CN104039345B - 来自放线菌放线异壁酸菌属(Actinoallomurus)的能在酸性pH水解谷蛋白肽和蛋白的新蛋白酶 - Google Patents

来自放线菌放线异壁酸菌属(Actinoallomurus)的能在酸性pH水解谷蛋白肽和蛋白的新蛋白酶 Download PDF

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CN104039345B
CN104039345B CN201280060514.5A CN201280060514A CN104039345B CN 104039345 B CN104039345 B CN 104039345B CN 201280060514 A CN201280060514 A CN 201280060514A CN 104039345 B CN104039345 B CN 104039345B
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endopeptidase
enzyme composition
actinoallomurus
endopep
seq
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CN104039345A (zh
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L·卡瓦莱逖
L·卡拉诺
M·阿邦迪
M·布鲁纳提
A·塔拉维拉
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Ying Sabo Rake Is Found Life Base Institute
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J3/00—Working-up of proteins for foodstuffs
    • A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
    • A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
    • A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
    • A23J3/346—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of vegetable proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21026—Prolyl oligopeptidase (3.4.21.26), i.e. proline-specific endopeptidase

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
CN201280060514.5A 2011-12-06 2012-11-05 来自放线菌放线异壁酸菌属(Actinoallomurus)的能在酸性pH水解谷蛋白肽和蛋白的新蛋白酶 Active CN104039345B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11425291.9 2011-12-06
EP11425291 2011-12-06
PCT/EP2012/071816 WO2013083338A1 (en) 2011-12-06 2012-11-05 New proteases able to hydrolyze gluten peptides and proteins at acidic ph, from the actinomycete actinoallomurus

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CN104039345A CN104039345A (zh) 2014-09-10
CN104039345B true CN104039345B (zh) 2016-11-09

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US (2) US20140356345A1 (enExample)
EP (1) EP2788018B1 (enExample)
JP (1) JP6203743B2 (enExample)
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AU (1) AU2012348782B2 (enExample)
BR (1) BR112014012100B1 (enExample)
CA (1) CA2852365C (enExample)
EA (1) EA028228B1 (enExample)
ES (1) ES2595500T3 (enExample)
IN (1) IN2014CN04131A (enExample)
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TR201806885T4 (tr) 2011-08-10 2018-06-21 Univ Washington Through Its Center For Commercialization Çölyak sprue hastalığının tedavisi için bileşimler ve yöntemler.
EP4008340A1 (en) * 2013-08-14 2022-06-08 University of Washington Through Its Center for Commercialization Compositions for treating celiac sprue disease
US9867872B2 (en) 2013-09-05 2018-01-16 Dsm Ip Assets B.V. Use of an acidic soft drink to enhance the efficacy of a gluten-digesting enzyme
US10308967B2 (en) * 2013-11-26 2019-06-04 Novozymes A/S Milling process
JP6878275B2 (ja) * 2014-10-24 2021-05-26 デュポン ニュートリション バイオサイエンシス エーピーエス プロリン耐性トリペプチジルペプチダーゼおよびその使用
JP7325030B2 (ja) 2015-06-08 2023-08-14 ユニヴァーシティ オブ ワシントン セリアックスプルー病を治療するための組成物および方法
US11124785B2 (en) 2016-02-11 2021-09-21 Trustees Of Boston University Rothia subtilisins, S8A family proteases, as therapeutic enzymes for application in gluten intolerance disorders
IT201900012942A1 (it) 2019-07-25 2021-01-25 Nemysis Ltd Metodo per la produzione di una composizione enzimatica comprendente una endopeptidasi ricombinante
US20220364069A1 (en) * 2019-07-25 2022-11-17 Nemysis Limited Method for the production of an enzymatic composition comprising a recombinant endopeptidase
CN111172138B (zh) * 2020-02-14 2022-03-25 江南大学 一种蛋白水解酶及其在蛋白肽生产中的应用
IT202100018254A1 (it) 2021-07-12 2023-01-12 Nemysis Ltd New systems for producing recombinant proteins/ nuovi sistemi di produzione di proteine ricombinanti
CN114438044B (zh) * 2022-01-14 2024-03-29 南昌大学 一种高效降解麸质蛋白的多酶复合体及其应用
WO2024233959A1 (en) * 2023-05-11 2024-11-14 Digestiva, Inc. Wine dehazing methods and compositions
WO2025067635A1 (en) * 2023-09-26 2025-04-03 Amyra Biotech Ag Pharmaceutical compositions comprising exopeptidases and uses thereof

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WO2003068170A2 (en) * 2002-02-14 2003-08-21 The Board Of Trustees Of The Leland Stanford Junior University Enzyme treatment of foodstuffs for celiac sprue
WO2005107786A1 (en) * 2004-04-26 2005-11-17 Celiac Sprue Research Foundation Therapeutic enzyme formulations and uses thereof
CN101663394A (zh) * 2007-04-25 2010-03-03 雀巢产品技术援助有限公司 来自担子菌纲的肽酶

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JP3104935B2 (ja) 1992-05-28 2000-10-30 株式会社ブリヂストン 空気入りタイヤ
US7265093B2 (en) * 2002-05-14 2007-09-04 The Board Of Trustees Of The Leland Stanford Junior University Drug therapy for Celiac Sprue
PL1673457T3 (pl) 2003-08-25 2011-12-30 Amyra Biotech Ag Nowe białka grzybów oraz kodujące je kwasy nukleinowe
HUE044812T2 (hu) 2003-09-23 2019-11-28 Dsm Ip Assets Bv Prolinspecifikus endoproteázok alkalmazása peptidek és fehérjék hidrolízisére
NL1027650C1 (nl) 2004-12-03 2006-06-07 Leonardus Antonius Luttikhold Transporthulpmiddel voor deuren en panelen.
EP2515932A2 (en) * 2009-12-21 2012-10-31 Centre Hospitalier Universitaire Vaudois (CHUV) Synergic action of a prolyl protease and tripeptidyl proteases
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WO2005107786A1 (en) * 2004-04-26 2005-11-17 Celiac Sprue Research Foundation Therapeutic enzyme formulations and uses thereof
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AU2012348782B2 (en) 2017-10-26
AU2012348782A1 (en) 2014-05-15
EA201491117A1 (ru) 2014-09-30
EA028228B1 (ru) 2017-10-31
WO2013083338A1 (en) 2013-06-13
US10201593B2 (en) 2019-02-12
EP2788018A1 (en) 2014-10-15
US20160114009A1 (en) 2016-04-28
JP2015500641A (ja) 2015-01-08
CA2852365C (en) 2021-01-26
JP6203743B2 (ja) 2017-09-27
CA2852365A1 (en) 2013-06-13
HK1198244A1 (en) 2015-03-20
CN104039345A (zh) 2014-09-10
BR112014012100A2 (pt) 2020-10-27
US20140356345A1 (en) 2014-12-04
BR112014012100B1 (pt) 2023-04-18
EP2788018B1 (en) 2016-06-29
ES2595500T3 (es) 2016-12-30
IN2014CN04131A (enExample) 2015-07-17

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