AU2012348782B2 - New proteases able to hydrolyze gluten peptides and proteins at acidic pH, from the Actinomycete Actinoallomurus - Google Patents

New proteases able to hydrolyze gluten peptides and proteins at acidic pH, from the Actinomycete Actinoallomurus Download PDF

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Publication number
AU2012348782B2
AU2012348782B2 AU2012348782A AU2012348782A AU2012348782B2 AU 2012348782 B2 AU2012348782 B2 AU 2012348782B2 AU 2012348782 A AU2012348782 A AU 2012348782A AU 2012348782 A AU2012348782 A AU 2012348782A AU 2012348782 B2 AU2012348782 B2 AU 2012348782B2
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Prior art keywords
endopep
seq
sequence
identity
endopeptidase
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AU2012348782A1 (en
Inventor
Monica ABBONDI
Mara BRUNATI
Lucia Carrano
Linda Cavaletti
Anna TARAVELLA
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Fondazione Istituto Insubrico di Ricerca per la Vita
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Fondazione St Insubrico Di Ricerca Per La Vita
Fondazione Istituto Insubrico di Ricerca per la Vita
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J3/00—Working-up of proteins for foodstuffs
    • A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
    • A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
    • A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
    • A23J3/346—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of vegetable proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21026—Prolyl oligopeptidase (3.4.21.26), i.e. proline-specific endopeptidase

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
AU2012348782A 2011-12-06 2012-11-05 New proteases able to hydrolyze gluten peptides and proteins at acidic pH, from the Actinomycete Actinoallomurus Active AU2012348782B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11425291 2011-12-06
EP11425291.9 2011-12-06
PCT/EP2012/071816 WO2013083338A1 (en) 2011-12-06 2012-11-05 New proteases able to hydrolyze gluten peptides and proteins at acidic ph, from the actinomycete actinoallomurus

Publications (2)

Publication Number Publication Date
AU2012348782A1 AU2012348782A1 (en) 2014-05-15
AU2012348782B2 true AU2012348782B2 (en) 2017-10-26

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AU2012348782A Active AU2012348782B2 (en) 2011-12-06 2012-11-05 New proteases able to hydrolyze gluten peptides and proteins at acidic pH, from the Actinomycete Actinoallomurus

Country Status (11)

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US (2) US20140356345A1 (enExample)
EP (1) EP2788018B1 (enExample)
JP (1) JP6203743B2 (enExample)
CN (1) CN104039345B (enExample)
AU (1) AU2012348782B2 (enExample)
BR (1) BR112014012100B1 (enExample)
CA (1) CA2852365C (enExample)
EA (1) EA028228B1 (enExample)
ES (1) ES2595500T3 (enExample)
IN (1) IN2014CN04131A (enExample)
WO (1) WO2013083338A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT2718434T (lt) 2011-08-10 2018-08-10 University Of Washington Through Its Center For Commercialization Kompozicijos ir būdai, skirti celiakijos gydymui
US10266815B2 (en) * 2013-08-14 2019-04-23 University Of Washington Through Its Center For Commercialization Compositions and methods for treating celiac sprue disease
US9867872B2 (en) 2013-09-05 2018-01-16 Dsm Ip Assets B.V. Use of an acidic soft drink to enhance the efficacy of a gluten-digesting enzyme
WO2015078372A1 (en) * 2013-11-26 2015-06-04 Novozymes A/S Milling process
CN107105707B (zh) * 2014-10-24 2022-07-22 杜邦营养生物科学有限公司 脯氨酸耐受性三肽基肽酶及其用途
TN2017000520A1 (en) 2015-06-08 2019-04-12 Univ California Compositions and methods for treating celiac sprue disease
WO2017139659A1 (en) 2016-02-11 2017-08-17 Trustees Of Boston University Rothia subtilisins, s8a family proteases, as therapeutic enzymes for application in gluten-intolerance disorders
IT201900012942A1 (it) 2019-07-25 2021-01-25 Nemysis Ltd Metodo per la produzione di una composizione enzimatica comprendente una endopeptidasi ricombinante
AU2020318422B2 (en) * 2019-07-25 2026-03-19 Nemysis Limited Method for the production of an enzymatic composition comprising a recombinant endopeptidase
CN111172138B (zh) * 2020-02-14 2022-03-25 江南大学 一种蛋白水解酶及其在蛋白肽生产中的应用
CA3186744A1 (en) 2020-06-09 2021-12-16 Dr. Schar S.P.A. Method to prepare a mixture and food products deriving therefrom
IT202100018254A1 (it) 2021-07-12 2023-01-12 Nemysis Ltd New systems for producing recombinant proteins/ nuovi sistemi di produzione di proteine ricombinanti
CN114438044B (zh) * 2022-01-14 2024-03-29 南昌大学 一种高效降解麸质蛋白的多酶复合体及其应用
TWI864494B (zh) 2022-11-17 2024-12-01 國立中興大學 天冬胺酸蛋白酶於水解麩質蛋白之用途、編碼該天冬胺酸蛋白酶之核酸分子、生產該天冬胺酸蛋白酶之方法及其應用
AU2024269012A1 (en) * 2023-05-11 2026-01-08 Amplifye, Inc. Wine dehazing methods and compositions
WO2025067635A1 (en) * 2023-09-26 2025-04-03 Amyra Biotech Ag Pharmaceutical compositions comprising exopeptidases and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003068170A2 (en) * 2002-02-14 2003-08-21 The Board Of Trustees Of The Leland Stanford Junior University Enzyme treatment of foodstuffs for celiac sprue
WO2005107786A1 (en) * 2004-04-26 2005-11-17 Celiac Sprue Research Foundation Therapeutic enzyme formulations and uses thereof
WO2011077359A2 (en) * 2009-12-21 2011-06-30 Centre Hospitalier Universitaire Vaudois (Chuv) Synergic action of a prolyl protease and tripeptidyl proteases

