JP6189754B2 - タンパク質を条件的に発現するベクター - Google Patents

タンパク質を条件的に発現するベクター Download PDF

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JP6189754B2
JP6189754B2 JP2013556905A JP2013556905A JP6189754B2 JP 6189754 B2 JP6189754 B2 JP 6189754B2 JP 2013556905 A JP2013556905 A JP 2013556905A JP 2013556905 A JP2013556905 A JP 2013556905A JP 6189754 B2 JP6189754 B2 JP 6189754B2
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gene
sequence
protein
ligand
transcription factor
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JP2014512808A5 (enExample
JP2014512808A (ja
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エフ． ロス，エレミア
エフ． ロス，エレミア
シー． リード，チャールズ
シー． リード，チャールズ
カスバートソン，ブランドン
チャダ，サニル
イー． フォグラー，ウィリアム
イー． フォグラー，ウィリアム
カズィ，ファヤツ
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イントレキソン コーポレーション
イントレキソン コーポレーション
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Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013158871A1 (en) * 2012-04-20 2013-10-24 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Use of erythropoietin and derivatives for treating hypertension
CA2945984C (en) * 2014-04-24 2023-09-26 University Of Florida Research Foundation, Inc. Aav-based gene therapy for multiple sclerosis
WO2015164723A1 (en) * 2014-04-25 2015-10-29 The Trustees Of The University Of Pennsylvania Methods and compositions for treating metastatic breast cancer and other cancers in the brain
US10478486B2 (en) * 2014-08-26 2019-11-19 Hsf Pharmaceuticals Sa Immunization agents and methods of use
JP6383621B2 (ja) * 2014-09-24 2018-08-29 太陽インキ製造株式会社 硬化性組成物、ドライフィルム、硬化物、プリント配線板およびプリント配線板の製造方法
KR20180014051A (ko) * 2015-05-28 2018-02-07 코넬 유니버시티 혈관 부종 치료제로서의 아데노-관련 바이러스 매개 c1e1의 전달
CN108025047B (zh) * 2015-05-28 2021-11-19 康奈尔大学 腺相关病毒介导的c1ei递送作为用于血管性水肿的疗法
EP3347373A1 (en) 2015-10-10 2018-07-18 Intrexon Corporation Improved therapeutic control of proteolytically sensitive, destabilized forms of interleukin-12
CA3004742A1 (en) 2015-11-11 2017-05-18 Intrexon Corporation Compositions and methods for expression of multiple biologically active polypeptides from a single vector for treatment of cardiac conditions and other pathologies
US11446398B2 (en) 2016-04-11 2022-09-20 Obsidian Therapeutics, Inc. Regulated biocircuit systems
EP3235516B1 (en) * 2016-04-22 2019-06-26 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts Universitätsmedizin Regulatable adeno-associated virus (aav) vector
US20200318079A1 (en) * 2016-05-25 2020-10-08 The Board Of Trustees Of The Leland Stanford Junior University Activity-dependent expression constructs and methods of using the same
WO2017214333A1 (en) 2016-06-08 2017-12-14 Intrexon Corporation Cd33 specific chimeric antigen receptors
UY37343A (es) 2016-07-25 2018-02-28 Intrexon Corp Control del fenotipo en plantas
CN110139933B (zh) * 2016-11-09 2024-03-08 英特瑞克斯顿股份有限公司 共济蛋白表达构建体
WO2018132494A1 (en) 2017-01-10 2018-07-19 Intrexon Corporation Modulating expression of polypeptides via new gene switch expression systems
IL270990B2 (en) 2017-06-07 2024-02-01 Precigen Inc Expression of new cell markers
BR112020015798A2 (pt) 2018-02-01 2021-03-09 Homology Medicines, Inc. Composições de vírus adeno-associado para restaurar função de gene da pah e métodos de uso das mesmas
US10610606B2 (en) 2018-02-01 2020-04-07 Homology Medicines, Inc. Adeno-associated virus compositions for PAH gene transfer and methods of use thereof
CN112041437A (zh) 2018-02-19 2020-12-04 同源药物公司 用于恢复f8基因功能的腺相关病毒组合物和其使用方法
IL277128B2 (en) 2018-03-06 2025-11-01 Precigen Inc Hepatitis b vaccines and uses of the same
WO2019173465A1 (en) 2018-03-06 2019-09-12 Intrexon Corporation Human papillomavirus vaccines and uses of the same
