pallasssana V | System for treating aneurysmal disease |
EP1912614A4 (en) | 2005-08-03 | 2009-08-05 | Univ Western Ontario | DIRECT COATING OF SOLID DOSAGE FORMS WITH POWDERFILLED SUBSTANCES |
US8214504B2 (en) | 2005-08-05 | 2012-07-03 | Telecom Italia S.P.A. | Method of establishing a connection on a communication network |
WO2007017707A1 (en) | 2005-08-11 | 2007-02-15 | Hilary Nwokeabia | The slanting toothbrush |
WO2007022055A1 (en) | 2005-08-12 | 2007-02-22 | Massicotte J Mathieu | Method and device for extracting objects from the body |
US20070043434A1 (en) * | 2005-08-18 | 2007-02-22 | David Meerkin | Biodegradable endovascular stent using stereocomplexation of polymers |
EP1764116A1 (en) | 2005-09-16 | 2007-03-21 | Debiotech S.A. | Porous coating process using colloidal particles |
US7935379B2 (en) | 2005-11-14 | 2011-05-03 | Boston Scientific Scimed, Inc. | Coated and imprinted medical devices and methods of making the same |
US20070196423A1 (en) | 2005-11-21 | 2007-08-23 | Med Institute, Inc. | Implantable medical device coatings with biodegradable elastomer and releasable therapeutic agent |
JP2009518479A (ja) | 2005-12-09 | 2009-05-07 | ディーエスエム アイピー アセッツ ビー.ブイ. | 高分子電解質を含む親水性コーティング |
US20070148251A1 (en) | 2005-12-22 | 2007-06-28 | Hossainy Syed F A | Nanoparticle releasing medical devices |
US7842312B2 (en) | 2005-12-29 | 2010-11-30 | Cordis Corporation | Polymeric compositions comprising therapeutic agents in crystalline phases, and methods of forming the same |
US8834912B2 (en) | 2005-12-30 | 2014-09-16 | Boston Scientific Scimed, Inc. | Medical devices having multiple charged layers |
US7919108B2 (en) | 2006-03-10 | 2011-04-05 | Cook Incorporated | Taxane coatings for implantable medical devices |
US20080286325A1 (en) | 2006-01-05 | 2008-11-20 | Med Institute, Inc. | Cyclodextrin elution media for medical device coatings comprising a taxane therapeutic agent |
US8142509B2 (en) | 2006-01-23 | 2012-03-27 | Smith & Nephew, Inc. | Patellar components |
JP2009525768A (ja) | 2006-01-27 | 2009-07-16 | エム イー ディ インスチィチュート インク | 薬物の制御放出用ナノコンポジットコーティングを伴う器具 |
WO2007089259A1 (en) | 2006-02-02 | 2007-08-09 | The Johns Hopkins University | Therapeutic electrospun fiber compositions |
JP4297221B2 (ja) | 2006-02-15 | 2009-07-15 | 株式会社ホソカワ粉体技術研究所 | 薬剤溶出型ステントの製造方法 |
WO2007096832A1 (en) | 2006-02-23 | 2007-08-30 | Agamatrix, Inc | Used test strip storage container |
US20070200268A1 (en) | 2006-02-24 | 2007-08-30 | Vipul Dave | Implantable device prepared from solution processing |
US20070203569A1 (en) | 2006-02-24 | 2007-08-30 | Robert Burgermeister | Implantable device formed from polymer blends having modified molecular structures |
US8500772B2 (en) | 2006-03-20 | 2013-08-06 | Cook Medical Technologies Llc | Distal protection device |
US20070225795A1 (en) * | 2006-03-24 | 2007-09-27 | Juan Granada | Composite vascular prosthesis |
US7955383B2 (en) | 2006-04-25 | 2011-06-07 | Medtronics Vascular, Inc. | Laminated implantable medical device having a metallic coating |
US8852625B2 (en) | 2006-04-26 | 2014-10-07 | Micell Technologies, Inc. | Coatings containing multiple drugs |
US20070254012A1 (en) * | 2006-04-28 | 2007-11-01 | Ludwig Florian N | Controlled degradation and drug release in stents |
