JP6203743B2 - アクチノミセス・アクチノアロムルス（ＡＣＴＩＮＯＭＹＣＥＴＥＡＣＴＩＮＯＡＬＬＯＭＵＲＵＳ）由来の、酸性ｐＨにてグルテンペプチドおよびタンパク質を加水分解できる新規プロテアーゼ - Google Patents

アクチノミセス・アクチノアロムルス（ＡＣＴＩＮＯＭＹＣＥＴＥＡＣＴＩＮＯＡＬＬＯＭＵＲＵＳ）由来の、酸性ｐＨにてグルテンペプチドおよびタンパク質を加水分解できる新規プロテアーゼ Download PDF

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JP6203743B2
JP6203743B2 JP2014545146A JP2014545146A JP6203743B2 JP 6203743 B2 JP6203743 B2 JP 6203743B2 JP 2014545146 A JP2014545146 A JP 2014545146A JP 2014545146 A JP2014545146 A JP 2014545146A JP 6203743 B2 JP6203743 B2 JP 6203743B2
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endopeptidase
seq
endopep
amino acid
enzyme composition
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JP2015500641A5 (enExample
JP2015500641A (ja
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カバレッティ，リンダ
カッラノ，ルチア
アッボンディ，モニカ
ブルナーティ，マーラ
タラベッラ，アンナ
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フオンダツイオーネ・イステイトウート・インスブリコ・デイ・リチエルカ・ペル・ラ・ビータ
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J3/00—Working-up of proteins for foodstuffs
    • A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
    • A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
    • A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
    • A23J3/346—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of vegetable proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21026—Prolyl oligopeptidase (3.4.21.26), i.e. proline-specific endopeptidase

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
JP2014545146A 2011-12-06 2012-11-05 アクチノミセス・アクチノアロムルス（ＡＣＴＩＮＯＭＹＣＥＴＥＡＣＴＩＮＯＡＬＬＯＭＵＲＵＳ）由来の、酸性ｐＨにてグルテンペプチドおよびタンパク質を加水分解できる新規プロテアーゼ Active JP6203743B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11425291 2011-12-06
EP11425291.9 2011-12-06
PCT/EP2012/071816 WO2013083338A1 (en) 2011-12-06 2012-11-05 New proteases able to hydrolyze gluten peptides and proteins at acidic ph, from the actinomycete actinoallomurus

Publications (3)

Publication Number Publication Date
JP2015500641A JP2015500641A (ja) 2015-01-08
JP2015500641A5 JP2015500641A5 (enExample) 2015-12-24
JP6203743B2 true JP6203743B2 (ja) 2017-09-27

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JP2014545146A Active JP6203743B2 (ja) 2011-12-06 2012-11-05 アクチノミセス・アクチノアロムルス（ＡＣＴＩＮＯＭＹＣＥＴＥＡＣＴＩＮＯＡＬＬＯＭＵＲＵＳ）由来の、酸性ｐＨにてグルテンペプチドおよびタンパク質を加水分解できる新規プロテアーゼ

