MX365540B - Ligandos quirales de diacilhidrazina para modular la expresion de genes exogenos por medio de un complejo receptor de ecdisona. - Google Patents

Ligandos quirales de diacilhidrazina para modular la expresion de genes exogenos por medio de un complejo receptor de ecdisona.

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Publication number
MX365540B
MX365540B MX2016006565A MX2016006565A MX365540B MX 365540 B MX365540 B MX 365540B MX 2016006565 A MX2016006565 A MX 2016006565A MX 2016006565 A MX2016006565 A MX 2016006565A MX 365540 B MX365540 B MX 365540B
Authority
MX
Mexico
Prior art keywords
ligands
chiral
ecdysone receptor
diachylhydrazine
modulating
Prior art date
Application number
MX2016006565A
Other languages
English (en)
Inventor
E Hormann Robert
Li Bing
Original Assignee
Intrexon Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intrexon Corp filed Critical Intrexon Corp
Publication of MX365540B publication Critical patent/MX365540B/es

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    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
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    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
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    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
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Abstract

La presente invención se refiere a un método in vitro para modular la expresión de un gen de interés en una célula hospedera, en donde la célula hospedera comprende un primer casete de expresión de génica recombinante que comprende un primer polinucleótido que codifica un primer polipéptido que comprende ligandos de diacilhidrazina y ligandos quirales de diacilhidrazina para uso con los sistemas de expresión génica inducibles basados en el receptor de ecdisoma.
MX2016006565A 2007-05-29 2008-05-29 Ligandos quirales de diacilhidrazina para modular la expresion de genes exogenos por medio de un complejo receptor de ecdisona. MX365540B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94052507P 2007-05-29 2007-05-29
PCT/US2008/006757 WO2008153801A1 (en) 2007-05-29 2008-05-29 Chiral diachylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex

Publications (1)

Publication Number Publication Date
MX365540B true MX365540B (es) 2019-06-06

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Application Number Title Priority Date Filing Date
MX2016006565A MX365540B (es) 2007-05-29 2008-05-29 Ligandos quirales de diacilhidrazina para modular la expresion de genes exogenos por medio de un complejo receptor de ecdisona.
MX2015013719A MX363066B (es) 2007-05-29 2008-05-29 Ligandos quirales de diacilhidrazina para modular la expresion de genes exogenos por medio de un complejo receptor de ecdisona.
MX2009012834A MX2009012834A (es) 2007-05-29 2008-05-29 Ligandos quirales de diacilhidrazina para modular la expresion de genes exogenos por medio de un complejo receptor de ecdisona.
MX2013007862A MX339349B (es) 2007-05-29 2009-11-26 Procesos para preparar ligandos quirales de diacilhidrazina .

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MX2015013719A MX363066B (es) 2007-05-29 2008-05-29 Ligandos quirales de diacilhidrazina para modular la expresion de genes exogenos por medio de un complejo receptor de ecdisona.
MX2009012834A MX2009012834A (es) 2007-05-29 2008-05-29 Ligandos quirales de diacilhidrazina para modular la expresion de genes exogenos por medio de un complejo receptor de ecdisona.
MX2013007862A MX339349B (es) 2007-05-29 2009-11-26 Procesos para preparar ligandos quirales de diacilhidrazina .

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US (6) US8076517B2 (es)
EP (2) EP3357904B1 (es)
JP (4) JP5881291B2 (es)
KR (1) KR101528378B1 (es)
CN (2) CN104761466A (es)
BR (1) BRPI0811348B1 (es)
CA (1) CA2689137C (es)
DK (1) DK2167458T3 (es)
ES (1) ES2672513T3 (es)
IL (2) IL202377A (es)
MX (4) MX365540B (es)
NZ (1) NZ582013A (es)
RU (2) RU2490253C2 (es)
WO (1) WO2008153801A1 (es)
ZA (1) ZA200909144B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7456315B2 (en) 2003-02-28 2008-11-25 Intrexon Corporation Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
EP3357904B1 (en) 2007-05-29 2022-07-06 Precigen, Inc. Chiral diachylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US20090136465A1 (en) 2007-09-28 2009-05-28 Intrexon Corporation Therapeutic Gene-Switch Constructs and Bioreactors for the Expression of Biotherapeutic Molecules, and Uses Thereof
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