EA201991918A1 - Самосборные белковые наночастицы со встроенными белками с шестиспиральным пучком - Google Patents

Самосборные белковые наночастицы со встроенными белками с шестиспиральным пучком

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Publication number
EA201991918A1
EA201991918A1 EA201991918A EA201991918A EA201991918A1 EA 201991918 A1 EA201991918 A1 EA 201991918A1 EA 201991918 A EA201991918 A EA 201991918A EA 201991918 A EA201991918 A EA 201991918A EA 201991918 A1 EA201991918 A1 EA 201991918A1
Authority
EA
Eurasian Patent Office
Prior art keywords
self
protein nanoparticles
proteins
hexiral
assembly protein
Prior art date
Application number
EA201991918A
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English (en)
Inventor
Кэролайн Кулангара
Сара Мария Паулильо
Маттео Пьяцца
Сентил Кумар Раман
Питер Буркхард
Original Assignee
Альфа-О Пептидс Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Альфа-О Пептидс Аг filed Critical Альфа-О Пептидс Аг
Publication of EA201991918A1 publication Critical patent/EA201991918A1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/21—Retroviridae, e.g. equine infectious anemia virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

В настоящем изобретении предложены самосборные белковые наночастицы со встроенными белками с шестиспиральным пучком. Белки или пептиды, содержащие петлевую область, стабилизированы путем их присоединения к белкам с шестиспиральным пучком (six-helix bundle, SHB) и их интеграции в самосборные белковые наночастицы (self-assembling protein nanoparticles, SAPN).
EA201991918A 2017-03-23 2018-03-22 Самосборные белковые наночастицы со встроенными белками с шестиспиральным пучком EA201991918A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17162540 2017-03-23
PCT/EP2018/057264 WO2018172447A1 (en) 2017-03-23 2018-03-22 Self-assembling protein nanoparticles with built-in six-helix bundle proteins

Publications (1)

Publication Number Publication Date
EA201991918A1 true EA201991918A1 (ru) 2020-05-15

Family

ID=58536715

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201991918A EA201991918A1 (ru) 2017-03-23 2018-03-22 Самосборные белковые наночастицы со встроенными белками с шестиспиральным пучком

Country Status (8)

Country Link
US (2) US20200017554A1 (ru)
EP (1) EP3600402A1 (ru)
JP (1) JP2020514382A (ru)
CN (1) CN110996995A (ru)
AU (2) AU2018238522A1 (ru)
CA (1) CA3056017A1 (ru)
EA (1) EA201991918A1 (ru)
WO (1) WO2018172447A1 (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA202092808A1 (ru) * 2018-06-13 2021-08-24 Зе Скриппс Рисёрч Инститьют Вакцины на основе наночастиц с новыми структурными компонентами
US11213582B2 (en) 2018-08-08 2022-01-04 The Regents Of The University Of California Protection against recurrent genital herpes by therapeutic immunization with herpes simplex virus type 2 ribonucleotide reductase protein subunits
KR20220004115A (ko) * 2019-04-25 2022-01-11 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 항체로 장식된 자가-조립 단백질 나노케이지(sapna) 및 이의 일부
CN110128510B (zh) * 2019-05-22 2021-02-26 中国人民解放军军事科学院军事医学研究院 MERS-CoV融合抑制剂
US11911482B2 (en) 2020-08-25 2024-02-27 The Regents Of The University Of California Self assembling protein nanoparticles as carrier molecules
CN114292314B (zh) * 2022-01-05 2022-08-09 武汉科前生物股份有限公司 一种鞭毛素突变体及其在制备非洲猪瘟抗原融合蛋白中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2581394B1 (fr) 1985-05-02 1988-08-05 Grp Genie Genetique Particules ayant les proprietes immunogenes de l'antigene hbs et portant un site antigenique etranger aux epitopes portes par l'antigene hbs, vecteurs et cellules animales pour la production de telles particules et compositions contenant de telles particules pour la production de vaccins mixtes
JP4085231B2 (ja) 2000-02-28 2008-05-14 株式会社ビークル タンパク質中空ナノ粒子とそれを用いた物質運搬体、ならびに細胞への物質導入方法
EP1594469B1 (en) 2003-02-17 2007-08-29 Peter Burkhard Peptidic nanoparticles as drug delivery and antigen display systems
CA2713879C (en) 2008-02-01 2020-01-07 Alpha-O Peptides Ag Self-assembling peptide nanoparticles useful as vaccines
WO2013044203A2 (en) * 2011-09-23 2013-03-28 THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPTARTMENT OF HEALTH & HUMAN SERVICES Novel influenza hemagglutinin protein-based vaccines
IN2014CN03364A (ru) * 2011-10-12 2015-09-04 Alpha O Peptides Ag
CN104853769A (zh) * 2012-11-20 2015-08-19 葛兰素史密丝克莱恩生物有限公司 Rsv f融合前三聚体
AU2015205567B2 (en) * 2014-01-09 2019-04-04 Alpha-O Peptides Ag Flagellin-containing protein nanoparticles as a vaccine platform

Also Published As

Publication number Publication date
WO2018172447A1 (en) 2018-09-27
US20230340031A1 (en) 2023-10-26
AU2022203647A1 (en) 2022-06-16
CN110996995A (zh) 2020-04-10
JP2020514382A (ja) 2020-05-21
US20200017554A1 (en) 2020-01-16
EP3600402A1 (en) 2020-02-05
AU2018238522A1 (en) 2019-10-03
CA3056017A1 (en) 2018-09-27

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