JP6088123B2 - ワクチンとして有用な自己会合ペプチドナノ粒子 - Google Patents
ワクチンとして有用な自己会合ペプチドナノ粒子 Download PDFInfo
- Publication number
- JP6088123B2 JP6088123B2 JP2010544697A JP2010544697A JP6088123B2 JP 6088123 B2 JP6088123 B2 JP 6088123B2 JP 2010544697 A JP2010544697 A JP 2010544697A JP 2010544697 A JP2010544697 A JP 2010544697A JP 6088123 B2 JP6088123 B2 JP 6088123B2
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- peptide
- epitope
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/002—Protozoa antigens
- A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
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- A—HUMAN NECESSITIES
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- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08101221.3 | 2008-02-01 | ||
| EP08101221 | 2008-02-01 | ||
| PCT/EP2009/050996 WO2009109428A2 (en) | 2008-02-01 | 2009-01-29 | Self-assembling peptide nanoparticles useful as vaccines |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011511773A JP2011511773A (ja) | 2011-04-14 |
| JP2011511773A5 JP2011511773A5 (https=) | 2012-03-08 |
| JP6088123B2 true JP6088123B2 (ja) | 2017-03-01 |
Family
ID=39276265
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010544697A Expired - Fee Related JP6088123B2 (ja) | 2008-02-01 | 2009-01-29 | ワクチンとして有用な自己会合ペプチドナノ粒子 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8546337B2 (https=) |
| EP (1) | EP2235043A2 (https=) |
| JP (1) | JP6088123B2 (https=) |
| CN (1) | CN101932594A (https=) |
| AU (1) | AU2009221419B2 (https=) |
| CA (1) | CA2713879C (https=) |
| RU (1) | RU2540871C2 (https=) |
| WO (1) | WO2009109428A2 (https=) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9492400B2 (en) | 2004-11-04 | 2016-11-15 | Massachusetts Institute Of Technology | Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals |
| US9267937B2 (en) | 2005-12-15 | 2016-02-23 | Massachusetts Institute Of Technology | System for screening particles |
| ES2776100T3 (es) | 2006-03-31 | 2020-07-29 | Massachusetts Inst Technology | Sistema para el suministro dirigido de agentes terapéuticos |
| US8367113B2 (en) | 2006-05-15 | 2013-02-05 | Massachusetts Institute Of Technology | Polymers for functional particles |
| WO2007150030A2 (en) | 2006-06-23 | 2007-12-27 | Massachusetts Institute Of Technology | Microfluidic synthesis of organic nanoparticles |
| US9217129B2 (en) | 2007-02-09 | 2015-12-22 | Massachusetts Institute Of Technology | Oscillating cell culture bioreactor |
| WO2008124632A1 (en) | 2007-04-04 | 2008-10-16 | Massachusetts Institute Of Technology | Amphiphilic compound assisted nanoparticles for targeted delivery |
| EP2630966B1 (en) | 2007-10-12 | 2017-04-19 | Massachusetts Institute of Technology | Vaccine nanotechnology |
| EP2313108A4 (en) * | 2008-06-30 | 2013-06-12 | Us Army As Represented By The Secretary Of The Army | MALARIA VACCINE FROM SELF-ORGANIZING POLYPEPTIDE NANOTEHICLES |
| US8277812B2 (en) * | 2008-10-12 | 2012-10-02 | Massachusetts Institute Of Technology | Immunonanotherapeutics that provide IgG humoral response without T-cell antigen |
| US8343498B2 (en) | 2008-10-12 | 2013-01-01 | Massachusetts Institute Of Technology | Adjuvant incorporation in immunonanotherapeutics |
| US8343497B2 (en) | 2008-10-12 | 2013-01-01 | The Brigham And Women's Hospital, Inc. | Targeting of antigen presenting cells with immunonanotherapeutics |