US7691400B2 (en) | 2006-05-05 | 2010-04-06 | Medtronic Vascular, Inc. | Medical device having coating with zeolite drug reservoirs |
US20080279909A1 (en) | 2006-05-12 | 2008-11-13 | Cleek Robert L | Immobilized Biologically Active Entities Having A High Degree of Biological Activity Following Sterilization |
US7959940B2 (en) | 2006-05-30 | 2011-06-14 | Advanced Cardiovascular Systems, Inc. | Polymer-bioceramic composite implantable medical devices |
US20070281117A1 (en) | 2006-06-02 | 2007-12-06 | Xtent, Inc. | Use of plasma in formation of biodegradable stent coating |
US20080124372A1 (en) | 2006-06-06 | 2008-05-29 | Hossainy Syed F A | Morphology profiles for control of agent release rates from polymer matrices |
BRPI0603437A2 (pt) | 2006-06-06 | 2010-07-06 | Luiz Gonzaga Granja Jr | prótese para anastomose tipo stent extraluminal |
US8535372B1 (en) | 2006-06-16 | 2013-09-17 | Abbott Cardiovascular Systems Inc. | Bioabsorbable stent with prohealing layer |
WO2008008291A2 (en) | 2006-07-13 | 2008-01-17 | Icon Medical Corp. | Stent |
US7820812B2 (en) | 2006-07-25 | 2010-10-26 | Abbott Laboratories | Methods of manufacturing crystalline forms of rapamycin analogs |
US7812032B2 (en) | 2006-07-25 | 2010-10-12 | Abbott Laboratories | Crystalline forms of rapamycin analogs |
WO2008024626A2 (en) | 2006-08-21 | 2008-02-28 | Innovational Holdings Llc | Bioresorbable stent with extended in vivo release of anti-restenotic agent |
WO2008033956A2 (en) | 2006-09-13 | 2008-03-20 | Elixir Medical Corporation | Macrocyclic lactone compounds and methods for their use |
US20080065192A1 (en) | 2006-09-13 | 2008-03-13 | Medtronic Vascular, Inc. | Compliance Graded Stent |
WO2008033603A2 (en) | 2006-09-15 | 2008-03-20 | Boston Scientific Limited | Medical devices having alloy compositions |
US20080071358A1 (en) | 2006-09-18 | 2008-03-20 | Boston Scientific Scimed, Inc. | Endoprostheses |
WO2008039749A2 (en) | 2006-09-25 | 2008-04-03 | Surmodics, Inc. | Multi-layered coatings and methods for controlling elution of active agents |
WO2008042909A2 (en) | 2006-10-02 | 2008-04-10 | Micell Technologies Inc. | Surgical sutures having increased strength |
EP1913960A1 (en) | 2006-10-19 | 2008-04-23 | Albert Schömig | Coated implant |
EP1916006A1 (en) | 2006-10-19 | 2008-04-30 | Albert Schömig | Implant coated with a wax or a resin |
US7959942B2 (en) | 2006-10-20 | 2011-06-14 | Orbusneich Medical, Inc. | Bioabsorbable medical device with coating |
US20080097591A1 (en) | 2006-10-20 | 2008-04-24 | Biosensors International Group | Drug-delivery endovascular stent and method of use |
US20080098178A1 (en) | 2006-10-23 | 2008-04-24 | Veazey Judson E | Data storage on a switching system coupling multiple processors of a computer system |
CA2667228C (en) | 2006-10-23 | 2015-07-14 | Micell Technologies, Inc. | Holder for electrically charging a substrate during coating |
US7981150B2 (en) | 2006-11-09 | 2011-07-19 | Boston Scientific Scimed, Inc. | Endoprosthesis with coatings |
US8425459B2 (en) | 2006-11-20 | 2013-04-23 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent |
US20080175887A1 (en) | 2006-11-20 | 2008-07-24 | Lixiao Wang | Treatment of Asthma and Chronic Obstructive Pulmonary Disease With Anti-proliferate and Anti-inflammatory Drugs |