US20210395773A1 (en) * 2018-06-27 2021-12-23 Precigen, Inc. In vivo controlled combination therapy for treatment of cancer
JP2021530217A (ja) 2018-07-10 2021-11-11 プレシゲン，インコーポレイテッド Ｒｏｒ−１特異的キメラ抗原受容体およびその使用
JP2022519734A (ja) 2019-02-08 2022-03-24 クリスタル バイオテック インコーポレイテッド Ｃｆｔｒポリペプチドを送達するための組成物及び方法
EP3903105A1 (en) * 2019-02-18 2021-11-03 The University Of Liverpool Method of diagnosis
SG11202109225WA (en) 2019-03-08 2021-09-29 Obsidian Therapeutics Inc Cd40l compositions and methods for tunable regulation
WO2020206056A1 (en) 2019-04-04 2020-10-08 Greenvenus Llc Peptides and methods of plant protection
EP4087861A1 (en) 2020-01-08 2022-11-16 Obsidian Therapeutics, Inc. Compositions and methods for tunable regulation of transcription
TW202140791A (zh) 2020-01-13 2021-11-01 美商霍蒙拉奇醫藥公司 治療苯酮尿症之方法
TW202204625A (zh) * 2020-04-14 2022-02-01 美商佛羅里達大學研究基金會公司 多發性硬化之基因免疫治療與免疫抑制劑之增強功效
US12297444B2 (en) 2020-04-14 2025-05-13 University Of Florida Research Foundation, Incorporated AAV-based gene therapies for treatment of autoimmune diseases
TW202208632A (zh) 2020-05-27 2022-03-01 美商同源醫藥公司 用於恢復ｐａｈ基因功能的腺相關病毒組成物及其使用方法
CN112741895A (zh) * 2021-01-19 2021-05-04 中国人民解放军陆军军医大学 Epo类似物在制备治疗脓毒症药物中的应用

Family Cites Families (132)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3360004A (en) 1965-09-07 1967-12-26 Bendix Corp Pressure proportioning valve
US4797368A (en) 1985-03-15 1989-01-10 The United States Of America As Represented By The Department Of Health And Human Services Adeno-associated virus as eukaryotic expression vector
US4985461A (en) 1985-10-21 1991-01-15 Rohm And Haas Company Insecticidal N'-substituted-N,N'-diacylhydrazines
US5117057A (en) 1985-10-21 1992-05-26 Rohm And Haas Company Insecticidal N' substituted-N-N'-disubstituted-hydrazines
FR2593630B1 (fr) 1986-01-27 1988-03-18 Maurice Francois Ecran d'affichage a matrice active a resistance de drain et procedes de fabrication de cet ecran
US5225443A (en) 1986-05-01 1993-07-06 Rohm And Haas Company Insecticidal N'-substituted-N'-substituted N,N'-diacylhydrazines
US4981784A (en) 1987-12-02 1991-01-01 The Salk Institute For Biological Studies Retinoic acid receptor method
US5354844A (en) 1989-03-16 1994-10-11 Boehringer Ingelheim International Gmbh Protein-polycation conjugates
US5693622A (en) 1989-03-21 1997-12-02 Vical Incorporated Expression of exogenous polynucleotide sequences cardiac muscle of a mammal
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
GB8918616D0 (en) 1989-08-15 1989-09-27 Univ Glasgow Herpes simplex virus type 1 mutant
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
CA2043775A1 (en) 1990-06-14 1991-12-15 Dat P. Le Dibenzoylakylcyanohydrazines
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
US5849572A (en) 1990-10-10 1998-12-15 Regents Of The University Of Michigan HSV-1 vector containing a lat promoter
IL100643A (en) 1991-01-25 1996-10-31 Nippon Kayaku Kk History of hydrazine and pesticides containing these histories as an active ingredient
US5530028A (en) 1992-11-23 1996-06-25 Rohm And Haas Company Insecticidal N'-substituted-N,N'-diacylhydrazines
US6013836A (en) 1992-02-28 2000-01-11 Rohm And Haas Company Insecticidal N'-substituted-N,N'-disubstitutedhydrazines
US5804413A (en) 1992-07-31 1998-09-08 University Of Pittsburgh Of The Commonwealth System Of Higher Education Herpes simplex virus strains for gene transfer
US5464758A (en) 1993-06-14 1995-11-07 Gossen; Manfred Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters
FR2714830B1 (fr) 1994-01-10 1996-03-22 Rhone Poulenc Rorer Sa Composition contenant des acides nucléiques, préparation et utilisations.
