JP6088123B2 - ワクチンとして有用な自己会合ペプチドナノ粒子 - Google Patents
ワクチンとして有用な自己会合ペプチドナノ粒子 Download PDFInfo
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- JP6088123B2 JP6088123B2 JP2010544697A JP2010544697A JP6088123B2 JP 6088123 B2 JP6088123 B2 JP 6088123B2 JP 2010544697 A JP2010544697 A JP 2010544697A JP 2010544697 A JP2010544697 A JP 2010544697A JP 6088123 B2 JP6088123 B2 JP 6088123B2
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- peptide
- epitope
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/002—Protozoa antigens
- A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
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- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Genetics & Genomics (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08101221 | 2008-02-01 | ||
| EP08101221.3 | 2008-02-01 | ||
| PCT/EP2009/050996 WO2009109428A2 (en) | 2008-02-01 | 2009-01-29 | Self-assembling peptide nanoparticles useful as vaccines |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011511773A JP2011511773A (ja) | 2011-04-14 |
| JP2011511773A5 JP2011511773A5 (https=) | 2012-03-08 |
| JP6088123B2 true JP6088123B2 (ja) | 2017-03-01 |
Family
ID=39276265
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010544697A Expired - Fee Related JP6088123B2 (ja) | 2008-02-01 | 2009-01-29 | ワクチンとして有用な自己会合ペプチドナノ粒子 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8546337B2 (https=) |
| EP (1) | EP2235043A2 (https=) |
| JP (1) | JP6088123B2 (https=) |
| CN (1) | CN101932594A (https=) |
| AU (1) | AU2009221419B2 (https=) |
| CA (1) | CA2713879C (https=) |
| RU (1) | RU2540871C2 (https=) |
| WO (1) | WO2009109428A2 (https=) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007001448A2 (en) | 2004-11-04 | 2007-01-04 | Massachusetts Institute Of Technology | Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals |
| WO2007070682A2 (en) | 2005-12-15 | 2007-06-21 | Massachusetts Institute Of Technology | System for screening particles |
| CA2648099C (en) | 2006-03-31 | 2012-05-29 | The Brigham And Women's Hospital, Inc | System for targeted delivery of therapeutic agents |
| JP5630998B2 (ja) | 2006-05-15 | 2014-11-26 | マサチューセッツ インスティテュート オブ テクノロジー | 機能的粒子のためのポリマー |
| WO2007150030A2 (en) | 2006-06-23 | 2007-12-27 | Massachusetts Institute Of Technology | Microfluidic synthesis of organic nanoparticles |
| EP2134830A2 (en) | 2007-02-09 | 2009-12-23 | Massachusetts Institute of Technology | Oscillating cell culture bioreactor |
| JP2010523595A (ja) | 2007-04-04 | 2010-07-15 | マサチューセッツ インスティテュート オブ テクノロジー | ポリ(アミノ酸)ターゲッティング部分 |
| JP2011500569A (ja) | 2007-10-12 | 2011-01-06 | マサチューセッツ インスティテュート オブ テクノロジー | ワクチンナノテクノロジー |
| US20120015000A1 (en) * | 2008-06-30 | 2012-01-19 | David Lanar | Malaria vaccine of self-assembling polypeptide nanoparticles |
| US8591905B2 (en) | 2008-10-12 | 2013-11-26 | The Brigham And Women's Hospital, Inc. | Nicotine immunonanotherapeutics |
| US8343498B2 (en) | 2008-10-12 | 2013-01-01 | Massachusetts Institute Of Technology | Adjuvant incorporation in immunonanotherapeutics |