WO2008067531A2 (en) | 2006-11-30 | 2008-06-05 | Smith & Nephew, Inc. | Fiber reinforced composite material |
CA2672496A1 (en) | 2006-12-13 | 2008-06-19 | Angiotech Pharmaceuticals, Inc. | Medical implants with a combination of compounds |
WO2008076383A2 (en) * | 2006-12-18 | 2008-06-26 | Med Institute Inc. | Stent graft with releasable therapeutic agent |
US8114466B2 (en) | 2007-01-03 | 2012-02-14 | Boston Scientific Scimed, Inc. | Methods of applying coating to the inside surface of a stent |
CN101711137B (zh) | 2007-01-08 | 2014-10-22 | 米歇尔技术公司 | 具有可生物降解层的支架 |
US20130150943A1 (en) * | 2007-01-19 | 2013-06-13 | Elixir Medical Corporation | Biodegradable endoprostheses and methods for their fabrication |
CN101972492B (zh) | 2007-01-21 | 2014-12-10 | 汉莫堤克股份有限公司 | 治疗体通道狭窄和预防危险的再狭窄的医学产品 |
US7745566B2 (en) | 2007-01-23 | 2010-06-29 | Ferro Corporation | Methods for the purification of polymers |
US7887830B2 (en) | 2007-02-27 | 2011-02-15 | Boston Scientific Scimed, Inc. | Medical devices having polymeric regions based on styrene-isobutylene copolymers |
WO2008115405A2 (en) | 2007-03-16 | 2008-09-25 | Sti Medicals Systems, Llc | A method of image quality assessment to procuce standardized imaging data |
US7815962B2 (en) | 2007-03-22 | 2010-10-19 | Medtronic Vascular, Inc. | Coated stent with evenly distributed therapeutic agent |
WO2008124634A1 (en) | 2007-04-04 | 2008-10-16 | Massachusetts Institute Of Technology | Polymer-encapsulated reverse micelles |
US20080249605A1 (en) * | 2007-04-04 | 2008-10-09 | Vipul Dave | Bioabsorbable Polymer, Non-Bioabsorbable Metal Composite Stents |
EP2146758A4 (en) | 2007-04-17 | 2012-11-21 | Micell Technologies Inc | STENTS WITH BIODEGRADABLE LAYERS |
US9433516B2 (en) | 2007-04-17 | 2016-09-06 | Micell Technologies, Inc. | Stents having controlled elution |
EP2146707A2 (en) | 2007-05-03 | 2010-01-27 | Abraxis BioScience, LLC | Methods and compositions for treating pulmonary hypertension |
US7952706B2 (en) | 2007-05-17 | 2011-05-31 | Prescient Medical, Inc. | Multi-channel fiber optic spectroscopy systems employing integrated optics modules |
GB0709517D0 (en) | 2007-05-17 | 2007-06-27 | Queen Mary & Westfield College | An electrostatic spraying device and a method of electrostatic spraying |
WO2008148013A1 (en) | 2007-05-25 | 2008-12-04 | Micell Technologies, Inc. | Polymer films for medical device coating |
US7922760B2 (en) | 2007-05-29 | 2011-04-12 | Abbott Cardiovascular Systems Inc. | In situ trapping and delivery of agent by a stent having trans-strut depots |
US20090068266A1 (en) | 2007-09-11 | 2009-03-12 | Raheja Praveen | Sirolimus having specific particle size and pharmaceutical compositions thereof |
US20090076446A1 (en) | 2007-09-14 | 2009-03-19 | Quest Medical, Inc. | Adjustable catheter for dilation in the ear, nose or throat |
US9248219B2 (en) | 2007-09-14 | 2016-02-02 | Boston Scientific Scimed, Inc. | Medical devices having bioerodable layers for the release of therapeutic agents |
CN101842362A (zh) | 2007-09-27 | 2010-09-22 | 沃尔特及伊莱萨霍尔医学研究院 | 苯并噻唑化合物 |
US8709071B1 (en) | 2007-09-28 | 2014-04-29 | Abbott Cardiovascular Systems Inc. | Stent with preferential coating |
