JP2015500641A5 - - Google Patents
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- Publication number
- JP2015500641A5 JP2015500641A5 JP2014545146A JP2014545146A JP2015500641A5 JP 2015500641 A5 JP2015500641 A5 JP 2015500641A5 JP 2014545146 A JP2014545146 A JP 2014545146A JP 2014545146 A JP2014545146 A JP 2014545146A JP 2015500641 A5 JP2015500641 A5 JP 2015500641A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- endopeptidase
- identity
- sequence
- endopep
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000005593 Endopeptidases Human genes 0.000 claims 22
- 108010059378 Endopeptidases Proteins 0.000 claims 22
- 102000004190 Enzymes Human genes 0.000 claims 18
- 108090000790 Enzymes Proteins 0.000 claims 18
- 239000000203 mixture Substances 0.000 claims 15
- 239000012634 fragment Substances 0.000 claims 10
- 238000000034 method Methods 0.000 claims 9
- 102000040430 polynucleotide Human genes 0.000 claims 7
- 108091033319 polynucleotide Proteins 0.000 claims 7
- 239000002157 polynucleotide Substances 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 208000015943 Coeliac disease Diseases 0.000 claims 4
- 108010068370 Glutens Proteins 0.000 claims 4
- 102000015636 Oligopeptides Human genes 0.000 claims 4
- 108010038807 Oligopeptides Proteins 0.000 claims 4
- 235000021312 gluten Nutrition 0.000 claims 4
- 238000003776 cleavage reaction Methods 0.000 claims 3
- 239000001963 growth medium Substances 0.000 claims 3
- 230000007017 scission Effects 0.000 claims 3
- 231100000331 toxic Toxicity 0.000 claims 3
- 230000002588 toxic effect Effects 0.000 claims 3
- 201000004624 Dermatitis Diseases 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 2
- 102000035195 Peptidases Human genes 0.000 claims 2
- 108091005804 Peptidases Proteins 0.000 claims 2
- 241000187747 Streptomyces Species 0.000 claims 2
- 235000015872 dietary supplement Nutrition 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000003301 hydrolyzing effect Effects 0.000 claims 2
- 230000000968 intestinal effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 210000000496 pancreas Anatomy 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 230000002797 proteolythic effect Effects 0.000 claims 2
- 241000894007 species Species 0.000 claims 2
- 210000002784 stomach Anatomy 0.000 claims 2
- 241000093906 Actinoallomurus sp. Species 0.000 claims 1
- 241000193830 Bacillus <bacterium> Species 0.000 claims 1
- 241001001250 Catenulispora Species 0.000 claims 1
- 102100034560 Cytosol aminopeptidase Human genes 0.000 claims 1
- 241001198387 Escherichia coli BL21(DE3) Species 0.000 claims 1
- 241001430082 Ktedonobacter Species 0.000 claims 1
- 241000186660 Lactobacillus Species 0.000 claims 1
- 101710118538 Protease Proteins 0.000 claims 1
- 241000589516 Pseudomonas Species 0.000 claims 1
- 101710135670 Putative Xaa-Pro dipeptidyl-peptidase Proteins 0.000 claims 1
- 241000205160 Pyrococcus Species 0.000 claims 1
- 101710143531 Xaa-Pro dipeptidyl-peptidase Proteins 0.000 claims 1
- 239000012190 activator Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000000593 degrading effect Effects 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 229940039696 lactobacillus Drugs 0.000 claims 1
- 235000021056 liquid food Nutrition 0.000 claims 1
- 244000005700 microbiome Species 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 239000008183 oral pharmaceutical preparation Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 108010017378 prolyl aminopeptidase Proteins 0.000 claims 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 235000019833 protease Nutrition 0.000 claims 1
- 239000003531 protein hydrolysate Substances 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000010187 selection method Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11425291 | 2011-12-06 | ||
| EP11425291.9 | 2011-12-06 | ||
| PCT/EP2012/071816 WO2013083338A1 (en) | 2011-12-06 | 2012-11-05 | New proteases able to hydrolyze gluten peptides and proteins at acidic ph, from the actinomycete actinoallomurus |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015500641A JP2015500641A (ja) | 2015-01-08 |
| JP2015500641A5 true JP2015500641A5 (enExample) | 2015-12-24 |
| JP6203743B2 JP6203743B2 (ja) | 2017-09-27 |
Family
ID=47137719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014545146A Active JP6203743B2 (ja) | 2011-12-06 | 2012-11-05 | アクチノミセス・アクチノアロムルス（ＡＣＴＩＮＯＭＹＣＥＴＥＡＣＴＩＮＯＡＬＬＯＭＵＲＵＳ）由来の、酸性ｐＨにてグルテンペプチドおよびタンパク質を加水分解できる新規プロテアーゼ |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20140356345A1 (enExample) |
| EP (1) | EP2788018B1 (enExample) |
| JP (1) | JP6203743B2 (enExample) |
| CN (1) | CN104039345B (enExample) |
| AU (1) | AU2012348782B2 (enExample) |