| US8343497B2 (en) | 2008-10-12 | 2013-01-01 | The Brigham And Women's Hospital, Inc. | Targeting of antigen presenting cells with immunonanotherapeutics |
| US8277812B2 (en) * | 2008-10-12 | 2012-10-02 | Massachusetts Institute Of Technology | Immunonanotherapeutics that provide IgG humoral response without T-cell antigen |
| SI2759306T1 (sl) * | 2008-12-09 | 2016-05-31 | Coley Pharmaceutical Group, Inc. | Imunostimulacijski oligonukleotidi |
| WO2010092963A1 (ja) * | 2009-02-10 | 2010-08-19 | 国立大学法人 琉球大学 | 薬物運搬体並びにこれを利用したアジュバントおよびワクチン |
| BRPI1012036A2 (pt) | 2009-05-27 | 2017-10-10 | Selecta Biosciences Inc | nanocarreadores que possuem componentes com diferentes taxas de liberação |
| ES2641892T3 (es) * | 2009-08-26 | 2017-11-14 | Selecta Biosciences, Inc. | Composiciones que inducen la ayuda de las células T |
| CN102939101A (zh) * | 2010-01-26 | 2013-02-20 | 科罗拉多大学董事会,法人 | 用于通用疫苗的流感病毒组合物和方法 |
| CA2798739A1 (en) * | 2010-05-26 | 2011-12-01 | Selecta Biosciences, Inc. | Nanocarrier compositions with uncoupled adjuvant |
| EA201390660A1 (ru) | 2010-11-05 | 2013-11-29 | Селекта Байосайенсиз, Инк. | Модифицированные никотиновые соединения и связанные способы |
| CA2833425C (en) * | 2011-04-07 | 2018-08-21 | Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Health | Protease cleavage site peptides as an hiv vaccine |
| KR20140050698A (ko) | 2011-07-29 | 2014-04-29 | 셀렉타 바이오사이언시즈, 인크. | 체액성 및 세포독성 t 림프구(ctl) 면역 반응을 발생시키는 합성 나노운반체 |
| ES2610779T3 (es) * | 2011-08-23 | 2017-05-03 | President And Fellows Of Harvard College | Nanopartículas de péptidos y usos de las mismas |
| SI23902A (sl) * | 2011-10-07 | 2013-04-30 | Kemijski inštitut | Samosestavljivi polipeptidni poliedri |
| CA2851917A1 (en) * | 2011-10-12 | 2013-04-18 | Alpha-O Peptides Ag | Self-assembling peptide nanoparticles as vaccines against infection with norovirus |
| US9550813B2 (en) | 2012-05-22 | 2017-01-24 | The Board Of Trustees Of The Leland Stanford Junior University | Disulfide stabilized foldon polypeptides |
| CN104582714A (zh) * | 2012-05-23 | 2015-04-29 | 斯坦福大学托管董事会 | 流感疫苗构建体 |
| EP2703483A1 (en) * | 2012-08-29 | 2014-03-05 | Affiris AG | PCSK9 peptide vaccine |
| EP2922570A1 (en) | 2012-11-20 | 2015-09-30 | GlaxoSmithKline Biologicals SA | Rsv f prefusion trimers |
| US10248758B2 (en) * | 2013-02-07 | 2019-04-02 | University Of Washington Through Its Center For Commercialization | Self-assembling protein nanostructures |
| JP2016532712A (ja) * | 2013-09-05 | 2016-10-20 | イミューン デザイン コーポレイション | 薬物中毒に対するワクチン組成物 |
| CN104513293A (zh) * | 2013-09-26 | 2015-04-15 | 深圳信立泰药业股份有限公司 | 一种多肽疫苗的盐及其制备方法和含有该盐的药物制品 |
| WO2015054639A1 (en) | 2013-10-11 | 2015-04-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Epstein-barr virus vaccines |
| JP6652500B2 (ja) * | 2014-01-09 | 2020-02-26 | アルファ−オ ペプティデス アクツィエンゲゼルシャフト | ワクチンプラットフォームとしてのフラジェリン含有タンパク質ナノ粒子 |
| WO2015164798A1 (en) * | 2014-04-25 | 2015-10-29 | Tria Bioscience Corp. | Synthetic hapten carrier compositions and methods |
| EP2974739A1 (en) | 2014-07-15 | 2016-01-20 | Novartis AG | RSVF trimerization domains |
| US11191727B2 (en) | 2014-12-31 | 2021-12-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Multivalent nanoparticle-based vaccines |