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
FR2715847B1 (fr) 1994-02-08 1996-04-12 Rhone Poulenc Rorer Sa Composition contenant des acides nucléiques, préparation et utilisations.
US6150137A (en) 1994-05-27 2000-11-21 Ariad Pharmaceuticals, Inc. Immunosuppressant target proteins
US5851806A (en) 1994-06-10 1998-12-22 Genvec, Inc. Complementary adenoviral systems and cell lines
JP3816518B2 (ja) 1994-06-10 2006-08-30 ジェンベク、インコーポレイティッド 相補的なアデノウイルスベクター系と細胞系
GB9415319D0 (en) 1994-07-29 1994-09-21 Medical Res Council HSV viral vector
US20020107211A1 (en) * 1995-06-07 2002-08-08 The Rockefeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
US5962311A (en) 1994-09-08 1999-10-05 Genvec, Inc. Short-shafted adenoviral fiber and its use
US5965541A (en) 1995-11-28 1999-10-12 Genvec, Inc. Vectors and methods for gene transfer to cells
US5846782A (en) 1995-11-28 1998-12-08 Genvec, Inc. Targeting adenovirus with use of constrained peptide motifs
US5559099A (en) 1994-09-08 1996-09-24 Genvec, Inc. Penton base protein and methods of using same
FR2727679B1 (fr) 1994-12-05 1997-01-03 Rhone Poulenc Rorer Sa Nouveaux agents de transfection et leurs applications pharmaceutiques
FR2730637B1 (fr) 1995-02-17 1997-03-28 Rhone Poulenc Rorer Sa Composition pharmaceutique contenant des acides nucleiques, et ses utilisations
US6127525A (en) 1995-02-21 2000-10-03 Cornell Research Foundation, Inc. Chimeric adenoviral coat protein and methods of using same
ES2237764T3 (es) 1995-03-03 2005-08-01 Syngenta Participations Ag Control de la expresion genica en plantas por transactivacion mediada por un receptor en presencia de un ligando quimico.
NZ308162A (en) 1995-05-26 2000-02-28 Zeneca Pharma Sa Insect steroid (ecdysone) receptors and such nucleic acids in screening methods and gene switches
US6187757B1 (en) 1995-06-07 2001-02-13 Ariad Pharmaceuticals, Inc. Regulation of biological events using novel compounds
DE69638058D1 (de) 1995-06-15 2009-11-26 Crucell Holland Bv Verpackungssysteme für humane rekombinante Adenoviren zur Gentherapie
US5837511A (en) 1995-10-02 1998-11-17 Cornell Research Foundation, Inc. Non-group C adenoviral vectors
US6723531B2 (en) 1996-04-05 2004-04-20 The Salk Institute For Biological Studies Method for modulating expression of exogenous genes in mammalian systems, and products related thereto
EP0874909A2 (en) * 1996-08-23 1998-11-04 Arch Development Corporation Long-term expression of gene products by transforming muscle cells
US6020191A (en) 1997-04-14 2000-02-01 Genzyme Corporation Adenoviral vectors capable of facilitating increased persistence of transgene expression
AU8067698A (en) 1997-06-09 1998-12-30 Genvec, Inc. Chimeric vectors comprising a phage packaging site and a portion derived from a genome of a eukaryotic virus
US20100190692A1 (en) 1997-07-04 2010-07-29 Van Groeninghen Johannes C Methods for reducing gnrh-positive tumor cell proliferation
AU3659497A (en) * 1997-07-11 1999-02-08 Canji, Inc. Organ-specific targeting of cationic amphiphile/retinobl astoma encoding dna complexes for gene therapy
AU8605598A (en) 1997-07-31 1999-02-22 University Of Pittsburgh Targeted hsv vectors
US6479653B1 (en) 1997-08-26 2002-11-12 Ariad Gene Therapeutics, Inc. Compositions and method for regulation of transcription
JP2003524368A (ja) 1997-08-26 2003-08-19 アリアド ジーン セラピューティクス インコーポレイテッド ニ量化ドメイン、三量化ドメインまたは四量化ドメインおよび補足的非相同転写活性化ドメイン、転写抑制ドメイン、ｄｎａ結合ドメインまたはリガンド結合ドメインを含む融合蛋白
US6015709A (en) 1997-08-26 2000-01-18 Ariad Pharmaceuticals, Inc. Transcriptional activators, and compositions and uses related thereto