JP5114788B2 (ja) | 2007-09-28 | 2013-01-09 | 三菱重工業株式会社 | リチウム二次電池 |
US20090105687A1 (en) | 2007-10-05 | 2009-04-23 | Angioscore, Inc. | Scoring catheter with drug delivery membrane |
DK2214646T3 (da) | 2007-10-05 | 2021-10-04 | Univ Wayne State | Dendrimers for sustained release of compounds |
US20090105809A1 (en) | 2007-10-19 | 2009-04-23 | Lee Michael J | Implantable and lumen-supporting stents and related methods of manufacture and use |
US20100298928A1 (en) | 2007-10-19 | 2010-11-25 | Micell Technologies, Inc. | Drug Coated Stents |
US9987399B2 (en) | 2007-10-30 | 2018-06-05 | Nanyang Technological University | Non-biodegradable stent comprising a biodegradable coating and method of coating the same |
US8642062B2 (en) | 2007-10-31 | 2014-02-04 | Abbott Cardiovascular Systems Inc. | Implantable device having a slow dissolving polymer |
US20090111787A1 (en) | 2007-10-31 | 2009-04-30 | Florencia Lim | Polymer blends for drug delivery stent matrix with improved thermal stability |
CN101161300B (zh) | 2007-11-27 | 2011-03-16 | 北京美中双和医疗器械有限公司 | 三氧化二砷药物洗脱支架及其制备方法 |
US20090202609A1 (en) | 2008-01-06 | 2009-08-13 | Keough Steven J | Medical device with coating composition |
WO2009096822A1 (en) | 2008-01-30 | 2009-08-06 | Micromuscle Ab | Drug delivery devices and methods and applications thereof |
US20100042206A1 (en) | 2008-03-04 | 2010-02-18 | Icon Medical Corp. | Bioabsorbable coatings for medical devices |
WO2009111709A2 (en) | 2008-03-06 | 2009-09-11 | Boston Scientific Scimed, Inc. | Balloon catheter devices with solvent-swellable polymer |
WO2009113605A1 (ja) | 2008-03-12 | 2009-09-17 | アンジェスMg株式会社 | 薬剤溶出型カテーテル及びその製造方法 |
US8951545B2 (en) | 2008-03-28 | 2015-02-10 | Surmodics, Inc. | Insertable medical devices having microparticulate-associated elastic substrates and methods for drug delivery |
CA2721832C (en) | 2008-04-17 | 2018-08-07 | Micell Technologies, Inc. | Stents having bioabsorbable layers |
US8557273B2 (en) | 2008-04-18 | 2013-10-15 | Medtronic, Inc. | Medical devices and methods including polymers having biologically active agents therein |
US20110143429A1 (en) | 2008-04-30 | 2011-06-16 | Iksoo Chun | Tissue engineered blood vessels |
WO2009136586A1 (ja) | 2008-05-08 | 2009-11-12 | 新日鐵化学株式会社 | 有機電界発光素子用化合物及び有機電界発光素子 |
US8298607B2 (en) | 2008-05-15 | 2012-10-30 | Abbott Cardiovascular Systems Inc. | Method for electrostatic coating of a medical device |
US7865562B2 (en) | 2008-05-20 | 2011-01-04 | International Business Machines Corporation | Selecting email signatures |
EP2131614B1 (en) | 2008-05-30 | 2014-01-01 | Alcatel Lucent | Method for transmitting broadcast services in a radiocommunication cellular network through a femto base station, as well as corresponding femto base station |
US20090297578A1 (en) | 2008-06-03 | 2009-12-03 | Trollsas Mikael O | Biosoluble coating comprising anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders |
US8206635B2 (en) * | 2008-06-20 | 2012-06-26 | Amaranth Medical Pte. | Stent fabrication via tubular casting processes |
JP5841708B2 (ja) | 2008-07-01 | 2016-01-13 | 日東電工株式会社 | 表面被覆微粒子の医薬組成物 |
US7770466B2 (en) | 2008-07-02 | 2010-08-10 | Abbott Cardiovascular Systems Inc. | Method for measuring stent dislodgement force |