| EP3250233A4 (en) * | 2015-01-29 | 2018-07-25 | Agency for Science, Technology and Research | Nanocapsules carrying chikungunya-associated peptides |
| WO2016138525A1 (en) | 2015-02-27 | 2016-09-01 | University Of Washington | Polypeptide assemblies and methods for the production thereof |
| US9944679B2 (en) | 2015-03-16 | 2018-04-17 | The Catholic University Of America | Authentic trimeric HIV-1 envelope glycoproteins comprising a long linker and tag |
| WO2016207782A1 (en) * | 2015-06-22 | 2016-12-29 | STRELNIKOV, Evgeny | Immunogenic synthetic oligopeptides for a vaccine against hiv |
| CN105393976A (zh) * | 2015-10-30 | 2016-03-16 | 河南科技学院 | 一种利用ghrelin促进新生雏鸡生长性能的方法及应用 |
| CN105409831A (zh) * | 2015-10-30 | 2016-03-23 | 河南科技学院 | 一种利用ghrelin减少新生雏鸡脂肪细胞分化和降低脂肪沉积的方法及应用 |
| CN105210995A (zh) * | 2015-10-30 | 2016-01-06 | 河南科技学院 | 一种利用ghrelin促进新生雏鸡免疫器官发育的方法及应用 |
| US10188136B2 (en) | 2016-02-16 | 2019-01-29 | Indian Institute Of Science Education And Research | Hydrophobin mimics: process for preparation thereof |
| FR3050448A1 (fr) * | 2016-04-21 | 2017-10-27 | Bioaster | Nanoparticules a base d'encapsuline. |
| IL299962A (en) | 2016-05-02 | 2023-03-01 | Scripps Research Inst | Compositions and methods related to HIV-1 immunogens |
| SG10201912944QA (en) | 2016-09-02 | 2020-02-27 | The Usa As Represented By The Secretary | Stabilized group 2 influenza hemagglutinin stem region trimers and uses thereof |
| EA201991377A1 (ru) | 2017-01-03 | 2020-01-21 | Эмерджекс Ваксинс Холдинг Лимитед | Композиции универсальной вакцины против гриппа |
| WO2018154010A1 (en) | 2017-02-23 | 2018-08-30 | Alpha-O Peptides Ag | Self-assembling protein nanoparticles encapsulating immunostimulatory nucleid acids |
| EP3600402A1 (en) | 2017-03-23 | 2020-02-05 | Alpha-O Peptides AG | Self-assembling protein nanoparticles with built-in six-helix bundle proteins |
| WO2019023811A1 (en) | 2017-08-04 | 2019-02-07 | The Hospital For Sick Children | NANOPARTICLE PLATFORM FOR ANTIBODY AND VACCINE DELIVERY |
| US12459965B2 (en) | 2017-10-09 | 2025-11-04 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| AU2018358238B2 (en) * | 2017-11-01 | 2022-08-18 | The Scripps Research Institute | Novel scaffolded HIV-1 vaccine immunogens |
| JP7314441B2 (ja) * | 2018-01-22 | 2023-07-26 | 国立感染症研究所長 | 選択的cd8陽性t細胞誘導ワクチン抗原 |
| US11225502B1 (en) * | 2018-06-11 | 2022-01-18 | Battelle Memorial Institute | Controlled synthesis of hierarchically-structured hybrid materials through peptoid engineering |
| WO2019241483A1 (en) | 2018-06-13 | 2019-12-19 | The Scripps Research Institute | Nanoparticle vaccines with novel structural components |
| US11213582B2 (en) * | 2018-08-08 | 2022-01-04 | The Regents Of The University Of California | Protection against recurrent genital herpes by therapeutic immunization with herpes simplex virus type 2 ribonucleotide reductase protein subunits |
