JP6141180B2 - アミノ−カルボン酸により修飾されたヒアルロン酸誘導体 - Google Patents

アミノ−カルボン酸により修飾されたヒアルロン酸誘導体 Download PDF

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JP6141180B2
JP6141180B2 JP2013502420A JP2013502420A JP6141180B2 JP 6141180 B2 JP6141180 B2 JP 6141180B2 JP 2013502420 A JP2013502420 A JP 2013502420A JP 2013502420 A JP2013502420 A JP 2013502420A JP 6141180 B2 JP6141180 B2 JP 6141180B2
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hyaluronic acid
acid derivative
hydrogen atom
formula
peak
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JPWO2012118189A1 (ja
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朋子 八杉
朋子 八杉
佳弘 反保
佳弘 反保
健司 八杉
健司 八杉
泰 平倉
泰 平倉
剛 下房地
剛 下房地
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Chugai Pharmaceutical Co Ltd
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Chugai Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials Engineering (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2013502420A 2011-03-03 2012-03-02 アミノ−カルボン酸により修飾されたヒアルロン酸誘導体 Active JP6141180B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2011046749 2011-03-03
JP2011046749 2011-03-03
PCT/JP2012/055421 WO2012118189A1 (fr) 2011-03-03 2012-03-02 Dérivé d'acide hyaluronique modifié par l'acide aminocarbonique

Related Child Applications (1)

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JP2017091352A Division JP2017179374A (ja) 2011-03-03 2017-05-01 アミノ−カルボン酸により修飾されたヒアルロン酸誘導体

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JPWO2012118189A1 JPWO2012118189A1 (ja) 2014-07-07
JP6141180B2 true JP6141180B2 (ja) 2017-06-07

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JP2013502420A Active JP6141180B2 (ja) 2011-03-03 2012-03-02 アミノ−カルボン酸により修飾されたヒアルロン酸誘導体
JP2017091352A Pending JP2017179374A (ja) 2011-03-03 2017-05-01 アミノ−カルボン酸により修飾されたヒアルロン酸誘導体

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JP2017091352A Pending JP2017179374A (ja) 2011-03-03 2017-05-01 アミノ−カルボン酸により修飾されたヒアルロン酸誘導体

Country Status (9)

Country Link
US (1) US9243077B2 (fr)
EP (2) EP3184553B1 (fr)
JP (2) JP6141180B2 (fr)
DK (1) DK2682409T3 (fr)
ES (1) ES2635087T3 (fr)
HU (1) HUE033169T2 (fr)
PL (1) PL2682409T3 (fr)
SI (1) SI2682409T1 (fr)
WO (1) WO2012118189A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7343058B2 (ja) 2020-11-12 2023-09-12 三菱電機株式会社 乗客コンベアの欄干

Families Citing this family (11)

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KR102130864B1 (ko) 2012-09-05 2020-07-08 추가이 세이야쿠 가부시키가이샤 아미노산 및 스테릴기가 도입된 히알루론산 유도체
US9572832B2 (en) * 2013-08-29 2017-02-21 Holy Stone Healthcare Co., Ltd. Compound of glycosaminoglycan and its fabrication method as well as application
JP6692051B2 (ja) 2015-02-27 2020-05-13 学校法人常翔学園 膜透過性ペプチド鎖を有する多糖誘導体
US20180086852A1 (en) * 2015-03-31 2018-03-29 Kewpie Corporation Hyaluronic Acid Derivative and Manufacturing Method Therefor and Cosmetics, Food Composition, and Pharmaceutical Composition Containing Hyaluronic Acid Derivative
EP3252080A1 (fr) * 2016-05-31 2017-12-06 Galderma S.A. Procédé de préparation de glycosaminoglycanes réticulés acylés
KR20180120142A (ko) * 2015-12-29 2018-11-05 갈데르마 소시에떼아노님 탄수화물 가교제
PT3623390T (pt) 2016-05-31 2023-10-27 Galderma Sa Reticulador de hidrato de carbono
CN110891611B (zh) 2017-03-22 2024-03-29 阿森迪斯制药公司 水凝胶交联透明质酸前药组合物和方法
US11512147B2 (en) 2017-11-15 2022-11-29 Chugai Seiyaku Kabushiki Kaisha Hyaluronic acid derivative modified with polyethylene glycol
CN109206537B (zh) * 2018-10-10 2021-04-09 华熙生物科技股份有限公司 一种乙酰化透明质酸钠的制备方法及其应用
IL293540A (en) 2019-12-02 2022-08-01 Galderma Holding SA High molecular weight aesthetic preparations