JP4557061B2 (ja) | 2008-07-11 | 2010-10-06 | トヨタ自動車株式会社 | ハイブリッド自動車およびその制御方法 |
JP2011528275A (ja) | 2008-07-17 | 2011-11-17 | ミセル テクノロジーズ,インク. | 薬物送達医療デバイス |
US9510856B2 (en) | 2008-07-17 | 2016-12-06 | Micell Technologies, Inc. | Drug delivery medical device |
JP2010052503A (ja) | 2008-08-27 | 2010-03-11 | Kawano Terukazu | 船舶用エンジン |
US20100055145A1 (en) | 2008-08-29 | 2010-03-04 | Biosensors International Group | Stent coatings for reducing late stent thrombosis |
WO2010024898A2 (en) | 2008-08-29 | 2010-03-04 | Lutonix, Inc. | Methods and apparatuses for coating balloon catheters |
US8367090B2 (en) | 2008-09-05 | 2013-02-05 | Abbott Cardiovascular Systems Inc. | Coating on a balloon comprising a polymer and a drug |
WO2010033482A1 (en) | 2008-09-19 | 2010-03-25 | Innovative Surface Technologies, Inc. | Drug eluting superhydrophobic coatings |
JP2012504032A (ja) | 2008-09-29 | 2012-02-16 | スターリング ヴァスキュラー システムズ インコーポレイテッド | 薬剤溶出ステント及びその製造方法 |
US8535655B2 (en) * | 2008-10-10 | 2013-09-17 | Polyactiva Pty Ltd. | Biodegradable polymer—bioactive moiety conjugates |
CA2743491C (en) | 2008-11-11 | 2016-10-11 | Zelton Dave Sharp | Inhibition of mammalian target of rapamycin |
AU2009316588B2 (en) | 2008-11-21 | 2014-09-11 | Stout Medical Group, L.P. | Reinforced biologic material |
WO2010075590A2 (en) | 2008-12-26 | 2010-07-01 | Battelle Memorial Institute | Medical implants and methods of making medical implants |
US8834913B2 (en) | 2008-12-26 | 2014-09-16 | Battelle Memorial Institute | Medical implants and methods of making medical implants |
US9572692B2 (en) | 2009-02-02 | 2017-02-21 | Abbott Cardiovascular Systems Inc. | Bioabsorbable stent that modulates plaque geometric morphology and chemical composition |
US20100198330A1 (en) * | 2009-02-02 | 2010-08-05 | Hossainy Syed F A | Bioabsorbable Stent And Treatment That Elicits Time-Varying Host-Material Response |
EP2391401A2 (en) * | 2009-02-02 | 2011-12-07 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | Crystalline drug-containing coatings |
CA2756388C (en) | 2009-03-23 | 2015-10-27 | Micell Technologies, Inc. | Biodegradable polymers with low acidic impurity |
EP2411083A4 (en) | 2009-03-23 | 2013-11-13 | Micell Technologies Inc | MEDICAL DEVICE FOR DELIVERY OF MEDICAMENT |
CA2756307C (en) * | 2009-03-23 | 2017-08-08 | Micell Technologies, Inc. | Peripheral stents having layers and reinforcement fibers |
CN102481195B (zh) | 2009-04-01 | 2015-03-25 | 米歇尔技术公司 | 涂覆支架 |
US20110301697A1 (en) | 2009-04-10 | 2011-12-08 | Hemoteq Ag | Manufacture, method and use of drug-eluting medical devices for permanently keeping blood vessels open |
US9492587B2 (en) | 2009-04-13 | 2016-11-15 | Abbott Cardiovascular Systems Inc. | Stent made from an ultra high molecular weight bioabsorbable polymer with high fatigue and fracture resistance |
US20100285085A1 (en) | 2009-05-07 | 2010-11-11 | Abbott Cardiovascular Systems Inc. | Balloon coating with drug transfer control via coating thickness |
AU2010249683B2 (en) | 2009-05-18 | 2015-06-25 | Dose Medical Corporation | Drug eluting ocular implant |
WO2010136604A1 (en) | 2009-05-29 | 2010-12-02 | Dsm Ip Assets B.V. | Transfer matrix for transferring a bioactive agent to body tissue |