| RU2713723C1 (ru) * | 2018-11-15 | 2020-02-06 | Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) | Искусственные гены, кодирующие белки-иммуногены EV.CTL и EV.Th, рекомбинантные плазмидные ДНК pEV.CTL и pEV.Th, обеспечивающие экспрессию искусственных генов, и искусственные Т-клеточные полиэпитопные белки-иммуногены EV.CTL и EV.Th, содержащие эпитопы антигенов вируса Эбола, используемые для создания вакцины против вируса Эбола |
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| CN111150841B (zh) * | 2019-12-31 | 2023-08-15 | 优锐生物医药科技(深圳)有限公司 | 一种主动免疫调控微粒及其制备方法和应用 |
| CN111150842B (zh) * | 2019-12-31 | 2023-09-05 | 优锐生物医药科技(深圳)有限公司 | 一种用于中和胃泌素的主动免疫调控微粒及其制备方法和应用 |
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| CN119060144B (zh) * | 2024-10-31 | 2025-03-18 | 南京澄实生物医药科技有限公司 | 一种预防犬瘟热病毒感染的融合蛋白和疫苗及其应用 |
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| DK519188D0 (da) * | 1988-09-16 | 1988-09-16 | Statens Seruminstitut | Kemisk forbindelse |
| CA2037151A1 (en) * | 1990-03-23 | 1991-09-24 | F. Hoffmann-La Roche Ag | Plasmodium sporozoite antigen |
| IL109664A0 (en) * | 1993-05-18 | 1994-08-26 | Rijksuniversiteit | Peptides of human influenza virus for use in human t cell response inducing compositions |
| CA2337754C (en) * | 1998-08-21 | 2011-05-24 | Altaf A. Lal | Recombinant multivalent malarial vaccine against plasmodium falciparum |
| MXPA01005389A (es) * | 1998-11-30 | 2003-03-27 | Cytos Biotechnology Ag | Presentacion molecular ordenada de antigenos, metodos de preparacion y uso. |
| US6756039B1 (en) * | 1999-05-10 | 2004-06-29 | The Regents Of The University Of California | Self assembling proteins |
| WO2001000010A1 (en) * | 1999-06-25 | 2001-01-04 | Kondejewski Leslie H | Polypeptide compositions formed using a coiled-coil template and methods of use |
| JP2003532740A (ja) * | 2000-05-05 | 2003-11-05 | アフトン コーポレーション | キメラペプチド免疫原 |
| WO2002100325A2 (en) * | 2000-10-13 | 2002-12-19 | Ligocyte Pharmaceuticals, Inc. | Polyvalent nanoparticles |
| AU2002349204A1 (en) * | 2001-11-26 | 2003-06-10 | University Health Network | Self-assembling p53 peptides as gene delivery vehicles |
| DE602004008582T2 (de) * | 2003-02-17 | 2008-05-21 | Peter Burkhard | Peptidische nanoteilchen als arzneimittelabgabe- und antigen-display-systeme |
| EP1773303A2 (en) * | 2004-05-25 | 2007-04-18 | Chimeracore, Inc. | Self-assembling nanoparticle drug delivery system |
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2009
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- 2009-01-29 CN CN2009801037674A patent/CN101932594A/zh active Pending
- 2009-01-29 US US12/864,576 patent/US8546337B2/en active Active
- 2009-01-29 JP JP2010544697A patent/JP6088123B2/ja not_active Expired - Fee Related
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| EP2235043A2 (en) | 2010-10-06 |
| RU2010135965A (ru) | 2012-03-10 |
| US8546337B2 (en) | 2013-10-01 |
| CA2713879C (en) | 2020-01-07 |
| WO2009109428A3 (en) | 2010-04-01 |
| WO2009109428A2 (en) | 2009-09-11 |
| AU2009221419B2 (en) | 2013-09-26 |
| CN101932594A (zh) | 2010-12-29 |
| JP2011511773A (ja) | 2011-04-14 |
| AU2009221419A1 (en) | 2009-09-11 |
| US20110020378A1 (en) | 2011-01-27 |
| CA2713879A1 (en) | 2009-09-11 |
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