| US8591905B2 (en) | 2008-10-12 | 2013-11-26 | The Brigham And Women's Hospital, Inc. | Nicotine immunonanotherapeutics |
| HUE027823T2 (hu) * | 2008-12-09 | 2016-11-28 | Coley Pharm Group Inc | Immunstimuláló oligonukleotidok |
| US8580274B2 (en) | 2009-02-10 | 2013-11-12 | University Of The Ryukyus | Drug transporter, and adjuvant and vaccine each utilizing same |
| CA2762653A1 (en) | 2009-05-27 | 2010-12-02 | Selecta Biosciences, Inc. | Immunomodulatory agent-polymeric compounds |
| CN107617110A (zh) * | 2009-08-26 | 2018-01-23 | 西莱克塔生物科技公司 | 诱导t细胞辅助的组合物 |
| CN102946901A (zh) * | 2010-01-26 | 2013-02-27 | 科罗拉多大学董事会,法人 | 模板化成双链卷曲螺旋的呼吸病毒表位及其在免疫中的应用 |
| AU2011258165B2 (en) | 2010-05-26 | 2016-11-17 | Selecta Biosciences, Inc. | Dose selection of adjuvanted synthetic nanocarriers |
| WO2012061717A1 (en) | 2010-11-05 | 2012-05-10 | Selecta Biosciences, Inc. | Modified nicotinic compounds and related methods |
| US10285942B2 (en) * | 2011-04-07 | 2019-05-14 | Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Health | Methods of inducing an immune response against HIV by administering immunogenic peptides obtained from protease cleavage sites |
| JP2014521687A (ja) | 2011-07-29 | 2014-08-28 | セレクタ バイオサイエンシーズ インコーポレーテッド | 体液性および細胞傷害性tリンパ球(ctl)免疫応答を生成する合成ナノキャリア |
| EP2748182B1 (en) * | 2011-08-23 | 2016-10-19 | President and Fellows of Harvard College | Peptide nanoparticles and uses thereof |
| SI23902A (sl) * | 2011-10-07 | 2013-04-30 | Kemijski inštitut | Samosestavljivi polipeptidni poliedri |
| CN104136454A (zh) * | 2011-10-12 | 2014-11-05 | 阿尔法-O肽股份公司 | 作为针对诺如病毒感染的疫苗的自装配肽纳米粒 |
| US9550813B2 (en) | 2012-05-22 | 2017-01-24 | The Board Of Trustees Of The Leland Stanford Junior University | Disulfide stabilized foldon polypeptides |
| JP2015519348A (ja) * | 2012-05-23 | 2015-07-09 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ | インフルエンザワクチン構築物 |
| EP2703483A1 (en) * | 2012-08-29 | 2014-03-05 | Affiris AG | PCSK9 peptide vaccine |
| EA201590683A1 (ru) | 2012-11-20 | 2015-11-30 | Глаксосмитклайн Байолоджикалс С.А. | Тримеры rsv f, предшествующие слиянию |
| US10248758B2 (en) * | 2013-02-07 | 2019-04-02 | University Of Washington Through Its Center For Commercialization | Self-assembling protein nanostructures |
| EP3041478A4 (en) * | 2013-09-05 | 2017-04-26 | Immune Design Corp. | Vaccine compositions for drug addiction |
| CN104513293A (zh) * | 2013-09-26 | 2015-04-15 | 深圳信立泰药业股份有限公司 | 一种多肽疫苗的盐及其制备方法和含有该盐的药物制品 |
| US10744199B2 (en) | 2013-10-11 | 2020-08-18 | The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | Epstein-Barr virus vaccines |
| CA2934472A1 (en) * | 2014-01-09 | 2015-07-16 | Alpha-O Peptides Ag | Flagellin-containing protein nanoparticles as a vaccine platform |
| EP3134104B1 (en) * | 2014-04-25 | 2018-12-26 | Tria Bioscience Corp. | Synthetic hapten carrier compositions and methods |
| EP2974739A1 (en) | 2014-07-15 | 2016-01-20 | Novartis AG | RSVF trimerization domains |
| SG11201705264WA (en) * | 2014-12-31 | 2017-07-28 | The Usa As Represented By The Secretary Detp Of Health And Human Services | Novel multivalent nanoparticle-based vaccines |
| SG11201706118XA (en) * | 2015-01-29 | 2017-08-30 | Agency Science Tech & Res | Nanocapsules carrying chikungunya-associated peptides |
| US10501733B2 (en) | 2015-02-27 | 2019-12-10 | University Of Washington | Polypeptide assemblies and methods for the production thereof |