EP2266507B1 (de) | 2009-06-22 | 2015-07-29 | Biotronik VI Patent AG | Stent mit verbessertem Stentdesign |
US9327060B2 (en) | 2009-07-09 | 2016-05-03 | CARDINAL HEALTH SWITZERLAND 515 GmbH | Rapamycin reservoir eluting stent |
US8039147B2 (en) | 2009-08-27 | 2011-10-18 | Sb Limotive Co., Ltd. | Rechargeable secondary battery having improved safety against puncture and collapse |
WO2011044533A2 (en) * | 2009-10-09 | 2011-04-14 | Specialized Vascular Technologies, Inc. | Coating system and method for drug elution management |
EP2531140B1 (en) | 2010-02-02 | 2017-11-01 | Micell Technologies, Inc. | Stent and stent delivery system with improved deliverability |
WO2011119607A2 (en) * | 2010-03-24 | 2011-09-29 | The Board Of Trustees Of The University Of Illinois | Viscoelastic ink for direct writing of hydrogel structures |
CA2793832C (en) | 2010-03-25 | 2018-09-18 | Lixiao Wang | Drug releasing coatings for medical devices |
US8795762B2 (en) | 2010-03-26 | 2014-08-05 | Battelle Memorial Institute | System and method for enhanced electrostatic deposition and surface coatings |
WO2011123798A2 (en) * | 2010-04-01 | 2011-10-06 | The Johns Hopkins University | Three-dimensional scaffolds, methods for fabricating the same, and methods of treating a peripheral nerve or spinal or spinal cord injury |
US20110257732A1 (en) | 2010-04-16 | 2011-10-20 | Micell Technologies, Inc. | Stents having controlled elution |
WO2011133655A1 (en) | 2010-04-22 | 2011-10-27 | Micell Technologies, Inc. | Stents and other devices having extracellular matrix coating |
EP2593039B1 (en) | 2010-07-16 | 2022-11-30 | Micell Technologies, Inc. | Drug delivery medical device |
US9636309B2 (en) | 2010-09-09 | 2017-05-02 | Micell Technologies, Inc. | Macrolide dosage forms |
US20120150275A1 (en) * | 2010-12-10 | 2012-06-14 | Micropen Technologies Corporation | Stents and methods of making stents |
US8974622B2 (en) | 2010-12-28 | 2015-03-10 | Boston Scientific Scimed, Inc. | Composite ePTFE-silicone covering for stent |
WO2012092504A2 (en) | 2010-12-30 | 2012-07-05 | Micell Technologies, Inc. | Nanoparticle and surface-modified particulate coatings, coated balloons, and methods therefore |
WO2012097381A1 (en) | 2011-01-14 | 2012-07-19 | Biomerix Corporation | At least partially resorbable reticulated elastomeric matrix elements and methods of making same |
US20120323311A1 (en) | 2011-04-13 | 2012-12-20 | Micell Technologies, Inc. | Stents having controlled elution |
TW201311226A (zh) * | 2011-05-06 | 2013-03-16 | Ind Tech Res Inst | 生物可吸收血管支架之製造方法 |
US9446172B2 (en) | 2011-05-10 | 2016-09-20 | Abbott Cardiovascular Systems Inc. | Modification of bioabsorbable stent to reduce thrombogenecity |
WO2012166819A1 (en) | 2011-05-31 | 2012-12-06 | Micell Technologies, Inc. | System and process for formation of a time-released, drug-eluting transferable coating |
JP6505438B2 (ja) | 2011-06-30 | 2019-04-24 | エリクシアー メディカル コーポレイション | 生分解性内部人工器官およびその作製方法 |
CA2841360A1 (en) | 2011-07-15 | 2013-01-24 | Micell Technologies, Inc. | Drug delivery medical device |
US20140257465A1 (en) * | 2011-08-12 | 2014-09-11 | Micell Technologies, Inc. | Stents having controlled elution |