US20020048792A1 (en) 1997-08-26 2002-04-25 Ariad Gene Therapeutics, Inc. Methods and materials for regulated production of proteins
CA2304173A1 (en) 1997-09-23 1999-04-01 Genvec, Inc. Plasmids for construction of eukaryotic viral vectors
US5981225A (en) 1998-04-16 1999-11-09 Baylor College Of Medicine Gene transfer vector, recombinant adenovirus particles containing the same, method for producing the same and method of use of the same
EA200001096A1 (ru) 1998-04-22 2001-04-23 Джинвек, Инк. Способ обогащения раствора аденовируса, способ точного подсчета числа аденовирусных частиц в образце раствора (варианты) и способ очистки аденовируса из клеток, инфицированных аденовирусом
US6333318B1 (en) 1998-05-14 2001-12-25 The Salk Institute For Biological Studies Formulations useful for modulating expression of exogenous genes in mammalian systems, and products related thereto
US6258603B1 (en) 1998-06-17 2001-07-10 Rohm And Haas Company Ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US6113913A (en) 1998-06-26 2000-09-05 Genvec, Inc. Recombinant adenovirus
DE19831420A1 (de) * 1998-07-14 2000-01-20 Hoechst Marion Roussel De Gmbh Expressionssysteme enthaltend chimäre Promotoren mit Bindungsstellen für rekombinante Transkriptionsfaktoren
US5965358A (en) 1998-08-26 1999-10-12 Genvec, Inc. Method for assessing the relative purity of viral gene transfer vector stocks
US6225289B1 (en) 1998-12-10 2001-05-01 Genvec, Inc. Methods and compositions for preserving adenoviral vectors
US7030098B2 (en) * 1999-03-12 2006-04-18 The Board Of Trustees Of The Leland Stanford Junior University DNA vaccination for treatment of autoimmune disease
US7309687B1 (en) 1999-04-13 2007-12-18 The Kenneth S. Warren Institute, Inc. Methods for treatment and prevention of neuromuscular and muscular conditions by peripherally administered erythropoietin
US7345019B1 (en) 1999-04-13 2008-03-18 The Kenneth S. Warren Institute, Inc. Modulation of excitable tissue function by peripherally administered erythropoietin
US6831060B2 (en) * 1999-05-07 2004-12-14 Genentech, Inc. Chimpanzee erythropoietin (CHEPO) polypeptides and nucleic acids encoding the same
JP4115671B2 (ja) 1999-05-17 2008-07-09 コンジュケム バイオテクノロジーズ インコーポレイテッド 長期間持続するインシュリン向性ペプチド
US6225895B1 (en) 1999-05-26 2001-05-01 Floyd E. Bigelow, Jr. Towed vehicle monitor system
AU6953100A (en) * 1999-07-09 2001-01-30 Mayo Foundation For Medical Education And Research Cftr polypeptides, fragments thereof and methods of use to overcome biosyntheticmisprocessing
US20030186386A1 (en) * 2000-02-11 2003-10-02 Hansen Christian Karsten Interleukin 10
ATE338135T1 (de) 2000-03-22 2006-09-15 Rheogene Holdings Inc Induziertes genexpressionssystem basierend auf ecdysonrezeptoren
US20040033600A1 (en) 2001-03-21 2004-02-19 Palli Subba Reddy Ecdysone receptor-based inducible gene expression system
US8105825B2 (en) 2000-10-03 2012-01-31 Intrexon Corporation Multiple inducible gene regulation system
US7767643B2 (en) 2000-12-29 2010-08-03 The Kenneth S. Warren Institute, Inc. Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs
US6531121B2 (en) 2000-12-29 2003-03-11 The Kenneth S. Warren Institute, Inc. Protection and enhancement of erythropoietin-responsive cells, tissues and organs
CA2438119C (en) 2001-02-20 2014-12-16 Rheogene Holdings, Inc. Chimeric retinoid x receptors and their use in a novel ecdysone receptor-based inducible gene expression system
ES2390070T3 (es) 2001-02-20 2012-11-06 Intrexon Corporation Nuevos receptores mutantes de sustitución y su uso en un sistema de expresión génica inducible basado en receptores nucleares
