EA202092808A1 - Вакцины на основе наночастиц с новыми структурными компонентами - Google Patents

Вакцины на основе наночастиц с новыми структурными компонентами

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Publication number
EA202092808A1
EA202092808A1 EA202092808A EA202092808A EA202092808A1 EA 202092808 A1 EA202092808 A1 EA 202092808A1 EA 202092808 A EA202092808 A EA 202092808A EA 202092808 A EA202092808 A EA 202092808A EA 202092808 A1 EA202092808 A1 EA 202092808A1
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EA
Eurasian Patent Office
Prior art keywords
nanoparticles
vaccine compositions
structural components
immunogens
new structural
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EA202092808A
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English (en)
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Линьлин Хэ
Цзян Чжу
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Зе Скриппс Рисёрч Инститьют
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Publication of EA202092808A1 publication Critical patent/EA202092808A1/ru

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    • A61K39/12—Viral antigens
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
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    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
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Abstract

Изобретение обеспечивает новые представленные на наночастицах композиции вакцины, стабилизированные с помощью сцепляющего домена. Для получения указанных композиций вакцины можно применять различные иммуногены, включая вирусные иммуногены, такие как иммуногены вирусов ВИЧ-1 и Эбола, и невирусные иммуногены, такие как иммуногены, происходящие из видов бактерий, паразитов и млекопитающих. Изобретение также обеспечивает способы применения таких композиций вакцины в различных терапевтических приложениях, например, для предотвращения или лечения вирусных инфекций.
EA202092808A 2018-06-13 2019-06-13 Вакцины на основе наночастиц с новыми структурными компонентами EA202092808A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862684229P 2018-06-13 2018-06-13
PCT/US2019/036917 WO2019241483A1 (en) 2018-06-13 2019-06-13 Nanoparticle vaccines with novel structural components

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EA202092808A1 true EA202092808A1 (ru) 2021-08-24

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US (2) US11097002B2 (ru)
EP (1) EP3807210A4 (ru)
JP (1) JP2021527077A (ru)
KR (1) KR20210021530A (ru)
CN (1) CN112469661B (ru)
AU (1) AU2019285048B2 (ru)
CA (1) CA3103460A1 (ru)
EA (1) EA202092808A1 (ru)
IL (1) IL279351A (ru)
SG (1) SG11202012313PA (ru)
WO (1) WO2019241483A1 (ru)
ZA (1) ZA202100032B (ru)

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WO2021249116A1 (en) 2020-06-10 2021-12-16 Sichuan Clover Biopharmaceuticals, Inc. Coronavirus vaccine compositions, methods, and uses thereof
WO2021262625A1 (en) * 2020-06-24 2021-12-30 Avalon GloboCare Corp. S-layer vaccine fusion proteins and methods of use
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