WO2013059509A1 (en) | 2011-10-18 | 2013-04-25 | Micell Technologies, Inc. | Drug delivery medical device |
US10188772B2 (en) | 2011-10-18 | 2019-01-29 | Micell Technologies, Inc. | Drug delivery medical device |
WO2013177211A1 (en) | 2012-05-21 | 2013-11-28 | Micell Technologies, Inc. | Safe drug eluting stent with absorbable coating |
US9090029B2 (en) | 2012-02-06 | 2015-07-28 | Warsaw Orthopedic, Inc. | Pultrusion process for preparing composites having low percentage of fibers and articles made from same |
US8859088B2 (en) | 2012-04-16 | 2014-10-14 | Auburn University | Minimal weight composites using open structure |
WO2013173657A1 (en) | 2012-05-16 | 2013-11-21 | Micell Technologies, Inc. | Low burst sustained release lipophilic and biologic agent compositions |
US8968387B2 (en) * | 2012-07-23 | 2015-03-03 | Abbott Cardiovascular Systems Inc. | Shape memory bioresorbable polymer peripheral scaffolds |
KR101231197B1 (ko) | 2012-09-20 | 2013-02-07 | 썬텍 주식회사 | 고분자 스텐트 |
JP2015533305A (ja) | 2012-10-18 | 2015-11-24 | ミセル テクノロジーズ,インク. | 薬物送達医療デバイス |
US9744058B2 (en) * | 2013-02-14 | 2017-08-29 | Abbott Cardiovascular Systems Inc. | Methods of treatment directed to neointimal proliferation generated by endothelial shear stress patterns from drug-eluting bioresorbable vascular scaffold implantation |
WO2014165264A1 (en) | 2013-03-12 | 2014-10-09 | Micell Technologies, Inc. | Bioabsorbable biomedical implants |
WO2014176451A1 (en) * | 2013-04-24 | 2014-10-30 | Trustees Of Tufts College | Bioresorbable biopolymer stent |
KR102079613B1 (ko) | 2013-05-15 | 2020-02-20 | 미셀 테크놀로지즈, 인코포레이티드 | 생흡수성 생체의학적 임플란트 |
EP3033053A4 (en) * | 2013-08-16 | 2017-04-05 | Amaranth Medical PTE | Bioresorbable scaffold for treatment of bifurcation lesion |
US9510976B2 (en) * | 2014-04-29 | 2016-12-06 | Abbott Cardiovascular Systems Inc. | Devices and methods for treatment of the Eustachian tube and sinus cavity |
WO2015181826A1 (en) | 2014-05-27 | 2015-12-03 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Crystalline coating and release of bioactive agents |
US11628077B2 (en) * | 2016-10-31 | 2023-04-18 | Razmodics Llc | Post deployment radial force recovery of biodegradable scaffolds |
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2014
- 2014-03-12 WO PCT/US2014/025017 patent/WO2014165264A1/en active Application Filing
- 2014-03-12 KR KR1020157028622A patent/KR20150143476A/ko active IP Right Grant
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- 2014-03-12 JP JP2016501719A patent/JP6330024B2/ja not_active Expired - Fee Related
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EP2967803A4 (en) | 2016-08-17 |
CN105307597A (zh) | 2016-02-03 |
AU2014248508B2 (en) | 2018-11-08 |
CA2905419C (en) | 2020-04-28 |
HK1220602A1 (zh) | 2017-05-12 |
CA2905419A1 (en) | 2014-10-09 |
EP2967803A1 (en) | 2016-01-20 |
AU2014248508A1 (en) | 2015-11-05 |
IL241421A0 (en) | 2015-11-30 |
IL241421B (en) | 2019-05-30 |
WO2014165264A1 (en) | 2014-10-09 |
EP2967803B1 (en) | 2023-12-27 |
CN110269959A (zh) | 2019-09-24 |
US20140277401A1 (en) | 2014-09-18 |
JP2016517311A (ja) | 2016-06-16 |
KR20150143476A (ko) | 2015-12-23 |
US11039943B2 (en) | 2021-06-22 |
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