ATE545705T1 (de) 2001-02-20 2012-03-15 Intrexon Corp Neues induzierbares genexpressionssystem auf ecdysonrezeptor/invertebraten-retinoid-x-rezept r-basis
WO2002066612A2 (en) 2001-02-20 2002-08-29 Rheogene, Inc. Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
US20020168739A1 (en) * 2001-03-09 2002-11-14 Wu Kenneth K. Vectors, compositions and methods for treating a vascular disorder
WO2002072019A2 (en) * 2001-03-13 2002-09-19 Vical Incorporated Interferon-beta polynucleotide therapy for autoimmune and inflammatory diseases
US7588758B2 (en) * 2001-09-11 2009-09-15 University Of Medicine And Dentistry Of New Jersey COX-2 function and wound healing
JP2005532781A (ja) 2001-09-26 2005-11-04 レオジーン・ホールディングス，インコーポレーテッド ヨコバイエクジソン受容体核酸、ポリペプチド、およびそれらの使用
JP2005507247A (ja) 2001-09-26 2005-03-17 レオジーン・ホールディングス，インコーポレーテッド コナジラミエクジソン受容体核酸、ポリペプチド、およびそれらの使用
US20030176328A1 (en) * 2001-12-21 2003-09-18 Maxygen Aps Adiponectin fragments and conjugates
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
US20050228016A1 (en) 2002-06-13 2005-10-13 Enrique Michelotti Tetrahydroquinolines for modulating the expression of exogenous genes via an ecdysone receptor complex
US7375093B2 (en) 2002-07-05 2008-05-20 Intrexon Corporation Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US20040049437A1 (en) 2002-09-11 2004-03-11 Govone Solutions, Lp Method, system and computer program product for automating transaction tax calculation
WO2004034971A2 (en) * 2002-09-25 2004-04-29 The Center For Blood Research, Inc. Methods for treating and preventing sepsis using modified c1 inhibitor or fragments thereof
US7785871B2 (en) 2002-10-09 2010-08-31 Intrexon Corporation DNA cloning vector plasmids and methods for their use
US20080050808A1 (en) 2002-10-09 2008-02-28 Reed Thomas D DNA modular cloning vector plasmids and methods for their use
US6989369B2 (en) 2003-02-07 2006-01-24 Dyax Corp. Kunitz domain peptides
US7304161B2 (en) 2003-02-10 2007-12-04 Intrexon Corporation Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
US7304162B2 (en) 2003-02-21 2007-12-04 Intrexon Corporation Oxadiazoline ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US7456315B2 (en) 2003-02-28 2008-11-25 Intrexon Corporation Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
CA2536873C (en) 2003-08-29 2019-09-10 Dyax Corp. Poly-pegylated protease inhibitors
WO2005026457A1 (en) 2003-09-15 2005-03-24 Jeong Ho Yang Removable attachement-type shower unit
HRP20141155T1 (hr) 2003-11-12 2015-01-16 Sino-Med International Alliance, Inc. Heterocikliäśki spojevi borne kiseline
US20050145385A1 (en) 2004-01-05 2005-07-07 Nguyen Philip D. Methods of well stimulation and completion
US7935510B2 (en) 2004-04-30 2011-05-03 Intrexon Corporation Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
ES2603062T3 (es) 2004-05-18 2017-02-23 Intrexon Corporation Métodos de ensamblaje dinámico de vectores para la clonación de ADN de vectores plasmídicos
US7786163B2 (en) 2004-07-12 2010-08-31 Forest Laboratories Holdings Limited (BM) Constrained cyano compounds
US20060027071A1 (en) 2004-08-06 2006-02-09 Barnett Ronald J Tensegrity musical structures
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
US8067365B2 (en) 2004-11-22 2011-11-29 University Of Utah Research Foundation Erythropoietin for treatment of multi-organ failure
WO2006068905A2 (en) 2004-12-20 2006-06-29 Wyeth Rapamycin derivatives and the uses thereof in the treatment of neurological disorders
KR20070090913A (ko) 2004-12-20 2007-09-06 와이어쓰 라파마이신 유사체 및 신경계, 증식성 및 염증성 장애의치료에서의 이들의 용도