| US9580477B2 (en) | 2015-03-16 | 2017-02-28 | The Catholic University Of America | Approach to produce HIV-1 GP140 envelope protein trimers |
| WO2016207782A1 (en) * | 2015-06-22 | 2016-12-29 | STRELNIKOV, Evgeny | Immunogenic synthetic oligopeptides for a vaccine against hiv |
| CN105393976A (zh) * | 2015-10-30 | 2016-03-16 | 河南科技学院 | 一种利用ghrelin促进新生雏鸡生长性能的方法及应用 |
| CN105210995A (zh) * | 2015-10-30 | 2016-01-06 | 河南科技学院 | 一种利用ghrelin促进新生雏鸡免疫器官发育的方法及应用 |
| CN105409831A (zh) * | 2015-10-30 | 2016-03-23 | 河南科技学院 | 一种利用ghrelin减少新生雏鸡脂肪细胞分化和降低脂肪沉积的方法及应用 |
| US10188136B2 (en) | 2016-02-16 | 2019-01-29 | Indian Institute Of Science Education And Research | Hydrophobin mimics: process for preparation thereof |
| FR3050448A1 (fr) * | 2016-04-21 | 2017-10-27 | Bioaster | Nanoparticules a base d'encapsuline. |
| SG11201809387QA (en) | 2016-05-02 | 2018-11-29 | Scripps Research Inst | Compositions and methods related to hiv-1 immunogens |
| SG11201901790YA (en) | 2016-09-02 | 2019-03-28 | The Usa As Represented By The Secretary | Stabilized group 2 influenza hemagglutinin stem region trimers and uses thereof |
| BR112019013724A2 (pt) | 2017-01-03 | 2020-04-14 | Emergex Vaccines Holding Limited | composições de vacina influenza universal |
| CA3054172A1 (en) | 2017-02-23 | 2018-08-30 | Alpha-O Peptides Ag | Self-assembling protein nanoparticles encapsulating immunostimulatory nucleid acids |
| EA201991918A1 (ru) * | 2017-03-23 | 2020-05-15 | Альфа-О Пептидс Аг | Самосборные белковые наночастицы со встроенными белками с шестиспиральным пучком |
| WO2019023811A1 (en) | 2017-08-04 | 2019-02-07 | The Hospital For Sick Children | NANOPARTICLE PLATFORM FOR ANTIBODY AND VACCINE DELIVERY |
| US12459965B2 (en) | 2017-10-09 | 2025-11-04 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| JP7730640B2 (ja) * | 2017-11-01 | 2025-08-28 | ザ スクリプス リサーチ インスティテュート | 新規足場hiv-1ワクチン免疫原 |
| EP3744847A4 (en) * | 2018-01-22 | 2021-12-08 | Japan as Represented by The Director-General of National Institute of Infectious Diseases | SELECTIVE CD8 POSITIVE T CELL INDUCING VACCINE ANTIGEN |
| US11225502B1 (en) * | 2018-06-11 | 2022-01-18 | Battelle Memorial Institute | Controlled synthesis of hierarchically-structured hybrid materials through peptoid engineering |
| CN112469661B (zh) | 2018-06-13 | 2024-04-26 | 斯克里普斯研究学院 | 具有新结构组分的纳米粒疫苗 |
| US11213582B2 (en) * | 2018-08-08 | 2022-01-04 | The Regents Of The University Of California | Protection against recurrent genital herpes by therapeutic immunization with herpes simplex virus type 2 ribonucleotide reductase protein subunits |
| RU2713723C1 (ru) * | 2018-11-15 | 2020-02-06 | Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) | Искусственные гены, кодирующие белки-иммуногены EV.CTL и EV.Th, рекомбинантные плазмидные ДНК pEV.CTL и pEV.Th, обеспечивающие экспрессию искусственных генов, и искусственные Т-клеточные полиэпитопные белки-иммуногены EV.CTL и EV.Th, содержащие эпитопы антигенов вируса Эбола, используемые для создания вакцины против вируса Эбола |
| CA3126544A1 (en) | 2019-01-12 | 2020-07-16 | The Methodist Hospital | Self-assembled peptide nanoparticle and use thereof |
| KR20220009954A (ko) | 2019-04-17 | 2022-01-25 | 컴퍼스 패쓰파인더 리미티드 | 신경인지 장애, 만성 통증을 치료하고 염증을 감소시키는 방법 |