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JPH03502704A (ja) * 1987-09-18 1991-06-20 ジェンザイム　コーポレイション 水不溶性バイオ適合性ゲルの製造方法
JPH09188705A (ja) * 1995-11-07 1997-07-22 Seikagaku Kogyo Co Ltd グリコサミノグリカン誘導体およびその製造法
JP2003518167A (ja) * 1999-12-22 2003-06-03 ジェンザイム、コーポレーション ポリアニオン性多糖類の水不溶性誘導体
WO2005054302A1 (fr) * 2003-12-05 2005-06-16 Chugai Seiyaku Kabushiki Kaisha Vecteur de medicament et procede de production associe
WO2006095775A1 (fr) * 2005-03-08 2006-09-14 Chugai Seiyaku Kabushiki Kaisha Conjugue d’acide hyaluronioue modifie soluble dans l’eau et analogue du glp-1
WO2010053140A1 (fr) * 2008-11-05 2010-05-14 国立大学法人 東京医科歯科大学 Dérivé d’acide hyaluronique et sa composition pharmaceutique
JP2010524979A (ja) * 2007-04-30 2010-07-22 プロメティック・バイオサイエンスィズ・インコーポレーテッド 化合物、そのような化合物を含有する組成物、及びそのような化合物を用いるがん及び自己免疫疾患の治療法

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JP2766303B2 (ja) 1989-04-13 1998-06-18 生化学工業株式会社 グリコサミノグリカンで修飾されたスーパーオキシドジスムターゼ及びその製造法
CA2070672C (fr) 1990-10-18 2002-10-08 Kazuo Akima Compose d'ingredient medical et d'acide hyaluronique, et son procede de production
JPH0585942A (ja) 1991-02-26 1993-04-06 Denki Kagaku Kogyo Kk インターフエロン−ヒアルロン酸及び／又はその塩の結合体
BR9814273A (pt) 1997-12-12 2000-10-03 Expression Genetics Inc Copolìmeros enxertados como carreadores de genes
ITPD980169A1 (it) 1998-07-06 2000-01-06 Fidia Advanced Biopolymers Srl Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione.
US6630457B1 (en) * 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
WO2001005434A2 (fr) 1999-07-20 2001-01-25 Amgen Inc. Conjugues hyaluroniques acide-proteine, compositions pharmaceutiques et procedes correspondants
JP2001081103A (ja) 1999-09-13 2001-03-27 Denki Kagaku Kogyo Kk ヒアルロン酸結合薬剤
IL151024A0 (en) 2000-02-15 2003-02-12 Genzyme Corp Conjugates of a biopolymer and a therapeutic agent
TW200524959A (en) 2003-09-08 2005-08-01 Chugai Pharmaceutical Co Ltd Hyaluronic acid modification product and drug carrier therefrom
US8575332B2 (en) 2003-11-14 2013-11-05 Chugai Seiyaku Kabushiki Kaisha Crosslinked polysaccharide microparticles and method for their preparation
EP1790665B1 (fr) 2004-09-07 2014-11-05 Chugai Seiyaku Kabushiki Kaisha Procedé de production d'acide hyaluronique modifié soluble dans l'eau
IT1399351B1 (it) 2009-06-16 2013-04-16 Fidia Farmaceutici Procedimento per la sintesi di coniugati di glicosamminoglicani (gag) con molecole biologicamente attive, coniugati polimerici e usi relativi
WO2011148116A2 (fr) 2010-05-27 2011-12-01 Laboratoire Idenov Acide hyaluronique modifie, procede de fabrication et utilisations

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JPH03502704A (ja) * 1987-09-18 1991-06-20 ジェンザイム　コーポレイション 水不溶性バイオ適合性ゲルの製造方法
JPH09188705A (ja) * 1995-11-07 1997-07-22 Seikagaku Kogyo Co Ltd グリコサミノグリカン誘導体およびその製造法
JP2003518167A (ja) * 1999-12-22 2003-06-03 ジェンザイム、コーポレーション ポリアニオン性多糖類の水不溶性誘導体
WO2005054302A1 (fr) * 2003-12-05 2005-06-16 Chugai Seiyaku Kabushiki Kaisha Vecteur de medicament et procede de production associe
WO2006095775A1 (fr) * 2005-03-08 2006-09-14 Chugai Seiyaku Kabushiki Kaisha Conjugue d’acide hyaluronioue modifie soluble dans l’eau et analogue du glp-1
JP2010524979A (ja) * 2007-04-30 2010-07-22 プロメティック・バイオサイエンスィズ・インコーポレーテッド 化合物、そのような化合物を含有する組成物、及びそのような化合物を用いるがん及び自己免疫疾患の治療法
WO2010053140A1 (fr) * 2008-11-05 2010-05-14 国立大学法人 東京医科歯科大学 Dérivé d’acide hyaluronique et sa composition pharmaceutique

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7343058B2 (ja) 2020-11-12 2023-09-12 三菱電機株式会社 乗客コンベアの欄干

Also Published As

Publication number Publication date
US9243077B2 (en) 2016-01-26
EP3184553A1 (fr) 2017-06-28
HUE033169T2 (en) 2017-11-28
US20130338352A1 (en) 2013-12-19
EP2682409B1 (fr) 2017-07-05
EP2682409A4 (fr) 2014-11-19
ES2635087T3 (es) 2017-10-02
SI2682409T1 (sl) 2017-08-31
JPWO2012118189A1 (ja) 2014-07-07
EP2682409A1 (fr) 2014-01-08
EP3184553B1 (fr) 2019-05-01
WO2012118189A1 (fr) 2012-09-07
JP2017179374A (ja) 2017-10-05
PL2682409T3 (pl) 2017-12-29
DK2682409T3 (en) 2017-09-11

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