US9034650B2 (en) 2005-02-02 2015-05-19 Intrexon Corporation Site-specific serine recombinases and methods of their use
ES2477868T3 (es) 2005-04-22 2014-07-18 Alantos Pharmaceuticals Holding, Inc. Inhibidores de dipeptidil peptidasa-IV
EP1907417A2 (en) 2005-06-23 2008-04-09 AplaGen GmbH Supravalent compounds
US20110027890A1 (en) 2005-12-26 2011-02-03 Kuraray Co., Ltd. Material for cell culture
EP2001500A4 (en) 2006-03-10 2010-07-28 Dyax Corp FORMULATIONS FOR ECALLANTIDE
JP5406710B2 (ja) * 2006-05-19 2014-02-05 グライコフィ， インコーポレイテッド エリスロポエチン組成物
EP2054074B8 (en) * 2006-08-04 2014-11-12 Prolong Pharmaceuticals, LLC Modified erythropoietin
US8895016B2 (en) 2006-12-18 2014-11-25 Acceleron Pharma, Inc. Antagonists of activin-actriia and uses for increasing red blood cell levels
PE20090722A1 (es) 2007-02-02 2009-07-13 Amgen Inc Hepcidina, antagonistas de la hepcidina y metodos de uso
EP1972349A1 (en) * 2007-03-21 2008-09-24 Biocompatibles UK Limited GLP-1 fusion peptides conjugated to polymer(s), their production and use
TWI407960B (zh) * 2007-03-23 2013-09-11 Jerini Ag 小分子緩激肽ｂ２受體調節劑
JP5881291B2 (ja) 2007-05-29 2016-03-09 イントレキソン コーポレーション エクジソン受容体複合体を通して外因性遺伝子の発現を調節するためのキラルジアシルヒドラジンリガンド
WO2009010107A1 (en) 2007-07-19 2009-01-22 Hannelore Ehrenreich Use of epo receptor activation or stimulation for the improvement of the edss score in patients with multiple sclerosis
CN101835908A (zh) 2007-08-23 2010-09-15 英特瑞克斯顿股份有限公司 诊断疾病的方法和组合物
AU2008304111B2 (en) 2007-09-27 2014-04-24 Amgen Inc. Pharmaceutical formulations
JP2010540534A (ja) 2007-09-28 2010-12-24 イントレキソン コーポレーション 生体治療分子の発現のための治療遺伝子スイッチ構築物およびバイオリアクター、ならびにその使用
ES2636460T3 (es) * 2007-10-08 2017-10-05 Intrexon Corporation Células dendríticas modificadas por ingeniería y usos para el tratamiento del cáncer
EP3381445B1 (en) 2007-11-15 2023-10-25 Amgen Inc. Aqueous formulation of antibody stablised by antioxidants for parenteral administration
MX2011000545A (es) 2008-07-14 2011-02-24 Otonomy Inc Composiciones de liberacion controlada para la modulacion de apoptosis y metodos para el tratamiento de trastornos oticos.
DK2342223T3 (en) 2008-09-26 2017-07-24 Ambrx Inc Modified animal erythropoietin polypeptides and their uses
EP2356219A4 (en) * 2008-10-08 2017-07-05 Intrexon Corporation Engineered cells expressing multiple immunomodulators and uses thereof
CN102215869B (zh) 2008-11-13 2015-05-13 通用医疗公司 用于通过调整bmp-6来调节铁稳态的方法和组合物
MX2011005910A (es) * 2008-12-04 2011-06-17 Opko Curna Llc Tratamiento de enfermedades relacionadas con eritropoyetina (epo) mediante inhibicion del transcrito antisentido natural a eritropoyetina.
CA2760153A1 (en) 2009-04-27 2010-11-11 Alex Chenchik Reagents and methods for producing bioactive secreted peptides
KR20180108886A (ko) 2010-03-23 2018-10-04 인트렉손 코포레이션 치료적 단백질을 조건부로 발현하는 벡터，상기 벡터를 포함하는 숙주 세포 및 이의 용도
EP2808057B1 (en) 2013-05-31 2016-02-03 RaySearch Laboratories AB Method and system for robust radiotherapy treatment planning

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CA2828411A1 (en) 2012-09-13
SG192856A1 (en) 2013-09-30
US20160317678A1 (en) 2016-11-03
WO2012122025A2 (en) 2012-09-13
US20180344876A1 (en) 2018-12-06
WO2012122025A3 (en) 2013-04-25
AU2012225749A1 (en) 2013-03-14
EP3450568A2 (en) 2019-03-06
US9402919B2 (en) 2016-08-02
EP2681327A4 (en) 2015-06-03
US20140308247A1 (en) 2014-10-16
JP2017141245A (ja) 2017-08-17
JP2017212995A (ja) 2017-12-07
SG10201600912SA (en) 2016-03-30
TWI582108B (zh) 2017-05-11
EP2681327B1 (en) 2018-11-21
TW201309726A (zh) 2013-03-01
CN103534355A (zh) 2014-01-22
JP2014512808A (ja) 2014-05-29
EP3450568A3 (en) 2019-04-24

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