| BR (1) | BR112014012100B1 (enExample) |
| CA (1) | CA2852365C (enExample) |
| EA (1) | EA028228B1 (enExample) |
| ES (1) | ES2595500T3 (enExample) |
| IN (1) | IN2014CN04131A (enExample) |
| WO (1) | WO2013083338A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2718434B1 (en) | 2011-08-10 | 2018-03-28 | University of Washington through its Center for Commercialization | Compositions and methods for treating celiac sprue disease |
| EP3520808B1 (en) * | 2013-08-14 | 2021-04-21 | University Of Washington Through Its Center For Commercialization | Compositions for treating celiac sprue disease |
| WO2015032620A1 (en) | 2013-09-05 | 2015-03-12 | Dsm Ip Assets B.V. | Use of an acidic soft drink to enhance the efficacy of a gluten-digesting enzyme |
| US10308967B2 (en) * | 2013-11-26 | 2019-06-04 | Novozymes A/S | Milling process |
| DK3209774T3 (da) * | 2014-10-24 | 2020-05-25 | Dupont Nutrition Biosci Aps | Anvendelse af prolintolerante tripeptidylpeptidaser i foderadditivsammensætninger |
| MX392140B (es) | 2015-06-08 | 2025-03-21 | Univ Washington | Composiciones y uso de las mismas para tratar la enfermedad celiaca. |
| US11124785B2 (en) | 2016-02-11 | 2021-09-21 | Trustees Of Boston University | Rothia subtilisins, S8A family proteases, as therapeutic enzymes for application in gluten intolerance disorders |
| IT201900012942A1 (it) | 2019-07-25 | 2021-01-25 | Nemysis Ltd | Metodo per la produzione di una composizione enzimatica comprendente una endopeptidasi ricombinante |
| WO2021013553A1 (en) | 2019-07-25 | 2021-01-28 | Nemysis Limited | Method for the production of an enzymatic composition comprising a recombinant endopeptidase |
| CN111172138B (zh) * | 2020-02-14 | 2022-03-25 | 江南大学 | 一种蛋白水解酶及其在蛋白肽生产中的应用 |
| IT202100018254A1 (it) | 2021-07-12 | 2023-01-12 | Nemysis Ltd | New systems for producing recombinant proteins/ nuovi sistemi di produzione di proteine ricombinanti |
| CN114438044B (zh) * | 2022-01-14 | 2024-03-29 | 南昌大学 | 一种高效降解麸质蛋白的多酶复合体及其应用 |
| WO2024233959A1 (en) * | 2023-05-11 | 2024-11-14 | Digestiva, Inc. | Wine dehazing methods and compositions |
| WO2025067635A1 (en) * | 2023-09-26 | 2025-04-03 | Amyra Biotech Ag | Pharmaceutical compositions comprising exopeptidases and uses thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3104935B2 (ja) | 1992-05-28 | 2000-10-30 | 株式会社ブリヂストン | 空気入りタイヤ |
| EP2364718B1 (en) | 2002-02-14 | 2016-07-06 | The Board of Trustees of the Leland Stanford Junior University | Enzyme treatment of foodstuffs for celiac sprue |
| US7320788B2 (en) * | 2002-02-14 | 2008-01-22 | The Board Of Trustees Of The Leland Stanford Junior University | Enzyme treatment of foodstuffs for Celiac Sprue |
| US7265093B2 (en) * | 2002-05-14 | 2007-09-04 | The Board Of Trustees Of The Leland Stanford Junior University | Drug therapy for Celiac Sprue |
| CN1871351B (zh) | 2003-08-25 | 2010-06-23 | 富诺齐梅生物技术股份有限公司 | 一种新的真菌蛋白及其编码核酸 |
| DK1663298T3 (da) | 2003-09-23 | 2019-10-14 | Dsm Ip Assets Bv | Anvendelse af prolinspecifikke endoproteaser til hydrolyse af peptider og proteiner |
| NL1027650C1 (nl) | 2004-12-03 | 2006-06-07 | Leonardus Antonius Luttikhold | Transporthulpmiddel voor deuren en panelen. |
| EP1985698A1 (en) * | 2007-04-25 | 2008-10-29 | Nestec S.A. | Peptidases from basidiomycetes |
| US20120276075A1 (en) | 2009-12-21 | 2012-11-01 | Centre Hospitalier Universitaire Vaudois (Chuv) | Synergic action of a prolyl protease and tripeptidyl proteases |
| EP2531521B1 (en) * | 2010-02-02 | 2017-09-06 | Amano Enzyme USA., Ltd. | Use of proteases for gluten intolerance |
| EP2555792A4 (en) * | 2010-03-30 | 2013-11-06 | Alvine Pharmaceuticals Inc | PROTEASES DEGRADING GLUTEN |
| JP2011211997A (ja) * | 2010-04-02 | 2011-10-27 | Astellas Pharma Inc | アントラサイクリン化合物を生産する微生物 |
-
2012
- 2012-11-05 CA CA2852365A patent/CA2852365C/en active Active
- 2012-11-05 BR BR112014012100-1A patent/BR112014012100B1/pt active IP Right Grant
- 2012-11-05 WO PCT/EP2012/071816 patent/WO2013083338A1/en not_active Ceased
- 2012-11-05 AU AU2012348782A patent/AU2012348782B2/en active Active
- 2012-11-05 ES ES12781098.4T patent/ES2595500T3/es active Active
- 2012-11-05 IN IN4131CHN2014 patent/IN2014CN04131A/en unknown
- 2012-11-05 EP EP12781098.4A patent/EP2788018B1/en active Active
- 2012-11-05 CN CN201280060514.5A patent/CN104039345B/zh active Active
- 2012-11-05 US US14/356,122 patent/US20140356345A1/en not_active Abandoned
- 2012-11-05 EA EA201491117A patent/EA028228B1/ru not_active IP Right Cessation
- 2012-11-05 JP JP2014545146A patent/JP6203743B2/ja active Active
-
2015
- 2015-11-23 US US14/949,503 patent/US10201593B2/en active Active
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