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JP3104935B2 (ja) 1992-05-28 2000-10-30 株式会社ブリヂストン 空気入りタイヤ
US7265093B2 (en) * 2002-05-14 2007-09-04 The Board Of Trustees Of The Leland Stanford Junior University Drug therapy for Celiac Sprue
DK1673457T3 (da) 2003-08-25 2011-09-05 Funzyme Biotechnologies Sa Nye svampeproteiner og nukleinsyrer, der koder for disse
US8524225B2 (en) 2003-09-23 2013-09-03 Dsm Ip Assets B.V. Use of proline specific endoproteases to hydrolyse peptides and proteins
NL1027650C1 (nl) 2004-12-03 2006-06-07 Leonardus Antonius Luttikhold Transporthulpmiddel voor deuren en panelen.
EP1985698A1 (en) * 2007-04-25 2008-10-29 Nestec S.A. Peptidases from basidiomycetes
EP2531521B1 (en) * 2010-02-02 2017-09-06 Amano Enzyme USA., Ltd. Use of proteases for gluten intolerance
JP2013523133A (ja) * 2010-03-30 2013-06-17 アルヴィン ファーマシューティカルズ インコーポレーティッド グルテンを分解するためのプロテアーゼ
JP2011211997A (ja) * 2010-04-02 2011-10-27 Astellas Pharma Inc アントラサイクリン化合物を生産する微生物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003068170A2 (en) * 2002-02-14 2003-08-21 The Board Of Trustees Of The Leland Stanford Junior University Enzyme treatment of foodstuffs for celiac sprue
WO2005107786A1 (en) * 2004-04-26 2005-11-17 Celiac Sprue Research Foundation Therapeutic enzyme formulations and uses thereof
WO2011077359A2 (en) * 2009-12-21 2011-06-30 Centre Hospitalier Universitaire Vaudois (Chuv) Synergic action of a prolyl protease and tripeptidyl proteases

Non-Patent Citations (1)

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Title
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Also Published As

Publication number Publication date
US20140356345A1 (en) 2014-12-04
ES2595500T3 (es) 2016-12-30
EA028228B1 (ru) 2017-10-31
IN2014CN04131A (enExample) 2015-07-17
CA2852365A1 (en) 2013-06-13
US20160114009A1 (en) 2016-04-28
CA2852365C (en) 2021-01-26
US10201593B2 (en) 2019-02-12
EP2788018B1 (en) 2016-06-29
AU2012348782A1 (en) 2014-05-15
HK1198244A1 (en) 2015-03-20
WO2013083338A1 (en) 2013-06-13
JP2015500641A (ja) 2015-01-08
JP6203743B2 (ja) 2017-09-27
CN104039345B (zh) 2016-11-09
CN104039345A (zh) 2014-09-10
BR112014012100A2 (pt) 2020-10-27
EA201491117A1 (ru) 2014-09-30
EP2788018A1 (en) 2014-10-15
BR112014012100B1 (pt) 2023-04-18

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