MX2009012834A - Ligandos quirales de diacilhidrazina para modular la expresion de genes exogenos por medio de un complejo receptor de ecdisona. - Google Patents

Ligandos quirales de diacilhidrazina para modular la expresion de genes exogenos por medio de un complejo receptor de ecdisona.

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Publication number
MX2009012834A
MX2009012834A MX2009012834A MX2009012834A MX2009012834A MX 2009012834 A MX2009012834 A MX 2009012834A MX 2009012834 A MX2009012834 A MX 2009012834A MX 2009012834 A MX2009012834 A MX 2009012834A MX 2009012834 A MX2009012834 A MX 2009012834A
Authority
MX
Mexico
Prior art keywords
ligands
chiral
ecdysone receptor
diachylhydrazine
modulating
Prior art date
Application number
MX2009012834A
Other languages
English (en)
Inventor
Robert E Hormann
Bing Li
Original Assignee
Intrexon Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intrexon Corp filed Critical Intrexon Corp
Publication of MX2009012834A publication Critical patent/MX2009012834A/es

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    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
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    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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Abstract

La presente invención proporciona ligandos de diacilhidrazina y ligandos quirales de diacilhidrazina para uso con los sistemas de expresión génica inducibles basados en el receptor de ecdisoma. Así, la presente invención es útil para las aplicaciones tales como terapia génica, producción a gran escala de las proteínas y anticuerpos, ensayos de separación por exclusión basados en células, genómica funcional, proteómica, metabolómica, y regulación de rasgos en organismos transgénicos, donde el control de los niveles de expresión génica es deseable. Una ventaja de la presente invención es que proporciona un medio para regular la expresión génica y para adaptar los niveles de expresión para adaptarlos a los requerimientos de los usuarios.
MX2009012834A 2007-05-29 2008-05-29 Ligandos quirales de diacilhidrazina para modular la expresion de genes exogenos por medio de un complejo receptor de ecdisona. MX2009012834A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94052507P 2007-05-29 2007-05-29
PCT/US2008/006757 WO2008153801A1 (en) 2007-05-29 2008-05-29 Chiral diachylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex

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MX2009012834A true MX2009012834A (es) 2010-05-17

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MX2016006565A MX365540B (es) 2007-05-29 2008-05-29 Ligandos quirales de diacilhidrazina para modular la expresion de genes exogenos por medio de un complejo receptor de ecdisona.
MX2015013719A MX363066B (es) 2007-05-29 2008-05-29 Ligandos quirales de diacilhidrazina para modular la expresion de genes exogenos por medio de un complejo receptor de ecdisona.
MX2009012834A MX2009012834A (es) 2007-05-29 2008-05-29 Ligandos quirales de diacilhidrazina para modular la expresion de genes exogenos por medio de un complejo receptor de ecdisona.
MX2013007862A MX339349B (es) 2007-05-29 2009-11-26 Procesos para preparar ligandos quirales de diacilhidrazina .

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MX2016006565A MX365540B (es) 2007-05-29 2008-05-29 Ligandos quirales de diacilhidrazina para modular la expresion de genes exogenos por medio de un complejo receptor de ecdisona.
MX2015013719A MX363066B (es) 2007-05-29 2008-05-29 Ligandos quirales de diacilhidrazina para modular la expresion de genes exogenos por medio de un complejo receptor de ecdisona.

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MX2013007862A MX339349B (es) 2007-05-29 2009-11-26 Procesos para preparar ligandos quirales de diacilhidrazina .

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US (6) US8076517B2 (es)
EP (2) EP3357904B1 (es)
JP (4) JP5881291B2 (es)
KR (1) KR101528378B1 (es)
CN (2) CN104761466A (es)
BR (1) BRPI0811348B1 (es)
CA (1) CA2689137C (es)
DK (1) DK2167458T3 (es)
ES (1) ES2672513T3 (es)
IL (2) IL202377A (es)
MX (4) MX365540B (es)
NZ (1) NZ582013A (es)
RU (2) RU2490253C2 (es)
WO (1) WO2008153801A1 (es)
ZA (1) ZA200909144B (es)

Families Citing this family (24)

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Publication number Priority date Publication date Assignee Title
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