| US20220265804A1 (en) * | 2019-04-29 | 2022-08-25 | Academy Of Military Medical Sciences | Fusion protein capable of self-assembling into protein nanoparticles and application thereof |
| CN111150841B (zh) * | 2019-12-31 | 2023-08-15 | 优锐生物医药科技(深圳)有限公司 | 一种主动免疫调控微粒及其制备方法和应用 |
| CN111150842B (zh) * | 2019-12-31 | 2023-09-05 | 优锐生物医药科技(深圳)有限公司 | 一种用于中和胃泌素的主动免疫调控微粒及其制备方法和应用 |
| CN112022066A (zh) * | 2020-09-25 | 2020-12-04 | 电子科技大学 | 一种基于深度学习的消化道钩虫发现方法及系统 |
| WO2022106860A1 (en) * | 2020-11-20 | 2022-05-27 | Pécsi Tudományegyetem | Recombinant peptides for use in therapy |
| WO2022149609A1 (ja) * | 2021-01-07 | 2022-07-14 | 国立大学法人東京工業大学 | Mhc分子に適合する病原微生物由来のペプチドが担持された複合蛋白質単量体、当該単量体の会合体、及び当該会合体を有効成分とするコンポーネントワクチン、並びに、免疫後の生理活性物質の分泌に関する情報の取得方法 |
| WO2025172892A1 (en) | 2024-02-16 | 2025-08-21 | Glaxosmithkline Biologicals Sa | Modified proteins and methods |
| WO2025242657A1 (en) | 2024-05-21 | 2025-11-27 | Shape Biopharmaceuticals Ag | Lipopeptide building blocks and aggregates |
| CN119060144B (zh) * | 2024-10-31 | 2025-03-18 | 南京澄实生物医药科技有限公司 | 一种预防犬瘟热病毒感染的融合蛋白和疫苗及其应用 |
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| DK519188D0 (da) * | 1988-09-16 | 1988-09-16 | Statens Seruminstitut | Kemisk forbindelse |
| CA2037151A1 (en) * | 1990-03-23 | 1991-09-24 | F. Hoffmann-La Roche Ag | Plasmodium sporozoite antigen |
| IL109664A0 (en) | 1993-05-18 | 1994-08-26 | Rijksuniversiteit | Peptides of human influenza virus for use in human t cell response inducing compositions |
| JP2002523430A (ja) * | 1998-08-21 | 2002-07-30 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ リプレゼンティッド バイ ザ セクレタリー デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 熱帯熱マラリア原虫に対する組換え多価マラリアワクチン |
| NZ512456A (en) * | 1998-11-30 | 2003-10-31 | Cytos Biotechnology Ag | Ordered molecular presentation of antigens |
| US6756039B1 (en) * | 1999-05-10 | 2004-06-29 | The Regents Of The University Of California | Self assembling proteins |
| EP1191836B1 (en) * | 1999-06-25 | 2004-09-29 | Leslie H. Kondejewski | Polypeptide compositions formed using a coiled-coil template and methods of use |
| EP1303533A2 (en) * | 2000-05-05 | 2003-04-23 | Aphton Corporation | Chimeric peptide immunogens, their preparation and use |
| AU2001297913A1 (en) * | 2000-10-13 | 2002-12-23 | Ligocyte Pharmaceuticals, Inc. | Polyvalent nanoparticles |
| AU2002349204A1 (en) * | 2001-11-26 | 2003-06-10 | University Health Network | Self-assembling p53 peptides as gene delivery vehicles |
| WO2004071493A1 (en) * | 2003-02-17 | 2004-08-26 | Peter Burkhard | Peptidic nanoparticles as drug delivery and antigen display systems |
| WO2006033679A2 (en) | 2004-05-25 | 2006-03-30 | Chimeracore, Inc. | Self-assembling nanoparticle drug delivery system |
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- 2009-01-29 CA CA2713879A patent/CA2713879C/en active Active
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| US20110020378A1 (en) | 2011-01-27 |
| CN101932594A (zh) | 2010-12-29 |
| EP2235043A2 (en) | 2010-10-06 |
| WO2009109428A3 (en) | 2010-04-01 |
| JP2011511773A (ja) | 2011-04-14 |
| WO2009109428A2 (en) | 2009-09-11 |
| AU2009221419B2 (en) | 2013-09-26 |
| US8546337B2 (en) | 2013-10-01 |
| AU2009221419A1 (en) | 2009-09-11 |
| RU2540871C2 (ru) | 2015-02-10 |
| CA2713879C (en) | 2020-01-07 |
| CA2713879A1 (en) | 2009-09-11 |
| RU2010135965A (ru) | 2012-03-10 |
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