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Country Link
US (2) US20140356345A1 (enExample)
EP (1) EP2788018B1 (enExample)
JP (1) JP6203743B2 (enExample)
CN (1) CN104039345B (enExample)
AU (1) AU2012348782B2 (enExample)
BR (1) BR112014012100B1 (enExample)
CA (1) CA2852365C (enExample)
EA (1) EA028228B1 (enExample)
ES (1) ES2595500T3 (enExample)
IN (1) IN2014CN04131A (enExample)
WO (1) WO2013083338A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2718434B1 (en) 2011-08-10 2018-03-28 University of Washington through its Center for Commercialization Compositions and methods for treating celiac sprue disease
EP3520808B1 (en) * 2013-08-14 2021-04-21 University Of Washington Through Its Center For Commercialization Compositions for treating celiac sprue disease
WO2015032620A1 (en) 2013-09-05 2015-03-12 Dsm Ip Assets B.V. Use of an acidic soft drink to enhance the efficacy of a gluten-digesting enzyme
US10308967B2 (en) * 2013-11-26 2019-06-04 Novozymes A/S Milling process
DK3209774T3 (da) * 2014-10-24 2020-05-25 Dupont Nutrition Biosci Aps Anvendelse af prolintolerante tripeptidylpeptidaser i foderadditivsammensætninger
MX392140B (es) 2015-06-08 2025-03-21 Univ Washington Composiciones y uso de las mismas para tratar la enfermedad celiaca.
US11124785B2 (en) 2016-02-11 2021-09-21 Trustees Of Boston University Rothia subtilisins, S8A family proteases, as therapeutic enzymes for application in gluten intolerance disorders
IT201900012942A1 (it) 2019-07-25 2021-01-25 Nemysis Ltd Metodo per la produzione di una composizione enzimatica comprendente una endopeptidasi ricombinante
WO2021013553A1 (en) 2019-07-25 2021-01-28 Nemysis Limited Method for the production of an enzymatic composition comprising a recombinant endopeptidase
CN111172138B (zh) * 2020-02-14 2022-03-25 江南大学 一种蛋白水解酶及其在蛋白肽生产中的应用
IT202100018254A1 (it) 2021-07-12 2023-01-12 Nemysis Ltd New systems for producing recombinant proteins/ nuovi sistemi di produzione di proteine ricombinanti
CN114438044B (zh) * 2022-01-14 2024-03-29 南昌大学 一种高效降解麸质蛋白的多酶复合体及其应用
WO2024233959A1 (en) * 2023-05-11 2024-11-14 Digestiva, Inc. Wine dehazing methods and compositions
WO2025067635A1 (en) * 2023-09-26 2025-04-03 Amyra Biotech Ag Pharmaceutical compositions comprising exopeptidases and uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3104935B2 (ja) 1992-05-28 2000-10-30 株式会社ブリヂストン 空気入りタイヤ
EP2364718B1 (en) 2002-02-14 2016-07-06 The Board of Trustees of the Leland Stanford Junior University Enzyme treatment of foodstuffs for celiac sprue
US7320788B2 (en) * 2002-02-14 2008-01-22 The Board Of Trustees Of The Leland Stanford Junior University Enzyme treatment of foodstuffs for Celiac Sprue
US7265093B2 (en) * 2002-05-14 2007-09-04 The Board Of Trustees Of The Leland Stanford Junior University Drug therapy for Celiac Sprue
CN1871351B (zh) 2003-08-25 2010-06-23 富诺齐梅生物技术股份有限公司 一种新的真菌蛋白及其编码核酸
DK1663298T3 (da) 2003-09-23 2019-10-14 Dsm Ip Assets Bv Anvendelse af prolinspecifikke endoproteaser til hydrolyse af peptider og proteiner
NL1027650C1 (nl) 2004-12-03 2006-06-07 Leonardus Antonius Luttikhold Transporthulpmiddel voor deuren en panelen.
EP1985698A1 (en) * 2007-04-25 2008-10-29 Nestec S.A. Peptidases from basidiomycetes
US20120276075A1 (en) 2009-12-21 2012-11-01 Centre Hospitalier Universitaire Vaudois (Chuv) Synergic action of a prolyl protease and tripeptidyl proteases
EP2531521B1 (en) * 2010-02-02 2017-09-06 Amano Enzyme USA., Ltd. Use of proteases for gluten intolerance
EP2555792A4 (en) * 2010-03-30 2013-11-06 Alvine Pharmaceuticals Inc PROTEASES DEGRADING GLUTEN
JP2011211997A (ja) * 2010-04-02 2011-10-27 Astellas Pharma Inc アントラサイクリン化合物を生産する微生物

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Publication number Publication date
AU2012348782B2 (en) 2017-10-26
IN2014CN04131A (enExample) 2015-07-17
CA2852365C (en) 2021-01-26
WO2013083338A1 (en) 2013-06-13
US20140356345A1 (en) 2014-12-04
EA028228B1 (ru) 2017-10-31
BR112014012100B1 (pt) 2023-04-18
US10201593B2 (en) 2019-02-12
BR112014012100A2 (pt) 2020-10-27
CA2852365A1 (en) 2013-06-13
ES2595500T3 (es) 2016-12-30
JP2015500641A (ja) 2015-01-08
AU2012348782A1 (en) 2014-05-15
CN104039345A (zh) 2014-09-10
HK1198244A1 (en) 2015-03-20
US20160114009A1 (en) 2016-04-28
EP2788018A1 (en) 2014-10-15
EP2788018B1 (en) 2016-06-29
EA201491117A1 (ru) 2014-09-30
CN104039345B (zh) 2016-11-09

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